Background:Nesting trees and habitat represent the key factor underpinning stand selection by forest-dwelling birds.While two large European species–the black stork(Ciconia nigra L.)and white-tailed eagle(Haliaaetus ...Background:Nesting trees and habitat represent the key factor underpinning stand selection by forest-dwelling birds.While two large European species–the black stork(Ciconia nigra L.)and white-tailed eagle(Haliaaetus albicilla L.)–are known to require old,large trees for nesting,we sought to investigate further by comparing species requirements at the levels of the nesting tree,nesting stand,and landscape.This entailed a detailed examination of forest features within circles of radius 15 m surrounding 16 and 19 trees holding the nests of storks and eagles respectively.The same parameters were also checked in the vicinity of 50 randomly-selected mature trees.Results:Our results indicate different nesting preferences,with the eagles entirely confining themselves to Scots pine(Pinus sylvestris L.)–a species also chosen by black storks,which nevertheless regularly favour pedunculate oak(Quercus robur L.).Both species select trees of greater girth than the random ones,but white-tailed eagles choose to nest in the vicinity of patches of mature old stands with a loose canopy,to the extent that nesting trees and surrounding trees are of similar ages.In contrast,black storks prefer“veteran”trees with low-set crowns that are much older than any others in their vicinity.Nesting trees of the eagles are away from roads and close to lakes,while black storks do not avoid roads.Conclusions:As the ages of nesting trees of both species are greater than ages at final cutting in this region’s managed forest,silvicultural measures will need to be adjusted,with small patches of forest spared,or larger areas as“islands”of old-growth.Likewise,as tending and thinning are engaged in,certain trees with horizontal branches will need to remain,with relict trees also left untouched.As it happens,all of these recommendations are anyway key elements of close-to nature silviculture and multifunctional forestry.展开更多
Maiden trees of apple cultivars ＇Topaz＇ and ＇Ariwa＇ grafted on M26 rootstock and of sour cherry cultivars ＇Debreceni Botermo and ＇Sabina＇ on mahaleb cherry （Prunus mahaleb L.） were fertilized with bioproducts...Maiden trees of apple cultivars ＇Topaz＇ and ＇Ariwa＇ grafted on M26 rootstock and of sour cherry cultivars ＇Debreceni Botermo and ＇Sabina＇ on mahaleb cherry （Prunus mahaleb L.） were fertilized with bioproducts such as： Fertigo-granulated manure, Micosat-microbial inoculum consisting of mycorrhizal fungi; Humus UP-an extract from vermicompost; Humus Active ＋ Aktywit PM-an extract from vermicomposts with PM （Positive Microorganism）; BioFeed Amin--a plant extract reinforced with amino acids; BioFeed Quality-a seaweed extract reinforced with humic and fulvic acids; Tytanit-titanium; Vinassa-molasses residue from yeast production; Florovit Eko-composed of many environmentally-friendly products. Control maidens were fertilized with mineral fertilizers containing mainly NPK. The maiden trees fertilized with the preparations Tytanit and Humus UP grew less vigorously and produced smaller increases in the length of lateral shoots than those fertilized with mineral fertilizers. On the other hand, bio preparations such as BF Amin, BF Quality, Micosat and Vinassa promoted tree branching and intensified the growth of lateral shoots, stimulating tree growth to a greater extent than the mineral fertilizers.展开更多
There is a deficiency of nurseries in the world producing fruit trees using the organic material management. However, such material has been produced since 2009 at the Research Institute of Horticulture in Skierniewic...There is a deficiency of nurseries in the world producing fruit trees using the organic material management. However, such material has been produced since 2009 at the Research Institute of Horticulture in Skierniewice. To stimulate plant growth, various biopreparations were applied in an organic nursery. Apple trees （＇Topaz＇/M26） obtained from the organic nursery were used to establish an orchard in 2011. One of the combinations in the orchard consisted of trees produced in a conventional nursery. Trees whose maidens had not been fertilized at all in the organic nursery served as the control. The study was conducted for four years （2011-2014）. The least vigorously growing trees were the control trees and those that had been treated in the nursery with the preparation Tytanit, and the most vigorously--those that had been treated there with manure and the biopreparations Micosat, Humus Active ＋ Aktywit PM, and BF Quality and BF Amin. Trees whose maidens had been produced by the conventional method did not differ, in terms of growth vigour, from those treated with the biopreparations Humus UP or Vinassa. The highest cumulative fruit yields from the four-year-old trees were obtained in the combinations where the maidens had been treated in the nursery with the biopreparations BF Amin and BF Quality. The type of fertilization applied to maiden trees in the nursery had no significant effect on mean fruit weight, but it influenced the distribution of fruit in size classes.展开更多
Biofertilizers consist mainly of beneficial microorganisms that can release nutrients from raw materials and plant residues in the soil and make them available commercially where specific strains are used as biologica...Biofertilizers consist mainly of beneficial microorganisms that can release nutrients from raw materials and plant residues in the soil and make them available commercially where specific strains are used as biological fertilizers. They become recently, positive alternatives to chemical fertilizers because they help bring down the costs of chemical fertilizers especially N and P and improve soil fertility by maintaining the physical properties of the soil. They may help in improving crop productivity and quality by increasing the biological N fixation, the availability and uptake of nutrients and stimulating the natural hormones. They are safe for humans, animals and environment and using them is accompanied with reducing the pollution occurring in our environment.展开更多
Biofertilization of crops with plant growth promoting microorganisms is currently considered as a healthy alternative to chemical fertilization. Biofertilizers are microbial preparations containing living cells of dif...Biofertilization of crops with plant growth promoting microorganisms is currently considered as a healthy alternative to chemical fertilization. Biofertilizers are microbial preparations containing living cells of different microorganisms which have the ability to mobilize plant nutrients in soil from unusable to usable form. They are environmentally friendly, play a significant role in the crop production, help to build up the lost microflora and improve the soil health. Also, they increase crop yield by 20% - 30%, stimulate plant growth, are cost effective and provide optimal conditions for soil biological activity. They suppress pathogenic soil organisms, restore natural soil fertility and provide protection against drought and some soil borne diseases. Moreover, they degrade toxic organic chemicals, improve seed germination and aid in balancing soil pH in reducing soil erosion.展开更多
Background:Forest management affects the habitat conditions for many forest-dwelling species.Among them,the capercaillie(Tetrao urogallus)is a rare forest grouse inhabiting old,mature forests.We compared the structure...Background:Forest management affects the habitat conditions for many forest-dwelling species.Among them,the capercaillie(Tetrao urogallus)is a rare forest grouse inhabiting old,mature forests.We compared the structure of forest habitat among 9 active and 9 abandoned leks in the Augustow Forest(North-Eastern Poland),within a radius of 1 km of the leks,defined as the Key Areas for the capercaillie in lowland temperate forest.Habitat measurements were conducted on 1779 circular plots.Assessments made on all plots related to 13 habitat variables measured or noted in the field,including stand structure,canopy closure,stand developmental stage,percentage of Scots pine(Pinus sylvestris),soil fertility and soil moisture,the share of undergrowth,the cover of shrubs,the cover of bilberry(Vaccinium sp.),and the presence of certain habitat elements important to the capercaillie.Results:To compare the still-occupied and the abandoned KAs for the capercaillie,a logistic regression model was developed.The variables best explaining differences between these two categories were:the occurrence of undergrowth layers,canopy closure in the second canopy layer,and stand age.According to the model,with the increase of the shrub-layer cover as well as the density of trees,the probability of the presence of the capercaillie decreased.The capercaillie in the area of the Augustow Forest occupy mainly dry and poor,middle-aged,pinedominated forests,with a moderate extent of stand canopy closure and only weakly-developed layers of undergrowth.Conclusions:The filling-in of mature stands with sub-canopy trees and shrubs(the process which is stimulated by climate change and site eutrophication)causes structural changes,which are unfavourable to the capercaillie.This might explain why in the course of the recent decades the capercaillie has abandoned the oldest stands,distinguished by the presence of bigger shares of undergrowth.The capercaillie has shifted to younger stands,which reveal a lesser extent of canopy closure and a more limited development of understorey vegetation.展开更多
Triple-negative breast cancer(TNBC),which accounts for approximately 15%of breast cancers(BCs)is characterized by a lack of expression of the hormone receptors(HRs)(estrogen receptor(ER)and progesterone receptor(PR)),...Triple-negative breast cancer(TNBC),which accounts for approximately 15%of breast cancers(BCs)is characterized by a lack of expression of the hormone receptors(HRs)(estrogen receptor(ER)and progesterone receptor(PR)),and human epidermal growth factor receptor 2(HER2).TNBC reveals very aggressive behavior and often leads to poor prognosis.Unfortunately,standard chemotherapy(CHT)is related to low response rates and short progression-free survival(PFS)in patients with metastatic TNBC,creating an unmet need.However,recent recognition of different molecular subtypes and mutations within TNBC has allowed exploring some innovative targeted therapies,bringing new hope for women suffering from TNBC.Currently,some promising systemic treatment options in this area have been developed,including targeted therapies,such as poly(ADP-ribose)polymerase(PARP)inhibitors,immune checkpoint inhibitors,antibody-drug conjugates,and AKT inhibitors.The aim of this mini-review is to address these novel treatment modalities and highlight the main directions for further research and clinical practice in the advanced or metastatic forms of TNBC.This article presents poly(ADP-ribose)polymerase(PARP)inhibitors(e.g.,olaparib,talazoparib,and valaparib for treatment of BRCA-mutated,HER2-negative metastatic BC),immune checkpoint inhibitors(atezolizumab and pembrolizumab),an antibody-drug conjugate(ADC)(sacituzumab govitecan),and AKT inhibitors(ipatasertib and capivasertib).A brief outline of the main clinical trials leading to the approval of these new medications has been provided.Moreover,this overview discusses the efficacy and safety of these innovative treatment options,focusing on women with metastatic TNBC.In addition,this paper comments on some recent considerations,regarding avenues of delivering care and conduct clinical trials in patients with BC,during the COVID-19 pandemic.展开更多
Apple/Malus x domestica cv. ＇Topaz＇/M26 and sour cherry cv. ＇Debreceni Botermo＇/Prunus mahaleb L. maidens were fertilized with different organic fertilizers and soil amendments in an organic nursery. A mycorrhizal...Apple/Malus x domestica cv. ＇Topaz＇/M26 and sour cherry cv. ＇Debreceni Botermo＇/Prunus mahaleb L. maidens were fertilized with different organic fertilizers and soil amendments in an organic nursery. A mycorrhizal inoculant, Micosat, was added to the non-fertilized control and to combinations fertilized with various bioproducts. Under assessment was the effect of nutrient delivery on the growth and development of maiden fruit trees focussing on tree height, thickness of the tree trunk, the number and the length of lateral shoots in each treatment combination. It was found that the introduction of mycorrhizal fungi into the soil without fertilizer application significantly improved the growth and development of apple and sour cherry maidens. Mineral fertilizer application （NPK） combined with mycorrhizal inoculation had a negligible effect on the above features. In the presence of bioproducts such as granular manure, Humus Active ＋ Aktywit PM, BF Amin, Vinassa and Florovit Eko, the mycorrhizal fungi were more biologically active than in the absence of these products.展开更多
Imaging has a central role in the context of focal therapy(FT)for prostate cancer(PCa).Prostate-specific membrane antigen(PSMA)positron emission tomography/magnetic resonance imaging(PET/MRI)is a novel imaging modalit...Imaging has a central role in the context of focal therapy(FT)for prostate cancer(PCa).Prostate-specific membrane antigen(PSMA)positron emission tomography/magnetic resonance imaging(PET/MRI)is a novel imaging modality that combines the morpho-functional information of MRI with the molecular characterization of PET.Some papers reported the potential advantages of PSMA PET/MRI in different clinical scenarios.Limited evidence on PSMA PET/MRI is available in the setting of FT.PSMA PET/MRI can be an effective imaging modality for detecting primary PCa and seems to provide accurate local staging of primary PCa.PSMA PET/MRI also shows high performance for restaging and detecting tumor recurrence.The higher soft-tissue contrast and the reduction of ionizing radiation are the main advantages reported in the literature compared to PET/computed tomography.PSMA PET/MRI could represent a turning point in the management of patients with PCa in the context of FT.Further studies are needed to confirm its applications in this specific clinical setting.展开更多
Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and humans.Identifying the genetic components underlying AsA accumulation is crucial for enhan...Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and humans.Identifying the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional quality.Here,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European areas.To account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and environments.AsA content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)analysis.Environmentally stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG 7C.Candidate genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,respectively.We show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA content.Furthermore,expression of FaGGP(3A)was two-fold higher in lines with high AsA.Markers here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content.展开更多
Fifteen patients with intestinal villous atrophy, but simultaneously negative results of antiendomysial antibodies (EMA) were studied. Two patients were final ly diagnosed as having coeliac disease. The predictive val...Fifteen patients with intestinal villous atrophy, but simultaneously negative results of antiendomysial antibodies (EMA) were studied. Two patients were final ly diagnosed as having coeliac disease. The predictive value of negative results of EMA ass essment in children suspected of coeliac disease is high, approaching 86.7%.展开更多
Background Obesity and diabetes became a grooving problem in both adults and children.Many hypotheses concerned agents involved in the excessive weight gain process and it's consequences.Not only genetic or enviro...Background Obesity and diabetes became a grooving problem in both adults and children.Many hypotheses concerned agents involved in the excessive weight gain process and it's consequences.Not only genetic or environmental factors,but also intestinal microbiome seems to play a role in the pathophysiology of this phenomenon.Data sources A systematic review was conducted using Pubmed as the medical database source.Studies concerning connection between microbiome and metabolic disorders such as obesity and diabetes from last 10 years were analyzed.Results Intestinal bacteria may be involved both in the development of obesity,and its further complications.The pro-inflammatory and immunomodulating effect of dysbiosis are possible triggers of insulin resistance and diabetes.Early interventions aimed at the microbiome,as well as attempts to modify the microbiome at later stages may become new opportunities in the prevention and treatment of obesity and carbohydrate metabolism disorders.Conclusions The gut microbiome has been shown to be an important part of the metabolic processes.The use of probiotic,prebiotics and symbiotics is promising,but requires further investigations to determine the specific metabolic effects of each bacteria strain and substance.展开更多
文摘Background:Nesting trees and habitat represent the key factor underpinning stand selection by forest-dwelling birds.While two large European species–the black stork(Ciconia nigra L.)and white-tailed eagle(Haliaaetus albicilla L.)–are known to require old,large trees for nesting,we sought to investigate further by comparing species requirements at the levels of the nesting tree,nesting stand,and landscape.This entailed a detailed examination of forest features within circles of radius 15 m surrounding 16 and 19 trees holding the nests of storks and eagles respectively.The same parameters were also checked in the vicinity of 50 randomly-selected mature trees.Results:Our results indicate different nesting preferences,with the eagles entirely confining themselves to Scots pine(Pinus sylvestris L.)–a species also chosen by black storks,which nevertheless regularly favour pedunculate oak(Quercus robur L.).Both species select trees of greater girth than the random ones,but white-tailed eagles choose to nest in the vicinity of patches of mature old stands with a loose canopy,to the extent that nesting trees and surrounding trees are of similar ages.In contrast,black storks prefer“veteran”trees with low-set crowns that are much older than any others in their vicinity.Nesting trees of the eagles are away from roads and close to lakes,while black storks do not avoid roads.Conclusions:As the ages of nesting trees of both species are greater than ages at final cutting in this region’s managed forest,silvicultural measures will need to be adjusted,with small patches of forest spared,or larger areas as“islands”of old-growth.Likewise,as tending and thinning are engaged in,certain trees with horizontal branches will need to remain,with relict trees also left untouched.As it happens,all of these recommendations are anyway key elements of close-to nature silviculture and multifunctional forestry.
文摘Maiden trees of apple cultivars ＇Topaz＇ and ＇Ariwa＇ grafted on M26 rootstock and of sour cherry cultivars ＇Debreceni Botermo and ＇Sabina＇ on mahaleb cherry （Prunus mahaleb L.） were fertilized with bioproducts such as： Fertigo-granulated manure, Micosat-microbial inoculum consisting of mycorrhizal fungi; Humus UP-an extract from vermicompost; Humus Active ＋ Aktywit PM-an extract from vermicomposts with PM （Positive Microorganism）; BioFeed Amin--a plant extract reinforced with amino acids; BioFeed Quality-a seaweed extract reinforced with humic and fulvic acids; Tytanit-titanium; Vinassa-molasses residue from yeast production; Florovit Eko-composed of many environmentally-friendly products. Control maidens were fertilized with mineral fertilizers containing mainly NPK. The maiden trees fertilized with the preparations Tytanit and Humus UP grew less vigorously and produced smaller increases in the length of lateral shoots than those fertilized with mineral fertilizers. On the other hand, bio preparations such as BF Amin, BF Quality, Micosat and Vinassa promoted tree branching and intensified the growth of lateral shoots, stimulating tree growth to a greater extent than the mineral fertilizers.
文摘There is a deficiency of nurseries in the world producing fruit trees using the organic material management. However, such material has been produced since 2009 at the Research Institute of Horticulture in Skierniewice. To stimulate plant growth, various biopreparations were applied in an organic nursery. Apple trees （＇Topaz＇/M26） obtained from the organic nursery were used to establish an orchard in 2011. One of the combinations in the orchard consisted of trees produced in a conventional nursery. Trees whose maidens had not been fertilized at all in the organic nursery served as the control. The study was conducted for four years （2011-2014）. The least vigorously growing trees were the control trees and those that had been treated in the nursery with the preparation Tytanit, and the most vigorously--those that had been treated there with manure and the biopreparations Micosat, Humus Active ＋ Aktywit PM, and BF Quality and BF Amin. Trees whose maidens had been produced by the conventional method did not differ, in terms of growth vigour, from those treated with the biopreparations Humus UP or Vinassa. The highest cumulative fruit yields from the four-year-old trees were obtained in the combinations where the maidens had been treated in the nursery with the biopreparations BF Amin and BF Quality. The type of fertilization applied to maiden trees in the nursery had no significant effect on mean fruit weight, but it influenced the distribution of fruit in size classes.
文摘Biofertilizers consist mainly of beneficial microorganisms that can release nutrients from raw materials and plant residues in the soil and make them available commercially where specific strains are used as biological fertilizers. They become recently, positive alternatives to chemical fertilizers because they help bring down the costs of chemical fertilizers especially N and P and improve soil fertility by maintaining the physical properties of the soil. They may help in improving crop productivity and quality by increasing the biological N fixation, the availability and uptake of nutrients and stimulating the natural hormones. They are safe for humans, animals and environment and using them is accompanied with reducing the pollution occurring in our environment.
基金supported by the grant from the EU Regional Development Fund through the Polish Innovation Economy Operational Program,contract No.UDA-POIG.01.03.01-10-109/08.
文摘Biofertilization of crops with plant growth promoting microorganisms is currently considered as a healthy alternative to chemical fertilization. Biofertilizers are microbial preparations containing living cells of different microorganisms which have the ability to mobilize plant nutrients in soil from unusable to usable form. They are environmentally friendly, play a significant role in the crop production, help to build up the lost microflora and improve the soil health. Also, they increase crop yield by 20% - 30%, stimulate plant growth, are cost effective and provide optimal conditions for soil biological activity. They suppress pathogenic soil organisms, restore natural soil fertility and provide protection against drought and some soil borne diseases. Moreover, they degrade toxic organic chemicals, improve seed germination and aid in balancing soil pH in reducing soil erosion.
文摘Background:Forest management affects the habitat conditions for many forest-dwelling species.Among them,the capercaillie(Tetrao urogallus)is a rare forest grouse inhabiting old,mature forests.We compared the structure of forest habitat among 9 active and 9 abandoned leks in the Augustow Forest(North-Eastern Poland),within a radius of 1 km of the leks,defined as the Key Areas for the capercaillie in lowland temperate forest.Habitat measurements were conducted on 1779 circular plots.Assessments made on all plots related to 13 habitat variables measured or noted in the field,including stand structure,canopy closure,stand developmental stage,percentage of Scots pine(Pinus sylvestris),soil fertility and soil moisture,the share of undergrowth,the cover of shrubs,the cover of bilberry(Vaccinium sp.),and the presence of certain habitat elements important to the capercaillie.Results:To compare the still-occupied and the abandoned KAs for the capercaillie,a logistic regression model was developed.The variables best explaining differences between these two categories were:the occurrence of undergrowth layers,canopy closure in the second canopy layer,and stand age.According to the model,with the increase of the shrub-layer cover as well as the density of trees,the probability of the presence of the capercaillie decreased.The capercaillie in the area of the Augustow Forest occupy mainly dry and poor,middle-aged,pinedominated forests,with a moderate extent of stand canopy closure and only weakly-developed layers of undergrowth.Conclusions:The filling-in of mature stands with sub-canopy trees and shrubs(the process which is stimulated by climate change and site eutrophication)causes structural changes,which are unfavourable to the capercaillie.This might explain why in the course of the recent decades the capercaillie has abandoned the oldest stands,distinguished by the presence of bigger shares of undergrowth.The capercaillie has shifted to younger stands,which reveal a lesser extent of canopy closure and a more limited development of understorey vegetation.
文摘Triple-negative breast cancer(TNBC),which accounts for approximately 15%of breast cancers(BCs)is characterized by a lack of expression of the hormone receptors(HRs)(estrogen receptor(ER)and progesterone receptor(PR)),and human epidermal growth factor receptor 2(HER2).TNBC reveals very aggressive behavior and often leads to poor prognosis.Unfortunately,standard chemotherapy(CHT)is related to low response rates and short progression-free survival(PFS)in patients with metastatic TNBC,creating an unmet need.However,recent recognition of different molecular subtypes and mutations within TNBC has allowed exploring some innovative targeted therapies,bringing new hope for women suffering from TNBC.Currently,some promising systemic treatment options in this area have been developed,including targeted therapies,such as poly(ADP-ribose)polymerase(PARP)inhibitors,immune checkpoint inhibitors,antibody-drug conjugates,and AKT inhibitors.The aim of this mini-review is to address these novel treatment modalities and highlight the main directions for further research and clinical practice in the advanced or metastatic forms of TNBC.This article presents poly(ADP-ribose)polymerase(PARP)inhibitors(e.g.,olaparib,talazoparib,and valaparib for treatment of BRCA-mutated,HER2-negative metastatic BC),immune checkpoint inhibitors(atezolizumab and pembrolizumab),an antibody-drug conjugate(ADC)(sacituzumab govitecan),and AKT inhibitors(ipatasertib and capivasertib).A brief outline of the main clinical trials leading to the approval of these new medications has been provided.Moreover,this overview discusses the efficacy and safety of these innovative treatment options,focusing on women with metastatic TNBC.In addition,this paper comments on some recent considerations,regarding avenues of delivering care and conduct clinical trials in patients with BC,during the COVID-19 pandemic.
文摘Apple/Malus x domestica cv. ＇Topaz＇/M26 and sour cherry cv. ＇Debreceni Botermo＇/Prunus mahaleb L. maidens were fertilized with different organic fertilizers and soil amendments in an organic nursery. A mycorrhizal inoculant, Micosat, was added to the non-fertilized control and to combinations fertilized with various bioproducts. Under assessment was the effect of nutrient delivery on the growth and development of maiden fruit trees focussing on tree height, thickness of the tree trunk, the number and the length of lateral shoots in each treatment combination. It was found that the introduction of mycorrhizal fungi into the soil without fertilizer application significantly improved the growth and development of apple and sour cherry maidens. Mineral fertilizer application （NPK） combined with mycorrhizal inoculation had a negligible effect on the above features. In the presence of bioproducts such as granular manure, Humus Active ＋ Aktywit PM, BF Amin, Vinassa and Florovit Eko, the mycorrhizal fungi were more biologically active than in the absence of these products.
文摘Imaging has a central role in the context of focal therapy(FT)for prostate cancer(PCa).Prostate-specific membrane antigen(PSMA)positron emission tomography/magnetic resonance imaging(PET/MRI)is a novel imaging modality that combines the morpho-functional information of MRI with the molecular characterization of PET.Some papers reported the potential advantages of PSMA PET/MRI in different clinical scenarios.Limited evidence on PSMA PET/MRI is available in the setting of FT.PSMA PET/MRI can be an effective imaging modality for detecting primary PCa and seems to provide accurate local staging of primary PCa.PSMA PET/MRI also shows high performance for restaging and detecting tumor recurrence.The higher soft-tissue contrast and the reduction of ionizing radiation are the main advantages reported in the literature compared to PET/computed tomography.PSMA PET/MRI could represent a turning point in the management of patients with PCa in the context of FT.Further studies are needed to confirm its applications in this specific clinical setting.
基金supported by the European Union’s Horizon 2020 research and innovation program(GoodBerrygrant agreement number 679303)Agencia Estatal de Investigación(PID2019-111496RR-I00/AEI/10.13039/501100011033)and PR.AVA.AVA2019.034(IFAPA,FEDER funds)。
文摘Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and humans.Identifying the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional quality.Here,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European areas.To account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and environments.AsA content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)analysis.Environmentally stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG 7C.Candidate genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,respectively.We show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA content.Furthermore,expression of FaGGP(3A)was two-fold higher in lines with high AsA.Markers here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content.
文摘Fifteen patients with intestinal villous atrophy, but simultaneously negative results of antiendomysial antibodies (EMA) were studied. Two patients were final ly diagnosed as having coeliac disease. The predictive value of negative results of EMA ass essment in children suspected of coeliac disease is high, approaching 86.7%.
文摘Background Obesity and diabetes became a grooving problem in both adults and children.Many hypotheses concerned agents involved in the excessive weight gain process and it's consequences.Not only genetic or environmental factors,but also intestinal microbiome seems to play a role in the pathophysiology of this phenomenon.Data sources A systematic review was conducted using Pubmed as the medical database source.Studies concerning connection between microbiome and metabolic disorders such as obesity and diabetes from last 10 years were analyzed.Results Intestinal bacteria may be involved both in the development of obesity,and its further complications.The pro-inflammatory and immunomodulating effect of dysbiosis are possible triggers of insulin resistance and diabetes.Early interventions aimed at the microbiome,as well as attempts to modify the microbiome at later stages may become new opportunities in the prevention and treatment of obesity and carbohydrate metabolism disorders.Conclusions The gut microbiome has been shown to be an important part of the metabolic processes.The use of probiotic,prebiotics and symbiotics is promising,but requires further investigations to determine the specific metabolic effects of each bacteria strain and substance.
