Low water solubility leading to poor bioavailability has an impact on the decreasing of curcumin uptake in the body,resulting in a deficiency of its medicinal benefits.This study aims to overcome the limitations of cu...Low water solubility leading to poor bioavailability has an impact on the decreasing of curcumin uptake in the body,resulting in a deficiency of its medicinal benefits.This study aims to overcome the limitations of curcumin by formulating a nano-emulsion called curcumin emulsion(CE).Furthermore,in order to improve the physi-cochemical properties and drug release features,the CE was encapsulated within chitosan-assembled mesoporous silica nanoparticles(Chi@SiO_(2)@CE).This material was prepared using a one-pot method and was characterized by Attenuated-total reflectance(ATR-FTIR),Particle Size Analyzer(PSA),Thermogravimetric analysis(TGA),N_(2)adsorption-desorption,Scanning Electron Microscopy(SEM),and Transmission Electron Microscopy(TEM).Additionally,antioxidant activity and in vitro drug release were also conducted.The study demonstrated that CE has strong antioxidant activity(IC_(50)=14.14μM)compared to curcumin alone.Additionally,the Chi@SiO_(2)@CE exhibited pH-controlled release behavior,with less than 20%release of curcumin under an artificial gastric environment and 50%release under pH 7.4 conditions within 24 h.Therefore,this research suggest that Chi@SiO_(2)@CE material has potential as a pH-responsive drug delivery material.展开更多
Numerous endeavours have been developed bio-based polymer packaging films to replace the use of petroleum-based packaging.In this study,as a response and support to the enduring research issues,we have developed the o...Numerous endeavours have been developed bio-based polymer packaging films to replace the use of petroleum-based packaging.In this study,as a response and support to the enduring research issues,we have developed the optimization composite film formulation based on chitosan(2%),Dioscorea alata starch(0.5%),and glycerol(1.5%)had satisfactory result on several parameters consisting thickness(0.45 mm),solubility(472.1%),moisture content(29.872%),biodegradability(38.346%),elastic modulus(971.2 N/m2)and tensile strength(98.71 N/m).Further,the optimized chitosan film(CF)formulation was enriched with several essential oils(EO),i.e.,lemongrass,garlic and aloe vera oil.Upon the addition of EO,the solubility,biodegradable tests,and elongation to break of CF tended to decrease whereas the contact angle and mechanical properties significantly increased.Finally,the antibacterial properties of CF against Escherichia coli,Salmonella typhi,Staphylococcus aureus and Staphylococcus epidermidis dramatically increased by the addition of EO.These impressive results are expected to be applied in the food packaging industry to maintain the quality of food products.展开更多
基金Directorate General of Higher Education,Ministry of Education,Culture,Research and Technology,Indonesia for funding this research through Program Kreativitas Mahasiswa(PKM)2021(No.1949/E2/KM.05.01/2021)partially supported by Universitas Sebelas Maret through Pene-litian Unggulan Terapan(PUT)2021 research scheme(No.260/UN27.22/HK.07.00/2021).
文摘Low water solubility leading to poor bioavailability has an impact on the decreasing of curcumin uptake in the body,resulting in a deficiency of its medicinal benefits.This study aims to overcome the limitations of curcumin by formulating a nano-emulsion called curcumin emulsion(CE).Furthermore,in order to improve the physi-cochemical properties and drug release features,the CE was encapsulated within chitosan-assembled mesoporous silica nanoparticles(Chi@SiO_(2)@CE).This material was prepared using a one-pot method and was characterized by Attenuated-total reflectance(ATR-FTIR),Particle Size Analyzer(PSA),Thermogravimetric analysis(TGA),N_(2)adsorption-desorption,Scanning Electron Microscopy(SEM),and Transmission Electron Microscopy(TEM).Additionally,antioxidant activity and in vitro drug release were also conducted.The study demonstrated that CE has strong antioxidant activity(IC_(50)=14.14μM)compared to curcumin alone.Additionally,the Chi@SiO_(2)@CE exhibited pH-controlled release behavior,with less than 20%release of curcumin under an artificial gastric environment and 50%release under pH 7.4 conditions within 24 h.Therefore,this research suggest that Chi@SiO_(2)@CE material has potential as a pH-responsive drug delivery material.
基金This work has been financially supported through Penelitian Dasar Unggulan Perguruan Tinggi 2021(221.1/UN27.22/HK.07.00/2021)by Ministry of Research,Technology and Higher Education,Indonesia。
文摘Numerous endeavours have been developed bio-based polymer packaging films to replace the use of petroleum-based packaging.In this study,as a response and support to the enduring research issues,we have developed the optimization composite film formulation based on chitosan(2%),Dioscorea alata starch(0.5%),and glycerol(1.5%)had satisfactory result on several parameters consisting thickness(0.45 mm),solubility(472.1%),moisture content(29.872%),biodegradability(38.346%),elastic modulus(971.2 N/m2)and tensile strength(98.71 N/m).Further,the optimized chitosan film(CF)formulation was enriched with several essential oils(EO),i.e.,lemongrass,garlic and aloe vera oil.Upon the addition of EO,the solubility,biodegradable tests,and elongation to break of CF tended to decrease whereas the contact angle and mechanical properties significantly increased.Finally,the antibacterial properties of CF against Escherichia coli,Salmonella typhi,Staphylococcus aureus and Staphylococcus epidermidis dramatically increased by the addition of EO.These impressive results are expected to be applied in the food packaging industry to maintain the quality of food products.
