The increasing occurrence of corrosion-related damage in steel pipelines has led to the growing use of composite-based repair techniques as an efficient alternative to traditional replacement methods.Computer modeling...The increasing occurrence of corrosion-related damage in steel pipelines has led to the growing use of composite-based repair techniques as an efficient alternative to traditional replacement methods.Computer modeling and structural analysis were performed for the repair reinforcement of a steel pipeline with a composite bandage.A preliminary analysis of possible contact interaction schemes was implemented based on the theory of cylindrical shells,taking into account transverse shear deformations.The finite element method was used for a detailed study of the stress state of the composite bandage and the reinforced section of the pipeline.The limit state of the reinforced section was assessed based on the von Mises criterion for steel and the Tsai-Wu criterion for composites.The effectiveness of the repair was demonstrated on a pipeline whose wall thickness had decreased by 20%as a result of corrosion damage.At a nominal pressure of P=6 MPa,the maximum normal stress in the weakened area reached 381 MPa.The installation of a composite bandage reduced this stress to 312 MPa,making the repaired section virtually as strong as the undamaged pipeline.Due to the linearity of the problem,the results obtained can be easily used to find critical internal pressure values.展开更多
The COVID-19 pandemic caused significant disruptions in the healthcare system,affecting vaccinations and the management of diphtheria cases.As a consequence of these disruptions,numerous countries have experienced a r...The COVID-19 pandemic caused significant disruptions in the healthcare system,affecting vaccinations and the management of diphtheria cases.As a consequence of these disruptions,numerous countries have experienced a resurgence or an increase in diphtheria cases.West Java province in Indonesia is identified as one of the high-risk areas for diphtheria,experiencing an upward trend in cases from 2021 to 2023.To analyze the situation,we developed an SIR model,which integrated DPT and booster vaccinations to determine the basic reproduction number,an essential parameter for infectious diseases.Through spatial analysis of geo-referenced data,we identified hotspots and explained diffusion in diphtheria case clusters.The calculation of R0 resulted in an R0=1.17,indicating the potential for a diphtheria outbreak in West Java.To control the increasing cases,one possible approach is to raise the booster vaccination coverage from the current 64.84%to 75.15%,as suggested by simulation results.Furthermore,the spatial analysis revealed that hot spot clusters were present in the western,central,and southern regions,posing a high risk not only in densely populated areas but also in rural regions.The diffusion pattern of diphtheria clusters displayed an expansion-contagious pattern.Understanding the rising trend of diphtheria cases and their geographic distribution can offer crucial insights for government and health authorities to manage the number of diphtheria cases and make informed decisions regarding the best prevention and intervention strategies.展开更多
In light of the pressing global challenges of climate change,declining crop resilience,and hidden hunger,it is imperative to overcome the limitations of conventional crop breeding to enhance both the nutritional quali...In light of the pressing global challenges of climate change,declining crop resilience,and hidden hunger,it is imperative to overcome the limitations of conventional crop breeding to enhance both the nutritional quality and stress tolerance of crops.Synthetic metabolic engineering presents innovative strategies for the precision modification and de novo design of metabolic pathways.This approach generally encompasses three essential steps:identifying key metabolites through metabolomics,integrating multi-omics technologies to investigate the synthesis and regulation of these metabolites,and utilizing gene editing or de novo design to modify crop metabolic pathways associated with desirable agronomic traits.This review underscores the vital role of plant metabolite diversity in enhancing crop nutritional quality and stress resilience.Integrated multi-omics analyses facilitate the metabolic engineering by identifying key genes,transporters,and transcription factors that regulate metabolite biosynthesis.Precision modification strategies employ genome editing tools to reprogram endogenous metabolic networks,while de novo design reconstructs metabolic pathways through the introduction of exogenous biological elements—thereby both approaches enable the targeted enhancement of desired traits.These strategies have been effectively implemented in major food crops.However,simultaneously enhancing nutritional quality and stress resilience remains challenging due to inherent trade-offs and resource competition in distinct metabolic pathways within plants.Future research should integrate AI-driven predictive models with multi-omics datasets to decipher dynamic metabolic homeostasis and engineer climate-smart crops that maximize yield while preserving quality and environmental adaptability.展开更多
In this research,the three-dimensional(3D)steady and incompressible laminar Homann stagnation point nanofluid flow over a porous moving surface is addressed.The disturbance in the porous medium has been characterized ...In this research,the three-dimensional(3D)steady and incompressible laminar Homann stagnation point nanofluid flow over a porous moving surface is addressed.The disturbance in the porous medium has been characterized by the Darcy-Forchheimer relation.The slip for viscous fluid is considered.The energy equation is organized in view of radiative heat flux which plays an important role in the heat transfer rate.The governing flow expressions are first altered into first-order ordinary ones and then solved numerically by the shooting method.Dual solutions are obtained for the velocity,skin friction coefficient,temperature,and Nusselt number subject to sundry flow parameters,magnetic parameter,Darcy-Forchheimer number,thermal radiation parameter,suction parameter,and dimensionless slip parameter.In this research,the main consideration is given to the engineering interest like skin friction coefficient(velocity gradient or surface drag force)and Nusselt number(temperature gradient or heat transfer rate)and discussed numerically through tables.In conclusion,it is noticed from the stability results that the upper branch solution(UBS)is more reliable and physically stable than the lower branch solution(LBS).展开更多
The Funding information section was missing from this arti-cle and should have read'The research is partially funded by the Ministry of Science and Higher Education of the Russian Federation as part of World-class...The Funding information section was missing from this arti-cle and should have read'The research is partially funded by the Ministry of Science and Higher Education of the Russian Federation as part of World-class Research Center program:Advanced Digital Technologies(contract No.075–15–2020–903 dated 16.11.2020)'.The original article has been corrected.展开更多
A nonlinear mathematical model of the injection molding process for electrohydraulic servo injection molding machine (IMM) is developed.It was found necessary to consider the characteristics of asymmetric cylinder for...A nonlinear mathematical model of the injection molding process for electrohydraulic servo injection molding machine (IMM) is developed.It was found necessary to consider the characteristics of asymmetric cylinder for electrohydraulic servo IMM.The model is based on the dynamics of the machine including servo valve,asymmetric cylinder and screw,and the non-Newtonian flow behavior of polymer melt in injection molding is also considered.The performance of the model was evaluated based on novel approach of molding - injection and compress molding,and the results of simulation and experimental data demonstrate the effectiveness of the model.展开更多
This paper discusses mathematical modeling of a ship equipped with energy-saving wing devices.Therewith,the ship is mathematically represented by an elongated hull with high-aspect-ratio wings mounted near its bow and...This paper discusses mathematical modeling of a ship equipped with energy-saving wing devices.Therewith,the ship is mathematically represented by an elongated hull with high-aspect-ratio wings mounted near its bow and stern.Equations,describing ship motions in regular oncoming waves,are written in the spirit of strip theory with account of inertial and damping influence of energy-saving wing elements with the use of linear expansion of wing-related forces with respect to heave and pitch perturbations.This approach readily yields fast numerical solutions for the propulsion of a ship with wings in waves.The latter solutions are then used as an input for calculation of thrust on wing elements on the basis of classical unsteady foil theories corrected for finite aspect ratio.To evaluate speed of the ship in the modes which allow cruising exclusively by wave power,it is hypothetically assumed that in this case,the wave-generated thrust on the wings equals total drag of the ship-plus-wings system,the latter being defined as a sum of its viscous,wave-making,induced(for wing elements)and added-wave components.Excepting the added-wave term and wings’contributions,the total drag is calculated herein by Holtrop method whereas added-wave resistance is evaluated with Beukelman-Gerritsma formula involving kinematic parameters of heaving and pitching motions of the ship calculated both without and with account of the wings.Also discussed in the paper is a decrease of added wave resistance for a ship with wings as compared to that of ship without wings.Finally,the energy efficiency design index(EEDI)introduced by the International Maritime Organization(IMO)is discussed for representative sea conditions as a measure of ship environmental friendliness.展开更多
The prime objective of the present communication is to examine the entropy-optimized second order velocity slip Darcy–Forchheimer hybrid nanofluid flow of viscous material between two rotating disks.Electrical conduc...The prime objective of the present communication is to examine the entropy-optimized second order velocity slip Darcy–Forchheimer hybrid nanofluid flow of viscous material between two rotating disks.Electrical conducting flow is considered and saturated through Darcy–Forchheimer relation.Both the disks are rotating with different angular frequencies and stretches with different rates.Here graphene oxide and titanium dioxide are considered for hybrid nanoparticles and water as a continuous phase liquid.Joule heating,heat generation/absorption and viscous dissipation effects are incorporated in the mathematical modeling of energy expression.Furthermore,binary chemical reaction with activation energy is considered.The total entropy rate is calculated in the presence of heat transfer irreversibility,fluid friction irreversibility,Joule heating irreversibility,porosity irreversibility and chemical reaction irreversibility through thermodynamics second law.The nonlinear governing equations are first converted into ordinary differential equations through implementation of appropriate similarity transformations and then numerical solutions are calculated through Built-in-Shooting method.Characteristics of sundry flow variables on the entropy generation rate,velocity,concentration,Bejan number,temperature are discussed graphically for both graphene oxide and titanium dioxide hybrid nanoparticles.The engineering interest like skin friction coefficient and Nusselt number are computed numerically and presented through tables.It is noticed from the obtained results that entropy generation rate and Bejan number have similar effects versus diffusion parameter.Also entropy generation rate is more against the higher Brinkman number.展开更多
We examine governing equations that could be used to model a one-dimensional blood flow within a pulsating elastic artery that is represented by a tube of varying cross-section. The model is considered from two perspe...We examine governing equations that could be used to model a one-dimensional blood flow within a pulsating elastic artery that is represented by a tube of varying cross-section. The model is considered from two perspectives. The first represents a singular perturbation theory providing explicit approximate solutions to the model, and the second is based on group theoretical modeling that provides exact solutions in implicit form. The main goal is to compare these two approaches and lay out the advantages and disadvantages of each approach.展开更多
This study focuses on the transient analysis of nonlinear dispersion of a polymeric pollutant ejected by an external source into a laminar pipe flow of a Newtonian liquid under axi-symmetric conditions.The influence o...This study focuses on the transient analysis of nonlinear dispersion of a polymeric pollutant ejected by an external source into a laminar pipe flow of a Newtonian liquid under axi-symmetric conditions.The influence of density variation with pollutant concentration is approximated according to the Boussinesq approximation and the nonlinear governing equations of momentum,pollutant concentration are obtained together with and Oldroyd-B constitutive model for the polymer stress.The problem is solved numerically using a semi-implicit finite difference method.Solutions are presented in graphical form for various parameter values and given in terms of fluid velocity,pollutant concentration,polymer stress components,skin friction and wall mass transfer rate.The model can be a useful tool in understanding the dynamics of industrial pollution situations arising from improper discharge of hydrocarbon pollutants into,say,water bodies.The model can also be quite useful for available necessary early warning methods for detecting or predicting the scale of pollution and hence help mitigate related damage downstream by earlier instituting relevant decontamination measures.展开更多
In this paper, the mathematical dynamical model of a PEMFC （proton exchange membrane fuel cells） stack, integrated with an automotive synchronous electrical power drive, developed in Matlab environment, is shown. Lo...In this paper, the mathematical dynamical model of a PEMFC （proton exchange membrane fuel cells） stack, integrated with an automotive synchronous electrical power drive, developed in Matlab environment, is shown. Lots of simulations have been executed in many load conditions. In this paper, the load conditions regarding an electrical vehicle for disabled people is reported. The innovation in this field concerns the integration, in the PEMFC stack mathematical dynamic model, of a synchronous electrical power drive for automotive purposes. Goal of the simulator design has been to create an useful tool which is able to evaluate the behaviour of the whole system so as to optimize the components choose. As regards the simulations with a synchronous electrical power drive, the complete mathematical model allows to evaluate the PEMFC stack performances and electrochemical efficiency.展开更多
DP-coloring as a generalization of list coloring was introduced recently by Dvo˘r´ak and Postle.In this paper,we show that planar graphs without 5-cycles adjacent to two triangles are DP-4-colorable,which improve...DP-coloring as a generalization of list coloring was introduced recently by Dvo˘r´ak and Postle.In this paper,we show that planar graphs without 5-cycles adjacent to two triangles are DP-4-colorable,which improves the results of[Discrete Math.,2018,341(7):1983–1986]and[Discrete Appl.Math.,2020,277:245–251].展开更多
Fractional differential equations(FDEs)provide a powerful tool for modeling systems with memory and non-local effects,but understanding their underlying structure remains a significant challenge.While numerous numeric...Fractional differential equations(FDEs)provide a powerful tool for modeling systems with memory and non-local effects,but understanding their underlying structure remains a significant challenge.While numerous numerical and semi-analytical methods exist to find solutions,new approaches are needed to analyze the intrinsic properties of the FDEs themselves.This paper introduces a novel computational framework for the structural analysis of FDEs involving iterated Caputo derivatives.The methodology is based on a transformation that recasts the original FDE into an equivalent higher-order form,represented as the sum of a closed-form,integer-order component G(y)and a residual fractional power seriesΨ(x).This transformed FDE is subsequently reduced to a first-order ordinary differential equation(ODE).The primary novelty of the proposed methodology lies in treating the structure of the integer-order component G(y)not as fixed,but as a parameterizable polynomial whose coefficients can be determined via global optimization.Using particle swarm optimization,the framework identifies an optimal ODE architecture by minimizing a dual objective that balances solution accuracy against a high-fidelity reference and the magnitude of the truncated residual series.The effectiveness of the approach is demonstrated on both a linear FDE and a nonlinear fractional Riccati equation.Results demonstrate that the framework successfully identifies an optimal,low-degree polynomial ODE architecture that is not necessarily identical to the forcing function of the original FDE.This work provides a new tool for analyzing the underlying structure of FDEs and gaining deeper insights into the interplay between local and non-local dynamics in fractional systems.展开更多
Steel cylindrical shells are widely used in engineering structures due to their high strength-to-weight ratio,but they are vulnerable to buckling under axial loads.To address this limitation,fiber-reinforced polymer(F...Steel cylindrical shells are widely used in engineering structures due to their high strength-to-weight ratio,but they are vulnerable to buckling under axial loads.To address this limitation,fiber-reinforced polymer(FRP)composites have emerged as promising materials for structural reinforcement.This study investigates the buckling behavior of steel cylindrical shells reinforced with inner and outer layers of polymer composite materials under axial compression.Using analytical and numerical modeling methods,the critical buckling loads for different reinforcement options were evaluated.Two-sided glass fiber reinforced plastic(GFRP)or carbon fiber reinforced plastic(CFRP)coatings,as well as combined coatings with layers of different composites,were considered.GFRP+CFRPIn the calculations,the coatings were treated as homogeneous orthotropic materials with equivalent averaged elastic characteristics.The numerical analysis revealed that CFRP reinforcement achieved the highest increase in buckling load,with improvements ranging from 9.84%to 47.29%,depending on the composite thickness and steel shell thickness.GFRP reinforcement,while beneficial,demonstrated a lower effectiveness,with buckling load increases between 5.89%and 19.30%.The hybrid reinforcement provided an optimal balance,improving buckling resistance by GFRP+CFRP6.94%to 43.95%.Statistical analysis further identified composite type and thickness as the most significant factors affecting buckling performance.The findings suggest that CFRP is the preferred reinforcement material,especially when applied to thin-walled cylindrical shells,while hybrid reinforcements can be effectively utilized for structures requiring a balance between stiffness and ductility.These insights provide a foundation for optimizing FRP reinforcement strategies to enhance the structural integrity of steel shells in engineering applications.展开更多
The work presents new methods for selecting adaptive artificial viscosity(AAV)in iterative algorithms of completely conservative difference schemes(CCDS)used to solve gas dynamics equations in Euler variables.These me...The work presents new methods for selecting adaptive artificial viscosity(AAV)in iterative algorithms of completely conservative difference schemes(CCDS)used to solve gas dynamics equations in Euler variables.These methods allow to effectively suppress oscillations,including in velocity profiles,as well as computational instabilities in modeling gas-dynamic processes described by hyperbolic equations.The methods can be applied both in explicit and implicit(method of separate sweeps)iterative processes in numerical modeling of gas dynamics in the presence of heat and mass transfer,as well as in solving problems of magnetohydrodynamics and computational astrophysics.In order to avoid loss of solution accuracy on spatially non-uniform grids,in this work an algorithm of grid embeddings is developed,which is applied near transition points between cells of different sizes.The developed algorithms of CCDS using the methods for AAV selection and the algorithm of grid embeddings are implemented for various iterative processes.Calculations are performed for the classical problem of decay of an arbitrary discontinuity(Sod’s problem)and the problem of propagation of two symmetric rarefaction waves in opposite directions(Einfeldt’s problem).In the case of using different methods for selecting the AAV,a comparison of the solutions of the Sod’s problem on uniform and non-uniform grids and a comparison of the solutions of the Einfeldt’s problem on a uniform grid are performed.As a result of the comparative analysis,the applicability of these methods is shown in the spatially one-dimensional case(explicit and implicit iterative processes).The obtained results are compared with the data from the literature.The results coincide with analytical solutions with high accuracy,where the relative error does not exceed 0.1%,which demonstrates the effectiveness of the developed algorithms and methods.展开更多
The turning performance of a ship is an important aspect of its maneuverability,and accurately predicting the hydrodynamic forces during ship turning motion is of great significance for the safe maneuvering design of ...The turning performance of a ship is an important aspect of its maneuverability,and accurately predicting the hydrodynamic forces during ship turning motion is of great significance for the safe maneuvering design of ships.This paper investigated the hydrodynamic performance of a KRISO container ship in steady turning using experimental and numerical approaches.The rotating arm tests were carried out in rotating arm basin of Zhejiang University,while the numerical simulations were conducted in commercial computational fluid dynamics software.Hydrodynamic forces and moments,hull surface wave height,wave patterns,and vorticity are studied under different velocities,radii,and drift angles.The results show that the increase in velocity has a significant impact on the forces and moments of the hull.The changes in longitudinal and transverse forces reflect the complex fluid dynamic interactions between the hull and water.Under conditions of small radius and large drift angle,the hull experiences greater forces and moments,indicating that stability and maneuverability will be more challenged during sudden turns.This study can provide experimental data and numerical simulation references for the research of ship turning maneuvers.展开更多
The authors regret that the affiliation b and c are wrong.Affiliation b should be changed to“School of Civil and Environmental Engineering,Harbin Institute of Technology,Shenzhen,China;Department of Data Analysis and...The authors regret that the affiliation b and c are wrong.Affiliation b should be changed to“School of Civil and Environmental Engineering,Harbin Institute of Technology,Shenzhen,China;Department of Data Analysis and Mathematical Modelling,Ghent University,Belgium”.And affiliation c should be changed to“State Key Laboratory of Urban Water Resource and Environment(SKLUWRE),School of Environment,Harbin Institute of Technology,China”.展开更多
This study examines the intricate occurrences of thermal and solutal Marangoni convection in three-layered flows of viscous fluids,with a particular emphasis on their relevance to renewable energy systems.This researc...This study examines the intricate occurrences of thermal and solutal Marangoni convection in three-layered flows of viscous fluids,with a particular emphasis on their relevance to renewable energy systems.This research examines the flow of a three-layered viscous fluid,considering the combined influence of heat and solutal buoyancy driven Rayleigh-Bénard convection,as well as thermal and solutal Marangoni convection.The homotopy perturbation method is used to examine and simulate complex fluid flow and transport phenomena,providing important understanding of the fundamental physics and assisting in the optimization of various battery configurations.The inquiry examines the primary elements that influence Marangoni convection and its impact on battery performance,providing insights on possible enhancements in energy storage devices.The findings indicate that the velocity profiles shown graphically exhibit a prominent core zone characterized by the maximum speed,which progressively decreases as it approaches the walls of the channel.This study enhances our comprehension of fluid dynamics and the transmission of heat and mass in intricate systems,which has substantial ramifications for the advancement of sustainable energy solutions.展开更多
Wave shoaling,which involves an increase in wave amplitude due to changes in water depth,can damage shore-lines.To mitigate this damage,we propose using porous structures such as mangrove forests.In this study,we use ...Wave shoaling,which involves an increase in wave amplitude due to changes in water depth,can damage shore-lines.To mitigate this damage,we propose using porous structures such as mangrove forests.In this study,we use a mathematical model to examine how mangroves,acting as porous breakwater,can reduce wave shoaling amplitude.The shallow water equations are used as the governing equations and are modified to account for the presence of porous media.To measure the wave reduction generated by the porous media,the wave transmis-sion coefficient is estimated using analytical and numerical approaches.The separation of variables method and the staggered finite volume method are utilized for each approach,respectively.The numerical results are then validated against the previously obtained analytical solutions.We then vary the friction and porosity parame-ters-determined by the presence and extent of porous media,to evaluate their effectiveness in reducing wave shoaling.展开更多
AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the...AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria.展开更多
文摘The increasing occurrence of corrosion-related damage in steel pipelines has led to the growing use of composite-based repair techniques as an efficient alternative to traditional replacement methods.Computer modeling and structural analysis were performed for the repair reinforcement of a steel pipeline with a composite bandage.A preliminary analysis of possible contact interaction schemes was implemented based on the theory of cylindrical shells,taking into account transverse shear deformations.The finite element method was used for a detailed study of the stress state of the composite bandage and the reinforced section of the pipeline.The limit state of the reinforced section was assessed based on the von Mises criterion for steel and the Tsai-Wu criterion for composites.The effectiveness of the repair was demonstrated on a pipeline whose wall thickness had decreased by 20%as a result of corrosion damage.At a nominal pressure of P=6 MPa,the maximum normal stress in the weakened area reached 381 MPa.The installation of a composite bandage reduced this stress to 312 MPa,making the repaired section virtually as strong as the undamaged pipeline.Due to the linearity of the problem,the results obtained can be easily used to find critical internal pressure values.
基金funded by Institut Teknologi Bandung(Research Grant ITB 2024).
文摘The COVID-19 pandemic caused significant disruptions in the healthcare system,affecting vaccinations and the management of diphtheria cases.As a consequence of these disruptions,numerous countries have experienced a resurgence or an increase in diphtheria cases.West Java province in Indonesia is identified as one of the high-risk areas for diphtheria,experiencing an upward trend in cases from 2021 to 2023.To analyze the situation,we developed an SIR model,which integrated DPT and booster vaccinations to determine the basic reproduction number,an essential parameter for infectious diseases.Through spatial analysis of geo-referenced data,we identified hotspots and explained diffusion in diphtheria case clusters.The calculation of R0 resulted in an R0=1.17,indicating the potential for a diphtheria outbreak in West Java.To control the increasing cases,one possible approach is to raise the booster vaccination coverage from the current 64.84%to 75.15%,as suggested by simulation results.Furthermore,the spatial analysis revealed that hot spot clusters were present in the western,central,and southern regions,posing a high risk not only in densely populated areas but also in rural regions.The diffusion pattern of diphtheria clusters displayed an expansion-contagious pattern.Understanding the rising trend of diphtheria cases and their geographic distribution can offer crucial insights for government and health authorities to manage the number of diphtheria cases and make informed decisions regarding the best prevention and intervention strategies.
基金supported by the Project of Sanya Yazhou Bay Science and Technology City(SKJC-JYRC-2024-26)the National Natural Science Foundation of China(32460072)+3 种基金Hainan Provincial Natural Science Foundation of China(323RC421)the Hainan Province Science and Technology Special Fund(ZDYF2022XDNY144)the Hainan Provincial Academician Innovation Platform Project(HD-YSZX-202004)the Collaborative Innovation Center of Nanfan and High-Efficiency Tropical Agriculture,Hainan University(XTCX2022NYB06),and Hainan Postdoctoral Research Grant Project.
文摘In light of the pressing global challenges of climate change,declining crop resilience,and hidden hunger,it is imperative to overcome the limitations of conventional crop breeding to enhance both the nutritional quality and stress tolerance of crops.Synthetic metabolic engineering presents innovative strategies for the precision modification and de novo design of metabolic pathways.This approach generally encompasses three essential steps:identifying key metabolites through metabolomics,integrating multi-omics technologies to investigate the synthesis and regulation of these metabolites,and utilizing gene editing or de novo design to modify crop metabolic pathways associated with desirable agronomic traits.This review underscores the vital role of plant metabolite diversity in enhancing crop nutritional quality and stress resilience.Integrated multi-omics analyses facilitate the metabolic engineering by identifying key genes,transporters,and transcription factors that regulate metabolite biosynthesis.Precision modification strategies employ genome editing tools to reprogram endogenous metabolic networks,while de novo design reconstructs metabolic pathways through the introduction of exogenous biological elements—thereby both approaches enable the targeted enhancement of desired traits.These strategies have been effectively implemented in major food crops.However,simultaneously enhancing nutritional quality and stress resilience remains challenging due to inherent trade-offs and resource competition in distinct metabolic pathways within plants.Future research should integrate AI-driven predictive models with multi-omics datasets to decipher dynamic metabolic homeostasis and engineer climate-smart crops that maximize yield while preserving quality and environmental adaptability.
基金Project supported by the National Natural Science Foundation of China(Nos.11971142,11871202,61673169,11701176,11626101,and 11601485)。
文摘In this research,the three-dimensional(3D)steady and incompressible laminar Homann stagnation point nanofluid flow over a porous moving surface is addressed.The disturbance in the porous medium has been characterized by the Darcy-Forchheimer relation.The slip for viscous fluid is considered.The energy equation is organized in view of radiative heat flux which plays an important role in the heat transfer rate.The governing flow expressions are first altered into first-order ordinary ones and then solved numerically by the shooting method.Dual solutions are obtained for the velocity,skin friction coefficient,temperature,and Nusselt number subject to sundry flow parameters,magnetic parameter,Darcy-Forchheimer number,thermal radiation parameter,suction parameter,and dimensionless slip parameter.In this research,the main consideration is given to the engineering interest like skin friction coefficient(velocity gradient or surface drag force)and Nusselt number(temperature gradient or heat transfer rate)and discussed numerically through tables.In conclusion,it is noticed from the stability results that the upper branch solution(UBS)is more reliable and physically stable than the lower branch solution(LBS).
文摘The Funding information section was missing from this arti-cle and should have read'The research is partially funded by the Ministry of Science and Higher Education of the Russian Federation as part of World-class Research Center program:Advanced Digital Technologies(contract No.075–15–2020–903 dated 16.11.2020)'.The original article has been corrected.
基金Foundation item: The National Torch Program of China (No. 2001EB000991)
文摘A nonlinear mathematical model of the injection molding process for electrohydraulic servo injection molding machine (IMM) is developed.It was found necessary to consider the characteristics of asymmetric cylinder for electrohydraulic servo IMM.The model is based on the dynamics of the machine including servo valve,asymmetric cylinder and screw,and the non-Newtonian flow behavior of polymer melt in injection molding is also considered.The performance of the model was evaluated based on novel approach of molding - injection and compress molding,and the results of simulation and experimental data demonstrate the effectiveness of the model.
基金the Ministry of Science and Higher Education of the Russian Federation as part of World-class Research Center program:Advanced Digital Technologies(contract No.075–15–2020–903 dated 16.11.2020).
文摘This paper discusses mathematical modeling of a ship equipped with energy-saving wing devices.Therewith,the ship is mathematically represented by an elongated hull with high-aspect-ratio wings mounted near its bow and stern.Equations,describing ship motions in regular oncoming waves,are written in the spirit of strip theory with account of inertial and damping influence of energy-saving wing elements with the use of linear expansion of wing-related forces with respect to heave and pitch perturbations.This approach readily yields fast numerical solutions for the propulsion of a ship with wings in waves.The latter solutions are then used as an input for calculation of thrust on wing elements on the basis of classical unsteady foil theories corrected for finite aspect ratio.To evaluate speed of the ship in the modes which allow cruising exclusively by wave power,it is hypothetically assumed that in this case,the wave-generated thrust on the wings equals total drag of the ship-plus-wings system,the latter being defined as a sum of its viscous,wave-making,induced(for wing elements)and added-wave components.Excepting the added-wave term and wings’contributions,the total drag is calculated herein by Holtrop method whereas added-wave resistance is evaluated with Beukelman-Gerritsma formula involving kinematic parameters of heaving and pitching motions of the ship calculated both without and with account of the wings.Also discussed in the paper is a decrease of added wave resistance for a ship with wings as compared to that of ship without wings.Finally,the energy efficiency design index(EEDI)introduced by the International Maritime Organization(IMO)is discussed for representative sea conditions as a measure of ship environmental friendliness.
基金supported by the National Natural Science Foundation of China(Grant Nos.11971142,11871202,61673169,11701176,11626101,and 11601485)。
文摘The prime objective of the present communication is to examine the entropy-optimized second order velocity slip Darcy–Forchheimer hybrid nanofluid flow of viscous material between two rotating disks.Electrical conducting flow is considered and saturated through Darcy–Forchheimer relation.Both the disks are rotating with different angular frequencies and stretches with different rates.Here graphene oxide and titanium dioxide are considered for hybrid nanoparticles and water as a continuous phase liquid.Joule heating,heat generation/absorption and viscous dissipation effects are incorporated in the mathematical modeling of energy expression.Furthermore,binary chemical reaction with activation energy is considered.The total entropy rate is calculated in the presence of heat transfer irreversibility,fluid friction irreversibility,Joule heating irreversibility,porosity irreversibility and chemical reaction irreversibility through thermodynamics second law.The nonlinear governing equations are first converted into ordinary differential equations through implementation of appropriate similarity transformations and then numerical solutions are calculated through Built-in-Shooting method.Characteristics of sundry flow variables on the entropy generation rate,velocity,concentration,Bejan number,temperature are discussed graphically for both graphene oxide and titanium dioxide hybrid nanoparticles.The engineering interest like skin friction coefficient and Nusselt number are computed numerically and presented through tables.It is noticed from the obtained results that entropy generation rate and Bejan number have similar effects versus diffusion parameter.Also entropy generation rate is more against the higher Brinkman number.
文摘We examine governing equations that could be used to model a one-dimensional blood flow within a pulsating elastic artery that is represented by a tube of varying cross-section. The model is considered from two perspectives. The first represents a singular perturbation theory providing explicit approximate solutions to the model, and the second is based on group theoretical modeling that provides exact solutions in implicit form. The main goal is to compare these two approaches and lay out the advantages and disadvantages of each approach.
文摘This study focuses on the transient analysis of nonlinear dispersion of a polymeric pollutant ejected by an external source into a laminar pipe flow of a Newtonian liquid under axi-symmetric conditions.The influence of density variation with pollutant concentration is approximated according to the Boussinesq approximation and the nonlinear governing equations of momentum,pollutant concentration are obtained together with and Oldroyd-B constitutive model for the polymer stress.The problem is solved numerically using a semi-implicit finite difference method.Solutions are presented in graphical form for various parameter values and given in terms of fluid velocity,pollutant concentration,polymer stress components,skin friction and wall mass transfer rate.The model can be a useful tool in understanding the dynamics of industrial pollution situations arising from improper discharge of hydrocarbon pollutants into,say,water bodies.The model can also be quite useful for available necessary early warning methods for detecting or predicting the scale of pollution and hence help mitigate related damage downstream by earlier instituting relevant decontamination measures.
文摘In this paper, the mathematical dynamical model of a PEMFC （proton exchange membrane fuel cells） stack, integrated with an automotive synchronous electrical power drive, developed in Matlab environment, is shown. Lots of simulations have been executed in many load conditions. In this paper, the load conditions regarding an electrical vehicle for disabled people is reported. The innovation in this field concerns the integration, in the PEMFC stack mathematical dynamic model, of a synchronous electrical power drive for automotive purposes. Goal of the simulator design has been to create an useful tool which is able to evaluate the behaviour of the whole system so as to optimize the components choose. As regards the simulations with a synchronous electrical power drive, the complete mathematical model allows to evaluate the PEMFC stack performances and electrochemical efficiency.
基金Partially supported by NSFC(No.12301436)NSF of Guangxi Province(No.2025GXNSFAA069811)。
文摘DP-coloring as a generalization of list coloring was introduced recently by Dvo˘r´ak and Postle.In this paper,we show that planar graphs without 5-cycles adjacent to two triangles are DP-4-colorable,which improves the results of[Discrete Math.,2018,341(7):1983–1986]and[Discrete Appl.Math.,2020,277:245–251].
基金Research Council of Lithuania(LMTLT),agreement No.S-PD-24-120Research Council of Lithuania(LMTLT),agreement No.S-PD-24-120funded by the Research Council of Lithuania.
文摘Fractional differential equations(FDEs)provide a powerful tool for modeling systems with memory and non-local effects,but understanding their underlying structure remains a significant challenge.While numerous numerical and semi-analytical methods exist to find solutions,new approaches are needed to analyze the intrinsic properties of the FDEs themselves.This paper introduces a novel computational framework for the structural analysis of FDEs involving iterated Caputo derivatives.The methodology is based on a transformation that recasts the original FDE into an equivalent higher-order form,represented as the sum of a closed-form,integer-order component G(y)and a residual fractional power seriesΨ(x).This transformed FDE is subsequently reduced to a first-order ordinary differential equation(ODE).The primary novelty of the proposed methodology lies in treating the structure of the integer-order component G(y)not as fixed,but as a parameterizable polynomial whose coefficients can be determined via global optimization.Using particle swarm optimization,the framework identifies an optimal ODE architecture by minimizing a dual objective that balances solution accuracy against a high-fidelity reference and the magnitude of the truncated residual series.The effectiveness of the approach is demonstrated on both a linear FDE and a nonlinear fractional Riccati equation.Results demonstrate that the framework successfully identifies an optimal,low-degree polynomial ODE architecture that is not necessarily identical to the forcing function of the original FDE.This work provides a new tool for analyzing the underlying structure of FDEs and gaining deeper insights into the interplay between local and non-local dynamics in fractional systems.
文摘Steel cylindrical shells are widely used in engineering structures due to their high strength-to-weight ratio,but they are vulnerable to buckling under axial loads.To address this limitation,fiber-reinforced polymer(FRP)composites have emerged as promising materials for structural reinforcement.This study investigates the buckling behavior of steel cylindrical shells reinforced with inner and outer layers of polymer composite materials under axial compression.Using analytical and numerical modeling methods,the critical buckling loads for different reinforcement options were evaluated.Two-sided glass fiber reinforced plastic(GFRP)or carbon fiber reinforced plastic(CFRP)coatings,as well as combined coatings with layers of different composites,were considered.GFRP+CFRPIn the calculations,the coatings were treated as homogeneous orthotropic materials with equivalent averaged elastic characteristics.The numerical analysis revealed that CFRP reinforcement achieved the highest increase in buckling load,with improvements ranging from 9.84%to 47.29%,depending on the composite thickness and steel shell thickness.GFRP reinforcement,while beneficial,demonstrated a lower effectiveness,with buckling load increases between 5.89%and 19.30%.The hybrid reinforcement provided an optimal balance,improving buckling resistance by GFRP+CFRP6.94%to 43.95%.Statistical analysis further identified composite type and thickness as the most significant factors affecting buckling performance.The findings suggest that CFRP is the preferred reinforcement material,especially when applied to thin-walled cylindrical shells,while hybrid reinforcements can be effectively utilized for structures requiring a balance between stiffness and ductility.These insights provide a foundation for optimizing FRP reinforcement strategies to enhance the structural integrity of steel shells in engineering applications.
基金carried out within the framework of the state assignment of KIAM RAS(No.125020701776-0).
文摘The work presents new methods for selecting adaptive artificial viscosity(AAV)in iterative algorithms of completely conservative difference schemes(CCDS)used to solve gas dynamics equations in Euler variables.These methods allow to effectively suppress oscillations,including in velocity profiles,as well as computational instabilities in modeling gas-dynamic processes described by hyperbolic equations.The methods can be applied both in explicit and implicit(method of separate sweeps)iterative processes in numerical modeling of gas dynamics in the presence of heat and mass transfer,as well as in solving problems of magnetohydrodynamics and computational astrophysics.In order to avoid loss of solution accuracy on spatially non-uniform grids,in this work an algorithm of grid embeddings is developed,which is applied near transition points between cells of different sizes.The developed algorithms of CCDS using the methods for AAV selection and the algorithm of grid embeddings are implemented for various iterative processes.Calculations are performed for the classical problem of decay of an arbitrary discontinuity(Sod’s problem)and the problem of propagation of two symmetric rarefaction waves in opposite directions(Einfeldt’s problem).In the case of using different methods for selecting the AAV,a comparison of the solutions of the Sod’s problem on uniform and non-uniform grids and a comparison of the solutions of the Einfeldt’s problem on a uniform grid are performed.As a result of the comparative analysis,the applicability of these methods is shown in the spatially one-dimensional case(explicit and implicit iterative processes).The obtained results are compared with the data from the literature.The results coincide with analytical solutions with high accuracy,where the relative error does not exceed 0.1%,which demonstrates the effectiveness of the developed algorithms and methods.
基金supported by the China Scholarship Council(Grant No.202306320084).
文摘The turning performance of a ship is an important aspect of its maneuverability,and accurately predicting the hydrodynamic forces during ship turning motion is of great significance for the safe maneuvering design of ships.This paper investigated the hydrodynamic performance of a KRISO container ship in steady turning using experimental and numerical approaches.The rotating arm tests were carried out in rotating arm basin of Zhejiang University,while the numerical simulations were conducted in commercial computational fluid dynamics software.Hydrodynamic forces and moments,hull surface wave height,wave patterns,and vorticity are studied under different velocities,radii,and drift angles.The results show that the increase in velocity has a significant impact on the forces and moments of the hull.The changes in longitudinal and transverse forces reflect the complex fluid dynamic interactions between the hull and water.Under conditions of small radius and large drift angle,the hull experiences greater forces and moments,indicating that stability and maneuverability will be more challenged during sudden turns.This study can provide experimental data and numerical simulation references for the research of ship turning maneuvers.
文摘The authors regret that the affiliation b and c are wrong.Affiliation b should be changed to“School of Civil and Environmental Engineering,Harbin Institute of Technology,Shenzhen,China;Department of Data Analysis and Mathematical Modelling,Ghent University,Belgium”.And affiliation c should be changed to“State Key Laboratory of Urban Water Resource and Environment(SKLUWRE),School of Environment,Harbin Institute of Technology,China”.
基金Project(52276068)supported by the National Natural Science Foundation of China。
文摘This study examines the intricate occurrences of thermal and solutal Marangoni convection in three-layered flows of viscous fluids,with a particular emphasis on their relevance to renewable energy systems.This research examines the flow of a three-layered viscous fluid,considering the combined influence of heat and solutal buoyancy driven Rayleigh-Bénard convection,as well as thermal and solutal Marangoni convection.The homotopy perturbation method is used to examine and simulate complex fluid flow and transport phenomena,providing important understanding of the fundamental physics and assisting in the optimization of various battery configurations.The inquiry examines the primary elements that influence Marangoni convection and its impact on battery performance,providing insights on possible enhancements in energy storage devices.The findings indicate that the velocity profiles shown graphically exhibit a prominent core zone characterized by the maximum speed,which progressively decreases as it approaches the walls of the channel.This study enhances our comprehension of fluid dynamics and the transmission of heat and mass in intricate systems,which has substantial ramifications for the advancement of sustainable energy solutions.
基金support from Program Riset Kolaborasi Indonesia(RKI)2024(Grant No.1841/IT1.B07.1/TA.00/2024).
文摘Wave shoaling,which involves an increase in wave amplitude due to changes in water depth,can damage shore-lines.To mitigate this damage,we propose using porous structures such as mangrove forests.In this study,we use a mathematical model to examine how mangroves,acting as porous breakwater,can reduce wave shoaling amplitude.The shallow water equations are used as the governing equations and are modified to account for the presence of porous media.To measure the wave reduction generated by the porous media,the wave transmis-sion coefficient is estimated using analytical and numerical approaches.The separation of variables method and the staggered finite volume method are utilized for each approach,respectively.The numerical results are then validated against the previously obtained analytical solutions.We then vary the friction and porosity parame-ters-determined by the presence and extent of porous media,to evaluate their effectiveness in reducing wave shoaling.
文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria.
