The epidermal growth factor receptor(EGFR)is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses.This review explores the function of EGFR in kidney physiology and its ...The epidermal growth factor receptor(EGFR)is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses.This review explores the function of EGFR in kidney physiology and its implications for various kidney diseases.EGFR signaling is essential for kidney function and repair mechanisms,and its dysregulation significantly impacts both acute and chronic kidney conditions.The review discusses the normal distribution of EGFR in kidney tubular segments,the mechanism of its activation and inhibition,and the therapeutic potential of EGFR-targeting antagonists and ligands.Additionally,it explores the pathophysiological characteristics observed in rodent models of kidney diseases through pharmacological and genetic inhibition of EGFR,highlighting therapeutic challenges and limitations such as species differences,variability in disease models,and potential adverse effects.Overall,the findings underscore the multifaceted role of EGFR in kidney diseases,influencing inflammation,fibrosis,and tissue injury.This complex involvement suggests that targeting EGFR may be a beneficial therapeutic strategy for managing these conditions,potentially mitigating inflammation and fibrosis while promoting tissue repair.展开更多
Kidney-tonifying recipe can reduce the accumulation of advanced glycation end products, prevent neuronal degeneration and improve cognitive functions in ovariectomized rats. Radix Achyranthis Bidentatae alcohol extrac...Kidney-tonifying recipe can reduce the accumulation of advanced glycation end products, prevent neuronal degeneration and improve cognitive functions in ovariectomized rats. Radix Achyranthis Bidentatae alcohol extracts may dose-dependently inhibit non-enzymatic saccharification in vitro. This study aimed to examine the effect of Radix Achyranthis Bidentatae on advanced glycation end products and on learning and memory capabilities in ovariectomized rats. Ovariectomized rats were treated with Radix Achyranthis Bidentatae alcohol extracts （containing 1.5 g/kg crude drug） or 0.1% aminoguanidine for 12 weeks and behavioral testing was performed with the Y-electrical maze. This test revealed that Radix Achyranthis Bidentatae and aminoguanidine could improve the learning and memory capabilities of ovariectomized rats. Results of competitive enzyme-linked immunosorbent assay showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine reduced the accumulation of advanced glycation end products in the frontal cortex of ovariectomized rats, while increasing content in the blood and urine. Biochemical tests showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine decreased superoxide dismutase activity in the serum and frontal cortex, and increased serum levels of glutathione peroxidase in ovariectomized rats. In addition there was no apparent effect on malondialdehyde levels. These experimental findings indicate that Radix Achyranthis Bidentatae inhibits production of advanced glycation end products and its accumulation in brain tissue, and improves learning and memory capabilities in ovariectomized rats. These effects may be associated with an anti-oxidative action of the extract.展开更多
The exfoliation of bulk graphitic carbon nitride(g-C_(3)N_(4))into monolayer has been intensively studied to induce maximum sur-face area for fundamental studies,but ended in failure to realize chemi-cally and physica...The exfoliation of bulk graphitic carbon nitride(g-C_(3)N_(4))into monolayer has been intensively studied to induce maximum sur-face area for fundamental studies,but ended in failure to realize chemi-cally and physically well-defined monolayer of g-C_(3)N_(4)mostly due to the difficulty in reducing the layer thickness down to an atomic level.It has,therefore,remained as a challenging issue in two-dimensional(2D)chemistry and physics communities.In this study,an“atomic monolayer of g-C_(3)N_(4)with perfect two-dimensional limit”was successfully prepared by the chemically well-defined two-step routes.The atomically resolved monolayer of g-C_(3)N_(4)was also confirmed by spectroscopic and micro-scopic analyses.In addition,the experimental Cs-HRTEM image was collected,for the first time,which was in excellent agreement with the theoretically simulated;the evidence of monolayer of g-C_(3)N_(4)in the perfect 2D limit becomes now clear from the HRTEM image of orderly hexagonal symmetry with a cavity formed by encirclement of three adjacent heptazine units.Compared to bulk g-C_(3)N_(4),the present g-C_(3)N_(4)monolayer showed significantly higher photocatalytic gen-eration of H2O2 and H2,and electrocatalytic oxygen reduction reaction.In addition,its photocatalytic efficiency for H2O2 production was found to be the best for any known g-C_(3)N_(4)nanomaterials,underscoring the remarkable advantage of monolayer formation in optimizing the catalyst performance of g-C_(3)N_(4).展开更多
Intestinal duplications are rare congenital anomalies that can occur anywhere in the gastrointestinal tract.They are most commonly located in the ileum and are usually detected in infancy or early childhood.Duplicated...Intestinal duplications are rare congenital anomalies that can occur anywhere in the gastrointestinal tract.They are most commonly located in the ileum and are usually detected in infancy or early childhood.Duplicated segments are usually firmly attached to and sometimes communicate with the normal gastrointestinal tract.Rarely,intestinal duplications are completely isolated,thus not associated at all with any part of the gastrointestinal tract.Such duplications do not share a common blood supply with the adjacent normal intestinal segment,unlike the usual form of duplication,but rather have a separate vascular pedicle.Reports of completely isolated duplication cysts in adults are extremely rare;we found only five such reports in the English-language medical literature.Here,we report a case of a completely isolated duplication cyst 12 cm long in an adult female.The cyst had no connection to any part of the intestinal tract and had a dedicated vascular pedicle.展开更多
Ephexin-1 functions as guanine nucleotide exchange factors for the Rho-type GTPases which have important roles in neuronal development including axon guidance, migration, morphogenesis, and plasticity of neurons. As l...Ephexin-1 functions as guanine nucleotide exchange factors for the Rho-type GTPases which have important roles in neuronal development including axon guidance, migration, morphogenesis, and plasticity of neurons. As little is known about ephexin-1 in the cerebellum, we investigated the immunolocalization of ephexin-1 in the developing canine cerebellum. While the cellular maturation was followed by the temporal pattern, the calbindin D-28k and ephexin-1 immunoreactivities gradually increased in developing canine cerebellum. When compared to the calbindin D-28k immunoreactivities, belated ephexin-1 immunolocalization was observed in the Purkinje cells which aligned a single layer during cerebellar development. These results suggest that ephexin-1 might play an important role in the development of the Purkinje cells during the first two postnatal weeks based on its immunolocalization in the present study.展开更多
Oxidation of lipids in various products,along with the growth of medically important pathogens,has led to a search for medicinal plants with antioxidant and antimicrobial activities.As a result,the aim of this study w...Oxidation of lipids in various products,along with the growth of medically important pathogens,has led to a search for medicinal plants with antioxidant and antimicrobial activities.As a result,the aim of this study was to evaluate the antioxidant and antibacterial activity of the essential oil of Eucalyptus globulus(EO-Eg).Antioxidant activity was assessed by using the 2,2-diphenyl-1-picrylhydrazyl hydrate(DPPH)assay method.Existing components were identified through gas chromatography-mass spectrometry(GC-MS)analysis.Antibacterial activity and minimum inhibitory concentration(MIC)were assessed by using the broth microdilution method with standard multidrug-resistant bacterial strains.The main EO-Eg compounds identified by GC-MS were isopulegol,citronellal,and citronellol,which are primarily used in the industrial sectors.EO-Eg demonstrated excellent antioxidant activity with an effective concentration(EC50)of 4.48μL/mL owing to the presence of phenolic compounds.Regarding antibacterial activity,the EO-Eg displayed a broad antimicrobial spectrum of antimicrobial activity across the different resistance phenotypes analyzed.The most notable antibacterial activity was observed against Staphylococcus aureus 169 MRSA(MIC=0.0625%).As a result,our findings suggest that EO-Eg has antioxidant and antibacterial potential against hospital-acquired multidrug-resistant pathogens,which may be correlated with its major components.展开更多
Energy harvesting was demonstrated in hydrothermal PZT nanocrystal films driven by ultra-sound.With high temperature sintering and solution infiltration,PZT films with nanograin sizewas found to exhibit bulk-like prop...Energy harvesting was demonstrated in hydrothermal PZT nanocrystal films driven by ultra-sound.With high temperature sintering and solution infiltration,PZT films with nanograin sizewas found to exhibit bulk-like properties such as large remnant polarization of 42μC/cm^(2).Withthe bulk-like properties,a packaged PZT film device was demonstrated to be capable of convertingmechanical energy carried by the ultrasonic wave into electrical energy in a reliable and efficient way.The result suggests an alternative potential solution for energy harvesting application.展开更多
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)and funded by the Ministry of Education(2021R1I1A3056002,to Jinu Kim,RS-2023-00274853,to Daeun MOON).
文摘The epidermal growth factor receptor(EGFR)is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses.This review explores the function of EGFR in kidney physiology and its implications for various kidney diseases.EGFR signaling is essential for kidney function and repair mechanisms,and its dysregulation significantly impacts both acute and chronic kidney conditions.The review discusses the normal distribution of EGFR in kidney tubular segments,the mechanism of its activation and inhibition,and the therapeutic potential of EGFR-targeting antagonists and ligands.Additionally,it explores the pathophysiological characteristics observed in rodent models of kidney diseases through pharmacological and genetic inhibition of EGFR,highlighting therapeutic challenges and limitations such as species differences,variability in disease models,and potential adverse effects.Overall,the findings underscore the multifaceted role of EGFR in kidney diseases,influencing inflammation,fibrosis,and tissue injury.This complex involvement suggests that targeting EGFR may be a beneficial therapeutic strategy for managing these conditions,potentially mitigating inflammation and fibrosis while promoting tissue repair.
基金financially supported by the National Science and Technology Major Project for New Drug Creation Program by the Ministry of Science and Technology No.2009ZX09502-014
文摘Kidney-tonifying recipe can reduce the accumulation of advanced glycation end products, prevent neuronal degeneration and improve cognitive functions in ovariectomized rats. Radix Achyranthis Bidentatae alcohol extracts may dose-dependently inhibit non-enzymatic saccharification in vitro. This study aimed to examine the effect of Radix Achyranthis Bidentatae on advanced glycation end products and on learning and memory capabilities in ovariectomized rats. Ovariectomized rats were treated with Radix Achyranthis Bidentatae alcohol extracts （containing 1.5 g/kg crude drug） or 0.1% aminoguanidine for 12 weeks and behavioral testing was performed with the Y-electrical maze. This test revealed that Radix Achyranthis Bidentatae and aminoguanidine could improve the learning and memory capabilities of ovariectomized rats. Results of competitive enzyme-linked immunosorbent assay showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine reduced the accumulation of advanced glycation end products in the frontal cortex of ovariectomized rats, while increasing content in the blood and urine. Biochemical tests showed that treatment with Radix Achyranthis Bidentatae or aminoguanidine decreased superoxide dismutase activity in the serum and frontal cortex, and increased serum levels of glutathione peroxidase in ovariectomized rats. In addition there was no apparent effect on malondialdehyde levels. These experimental findings indicate that Radix Achyranthis Bidentatae inhibits production of advanced glycation end products and its accumulation in brain tissue, and improves learning and memory capabilities in ovariectomized rats. These effects may be associated with an anti-oxidative action of the extract.
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2020R1I1A1A01072161)and under the framework of the International Cooperation Program managed by NRF(No.2017K2A9A2A10013104)supported by the NRF grant funded by the Korea government(MSIP)(No.NRF-2020R1A2C3008671).
文摘The exfoliation of bulk graphitic carbon nitride(g-C_(3)N_(4))into monolayer has been intensively studied to induce maximum sur-face area for fundamental studies,but ended in failure to realize chemi-cally and physically well-defined monolayer of g-C_(3)N_(4)mostly due to the difficulty in reducing the layer thickness down to an atomic level.It has,therefore,remained as a challenging issue in two-dimensional(2D)chemistry and physics communities.In this study,an“atomic monolayer of g-C_(3)N_(4)with perfect two-dimensional limit”was successfully prepared by the chemically well-defined two-step routes.The atomically resolved monolayer of g-C_(3)N_(4)was also confirmed by spectroscopic and micro-scopic analyses.In addition,the experimental Cs-HRTEM image was collected,for the first time,which was in excellent agreement with the theoretically simulated;the evidence of monolayer of g-C_(3)N_(4)in the perfect 2D limit becomes now clear from the HRTEM image of orderly hexagonal symmetry with a cavity formed by encirclement of three adjacent heptazine units.Compared to bulk g-C_(3)N_(4),the present g-C_(3)N_(4)monolayer showed significantly higher photocatalytic gen-eration of H2O2 and H2,and electrocatalytic oxygen reduction reaction.In addition,its photocatalytic efficiency for H2O2 production was found to be the best for any known g-C_(3)N_(4)nanomaterials,underscoring the remarkable advantage of monolayer formation in optimizing the catalyst performance of g-C_(3)N_(4).
基金Supported by The 2013 scientific promotion program funded by Jeju National UniversityNo.2013-0237
文摘Intestinal duplications are rare congenital anomalies that can occur anywhere in the gastrointestinal tract.They are most commonly located in the ileum and are usually detected in infancy or early childhood.Duplicated segments are usually firmly attached to and sometimes communicate with the normal gastrointestinal tract.Rarely,intestinal duplications are completely isolated,thus not associated at all with any part of the gastrointestinal tract.Such duplications do not share a common blood supply with the adjacent normal intestinal segment,unlike the usual form of duplication,but rather have a separate vascular pedicle.Reports of completely isolated duplication cysts in adults are extremely rare;we found only five such reports in the English-language medical literature.Here,we report a case of a completely isolated duplication cyst 12 cm long in an adult female.The cyst had no connection to any part of the intestinal tract and had a dedicated vascular pedicle.
文摘Ephexin-1 functions as guanine nucleotide exchange factors for the Rho-type GTPases which have important roles in neuronal development including axon guidance, migration, morphogenesis, and plasticity of neurons. As little is known about ephexin-1 in the cerebellum, we investigated the immunolocalization of ephexin-1 in the developing canine cerebellum. While the cellular maturation was followed by the temporal pattern, the calbindin D-28k and ephexin-1 immunoreactivities gradually increased in developing canine cerebellum. When compared to the calbindin D-28k immunoreactivities, belated ephexin-1 immunolocalization was observed in the Purkinje cells which aligned a single layer during cerebellar development. These results suggest that ephexin-1 might play an important role in the development of the Purkinje cells during the first two postnatal weeks based on its immunolocalization in the present study.
文摘Oxidation of lipids in various products,along with the growth of medically important pathogens,has led to a search for medicinal plants with antioxidant and antimicrobial activities.As a result,the aim of this study was to evaluate the antioxidant and antibacterial activity of the essential oil of Eucalyptus globulus(EO-Eg).Antioxidant activity was assessed by using the 2,2-diphenyl-1-picrylhydrazyl hydrate(DPPH)assay method.Existing components were identified through gas chromatography-mass spectrometry(GC-MS)analysis.Antibacterial activity and minimum inhibitory concentration(MIC)were assessed by using the broth microdilution method with standard multidrug-resistant bacterial strains.The main EO-Eg compounds identified by GC-MS were isopulegol,citronellal,and citronellol,which are primarily used in the industrial sectors.EO-Eg demonstrated excellent antioxidant activity with an effective concentration(EC50)of 4.48μL/mL owing to the presence of phenolic compounds.Regarding antibacterial activity,the EO-Eg displayed a broad antimicrobial spectrum of antimicrobial activity across the different resistance phenotypes analyzed.The most notable antibacterial activity was observed against Staphylococcus aureus 169 MRSA(MIC=0.0625%).As a result,our findings suggest that EO-Eg has antioxidant and antibacterial potential against hospital-acquired multidrug-resistant pathogens,which may be correlated with its major components.
文摘Energy harvesting was demonstrated in hydrothermal PZT nanocrystal films driven by ultra-sound.With high temperature sintering and solution infiltration,PZT films with nanograin sizewas found to exhibit bulk-like properties such as large remnant polarization of 42μC/cm^(2).Withthe bulk-like properties,a packaged PZT film device was demonstrated to be capable of convertingmechanical energy carried by the ultrasonic wave into electrical energy in a reliable and efficient way.The result suggests an alternative potential solution for energy harvesting application.
