This article presents a type of plate Finite Element(FE)models with adaptive mathematical refinement capabilities for modeling laminated smart structures with piezoelectric layers or distributed patches.The p-version ...This article presents a type of plate Finite Element(FE)models with adaptive mathematical refinement capabilities for modeling laminated smart structures with piezoelectric layers or distributed patches.The p-version shape functions are used in combination with the higher-order Layer-Wise(LW)kinematics adopting hierarchical Legendre polynomials.Node-Dependent Kinematics(NDK)is employed to implement local LW models in the regions with piezoelectric components and simulate the global substrate structure with the Equivalent Single-Layer(ESL)approach.Through the proposed NDK FE models,the electro-mechanical behavior of smart structures can be predicted with high fidelity and numerical efficiency,and various patch configurations can be conveniently modeled through one set of mesh grids.Moreover,the effectiveness and efficiency of the NDK FE approach are assessed through numerical examples and its application is demonstrated.展开更多
The studypresents theHalfMax InsertionHeuristic (HMIH) as a novel approach to solving theTravelling SalesmanProblem (TSP). The goal is to outperform existing techniques such as the Farthest Insertion Heuristic (FIH) a...The studypresents theHalfMax InsertionHeuristic (HMIH) as a novel approach to solving theTravelling SalesmanProblem (TSP). The goal is to outperform existing techniques such as the Farthest Insertion Heuristic (FIH) andNearest Neighbour Heuristic (NNH). The paper discusses the limitations of current construction tour heuristics,focusing particularly on the significant margin of error in FIH. It then proposes HMIH as an alternative thatminimizes the increase in tour distance and includes more nodes. HMIH improves tour quality by starting withan initial tour consisting of a ‘minimum’ polygon and iteratively adding nodes using our novel Half Max routine.The paper thoroughly examines and compares HMIH with FIH and NNH via rigorous testing on standard TSPbenchmarks. The results indicate that HMIH consistently delivers superior performance, particularly with respectto tour cost and computational efficiency. HMIH’s tours were sometimes 16% shorter than those generated by FIHand NNH, showcasing its potential and value as a novel benchmark for TSP solutions. The study used statisticalmethods, including Friedman’s Non-parametric Test, to validate the performance of HMIH over FIH and NNH.This guarantees that the identified advantages are statistically significant and consistent in various situations. Thiscomprehensive analysis emphasizes the reliability and efficiency of the heuristic, making a compelling case for itsuse in solving TSP issues. The research shows that, in general, HMIH fared better than FIH in all cases studied,except for a few instances (pr439, eil51, and eil101) where FIH either performed equally or slightly better thanHMIH. HMIH’s efficiency is shown by its improvements in error percentage (δ) and goodness values (g) comparedto FIH and NNH. In the att48 instance, HMIH had an error rate of 6.3%, whereas FIH had 14.6% and NNH had20.9%, indicating that HMIH was closer to the optimal solution. HMIH consistently showed superior performanceacross many benchmarks, with lower percentage error and higher goodness values, suggesting a closer match tothe optimal tour costs. This study substantially contributes to combinatorial optimization by enhancing currentinsertion algorithms and presenting a more efficient solution for the Travelling Salesman Problem. It also createsnew possibilities for progress in heuristic design and optimization methodologies.展开更多
Microbiologically influenced corrosion （MIC） is a major cause of corrosion damages, facility failures, and financial losses, making MIC an important research topic. Due to complex microbiological activities and a la...Microbiologically influenced corrosion （MIC） is a major cause of corrosion damages, facility failures, and financial losses, making MIC an important research topic. Due to complex microbiological activities and a lack of deep understanding of the interactions between biofilms and metal surfaces, MIC occurrences and mechanisms are difficult to predict and interpret. Many theories and mechanisms have been pro- posed to explain MIC. In this review, the mechanisms of MIC are discussed using hioenergetics, microbial respiration types, and biofilm extracellular electron transfer （EET）. Two main MIC types, namely EET-MIC and metabolite MIC （M-ME）, are discussed. This brief review provides a state of the art insight into MIC mechanisms and it helps the diagnosis and prediction of occurrences of MIC under anaerobic conditions in the oil and gas industry.展开更多
The effect of copper addition to 2205 duplex stainless steel（DSS） on its resistance against pitting corrosion by the Pseudomonas aeruginosa biofilm was investigated using electrochemical and surface analysis techniq...The effect of copper addition to 2205 duplex stainless steel（DSS） on its resistance against pitting corrosion by the Pseudomonas aeruginosa biofilm was investigated using electrochemical and surface analysis techniques. Cu addition decreased the general corrosion resistance, resulting in a higher general corrosion rate in the sterile medium. Because DSS usually has a very small general corrosion rate, its pitting corrosion resistance is far more important. In this work, it was shown that 2205-3%Cu DSS exhibited a much higher pitting corrosion resistance against the P. aeruginosa biofilm compared with the 2205 DSS control, characterized by no significant change in the pitting potential and critical pitting temperature（CPT） values. The strong pitting resistance ability of 2205-3%Cu DSS could be attributed to the copper-rich phases on the surface and the release of copper ions, providing a strong antibacterial ability that inhibited the attachment and growth of the corrosive P. aeruginosa biofilm.展开更多
In this study, mitochondrial 16S rRNA sequences of snow leopard, gray wolf, domestic horse and Bactrian camel inhabited or domesticated in Mongolian territory were obtained by using polymerase chain reaction （PCR） b...In this study, mitochondrial 16S rRNA sequences of snow leopard, gray wolf, domestic horse and Bactrian camel inhabited or domesticated in Mongolian territory were obtained by using polymerase chain reaction （PCR） based on universal primers for 16S rRNA （F-5＇-AACGAGCCTGGTGATA-3＇ and R-5＇-CTCCGGTCTGAACTCAGATCACGTA-3＇）. The 16S rRNA sequence was 1,048 bp to 1,086 bp in length, and each sequence was compared to other related species （Felidae, Camelidae, Equidae and Canidae） by using NCBI Basic Local Alignment Search Tool （BLAST）. Results showed that sequences were highly similar to sequences in GenBank database （93%-99%）. Then phylogenetic analysis was performed based on about 1,100 bp sequence of 16S rRNA for Panthera uncia, Canis lupus, Equus caballus, Camelus bactrianus and other related species. The result revealed that P. uncia and P. leo were sister species, C. bactrianus and C. ferus were more closely related species, and wolf and dog were the almost similar species. This finding could be important for designing species specific primers for PCR based analysis of animal species identification and forensic veterinary medicine.展开更多
In developed countries, study on special or candidate genes, which are useful for identifying species, breed and productivity of livestock, was conducted at high level and the results have already been used in practic...In developed countries, study on special or candidate genes, which are useful for identifying species, breed and productivity of livestock, was conducted at high level and the results have already been used in practice. Such advanced technology and innovation that we are facing is necessary to adopt in Mongolia. In this study, the myostatin gene （MSTN） was investigated as a candidate gene for meat animal in Mongolian breeds of cattle. The conventional phenol-chloroform method and FavorPrepTM tissue DNA extraction kit were used for DNA isolation, and the polymerase chain reaction （PCR） and sequencing analysis were used for further study. The nucleotide sequences of MSTN gene from Selenge, Kazakh white head breeds and Mongolian cattle were sequenced and reported on the DDBJ/EMBL/GenBank database （LC142726, LC146648, LC146649）, and Selenge breed showed the result of single nucleotide mutation in MSTN gene.展开更多
The interaction of a screw dislocation in the interphase layer with the circular inhomogeneity and matrix was dealt with . An efficient method for multiply connected regions was developed by combining the sectionally ...The interaction of a screw dislocation in the interphase layer with the circular inhomogeneity and matrix was dealt with . An efficient method for multiply connected regions was developed by combining the sectionally subholomorphic function theory, Schwatz symmetric principle and Cauchy integral technique. The Hilbert problem of the complex potentials for three material regions was reduced to a functional equation in the complex potential of the interphase layer, resulting in an explicit series solution . By using the present solution the interaction energy and force acting dislocation were evaluated and discussed.展开更多
近年来,随着公共交通领域大数据、云计算、移动支付等新兴科技的应用,城市公交、轨道交通等公共交通行业都推出了二维码App实现了“刷手机”乘车。在为用户出行带来便捷的同时,出现了各App平台的信息数据不互联互通和二维码规范不一等...近年来,随着公共交通领域大数据、云计算、移动支付等新兴科技的应用,城市公交、轨道交通等公共交通行业都推出了二维码App实现了“刷手机”乘车。在为用户出行带来便捷的同时,出现了各App平台的信息数据不互联互通和二维码规范不一等问题。这给用户换乘交通工具时带来了不便,同时增加了交通部门的管理成本。本文基于HTTPS(Hyper Text Transfer Protocol over Secure Socket Layer)通信协议、HTML5(HyperText Markup Language 5)通信协议以及MQ(Message Queue)通信协议等多种通信协议构建一码通乘平台,统一各平台的二维码规范和对信息数据,让公共交通资源和数据管理朝着高效化、便捷化、规范化的方向发展。展开更多
Petroleum and Natural Gas still represent a considerable share in terms of energy consumption in the current global matrix, so that its exploration/exploitation is present in the market and driving activities in locat...Petroleum and Natural Gas still represent a considerable share in terms of energy consumption in the current global matrix, so that its exploration/exploitation is present in the market and driving activities in locations of specific complexities, as the ones along unconventional hydrocarbon resources from the Brazilian pre-salt. The daily cost of well drilling under harsh conditions can exceed US $1 million a day, turning any type of downtime or necessary maintenance during the activities to be very costly, moment in which processes optimization starts to be a key factor in costs reduction. Thus, new technologies and methods in terms of automating and optimizing the processes may be of great advantages, having its impact in total related project costs. In this context, the goal of this research is to allow a computation tool supporting achieving a more efficient drilling process, by means of drilling mechanics parameters choosiness aiming rate of penetration (ROP) maximization and mechanic specific energy (MSE) minimization. Conceptually, driven by the pre-operational drilling test curve trends, the proposed system allows it to be performed with less human influences and being updateable automatically, allowing more precision and time reduction by selecting optimum parameters. A Web Operating System (Web OS) was designed and implemented, running in online servers, granting accessibility to it with any device that has a browser and internet connection. It allows processing the drilling parameters supplied and feed into it, issuing outcomes with optimum values in a faster and precise way, allowing reducing operating time.展开更多
Hypoxia,a prevalent characteristic of solid tumors,substantially impairs the efficacy of cancer treatments.However,there are no feasible clinical approaches for treating hypoxic tumors.Here,we develop metal-phenolic n...Hypoxia,a prevalent characteristic of solid tumors,substantially impairs the efficacy of cancer treatments.However,there are no feasible clinical approaches for treating hypoxic tumors.Here,we develop metal-phenolic networks(CuGI)utilizing the natural glycolysis inhibitor(epigallocatechin gallate)and the essential metal element in the human body(copper ions),specifically targeting and annihilating hypoxic cancer cells.CuGI redirects the metabolic pathway of hypoxic cancer cells from anaerobic glycolysis to oxidative phosphorylation,thereby enhancing reactive oxygen species production and promoting oligomerization of lipoylated proteins in the tricarboxylic acid cycle.Through targeted induction of oxidative and proteotoxic stresses,CuGI induces apoptosis and cuproptosis specifically in cancer cells under hypoxic conditions while sparing normal cells.Moreover,cancer cell membrane-coated CuGI(CuGI@CM)exhibits enhanced tumor penetration effect and demonstrates commendable biocompatibility,effectively suppressing colorectal tumor growth.Importantly,CuGI@CM,when combined with vascular disruptors or radiotherapy which aggravate tumor hypoxia,syner-gistically potentiates therapeutic efficacy.Thus,CuGI represents a specific and potent nanotherapeutic capable of selectively eliminating hypoxic tumors,offering promise in combination therapies to address tumor hypoxia.展开更多
To the editor:ATP-citrate lyase(ACLY)is the key enzyme linking glucose catabolism to lipogenesis.Targeting hepatic ACLY for lowering low density lipoprotein-cholesterol(LDL-C)and attenuating atherosclerosis has been v...To the editor:ATP-citrate lyase(ACLY)is the key enzyme linking glucose catabolism to lipogenesis.Targeting hepatic ACLY for lowering low density lipoprotein-cholesterol(LDL-C)and attenuating atherosclerosis has been validated in preclinical animal models and hypercholesterolemic patients1.Bempedoic acid(ETC1002),a first-in-class,potent and orally bioavailable inhibitor of ACLY,has been approved by the US FDA to reduce cardiovascular risk in patients who do not achieve their recommended LDL-C levels through other means.展开更多
The present paper presents an innovative approach for the numerical modeling of piezo-electric transducers for the health-monitoring of layered structures.The numerical approach has been developed in the frameworks of...The present paper presents an innovative approach for the numerical modeling of piezo-electric transducers for the health-monitoring of layered structures.The numerical approach has been developed in the frameworks of the Carrera Unified Formulation.This computa-tional tool allows refined numerical models to be derived in a unified and efficient fashion.The use of higher-order models and the cap-ability to connect different kinematic models using the node-depen-dent kinematic approach has led to an efficient modeling technique for global-local analysis.This approach can refine the model only in those regions where it is required,e.g.,the areas where piezo-electric transducers are placed.The model has been used to study embedded and surface-mounted sensors.The accuracy of the pre-sent model has been verified by comparing the current results with numerical and experimental data from the literature.Different mod-eling solutions have been developed,mixing one-,two-and threedimensional finite elements.The results show that the use of the present modeling technique allows the computational cost to be reduced with respect to the classical approaches preserving the ccuracy of the results in the critical areas.展开更多
基金carried out within the project FULLCOMP(Fully analysis,design,manufacturing,and health monitoring of Composite structures),funded by the European Union Horizon 2020 Research and Innovation Program under the Marie Sklodowska Curie Grant Agreement(No.642121)the Russian Science Foundation(No.18-19-00092)the financial support from National Natural Science Foundation of China(No.52005451)。
文摘This article presents a type of plate Finite Element(FE)models with adaptive mathematical refinement capabilities for modeling laminated smart structures with piezoelectric layers or distributed patches.The p-version shape functions are used in combination with the higher-order Layer-Wise(LW)kinematics adopting hierarchical Legendre polynomials.Node-Dependent Kinematics(NDK)is employed to implement local LW models in the regions with piezoelectric components and simulate the global substrate structure with the Equivalent Single-Layer(ESL)approach.Through the proposed NDK FE models,the electro-mechanical behavior of smart structures can be predicted with high fidelity and numerical efficiency,and various patch configurations can be conveniently modeled through one set of mesh grids.Moreover,the effectiveness and efficiency of the NDK FE approach are assessed through numerical examples and its application is demonstrated.
基金the Centre of Excellence in Mobile and e-Services,the University of Zululand,Kwadlangezwa,South Africa.
文摘The studypresents theHalfMax InsertionHeuristic (HMIH) as a novel approach to solving theTravelling SalesmanProblem (TSP). The goal is to outperform existing techniques such as the Farthest Insertion Heuristic (FIH) andNearest Neighbour Heuristic (NNH). The paper discusses the limitations of current construction tour heuristics,focusing particularly on the significant margin of error in FIH. It then proposes HMIH as an alternative thatminimizes the increase in tour distance and includes more nodes. HMIH improves tour quality by starting withan initial tour consisting of a ‘minimum’ polygon and iteratively adding nodes using our novel Half Max routine.The paper thoroughly examines and compares HMIH with FIH and NNH via rigorous testing on standard TSPbenchmarks. The results indicate that HMIH consistently delivers superior performance, particularly with respectto tour cost and computational efficiency. HMIH’s tours were sometimes 16% shorter than those generated by FIHand NNH, showcasing its potential and value as a novel benchmark for TSP solutions. The study used statisticalmethods, including Friedman’s Non-parametric Test, to validate the performance of HMIH over FIH and NNH.This guarantees that the identified advantages are statistically significant and consistent in various situations. Thiscomprehensive analysis emphasizes the reliability and efficiency of the heuristic, making a compelling case for itsuse in solving TSP issues. The research shows that, in general, HMIH fared better than FIH in all cases studied,except for a few instances (pr439, eil51, and eil101) where FIH either performed equally or slightly better thanHMIH. HMIH’s efficiency is shown by its improvements in error percentage (δ) and goodness values (g) comparedto FIH and NNH. In the att48 instance, HMIH had an error rate of 6.3%, whereas FIH had 14.6% and NNH had20.9%, indicating that HMIH was closer to the optimal solution. HMIH consistently showed superior performanceacross many benchmarks, with lower percentage error and higher goodness values, suggesting a closer match tothe optimal tour costs. This study substantially contributes to combinatorial optimization by enhancing currentinsertion algorithms and presenting a more efficient solution for the Travelling Salesman Problem. It also createsnew possibilities for progress in heuristic design and optimization methodologies.
基金supported by Science Foundation of China University of Petroleum,Beijing(Nos.2462017YJRC038 and 2462018BJC005)supported by the National Natural Science Foundation of China(Grant U1660118)+1 种基金the National Basic Research Program of China(973 Program,No.2014CB643300)the National Environmental Corrosion Platform(NECP)
文摘Microbiologically influenced corrosion （MIC） is a major cause of corrosion damages, facility failures, and financial losses, making MIC an important research topic. Due to complex microbiological activities and a lack of deep understanding of the interactions between biofilms and metal surfaces, MIC occurrences and mechanisms are difficult to predict and interpret. Many theories and mechanisms have been pro- posed to explain MIC. In this review, the mechanisms of MIC are discussed using hioenergetics, microbial respiration types, and biofilm extracellular electron transfer （EET）. Two main MIC types, namely EET-MIC and metabolite MIC （M-ME）, are discussed. This brief review provides a state of the art insight into MIC mechanisms and it helps the diagnosis and prediction of occurrences of MIC under anaerobic conditions in the oil and gas industry.
基金support of the program of Outstanding Young Scholars, the National Natural Science Foundation of China (No. 51371182)financially supported by Shenzhen Science and Technology Research funding (JCYJ20160608153641020)+3 种基金the National Basic Research Program of China (973 Program Project No. 2014CB643300)the National Natural Science Foundation (No. 51501203 and U1660118)the National Environmental Corrosion Platform (NECP)the “Young Merit Scholars” program of the Institute of Metal Research, Chinese Academy of Sciences
文摘The effect of copper addition to 2205 duplex stainless steel（DSS） on its resistance against pitting corrosion by the Pseudomonas aeruginosa biofilm was investigated using electrochemical and surface analysis techniques. Cu addition decreased the general corrosion resistance, resulting in a higher general corrosion rate in the sterile medium. Because DSS usually has a very small general corrosion rate, its pitting corrosion resistance is far more important. In this work, it was shown that 2205-3%Cu DSS exhibited a much higher pitting corrosion resistance against the P. aeruginosa biofilm compared with the 2205 DSS control, characterized by no significant change in the pitting potential and critical pitting temperature（CPT） values. The strong pitting resistance ability of 2205-3%Cu DSS could be attributed to the copper-rich phases on the surface and the release of copper ions, providing a strong antibacterial ability that inhibited the attachment and growth of the corrosive P. aeruginosa biofilm.
文摘In this study, mitochondrial 16S rRNA sequences of snow leopard, gray wolf, domestic horse and Bactrian camel inhabited or domesticated in Mongolian territory were obtained by using polymerase chain reaction （PCR） based on universal primers for 16S rRNA （F-5＇-AACGAGCCTGGTGATA-3＇ and R-5＇-CTCCGGTCTGAACTCAGATCACGTA-3＇）. The 16S rRNA sequence was 1,048 bp to 1,086 bp in length, and each sequence was compared to other related species （Felidae, Camelidae, Equidae and Canidae） by using NCBI Basic Local Alignment Search Tool （BLAST）. Results showed that sequences were highly similar to sequences in GenBank database （93%-99%）. Then phylogenetic analysis was performed based on about 1,100 bp sequence of 16S rRNA for Panthera uncia, Canis lupus, Equus caballus, Camelus bactrianus and other related species. The result revealed that P. uncia and P. leo were sister species, C. bactrianus and C. ferus were more closely related species, and wolf and dog were the almost similar species. This finding could be important for designing species specific primers for PCR based analysis of animal species identification and forensic veterinary medicine.
文摘In developed countries, study on special or candidate genes, which are useful for identifying species, breed and productivity of livestock, was conducted at high level and the results have already been used in practice. Such advanced technology and innovation that we are facing is necessary to adopt in Mongolia. In this study, the myostatin gene （MSTN） was investigated as a candidate gene for meat animal in Mongolian breeds of cattle. The conventional phenol-chloroform method and FavorPrepTM tissue DNA extraction kit were used for DNA isolation, and the polymerase chain reaction （PCR） and sequencing analysis were used for further study. The nucleotide sequences of MSTN gene from Selenge, Kazakh white head breeds and Mongolian cattle were sequenced and reported on the DDBJ/EMBL/GenBank database （LC142726, LC146648, LC146649）, and Selenge breed showed the result of single nucleotide mutation in MSTN gene.
基金Foundation items: the National Natural Science Foundation of China (10272009) the Science Foundation of Aviation of China (99G51022)
文摘The interaction of a screw dislocation in the interphase layer with the circular inhomogeneity and matrix was dealt with . An efficient method for multiply connected regions was developed by combining the sectionally subholomorphic function theory, Schwatz symmetric principle and Cauchy integral technique. The Hilbert problem of the complex potentials for three material regions was reduced to a functional equation in the complex potential of the interphase layer, resulting in an explicit series solution . By using the present solution the interaction energy and force acting dislocation were evaluated and discussed.
文摘近年来,随着公共交通领域大数据、云计算、移动支付等新兴科技的应用,城市公交、轨道交通等公共交通行业都推出了二维码App实现了“刷手机”乘车。在为用户出行带来便捷的同时,出现了各App平台的信息数据不互联互通和二维码规范不一等问题。这给用户换乘交通工具时带来了不便,同时增加了交通部门的管理成本。本文基于HTTPS(Hyper Text Transfer Protocol over Secure Socket Layer)通信协议、HTML5(HyperText Markup Language 5)通信协议以及MQ(Message Queue)通信协议等多种通信协议构建一码通乘平台,统一各平台的二维码规范和对信息数据,让公共交通资源和数据管理朝着高效化、便捷化、规范化的方向发展。
文摘Petroleum and Natural Gas still represent a considerable share in terms of energy consumption in the current global matrix, so that its exploration/exploitation is present in the market and driving activities in locations of specific complexities, as the ones along unconventional hydrocarbon resources from the Brazilian pre-salt. The daily cost of well drilling under harsh conditions can exceed US $1 million a day, turning any type of downtime or necessary maintenance during the activities to be very costly, moment in which processes optimization starts to be a key factor in costs reduction. Thus, new technologies and methods in terms of automating and optimizing the processes may be of great advantages, having its impact in total related project costs. In this context, the goal of this research is to allow a computation tool supporting achieving a more efficient drilling process, by means of drilling mechanics parameters choosiness aiming rate of penetration (ROP) maximization and mechanic specific energy (MSE) minimization. Conceptually, driven by the pre-operational drilling test curve trends, the proposed system allows it to be performed with less human influences and being updateable automatically, allowing more precision and time reduction by selecting optimum parameters. A Web Operating System (Web OS) was designed and implemented, running in online servers, granting accessibility to it with any device that has a browser and internet connection. It allows processing the drilling parameters supplied and feed into it, issuing outcomes with optimum values in a faster and precise way, allowing reducing operating time.
基金supported by the National Natural Science Foundation of China Programs(82072068,82072167,82472135,82272277,and 82173315)Natural Science Foundation of Hubei Province(2024AFA053)+4 种基金the Major Scientific and Technological Innovation Projects in Hubei Province(2022BCA013)the Union Hospital Foun-dation for Young Scientist(2021xhqh01)the Knowledge Innovation Special Project for Fundamental Research of Wuhan(2022020801010461)Hubei Province Science and Technology Inno-vation Team Project([2022]No.11)the Open Foundation of Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research(2022zsyx001).
文摘Hypoxia,a prevalent characteristic of solid tumors,substantially impairs the efficacy of cancer treatments.However,there are no feasible clinical approaches for treating hypoxic tumors.Here,we develop metal-phenolic networks(CuGI)utilizing the natural glycolysis inhibitor(epigallocatechin gallate)and the essential metal element in the human body(copper ions),specifically targeting and annihilating hypoxic cancer cells.CuGI redirects the metabolic pathway of hypoxic cancer cells from anaerobic glycolysis to oxidative phosphorylation,thereby enhancing reactive oxygen species production and promoting oligomerization of lipoylated proteins in the tricarboxylic acid cycle.Through targeted induction of oxidative and proteotoxic stresses,CuGI induces apoptosis and cuproptosis specifically in cancer cells under hypoxic conditions while sparing normal cells.Moreover,cancer cell membrane-coated CuGI(CuGI@CM)exhibits enhanced tumor penetration effect and demonstrates commendable biocompatibility,effectively suppressing colorectal tumor growth.Importantly,CuGI@CM,when combined with vascular disruptors or radiotherapy which aggravate tumor hypoxia,syner-gistically potentiates therapeutic efficacy.Thus,CuGI represents a specific and potent nanotherapeutic capable of selectively eliminating hypoxic tumors,offering promise in combination therapies to address tumor hypoxia.
基金supported by grants from the National Key R&D Program of China(Grant No.2021YFC2500500)the National Natural Science Foundation of China(Grant Nos.82370444,82070464,12411530127)+1 种基金supported by the Program for Innovative Research Team of The First Affiliated Hospital of USTC(CXGG02,China)Anhui Provincial Natural Science Foundation(Grant No.2208085J08,China).
文摘To the editor:ATP-citrate lyase(ACLY)is the key enzyme linking glucose catabolism to lipogenesis.Targeting hepatic ACLY for lowering low density lipoprotein-cholesterol(LDL-C)and attenuating atherosclerosis has been validated in preclinical animal models and hypercholesterolemic patients1.Bempedoic acid(ETC1002),a first-in-class,potent and orally bioavailable inhibitor of ACLY,has been approved by the US FDA to reduce cardiovascular risk in patients who do not achieve their recommended LDL-C levels through other means.
文摘The present paper presents an innovative approach for the numerical modeling of piezo-electric transducers for the health-monitoring of layered structures.The numerical approach has been developed in the frameworks of the Carrera Unified Formulation.This computa-tional tool allows refined numerical models to be derived in a unified and efficient fashion.The use of higher-order models and the cap-ability to connect different kinematic models using the node-depen-dent kinematic approach has led to an efficient modeling technique for global-local analysis.This approach can refine the model only in those regions where it is required,e.g.,the areas where piezo-electric transducers are placed.The model has been used to study embedded and surface-mounted sensors.The accuracy of the pre-sent model has been verified by comparing the current results with numerical and experimental data from the literature.Different mod-eling solutions have been developed,mixing one-,two-and threedimensional finite elements.The results show that the use of the present modeling technique allows the computational cost to be reduced with respect to the classical approaches preserving the ccuracy of the results in the critical areas.
