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Generation and clearance of myelin debris after spinal cord injury
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作者 Chaoyuan Li Wenqi Luo +6 位作者 Irshad Hussain Renrui Niu Xiaodong He Chunyu Xiang Fengshuo Guo Wanguo Liu Rui Gu 《Neural Regeneration Research》 2026年第4期1512-1527,共16页
Traumatic spinal cord injury often leads to the disintegration of nerve cells and axons,resulting in a substantial accumulation of myelin debris that can persist for years.The abnormal buildup of myelin debris at site... Traumatic spinal cord injury often leads to the disintegration of nerve cells and axons,resulting in a substantial accumulation of myelin debris that can persist for years.The abnormal buildup of myelin debris at sites of injury greatly impedes nerve regeneration,making the clearance of debris within these microenvironments crucial for effective post-spinal cord injury repair.In this review,we comprehensively outline the mechanisms that promote the clearance of myelin debris and myelin metabolism and summarize their roles in spinal cord injury.First,we describe the composition and characteristics of myelin debris and explain its effects on the injury site.Next,we introduce the phagocytic cells involved in myelin debris clearance,including professional phagocytes(macrophages and microglia)and non-professional phagocytes(astrocytes and microvascular endothelial cells),as well as other cells that are also proposed to participate in phagocytosis.Finally,we focus on the pathways and associated targets that enhance myelin debris clearance by phagocytes and promote lipid metabolism following spinal cord injury.Our analysis indicates that myelin debris phagocytosis is not limited to monocyte-derived macrophages,but also involves microglia,astrocytes,and microvascular endothelial cells.By modulating the expression of genes related to phagocytosis and lipid metabolism,it is possible to modulate lipid metabolism disorders and influence inflammatory phenotypes,ultimately affecting the recovery of motor function following spinal cord injury.Additionally,therapies such as targeted mitochondrial transplantation in phagocytic cells,exosome therapy,and repeated trans-spinal magnetic stimulation can effectively enhance the removal of myelin debris,presenting promising potential for future applications. 展开更多
关键词 foam cells lipid droplets lipid metabolism MACROPHAGES MICROGLIA myelin debris myelin proteins myelin sheath nerve regeneration PHAGOCYTOSIS spinal cord injury
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The Application of Busywork Flow in Supply Chain Management of Fruits 被引量:3
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作者 OUYANG Bin 《Asian Agricultural Research》 2012年第11期115-119,共5页
Firstly,I point out the problems in the fruit supply chain management.Then through field survey,we know that busywork flow plays a very important role in the fruit supply chain management.I establish the mathematical ... Firstly,I point out the problems in the fruit supply chain management.Then through field survey,we know that busywork flow plays a very important role in the fruit supply chain management.I establish the mathematical model,to derive that the supply chain management of corporate procurement and supply network is the optimal economic model.In terms of the performance of supply chain,I draw the following conclusions:(i) Busywork flow can achieve the supply chain management,and reduces logistics costs in the whole process of circulation;(ii) Busywork flow can improve logistics services for the customers and reduces coordination costs;(iii) The establishment of modern information system can reduce logistics costs;(iv) Busywork flow can improve distribution efficiency and reduce costs;(v) Busywork flow can reduce and avoid the costs of return of goods;(vi) The operation of the busywork flow can achieve integrated transport and business outsourcing to third-party logistics,thereby reducing costs,reducing transport links,reasonably choosing the means of transport,formulating the optimal transportation plan,improving the mode of transport,and increasing the cargo loading amount.(vii) Busywork flow promotes the use of e-commerce.I also express my own views on upgrade version of corporate procurement and supply network.Finally I point out some problems in the existing corporate procurement and supply network,and put forward the following recommendations:developing township-level 4S fruit shop according to the business development,with the functions of purchasing apple,supplying means of agricultural production,providing technical services and developing market;building " corporate ecological orchard" through holding. 展开更多
关键词 Busywork FLOW FRUITS Supply CHAIN management Corpo
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Path Selection in Disaster Response Management Based on Q-learning 被引量:3
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作者 Zhao-Pin Su Jian-Guo Jiang +1 位作者 Chang-Yong Liang2' 3 Guo-Fu Zhang Guo-Fu Zhang 《International Journal of Automation and computing》 EI 2011年第1期100-106,共7页
Suitable rescue path selection is very important to rescue lives and reduce the loss of disasters, and has been a key issue in the field of disaster response management. In this paper, we present a path selection algo... Suitable rescue path selection is very important to rescue lives and reduce the loss of disasters, and has been a key issue in the field of disaster response management. In this paper, we present a path selection algorithm based on Q-learning for disaster response applications. We assume that a rescue team is an agent, which is operating in a dynamic and dangerous environment and needs to find a safe and short path in the least time. We first propose a path selection model for disaster response management, and deduce that path selection based on our model is a Markov decision process. Then, we introduce Q-learning and design strategies for action selection and to avoid cyclic path. Finally, experimental results show that our algorithm can find a safe and short path in the dynamic and dangerous environment, which can provide a specific and significant reference for practical management in disaster response applications. 展开更多
关键词 Disaster response management path selection AGENT SELF-ORGANIZING Markov decision process Q-learning.
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A software-defined networking approach for handover management with real-time video in WLANs 被引量:3
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作者 Peter Dely Andreas Kassler +6 位作者 Lawrence Chow Nicholas Bambos Nico Bayer Hans Einsiedler Christoph Peylo Daniel Mellado Miguel Sanchez 《Journal of Modern Transportation》 2013年第1期58-65,共8页
To achieve high performance and reliability in video streaming over wireless local area networks (WLANs), one must jointly consider both optimized association to access points (APs) and handover management based o... To achieve high performance and reliability in video streaming over wireless local area networks (WLANs), one must jointly consider both optimized association to access points (APs) and handover management based on dynamic scanning of alternate APs. In this article, we propose a new architecture within the software-defined networking (SDN) framework, which allows stations to be connected to several APs simultaneously and to switch fast between them. We evaluate our system in a real-time testbed and demonstrate that our SDN-based handover mechanism significantly reduces the number and duration of video freeze events and allows for smaller playout buffers. 展开更多
关键词 Openflow Handover - Video streaming
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Contingent convertible lease modeling and credit risk management 被引量:1
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作者 Ons Triki Fathi Abid 《Financial Innovation》 2022年第1期2382-2410,共29页
The main objective of this study is to determine a lease agreement to finance an investment project and a solution for managing credit risk.This study investigates three types of contingent leases to reduce the costs ... The main objective of this study is to determine a lease agreement to finance an investment project and a solution for managing credit risk.This study investigates three types of contingent leases to reduce the costs associated with bankruptcy and compensate for the lessor’s position.A leasing defaultable contract allows the lessor to obtain the rent that will be recovered if the lessee defaults.A leasing convertible contract can be automatically converted into shares when certain default conditions related to the cash flows generated by the firm are met.These conditions are triggered by the ratio of the firm’s value and leasing payments.A Defaultable-Convertible-Leasing contract with a payback option grants the lessor the right but not the obligation to convert the remaining lease payments into stocks or to break up the contract and pick up the rented equipment when the firm reaches the default threshold.These contracts are motivated by contributing to the range of risk-management strategies by adding more flexibility to standard leasing contracts and contingent rents.Closed-form securities pricing solutions are set forward in a dynamic model for firms with existing assets and a growth option financed by shares and a contingent lease.Risk-neutral pricing theory and the backward induction method are used to determine the pricing of corporate securities.Numerical analysis shows that leasing convertible contracts and defaultable-convertible contracts with payback options impact the service value of the leased asset,maturity,and inefficiencies resulting from insolvency and asset substitution.An optimal conversion rate reduces inefficiencies,thus making the leasing convertible contract and defaultable-convertible-leasing contract with payback option a reliable solution to ensure business continuity and loss coverage of the leasers upon default. 展开更多
关键词 Contingent convertible lease Growth option Risk of default Asset pricing Stochastic process
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What determine herder households' sustainable grassland management behaviors in western China? 被引量:1
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作者 TAN Shu-hao TAN Zhong-chun 《Ecological Economy》 2014年第2期108-119,共12页
Grassland is most important in China due to its multi-functions. However, about 90% of total usable grassland in China has been degraded and the degradation expands at a rate of 2 million ha per year. Western China co... Grassland is most important in China due to its multi-functions. However, about 90% of total usable grassland in China has been degraded and the degradation expands at a rate of 2 million ha per year. Western China covers 6.12 million square kilometers and 63.8% of the total national area with a distribution of 50 minority nationalities and 75% of the minority national population. Ecological environment there is very vulnerable with more than 90% areas of the annually increased degradation taking place. Under the current tenure arrangement, the individual herder households become the main and direct users of grassland, their decision-making on grassland management may have crucial impact on ecological environment as well as their livelihoods. Thus, it is necessary to examine the determinants of their grassland management behaviors. This study applies 231 household field data from 6 provinces of western China and uses econometric models to explore the major constraints for restricting the herd households' grassland management behaviors. Main results show that under the current tenure and other governance measures, institutional factors, market price and herder's farm and household's characteristics affect the grassland management behaviors. 展开更多
关键词 GRASSLAND herd household model institutions land governance western China
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Home Energy Management System Using NILM and Low-Cost HAN
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作者 Qasim Khalid Naveed Arshad +3 位作者 Nasir Khan Taha Hassan Fahad Javed Jahangir Ikram 《Journal of Electronic Science and Technology》 CAS 2014年第1期20-25,共6页
Home energy management systems (HEMs) are used to provide comfortable life for consumers as well as to save energy. An essential component of HEMs is a home area network (HAN) that is used to remotely control the ... Home energy management systems (HEMs) are used to provide comfortable life for consumers as well as to save energy. An essential component of HEMs is a home area network (HAN) that is used to remotely control the electric devices at homes and buildings. Although HAN prices have dropped in ~ecent years but they are still expensive enough to prohibit a mass scale deployments. In this paper, a very low cost alternative to the expensive HANs is presented. We have applied a combination of non-intrusive load monitoring (NILM) and very low cost one-way HAN to develop a HEM. By using NILM and machine learning algorithms we find the status of devices and their energy consumption from a central meter and communicate with devices through the one-way HAN. The evaluations show that the proposed machine learning algorithm for NILM achieves up to 99% accuracy in certain cases. On the other hand our radio frequency (RF)-based one-way HAN achieves a range of 80 feet in all settings. 展开更多
关键词 Adaptive boosting home areanetwork home energy management non-intrusive loadmanagement radio frequency wireless.
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Biological Management of Damping-Off, Buckeye Rot and Fusarial Wilt of Tomato (cv. Solan Lalima) under Mid-Hill Conditions of Himachal Pradesh
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作者 Nitika Thakur Astha Tripathi 《Agricultural Sciences》 2015年第5期535-544,共10页
Disease management is often complicated by the presence of multiple types of pathogens;in an organic system, it is appropriate to develop disease control strategies. The available literature so far reflects that the m... Disease management is often complicated by the presence of multiple types of pathogens;in an organic system, it is appropriate to develop disease control strategies. The available literature so far reflects that the management of important disease of tomato is through the integrated approaches and very few organic approaches have been tried with various degree of success. Boiopriming of seeds with biocontrol agents (Trichoderma viridae, Trichoderma harzianum and Pseudomonas fluorescens) in combination with different biofertilizers (Azotobacter, Azospirillum and PSB) and organic manures (FYM and vermi-compost) were tested against disease incidence and health management of tomato seedling under nursery as well as field conditions. The studies were conducted during two successive years (2012-2013) at farmer’s field with the objective to combat with the increasing disease incidence of three major disease damping-off, fusarium wilt and buckeye rot from nursery stage to the final harvesting. The study focused on the use of biocontrol agents as the suitable alternative to chemical pesticides with sustainable disease management without pesticide residues in foodstuff. The bio priming of seeds with fungal antagonist Trichoderma viridae and harzianum and bacterial antagonist Pseudomonas fluorescens significantly improved the germination behavior of tomato seeds as compared to untreated control. Highest mean germination (93.1%) and seedling vigour (953.33) was recorded in Treatment 3 (FYM @ 200 q/ ha + Azospirillum + PSB + Trichoderma herzianum (4 kg/ha each) and lowest in control (60.3%) and (304.83), thus indicating a significant per cent increase in seedling emergence (54.4%) and seedling vigour (95.23%). A considerable reduction in disease incidence (pre and post) of damping off was observed in treatment T? and T? (VC @ 50 q/ha + Azospirillum + PSB + Trichoderma herzianum @ (4 kg/ha) with 45.6% and 35.4% respectively). Treatment T? proved highest in terms of yield (665 Kg/Ha), Hence these diseases can be managed by successful application of Biocontrol agents. 展开更多
关键词 BIOCONTROL Agents BIOFERTILIZERS Disease Incidence Organic Manure TOMATO Yield
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Exploration of Operation and Maintenance Management Mode and Innovation Mechanism of Pilot Base of Chemical Park
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作者 Shenggan ZHU Tengfei SHANG 《Asian Agricultural Research》 2024年第9期16-18,22,共4页
Based on the current situation of the operation and maintenance management of the pilot base in many chemical parks in China,this paper conducts an in-depth exploration of the operation and maintenance management and ... Based on the current situation of the operation and maintenance management of the pilot base in many chemical parks in China,this paper conducts an in-depth exploration of the operation and maintenance management and innovation mode of the pilot base from the aspects of the evaluation of the pilot project entering the park,safety and environmental protection supervision,pilot mode,and industrialization mode of the pilot test results,so as to provide solutions for accelerating the process and industrialization of the pilot project and realizing the innovation value of the pilot base. 展开更多
关键词 Chemical parks Pilot base Operation and maintenance MODE INDUSTRIALIZATION EXPLORATION
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Testing Point of Care Portable Data Capture in a Hospital HIV Transmission Prevention Programme and Experience from Computerized Patient Management in a Sub-Saharan Clinic Setting
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作者 Michael Kavuma Maurice Mars 《Computer Technology and Application》 2011年第12期1015-1022,共8页
Clinicians involved in HIV/AIDS (Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome) prevention of mother to child transmission (PMTCT) programme and research activities can benefit from the advantag... Clinicians involved in HIV/AIDS (Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome) prevention of mother to child transmission (PMTCT) programme and research activities can benefit from the advantages that computerized systems add to medical practice even in resource constrained sub-Saharan clinic settings. Their continued use of paper based systems presents clinical data management and patient care challenges. A portable point of care data capture electronic system and a computerized clinic patient management system (CCPMS) were implemented to remedy these challenges. PMTCT report compilation was easier with the portable data collection system whose data were found to be more complete and accurate with a 0.83% error rate compared to a 4.1% error rate in the paper registers. A resounding majority of clinicians preferred using the new CCPMS with many of the view that it improved drug inventory and general clinic management with a positive effect on patient care. 展开更多
关键词 TESTING PORTABLE COMPUTERIZED HIV/AIDS (human immunodeficiency virus/acquired immune deficiency syndrome) care systems.
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Traffic Queuing Management in the Internet of Things: An Optimized RED Algorithm Based Approach
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作者 Abdul Waheed Naila Habib Khan +4 位作者 Mahdi Zareei Shahab Ul Islam Latif Jan Arif Iqbal Umar Ehab Mahmoud Mohamed 《Computers, Materials & Continua》 SCIE EI 2021年第1期359-372,共14页
Congestion control is one of the main obstacles in cyberspace traffic.Overcrowding in internet traffic may cause several problems;such as high packet hold-up,high packet dropping,and low packet output.In the course of... Congestion control is one of the main obstacles in cyberspace traffic.Overcrowding in internet traffic may cause several problems;such as high packet hold-up,high packet dropping,and low packet output.In the course of data transmission for various applications in the Internet of things,such problems are usually generated relative to the input.To tackle such problems,this paper presents an analytical model using an optimized Random Early Detection(RED)algorithm-based approach for internet traffic management.The validity of the proposed model is checked through extensive simulation-based experiments.An analysis is observed for different functions on internet traffic.Four performance metrics are taken into consideration,namely,the possibility of packet loss,throughput,mean queue length and mean queue delay.Three sets of experiments are observed with varying simulation results.The experiments are thoroughly analyzed and the best packet dropping operation with minimum packet loss is identified using the proposed model. 展开更多
关键词 Random early detection(RED) active queue management(AQM) quality of service(QOS) THROUGHPUT
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How do international agreement constraints affect marine litter management strategies?A research based on differential game
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作者 LENG Jie QI Xin CAO Zeng 《Ecological Economy》 2023年第1期27-43,共17页
Based on differential game theory,the decision-making problem of two homogeneous countries facing transboundary marine litter governance is studied.On the basis of assuming that the input of marine litter is an exogen... Based on differential game theory,the decision-making problem of two homogeneous countries facing transboundary marine litter governance is studied.On the basis of assuming that the input of marine litter is an exogenous variable,the focus is on reducing the accumulation of marine litter through cleanup and transfer processing by both parties.Considering the constant and increasing input of marine litter,in the framework of international agreement constraints,the analysis of the game behavior of the players in the marine litter governance under the open-loop strategy(in the case of agreement constraints)and the Markov strategy(in the case of no agreement constraints)was compared and analyzed.The research results show that when the direct pollution cost of marine litter is high enough,both sides of the game adopt an open-loop strategy that complies with the constraints of the agreement,which can reduce the accumulation of marine litter and improve the environmental quality.However,when there is a high initial accumulation of marine litter,the Markov strategy without protocol constraints will be better than the open-loop strategy.In the case that marine litter does not need to be transferred,there will be no difference between the two sides of the game adopting the Markov strategy and adopting the open-loop strategy on the equilibrium growth path. 展开更多
关键词 arine litter governance clean-up strategy differential game protocol constraints
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Knowledge of Health Communications Management and Treatment Seeking-Behavior Regarding Malaria in Uganda
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作者 Frank B. Ahimbisibwe Leon Matagi +1 位作者 Mohamed Senkumba Privah Atuhaire 《Open Journal of Epidemiology》 2020年第3期203-219,共17页
In Uganda, there is still insufficient comprehension of malaria as a lethal disease especially in rural areas despite universal bed-net distribution coverage and effective anti-malarial treatment. <strong>Aim:&l... In Uganda, there is still insufficient comprehension of malaria as a lethal disease especially in rural areas despite universal bed-net distribution coverage and effective anti-malarial treatment. <strong>Aim:</strong> To get evidence-based knowledge to establish the contribution of an individuals’ knowledge from various health communications that could increase their active involvement in health care especially seeking timely appropriate treatment for malaria or suspected malaria. <strong>Method:</strong> A cross-sectional survey using a correlational design was employed on a clustered sample of 380 rural households in 05 sub-counties of Kanungu district. Data were corrected between October 2016-January 2017 using researcher-administered questionnaires, key-informant interviews and focus group discussions. Correlation analysis was done. <strong>Result:</strong> There is a significant positive relationship between knowledge of health communications and treatment-seeking behavior (r = 0.312;<em>p</em> ≤ 0.01). <strong>Conclusion:</strong> Exposure to consistent Behavioral Change Communications messages influences treatment-seeking behaviour. Thus, in malaria-prone communities, it appears that other factors including sufficient targeted persuasive health communication are lacking in influencing personal orientations towards treatment-seeking behaviour. Therefore, proper Health Communications management supplements efforts from other disciplines and players, against malaria in Uganda. 展开更多
关键词 Health Communications Treatment Seeking Behavior
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Selection of Operation and Management Model for Industrial Mesoeconomy
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作者 Xiaozhou Wang Futing Gao Bo Lu 《Chinese Business Review》 2004年第6期66-70,共5页
Just as the regional economy and city economy, the industrial economy is the economic aggregation lying in between the macroeconomy and microeconomy. Mesoeconomic management is the extension of the macroeconomic manag... Just as the regional economy and city economy, the industrial economy is the economic aggregation lying in between the macroeconomy and microeconomy. Mesoeconomic management is the extension of the macroeconomic management and has its own operation rules. The relationship between the macroeconomic and the mesoeconomic management is just like between the general department and the specialized department of the government while reflecting on the subject of the management. Establishment of the mesoeconomic management system is a model of the reform in the specialized economic departments of Chinese government. 展开更多
关键词 industrial mesoeconomy management systems
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Study on Multilevel Fuzzy Synthetical Evaluating Model of Science & Technology Awarding
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作者 Zhe Wang Xiaoxia Wang Daisong Li 《Chinese Business Review》 2004年第7期66-69,共4页
In order to realize the impersonality, justness, impartiality and rationality in the awarding work of science & technology, it is necessary to establish an evaluating model to make the evaluating course numeric as we... In order to realize the impersonality, justness, impartiality and rationality in the awarding work of science & technology, it is necessary to establish an evaluating model to make the evaluating course numeric as well as a complete system of evaluating indexes. The theory of fuzzy mathematics is adopted in this paper to establish a multilevel fuzzy synthetical model to quantitate the evaluating index system for science & technology awarding and to provide the scientific decision-making basis for science & technology awarding. 展开更多
关键词 science technology awarding fuzzy synthetical evaluating model
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The Empirical Studies on IT Management Effectiveness in Japan: 2000,2002 and the Future
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作者 KADONO Yasuo 《Journal of Electronic Science and Technology of China》 2004年第3期70-73,共4页
Many corporate senior managers have not been fully convinced of successful IT management over a period of decades. In order to clarify the mechanism of IT management in companies, we conducted the surveys on IT manage... Many corporate senior managers have not been fully convinced of successful IT management over a period of decades. In order to clarify the mechanism of IT management in companies, we conducted the surveys on IT management in 2000 and 2002. Through the surveys and analyses, we found the causal structure in IT management, developed 'IT Management Effectiveness' as a new measurement tool, published ranking lists of high scored companies, and analyzed characteristics of industry/sizes of respondents and so on. Based on the surveys and researches so far, we would suggest future works, such as comparison of Japanese companies with overseas companies, time series analyses. 展开更多
关键词 IT management effectiveness empirical study RANKING
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Predictive Model to Evaluate Accommodation of Conflict Management Strategies and Board Performance of Oil and Gas Companies in Port Harcourt
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作者 Eluozo S.N. Ukpong Uwem Johnson Eluozo.S. 《Journal of Management Science & Engineering Research》 2021年第2期1-8,共8页
This paper evaluates accommodation of conflict management strategies and board performances in oil and gas sector.The study details the re­flection of effectiveness,efficiency and productivity as the answer to th... This paper evaluates accommodation of conflict management strategies and board performances in oil and gas sector.The study details the re­flection of effectiveness,efficiency and productivity as the answer to thorough efficiency in accommodation of conflict management in oil and gas sector,these parameters in the system express their efficacy on con­flict management in these multinationals,this implies that for thorough efficiency,these variables must work simultaneously for effective and efficient in structural organization that can be a leading multinational sector in oil and gas environment.The study observed Linearized result from graphical representation explaining predominant lower efficiency and little higher efficiency in accommodation of conflict management in oil and gas companies.These experiences from the study monitor the system from generated simulation values that describe the growth rates in exponential phase of accommodation conflict strategic management.Despite exponential phase the results experienced lower parameters,when comparing on its variations showing its poor efficiency as observed in the study.Few periods observed higher effective accommodation on conflict strategic management.The developed model stimulation values were subjected to validation and both parameters generated favourable fits correlation,the study expressed the deficiency on accommodation of conflict management strategy thus developed models that can monitor the fluctuation and progressive state of accommodation on conflict manage­ment strategy,it defines the reflection of other parameters that express the behaviour of the system in terms of conceptual approach to monitor these type of strategic management in oil and gas companies. 展开更多
关键词 Predictive model conflict management Board performance oil and gas
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基于数据挖掘、网络药理学及实验验证探究金陵医派治疗慢性肾衰竭的用药规律及作用机制
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作者 王金龙 吴薇 +7 位作者 万毅刚 房其军 王玉 李雅静 CHONG Fee-lan 穆森林 黄楚博 黄煌 《中国中药杂志》 北大核心 2025年第6期1637-1649,共13页
基于数据挖掘、网络药理学及实验验证系统而深入地探究金陵医派治疗慢性肾衰竭(chronic renal failure,CRF)的用药规律及作用机制。首先,利用中国知网、万方、维普等数据库,以“中药+慢性肾衰竭”“中药+慢性肾功能不全”“中药+虚劳”... 基于数据挖掘、网络药理学及实验验证系统而深入地探究金陵医派治疗慢性肾衰竭(chronic renal failure,CRF)的用药规律及作用机制。首先,利用中国知网、万方、维普等数据库,以“中药+慢性肾衰竭”“中药+慢性肾功能不全”“中药+虚劳”为主题词,选取金陵医派传承医家公开发表的中文期刊文献,按照纳入与排除标准筛选临床治疗CRF的中药处方,进行单味中药用药的频次分析,高频中药四气、五味、归经、功效的分析,关联规则分析以及聚类分析,筛选出215首中药处方和235味单味中药;其中,高频中药包括“黄芪、大黄、丹参、茯苓、白术”(前5位)等;“寒性、甘味、归脾经”的单味中药和“补虚类”中药应用频数最高,其次分别是“活血化瘀类”“利水渗湿类”中药;频数最高的核心中药组合[“核心方”(Hexin Formula,HXF)]是“黄芪、大黄、茯苓、丹参、当归”。其次,借助网络药理学分析发现HXF中的活性成分共有91个,对应的潜在靶点共有250个,包括前列腺素内过氧化物合酶2、前列腺素内过氧化物合酶1、电压门控钠离子通道α亚单位5、毒蕈碱型胆碱受体1、热休克蛋白90α家族A成员1(前5个)等。基因本体论功能的富集分析结果显示,核心靶点参与的主要生物进程、细胞组分以及分子功能分别是核糖核酸聚合酶Ⅱ诱导的转录正向调控和脱氧核糖核酸模板转录的正向调控,细胞溶质、分子、质膜的形成以及同种蛋白的结合和酶的结合;京都基因与基因组百科全书通路的富集分析结果显示,CRF相关基因富集在多种信号通路和细胞代谢通路中,主要涉及“磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)-蛋白激酶B(protein kinase B,Akt)通路”和“晚期糖基化终产物-晚期糖基化终产物受体通路”。分子对接的结果显示,HXF中的活性成分,如黄芪异黄烷苷、白桦脂酸、谷甾醇、紫丹参乙素等在治疗CRF中可能发挥重要作用。最后,基于上述预测结果,借助腺嘌呤诱导的改良型大鼠肾衰竭模型开展体内实验验证。结果证实,HXF在体内调控肾组织线粒体自噬及其上游的PI3K-Akt-哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)信号通路活性,减轻肾小管间质纤维化,进而延缓CRF进展。 展开更多
关键词 金陵医派 慢性肾衰竭 线粒体自噬 数据挖掘 网络药理学
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基于足细胞“内质网自噬-泛凋亡”信号途径探究金陵医派核心方改善糖尿病肾脏疾病肾小球硬化的作用和机制
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作者 沈诗雨 陈好利 +8 位作者 万毅刚 沈山梅 王玉 吴薇 房其军 刘莹露 何其函 桑天庆 CHONG Fee-lan 《中国中药杂志》 北大核心 2025年第21期6109-6119,共11页
该研究旨在探究金陵医派核心方(TCF)通过调控足细胞“内质网自噬-泛凋亡”信号途径改善糖尿病肾脏疾病(DKD)肾小球硬化的作用和机制。首先建立改良型DKD大鼠模型。造模成功后分组,DKD模型鼠分别经灌胃给予TCF、恩格列净(EMPA)以及生理... 该研究旨在探究金陵医派核心方(TCF)通过调控足细胞“内质网自噬-泛凋亡”信号途径改善糖尿病肾脏疾病(DKD)肾小球硬化的作用和机制。首先建立改良型DKD大鼠模型。造模成功后分组,DKD模型鼠分别经灌胃给予TCF、恩格列净(EMPA)以及生理盐水连续8周的干预。其次使用高糖(HG)或分别联合低剂量TCF(L-TCF)和高剂量TCF(H-TCF)含药血清以及EMPA、自噬激动剂Torin 1处理MPC5细胞。在体内研究中观察了模型鼠一般状态和肾损伤指标、肾小球硬化病理特征和足细胞标志分子蛋白表达水平的变化;还观察了肾脏中活性氧(ROS)水平、内质网自噬核心受体和标志分子表达水平、Z-DNA结合蛋白1(ZBP1)表达程度。在体内、外研究中分析了肾脏和足细胞中ZBP1蛋白表达水平以及细胞泛凋亡通路关键信号分子蛋白表达水平的变化。体内研究结果显示,对于DKD模型鼠,TCF和EMPA能改善一般状态和肾损伤指标;能改善肾小球硬化病理特征和足细胞标志分子蛋白表达水平;能改善肾脏中ROS水平以及内质网自噬核心受体、标志分子表达程度和蛋白表达水平;能改善肾脏中ZBP1表达程度和蛋白表达水平;能改善肾脏中细胞泛凋亡通路关键信号分子蛋白表达水平。值得注意的是,TCF和EMPA的改善作用基本相似,但是,对于炎症效应分子白细胞介素-18(IL-18)在肾脏中蛋白表达水平的改善作用,TCF优于EMPA。体外研究结果显示,高、低剂量TCF含药血清和EMPA都能改善HG处理的足细胞中泛凋亡通路关键信号分子蛋白表达水平,而且H-TCF的改善作用均优于L-TCF或EMPA。总之,该研究阐明TCF通过调控足细胞“内质网自噬-泛凋亡”信号途径改善DKD肾小球硬化,为探究金陵医派治疗糖尿病肾脏疾病的作用机制和科学内涵奠定了基础。 展开更多
关键词 金陵医派 糖尿病肾脏疾病 肾小球硬化 内质网自噬 泛凋亡
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Atomic surface of diamond induced by novel green photocatalytic chemical mechanical polishing with high material removal rate 被引量:1
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作者 Zhibin Yu Zhenyu Zhang +6 位作者 Zinuo Zeng Cheng Fan Yang Gu Chunjing Shi Hongxiu Zhou Fanning Meng Junyuan Feng 《International Journal of Extreme Manufacturing》 2025年第2期661-676,共16页
Atomic surfaces are strictly required by high-performance devices of diamond.Nevertheless,diamond is the hardest material in nature,leading to the low material removal rate(MRR)and high surface roughness during machin... Atomic surfaces are strictly required by high-performance devices of diamond.Nevertheless,diamond is the hardest material in nature,leading to the low material removal rate(MRR)and high surface roughness during machining.Noxious slurries are widely used in conventional chemical mechanical polishing(CMP),resulting in the possible pollution to the environment.Moreover,the traditional slurries normally contain more than four ingredients,causing difficulties to control the process and quality of CMP.To solve these challenges,a novel green CMP for single crystal diamond was developed,consisting of only hydrogen peroxide,diamond abrasive and Prussian blue(PB)/titania catalyst.After CMP,atomic surface is achieved with surface roughness Sa of 0.079 nm,and the MRR is 1168 nm·h^(-1).Thickness of damaged layer is merely 0.66 nm confirmed by transmission electron microscopy(TEM).X-ray photoelectron spectroscopy,electron paramagnetic resonance and TEM reveal that·OH radicals form under ultraviolet irradiation on PB/titania catalyst.The·OH radicals oxidize diamond,transforming it from monocrystalline to amorphous atomic structure,generating a soft amorphous layer.This contributes the high MRR and formation of atomic surface on diamond.The developed novel green CMP offers new insights to achieve atomic surface of diamond for potential use in their high-performance devices. 展开更多
关键词 photocatalytic chemical mechanical polishing DIAMOND photocatalytic Fenton reaction material removal rate atomic diamond surface
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