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Preparation of Biodegradable Polylactic Acid/Ethyl Cellulose/Zein Composite Film and Its Effect on the Preservation of Chilled Fresh Meat
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作者 ZHOU Ling YU Ya +8 位作者 YUAN Mengting WU Dongxu CHEN Ya LIU Yanan SU Jingjing CHEN Sihan WANG Juhua SHENG Bulei XUE Xiuheng 《食品科学》 北大核心 2025年第15期324-337,共14页
In this study,composite films consisting of polylactic acid(PLA),ethyl cellulose(EC),and zein were prepared by solution casting method,and their performance and application in chilled fresh meat preservation were inve... In this study,composite films consisting of polylactic acid(PLA),ethyl cellulose(EC),and zein were prepared by solution casting method,and their performance and application in chilled fresh meat preservation were investigated.The results showed that the three materials had satisfactory compatibility in the composite film.Addition of EC and zein effectively improved the mechanical properties,thermodynamic properties,surface hydrophilicity,oxygen permeability,and degradation properties of PLA films.When the ratio of PLA to EC was 3:7,the tensile strength and elongation at break reached maximum values of 16.6 MPa and 30.5%,respectively.Moreover,under different conditions,the composite film exhibited better degradability than the PLA film.The composite film with a 3:7 ratio of PLA to EC had the best performance,with a degradation rate of 21.75%after 84 days.Chilled fresh meat wrapped with the composite film showed significantly improved antioxidant,antibacterial,and water-holding properties. 展开更多
关键词 biodegradable film polylactic acid ethyl cellulose ZEIN chilled fresh meat PRESERVATION
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Microstructure and mechanical properties of large-size titanium alloy components fabricated by laser melting deposition
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作者 Zhenlin Zhang Ping Lu +6 位作者 Changchun Wang Yan Liu Yong Chen Peng Rong Jing Cheng Zhong Wang Hui Chen 《China Welding》 2025年第2期110-118,共9页
High-power laser melting deposition stands as a viable solution for the high-quality and efficient manufacturing of large-sized titani-um alloy components.This article explores how laser influences the quality of depo... High-power laser melting deposition stands as a viable solution for the high-quality and efficient manufacturing of large-sized titani-um alloy components.This article explores how laser influences the quality of deposited layers when operating within a laser power range of 3-8 kW,and a H-shaped TC4 component with half-meter high was successfully fabricated by the laser melting deposition technology with a power of 5 kW,exhibiting a well-formed surface.In addition,the microstructure and properties of deposited TC4 components were examined.The as-deposited component is mainly composed of coarse columnar crystals.However,the distribu-tion and size of grains are particularly uneven with a range of 1-5 mm in length.The deposited TC4 is made up of lots of basketweave structure and a bit Widmanstatten structures at the grain boundaries.What’s more,lath-shapedαphase and a small amount ofβphase can be found in the grain.There is no significant disparity in grain size along the height direction;however,the heat accumula-tion resulting from deposition leads to a reduced length-to-width ratio ofα-laths in the bottom region.The tensile performance of samples from the top area marginally surpasses that of the bottom,and the tensile performance in the vertical direction is marginally better than that in the horizontal direction.According to the prevailing GB/T 38915-2020 and HB 5432-89 standards,the tensile properties of the fabricated components,sampled from various regions and directions,exceed those of forgings.The direction of sampling has weak influence on impact energy;however,fatigue crack propagation experiments indicate that cracks are more pre-valent and propagate at a slightly faster rate in horizontally-oriented specimens,a phenomenon attributed to the combined effects of grain morphology and microstructure. 展开更多
关键词 Titanium alloy Laser melting deposition MICROSTRUCTURE Mechanical properties
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Design and Manufacturing Strategies for Fused Deposition Modelling in Additive Manufacturing:A Review 被引量:4
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作者 Hugo I.Medellin-Castillo Jorge Zaragoza-Siqueiros 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2019年第3期1-16,共16页
Although several research works in the literature have focused on studying the capabilities of additive manufacturing(AM) systems, few works have addressed the development of Design for Additive Manufacturing(DfAM) kn... Although several research works in the literature have focused on studying the capabilities of additive manufacturing(AM) systems, few works have addressed the development of Design for Additive Manufacturing(DfAM) knowledge,tools, rules, and methodologies, which has limited the penetration and impact of AM in industry. In this paper a comprehensive review of design and manufacturing strategies for Fused Deposition Modelling(FDM) is presented.Consequently, several DfAM strategies are proposed and analysed based on existing research works and the operation principles, materials, capabilities and limitations of the FDM process. These strategies have been divided into four main groups: geometry, quality, materials and sustainability. The implementation and practicality of the proposed DfAM is illustrated by three case studies. The new proposed DfAM strategies are intended to assist designers and manufacturers when making decisions to satisfy functional needs, while ensuring manufacturability in FDM systems.Moreover, many of these strategies can be applied or extended to other AM processes besides FDM. 展开更多
关键词 Additive manufacturing(AM) Design for additive manufacturing(DfAM) Fused Deposition Modelling(FDM) Design and manufacturing strategies
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Layout Planning Technology of Cellular Manufacturing System Based on Process Interconnection Analysis 被引量:2
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作者 CHEN Huawei WANG Aimin +1 位作者 NING Ruxin SHAO Canxia 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2011年第6期1035-1044,共10页
With sustaining change of production mode,layout planning is no longer a thing built once for all.Cellular layout(CL) is becoming a hotspot in the research field of manufacturing system layout.Traditional researches o... With sustaining change of production mode,layout planning is no longer a thing built once for all.Cellular layout(CL) is becoming a hotspot in the research field of manufacturing system layout.Traditional researches on layout planning are mainly concentrating on aspects of layout arithmetic,style and evaluation,etc.Relatively seldom efforts are paid to CL and its specific problems as cell formation(CF),equipment sharing and CL analysis.Through problem analyzing of layout in cellular manufacturing system(CMS),research approach of cell formation,interactive layout and layout analysis threaded with process interconnection relationship(PIR) is proposed.Typical key technologies in CL like CF technology based on similarity analysis of part processes,interactive visual layout technology,layout evaluation technology founded on PIR analysis and algorithm of cell equipment sharing are put forward.Against the background of one enterprise which encounters problems of low utility of key equipments and disperse material logistic,an example of four-cell layout is given.The CL adjustment and analysis results show that equipment with high level of sharing degree should be disposed around the boundary of its main cell,and be near to other sharing cells as possible; process route should be centralized by all means,so equipment adjustment is to be implemented along direction that route intersection can be decreased; giving consideration to the existence of discrete cell,logistic route and its density should be centralized to cells formed.The proposed research can help improve equipment utility and material logistic efficiency of CL,and can be popularized to other application availably. 展开更多
关键词 cellular manufacturing system layout planning process interconnection relationship cell formation equipment sharing interactive layout
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Integrated Manufacturing Cell Formation Technology Orienting Multi-product Type and Variant Volume Production 被引量:2
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作者 CHEN Huawei WANG Aimin NING Ruxin SHAO Canxia 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2011年第1期12-22,共11页
What is pursued by multi-product type and variant volume(MPTVV) production is rapid response and quick switching,so that structure of transferring line in manufacturing system is no longer unalterable.Cell formation... What is pursued by multi-product type and variant volume(MPTVV) production is rapid response and quick switching,so that structure of transferring line in manufacturing system is no longer unalterable.Cell formation(CF) algorithm is the key technology of cellular manufacturing system(CMS).Currently,CF methods are mainly extended on the idea of group technology(GT) that covers a lot on analysis of resource capability matching and its algorithm.Various constraints are considered,but seldom utilized comprehensively.Aimed to the problem of manufacturing cell(MC) formation under MPTVV production mode,integrated formation technologies for typical MC as group type of cell(GC),flow type of cell(FC) and inherited cell(IC) are presented based on technical analysis of CF.Oriented to practical production constraints like delivery time,product batch,equipment ability,key machine,key part and machine sharing,etc,an integrated formation model is constructed and internal interrelations of these constraints are analyzed synthetically.Ulteriorly,formation goals of types of MCs and their formation procedures under joint effect of formation constraints and rules are spread.In case study,three highly balanced GC are formed first;then FC formation are implemented based on the same data which indicate good balancing effect of cell load and flow-style production for key tasks;When task is adjusted,a new scheme is constructed on the result of FC configuration by using IC formation method,and more optimal performance of flow-style production is manifested.The proposed comparative study of different type of cells strongly explains the validation of integrated MC formation in support of rapid manufacturing resource transformation under MPTVV production mode. 展开更多
关键词 multi-product type and variant volume production cell formation flow style manufacturing cell inheriting manufacturing cell
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Blade Segment with a 3D Lattice of Diamond Grits Fabricated via an Additive Manufacturing Process 被引量:2
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作者 Bin Chen Peng Chen +3 位作者 Yongjun Huang Xiangxi Xu Yibo Liu Shuangxi Wang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2020年第5期185-196,共12页
Diamond tools with orderly arrangements of diamond grits have drawn considerable attention in the machining field owing to their outstanding advantages of high sharpness and long service life.This diamond super tool,a... Diamond tools with orderly arrangements of diamond grits have drawn considerable attention in the machining field owing to their outstanding advantages of high sharpness and long service life.This diamond super tool,as well as the manufacturing equipment,has been unavailable to Chinese enterprises for a long time due to patents.In this paper,a diamond blade segment with a 3D lattice of diamond grits was additively manufactured using a new type of cold pressing equipment(AME100).The equipment,designed with a rotary working platform and 16 molding stations,can be used to additively manufacture segments with diamond grits arranged in an orderly fashion,layer by layer;under this additive manufacturing process,at least 216000 pcs of diamond green segments with five orderly arranged grit layers can be produced per month.The microstructure of the segment was observed via SEM and the diamond blade fabricated using these segments was compared to other commercial cutting tools.The experimental results showed that the 3D lattice of diamond grits was formed in the green segment.The filling rate of diamond grits in the lattice could be guaranteed to be above 95%;this is much higher than the 90%filling rate of the automatic array system(ARIX).When used to cut stone,the cutting amount of the blade with segments made by AME100 is two times that of ordinary tools,with the same diamond concentration.When used to dry cut reinforced concrete,its cutting speed is 10%faster than that of ARIX.Under wet cutting conditions,its service life is twice that of ARIX.By applying the machine vision online inspection system and a special needle jig with a negative pressure system,this study developed a piece of additive manufacturing equipment for efficiently fabricating blade segments with a 3D lattice of diamond grits. 展开更多
关键词 Diamond blade segment Additive manufacturing 3D lattice of diamond grits Cold pressing equipment Machine vision inspection
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Efficient Electromagnetic Wave Absorption and Thermal Infrared Stealth in PVTMS@MWCNT Nano‑Aerogel via Abundant Nano‑Sized Cavities and Attenuation Interfaces 被引量:3
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作者 Haoyu Ma Maryam Fashandi +5 位作者 Zeineb Ben Rejeb Xin Ming Yingjun Liu Pengjian Gong Guangxian Li Chul B.Park 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第1期370-383,共14页
Pre-polymerized vinyl trimethoxy silane(PVTMS)@MWCNT nano-aerogel system was constructed via radical polymerization,sol-gel transition and supercritical CO_(2)drying.The fabricated organic-inorganic hybrid PVTMS@MWCNT... Pre-polymerized vinyl trimethoxy silane(PVTMS)@MWCNT nano-aerogel system was constructed via radical polymerization,sol-gel transition and supercritical CO_(2)drying.The fabricated organic-inorganic hybrid PVTMS@MWCNT aerogel structure shows nano-pore size(30-40 nm),high specific surface area(559 m^(2)g^(−1)),high void fraction(91.7%)and enhanced mechanical property:(1)the nano-pore size is beneficial for efficiently blocking thermal conduction and thermal convection via Knudsen effect(beneficial for infrared(IR)stealth);(2)the heterogeneous interface was beneficial for IR reflection(beneficial for IR stealth)and MWCNT polarization loss(beneficial for electromagnetic wave(EMW)attenuation);(3)the high void fraction was beneficial for enhancing thermal insulation(beneficial for IR stealth)and EMW impedance match(beneficial for EMW attenuation).Guided by the above theoretical design strategy,PVTMS@MWCNT nano-aerogel shows superior EMW absorption property(cover all Ku-band)and thermal IR stealth property(ΔT reached 60.7℃).Followed by a facial combination of the above nano-aerogel with graphene film of high electrical conductivity,an extremely high electromagnetic interference shielding material(66.5 dB,2.06 mm thickness)with superior absorption performance of an average absorption-to-reflection(A/R)coefficient ratio of 25.4 and a low reflection bandwidth of 4.1 GHz(A/R ratio more than 10)was experimentally obtained in this work. 展开更多
关键词 Nano-pore size Heterogeneous interface Electromagnetic wave absorption Thermal infrared stealth Nano-aerogel
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Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification 被引量:1
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作者 Yu-Hua Du Jian-Jun Zhao +6 位作者 Xia Li Shi-Cong Huang Na Ning Guo-Qing Chen Yi Yang Yi Nan Ling Yuan 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第1期30-50,共21页
BACKGROUND Pachymic acid(PA)is derived from Poria cocos.PA has a variety of pharmacological and inhibitory effects on various tumors.However,the mechanism of action of PA in gastric cancer(GC)remains unclear.AIM To in... BACKGROUND Pachymic acid(PA)is derived from Poria cocos.PA has a variety of pharmacological and inhibitory effects on various tumors.However,the mechanism of action of PA in gastric cancer(GC)remains unclear.AIM To investigate the mechanism of PA in treating GC via the combination of network pharmacology and experimental verification.METHODS The GeneCards and OMIM databases were used to derive the GC targets,while the Pharm Mapper database provided the PA targets.Utilizing the STRING database,a protein-protein interaction network was constructed and core targets were screened.The analyses of Gene Ontology,Kyoto Encyclopedia of Genes and Genomes(KEGG),and gene set enrichment analysis were conducted,and molecular docking and clinical correlation analyses were performed on the core targets.Ultimately,the network pharmacology findings were validated through in vitro cell assays,encompassing assessments of cell viability,apoptosis,cell cycle,cloning,and western blot analysis.RESULTS According to network pharmacology analysis,the core targets were screened,and the PI3K/AKT signaling pathway is likely to be the mechanism by which PA effectively treats GC,according to KEGG enrichment analysis.The experimental findings showed that PA could control PI3K/AKT signaling to prevent GC cell proliferation,induce apoptosis,and pause the cell cycle.CONCLUSION Network pharmacology demonstrated that PA could treat GC by controlling a variety of signaling pathways and acting on a variety of targets.This has also been supported by in vitro cell studies,which serve as benchmarks for further research. 展开更多
关键词 Pachymic acid Gastric cancer Network pharmacology Enrichment analysis Cell proliferation
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Microstructure transformations and improving wear resistance of austenitic stainless steel additively fabricated by arc-based DED process
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作者 Ashish Yadav Manu Srivastava +1 位作者 Prashant K.Jain Sandeep Rathee 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第8期194-204,共11页
In this study, austenitic stainless steel(ASS) was additively fabricated by an arc-based direct energy deposition(DED) technique. Macrostructure, microstructure, mechanical characteristics at different spatial orienta... In this study, austenitic stainless steel(ASS) was additively fabricated by an arc-based direct energy deposition(DED) technique. Macrostructure, microstructure, mechanical characteristics at different spatial orientations(0°, 90°, and 45°), and wear characteristics were evaluated at the deposited structure top, middle, and bottom regions. Results show that austenite(γ) and delta-ferrite(δ) phases make up most of the microstructure of additively fabricated SS316LSi steel. Within γ matrix, δ phase is dispersed both(within and along) grain boundaries, exhibiting a fine vermicular morphology. The bottom, middle,and top regions of WAAM deposited ASS exhibit similar values to those of wrought SS316L in the tensile and impact test findings. Notably, a drop in hardness values is observed as build height increases. During SEM examinations of fractured surfaces from tensile specimen, closed dimples were observed, indicating good ductility of as-built structure. Wear test findings show signs of mild oxidation and usual adhesive wear. By depositing a mechanically mixed composite layer, an increase in the oxidation percentage was discovered to facilitate healing of worn surfaces. The findings of this study will help in design, production and renovation of products/components that are prone to wear. WAAM-deposited ASS has remarkable strength and ability to withstand impacts;it can be used in the production of armour plates for defence applications, mainly military vehicles and aircraft. 展开更多
关键词 Metal additive deposition Defence applications Arc-based DED Characterization Wear behaviour FRACTOGRAPHY
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气化冲击焊飞板碰撞速度测量及影响因素分析 被引量:1
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作者 陈树君 苏珊 +3 位作者 肖珺 毛羽 Anupam Vivik Glenn S.Daehn 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2018年第11期3439-3443,共5页
气化冲击焊接技术可广泛用于难以焊接成形的钛、镁和铝等有色金属材料与钢材的连接。铝箔作为气化冲击焊接过程能量转换的载体,它的工作效率对气化冲击焊接工艺起到至关重要的作用。分析了气化冲击焊接过程中能量转换的过程,采用光子多... 气化冲击焊接技术可广泛用于难以焊接成形的钛、镁和铝等有色金属材料与钢材的连接。铝箔作为气化冲击焊接过程能量转换的载体,它的工作效率对气化冲击焊接工艺起到至关重要的作用。分析了气化冲击焊接过程中能量转换的过程,采用光子多普勒测速系统分析了3种不同厚度的铝箔在不同能量输入条件下铝箔的工作效率和对飞板与靶板碰撞速度的影响规律。结果表明,当飞板与靶板间距(碰撞角度5°)为2.5 mm时,铝箔的气化能量是影响飞板与靶板碰撞速度的关键因素。通过碰撞速度的分析可以发现,0.051 mm铝箔在输入能量小于3 kJ时效率最高,0.076 mm铝箔在3~6 kJ效率最高,6~12 kJ时,0.127 mm的铝箔可以获得最佳效率。 展开更多
关键词 铝箔 气化冲击焊 光子多普勒测速 能量转换:碰撞速度
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基于中间过渡层的5A06/0Cr18Ni10Ti气化冲击焊接工艺研究 被引量:4
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作者 苏珊 陈树君 +3 位作者 肖珺 Yu MAO Anupam VIVEK Glenn DAEHN 《金属学报》 SCIE EI CAS CSCD 北大核心 2019年第8期1041-1048,共8页
利用气化冲击焊接技术,制备了力学性能良好基于中间层的5A06铝合金与0Cr18Ni10Ti不锈钢气化冲击焊接接头,中间层3003铝合金与飞板5A06铝合金和靶板0Cr18Ni10Ti界面焊接良好,接头结合区域呈圆环状。通过信号采集系统分析了铝箔气化时间... 利用气化冲击焊接技术,制备了力学性能良好基于中间层的5A06铝合金与0Cr18Ni10Ti不锈钢气化冲击焊接接头,中间层3003铝合金与飞板5A06铝合金和靶板0Cr18Ni10Ti界面焊接良好,接头结合区域呈圆环状。通过信号采集系统分析了铝箔气化时间和电流随能量输入的变化,采用OM和SEM分析了接头界面的微观形貌和元素分布。研究了能量输入对铝箔气化的时刻和接头力学性能的影响。结果表明,随着能量输入的增加,铝箔气化所需时间减小,最终碰撞速率增大,从而使焊接区域直径增大;接头的抗拉力和抗剪力随能量输入的增大而增大。当能量输入为9 kJ时,接头的最大抗拉力为44.0 k N,抗剪力为2.1 kN;5A06/3003界面呈中间对称波状结合,3003/0Cr18Ni10Ti界面以金属间化合物连接,结合区域错位分布。 展开更多
关键词 中间过渡层 异种材料 气化冲击焊接 光子多普勒测速
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聚乙烯醇/微纤化纤维素复合微发泡材料的制备 被引量:5
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作者 赵娜 李倩 Chul B.Park 《化工学报》 EI CAS CSCD 北大核心 2015年第2期806-813,共8页
通过溶液浇铸法制备了聚乙烯醇(PVOH)/微纤化纤维素(MFC)复合薄膜材料,以超临界二氧化碳(scCO2)为物理发泡剂,采用间歇式降压法制备了一系列PVOH/MFC复合微发泡材料,主要讨论了在没有水分的影响下,不同发泡温度和时间以及MFC含量对PVOH/... 通过溶液浇铸法制备了聚乙烯醇(PVOH)/微纤化纤维素(MFC)复合薄膜材料,以超临界二氧化碳(scCO2)为物理发泡剂,采用间歇式降压法制备了一系列PVOH/MFC复合微发泡材料,主要讨论了在没有水分的影响下,不同发泡温度和时间以及MFC含量对PVOH/MFC复合微发泡材料的泡孔形貌、泡孔尺寸和泡孔密度的影响;同时,也对MFC的分散性和PVOH/MFC复合材料的流变性能和热性能对发泡行为的影响进行了研究。实验结果表明,均匀分散在PVOH基体中的MFC作为异相成核剂提高了气孔成核能力,且随着MFC含量的增加,泡孔尺寸降低,泡孔密度增大;并研究了发泡温度对PVOH/MFC复合材料的发泡形貌的影响,获得最优发泡温度。 展开更多
关键词 聚乙烯醇 超临界二氧化碳 挤出 发泡 成核
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Material Removal Model Considering Influence of Curvature Radius in Bonnet Polishing Convex Surface 被引量:6
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作者 SONG Jianfeng YAO Yingxue 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第6期1109-1116,共8页
The bonnet tool polishing is a novel, advanced and ultra-precise polishing process, by which the freeform surface can be polished. However, during the past few years, not only the key technology of calculating the dwe... The bonnet tool polishing is a novel, advanced and ultra-precise polishing process, by which the freeform surface can be polished. However, during the past few years, not only the key technology of calculating the dwell time and controlling the surface form in the bonnet polishing has been little reported so far, but also little attention has been paid to research the material removal function of the convex surface based on the geometry model considering the influence of the curvature radius. Firstly in this paper, for realizing the control of the freeform surface automatically by the bonnet polishing, on the basis of the simplified geometric model of convex surface, the calculation expression of the polishing contact spot on the convex surface considering the influence of the curvature radius is deduced, and the calculation model of the pressure distribution considering the influence of the curvature radius on the convex surface is derived by the coordinate transformation. Then the velocity distribution model is built in the bonnet polishing the convex surface. On the basis of the above research and the semi-experimental modified Preston equation obtained from the combination method of experimental and theoretical derivation, the material removal model of the convex surface considering the influence of the curvature radius in the bonnet polishing is established. Finally, the validity of the model through the simulation method has been validated. This research presents an effective prediction model and the calculation method of material removal for convex surface in bonnet polishing and prepares for the bonnet polishing the free surface numerically and automatically. 展开更多
关键词 bonnet polishing convex surface material removal model curvature radius
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Numerical simulation of thermal behavior during laser metal deposition shaping 被引量:6
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作者 龙日升 刘伟军 +1 位作者 邢飞 王华兵 《中国有色金属学会会刊:英文版》 EI CSCD 2008年第3期691-699,共9页
Abstract: Based on the element life and death theory of finite element analysis(FEA), a three-dimensional multi-track and multi-layer model for laser metal deposition shaping(LMDS) was developed with ANSYS parametric ... Abstract: Based on the element life and death theory of finite element analysis(FEA), a three-dimensional multi-track and multi-layer model for laser metal deposition shaping(LMDS) was developed with ANSYS parametric design language(APDL), and detailed numerical simulations of temperature and thermal stress were conducted. Among those simulations, long-edge parallel reciprocating scanning method was introduced. The distribution regularities of temperature, temperature gradient, Von Mise’s effective stress, X-directional, Y-directional and Z-directional thermal stresses were studied. LMDS experiments were carried out with nickel-based superalloy using the same process parameters as those in simulation. The measured temperatures of molten pool are in accordance with the simulated results. The crack engendering and developing regularities of samples show good agreement with the simulation results. 展开更多
关键词 激光金属沉积 热处理 数字模式 成型方式
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Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis 被引量:18
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作者 Xi-Ping Zhang Hua Tian +8 位作者 Yue-Hong Lai Li Chen Ling Zhang Qi-Hui Cheng Wei Yan Yun Li Qing-Yu Li Qing He Fei Wang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第38期5079-5089,共11页
AIM: To investigate the protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis (SAP). METHODS: One hundred and eighty SD rats were randomly assigned to the ... AIM: To investigate the protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis (SAP). METHODS: One hundred and eighty SD rats were randomly assigned to the model group, Baicalin-treated group, octreotide-treated group and sham operation group. The mortality, plasma endotoxin level, contents of blood urea nitrogen (BUN), creatinine (CREA), phospholipase A2 (PLA2), nitrogen monoxide (NO), tumor necrosis factor (TNF)-α, IL-6 and endothelin-1 (ET-1) in serum, expression levels of renal Bax and Bcl-2 protein, apoptotic indexes and pathological changes of kidney were observed at 3, 6 and 12 h after operation. RESULTS: The renal pathological changes were milder in treated group than in model group. The survival at 12 h and renal apoptotic indexes at 6 h were significantly (P < 0.05) higher in treated group than in model group [66.67% vs 100%; 0.00 (0.02)% and 0.00 (0.04)% vs 0.00 (0.00)%, respectively]. The serum CREA content was markedly lower in octreotide-treated group than in model group at 3 h and 6 h (P < 0.01, 29.200 ± 5.710 μmol/L vs 38.400 ± 11.344 μmol/L; P < 0.05, 33.533 ± 10.106 μmol/L vs 45.154 ± 17.435 μmol/L, respectively). The expression level of renal Bax protein was not significantly different between model group and treated groups at all time points. The expression level of renal Bcl-2 protein was lower in Baicalin-treated group than in model group at 6 h [P < 0.001, 0.00 (0.00) grade score vs 3.00 (3.00) grade score]. The Bcl-2 expression level was lower in octreotide-treated group than in model group at 6 h and 12 h [P < 0.05, 0.00 (0.00) grade score vs 3.00 (3.00) grade score; 0.00 (0.00) grade score vs 0.00 (1.25) grade score, respectively]. The serum NO contents were lower in treated groups than in model group at 3 h and 12 h [P < 0.05, 57.50 (22.50) and 52.50 (15.00) μmol/L vs 65.00 (7.50) μmol/L; P < 0.01, 57.50 (27.50) and 45.00 (12.50) μmol/L vs 74.10 (26.15) μmol/L, respectively]. The plasma endotoxin content and serum BUN content (at 6 h and 12 h) were lower in treated groups than in model group. The contents of IL-6, ET-1, TNF-α (at 6 h) and PLA2 (at 6 h and 12 h) were lower in treated groups than in model group [P < 0.001, 3.031 (0.870) and 2.646 (1.373) pg/mL vs 5.437 (1.025) pg/mL; 2.882 (1.392) and 3.076 (1.205) pg/mL vs 6.817 (0.810) pg/mL; 2.832 (0.597) and 2.462 (1.353) pg/mL vs 5.356 (0.747) pg/mL; 16.226 (3.174) and 14.855 (5.747) pg/mL vs 25.625 (7.973) pg/mL; 18.625 (5.780) and 15.185 (1.761) pg/mL vs 24.725 (3.759) pg/mL; 65.10 (27.51) and 47.60 (16.50) pg/mL vs 92.15 (23.12) pg/mL; 67.91 ± 20.61 and 66.86 ± 22.10 U/mL, 63.13 ± 26.31 and 53.63 ± 12.28 U/mL vs 101.46 ± 14.67 and 105.33 ± 18.10 U/mL, respectively]. CONCLUSION: Both Baicalin and octreotide can protect the kidney of rats with severe acute pancreatitis. The therapeutic mechanisms of Baicalin and octreotide might be related to their inhibition of inflammatory mediators and induction of apoptosis. Baicalin might be a promising therapeutic tool for severe acute pancreatitis. 展开更多
关键词 Severe acute pancreatitis BAICALIN OCTREOTIDE Renal injury RATS Tissue microarrays
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Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis 被引量:29
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作者 Xi-Ping Zhang Li Chen +10 位作者 Qi-Fang Hu Hua Tian Ru-Jun Xu Zhi-Wei Wang Ke-Yi Wang Qi-Hui Cheng Wei Yan Yun Li Qing-Yu Li Qing He Fei Wang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第41期5506-5511,共6页
AIM: To investigate the influence of high dose of dexamethasone on inflammatory mediators and apoptosis of rats with severe acute pancreatitis (SAP). METHODS: SAP rats were randomly assigned to the model group and tre... AIM: To investigate the influence of high dose of dexamethasone on inflammatory mediators and apoptosis of rats with severe acute pancreatitis (SAP). METHODS: SAP rats were randomly assigned to the model group and treatment group while the normal rats were assigned to the sham operation group. The mortality,ascite volumes,ascites/body weight ratio and pancreas pathological changes of all rats were observed at 3,6 and 12 h after operation. Their contents of amylase and endotoxin in plasma and contents of tumor necrosis factor (TNF-α),phospholipase A2 (PLA2) and IL-6 in serum were also determined. The microarray sections of their pancreatic tissues were prepared,terminal transferase dUTP nick end labeling (TUNEL) staining was performed and apoptotic indexes were calculated. RESULTS: There was no marked difference between treatment group and model group in survival. The contents of amylase and endotoxin in plasma and contents of TNF-α,PLA2 and IL-6 in serum,ascite volumes,ascites/body weight ratio and pancreas pathological scores were all lower in treatment group than in model group to different extents at different time points P < 0.05,58.3 (26.4) ng/L vs 77.535 (42.157) ng/L in TNF-α content,8.00 (2.00) points vs 9.00 (2.00) points in pathological score of pancreas respectively; P < 0.01,0.042 (0.018) EU/mL vs 0.056 (0.0195) EU/mL in endotoxin content,7791 (1863) U/L vs 9195 (1298) U/L in plasma amylase content,1.53 (0.79) vs 2.38 (1.10) in ascites/body weight ratio,8.00 (1.00) points vs 11.00 (1.50) points in pathological score of pancreas; P < 0.001,3.36 (1.56) ng/L vs 5.65 (1.08) ng/L in IL-6 content,4.50 (2.00) vs 7.20 (2.00),4.20 (1.60) vs 6.40 (2.30),3.40 (2.70) vs 7.90 (1.70) in ascite volumes,respectively. The apoptotic indexes of pancreas head and pancreas tail were all higher in treatment group than in model group at 6 h P < 0.01,0.00 (2.00)% vs 0.00 (0.00)%,0.20 (1.80) vs 0.00 (0.00) in apoptosis indexes,respectively. CONCLUSION: The mechanism of dexamethasone treatment in acute pancreatitis is related to its inhibition of inflammatory mediator generation and induction of pancreatic acinar cell apoptosis. 展开更多
关键词 Severe acute pancreatitis APOPTOSIS Inflammatory mediators DEXAMETHASONE Tissue microarrays
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Actualities and Development of Heavy-Duty CNC Machine Tool Thermal Error Monitoring Technology 被引量:7
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作者 Zu-De Zhou Lin Gui +3 位作者 Yue-Gang Tan Ming-Yao Liu Yi Liu Rui-Ya Li 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2017年第5期1262-1281,共20页
Thermal error monitoring technology is the key technological support to solve the thermal error problem of heavy-duty CNC (computer numerical control) machine tools. Currently, there are many review literatures intr... Thermal error monitoring technology is the key technological support to solve the thermal error problem of heavy-duty CNC (computer numerical control) machine tools. Currently, there are many review literatures intro- ducing the thermal error research of CNC machine tools, but those mainly focus on the thermal issues in small and medium-sized CNC machine tools and seldom introduce thermal error monitoring technologies. This paper gives an overview of the research on the thermal error of CNC machine tools and emphasizes the study of thermal error of the heavy-duty CNC machine tool in three areas. These areas are the causes of thermal error of heavy-duty CNC machine tool and the issues with the temperature moni- toring technology and thermal deformation monitoring technology. A new optical measurement technology called the "fiber Bragg grating (FBG) distributed sensing tech- nology" for heavy-duty CNC machine tools is introduced in detail. This technology forms an intelligent sensing and monitoring system for heavy-duty CNC machine tools. This paper fills in the blank of this kind of review articlesto guide the development of this industry field and opens up new areas of research on the heavy-duty CNC machine tool thermal error. 展开更多
关键词 Heavy-duty CNC machine tool Thermalerror Temperature field Deformation field Fiber Bragggrating
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Function Combined Method for Design Innovation of Children's Bike 被引量:4
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作者 WU Xiaoli QIU Tingting CHEN Huijuan 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2013年第2期242-247,共6页
As children mature, bike products for children in the market develop at the same time, and the conditions are frequently updated. Certain problems occur when using a bike, such as cycle overlapping, repeating function... As children mature, bike products for children in the market develop at the same time, and the conditions are frequently updated. Certain problems occur when using a bike, such as cycle overlapping, repeating function, and short life cycle, which go against the principles of energy conservation and the environmental protection intensive design concept. In this paper, a rational multi-function method of design through functional superposition, transformation, and technical implementation is proposed. An organic combination of frog-style scooter and children’s tricycle is developed using the multi-function method. From the ergonomic perspective, the paper elaborates on the body size of children aged 5 to 12 and effectively extracts data for a multi-function children’s bike, which can be used for gliding and riding. By inverting the body, parts can be interchanged between the handles and the pedals of the bike. Finally, the paper provides a detailed analysis of the components and structural design, body material, and processing technology of the bike. The study of Industrial Product Innovation Design provides an effective design method to solve the bicycle problems, extends the function problems, improves the product market situation, and enhances the energy saving feature while implementing intensive product development effectively at the same time. 展开更多
关键词 children’s bike function combined method ERGONOMICS function transformed
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A Fast Charging–Cooling Coupled Scheduling Method for a Liquid Cooling-Based Thermal Management System for Lithium-Ion Batteries 被引量:6
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作者 Siqi Chen Nengsheng Bao +2 位作者 Akhil Garg Xiongbin Peng Liang Gao 《Engineering》 SCIE EI 2021年第8期1165-1176,共12页
Efficient fast-charging technology is necessary for the extension of the driving range of electric vehicles.However,lithium-ion cells generate immense heat at high-current charging rates.In order to address this probl... Efficient fast-charging technology is necessary for the extension of the driving range of electric vehicles.However,lithium-ion cells generate immense heat at high-current charging rates.In order to address this problem,an efficient fast charging–cooling scheduling method is urgently needed.In this study,a liquid cooling-based thermal management system equipped with mini-channels was designed for the fastcharging process of a lithium-ion battery module.A neural network-based regression model was proposed based on 81 sets of experimental data,which consisted of three sub-models and considered three outputs:maximum temperature,temperature standard deviation,and energy consumption.Each sub-model had a desirable testing accuracy(99.353%,97.332%,and 98.381%)after training.The regression model was employed to predict all three outputs among a full dataset,which combined different charging current rates(0.5C,1C,1.5C,2C,and 2.5C(1C=5 A))at three different charging stages,and a range of coolant rates(0.0006,0.0012,and 0.0018 kg·s^(-1)).An optimal charging–cooling schedule was selected from the predicted dataset and was validated by the experiments.The results indicated that the battery module’s state of charge value increased by 0.5 after 15 min,with an energy consumption lower than 0.02 J.The maximum temperature and temperature standard deviation could be controlled within 33.35 and 0.8C,respectively.The approach described herein can be used by the electric vehicles industry in real fast-charging conditions.Moreover,optimal fast charging-cooling schedule can be predicted based on the experimental data obtained,that in turn,can significantly improve the efficiency of the charging process design as well as control energy consumption during cooling. 展开更多
关键词 Lithium-ion battery module Fast-charging Neural network regression SCHEDULING State of charge Energy consumption
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Prediction of fracture limits of Ni-Cr based alloy under warm forming condition using ductile damage models and numerical method 被引量:3
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作者 Ayush MORCHHALE Anand BADRISH +4 位作者 Nitin KOTKUNDE Swadesh Kumar SINGH Navneet KHANNA Ambuj SAXENA Chetan NIKHARE 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2021年第8期2372-2387,共16页
The stretch forming and the deep-drawing processes were carried out at 300 and 673 K to determine the safe forming and fracture limits of IN625 alloy.The experimentally obtained strain-based fracture forming limit dia... The stretch forming and the deep-drawing processes were carried out at 300 and 673 K to determine the safe forming and fracture limits of IN625 alloy.The experimentally obtained strain-based fracture forming limit diagram(FFLD)was transformed into a stress-based(σ-FFLD)and effective plastic strain(EPS)vs triaxiality(η)plot to remove the excess dependency of fracture limits over the strains.For the prediction of fracture limits,seven different damage models were calibrated.The Oh model displayed the best ability to predict the fracture locus with the least absolute error.Though the experimentally obtained fracture limits have only been used for the numerical analysis,none of the considered damage models predicted the fracture strains over the entire considered range of stress triaxiality(0.33<η<0.66).The deep drawing process window helped to determine wrinkling,safe and fracture zones while drawing the cylindrical cups under different temperature and lubricating conditions.Further,the highest drawing ratio of 2 was achieved at 673 K under the lubricating condition.All the numerically predicted results of both stretch forming and deep drawing processes using the Hill 1948 anisotropic yielding function were found to be good within the acceptable range of error. 展开更多
关键词 IN625 alloy warm forming ductile damage models FORMABILITY forming limit diagram deep drawing processing window finite element analysis
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