This paper proposes an efficient strategy for resource utilization in Elastic Optical Networks (EONs) to minimize spectrum fragmentation and reduce connection blocking probability during Routing and Spectrum Allocatio...This paper proposes an efficient strategy for resource utilization in Elastic Optical Networks (EONs) to minimize spectrum fragmentation and reduce connection blocking probability during Routing and Spectrum Allocation (RSA). The proposed method, Dynamic Threshold-Based Routing and Spectrum Allocation with Fragmentation Awareness (DT-RSAF), integrates rerouting and spectrum defragmentation as needed. By leveraging Yen’s shortest path algorithm, DT-RSAF enhances resource utilization while ensuring improved service continuity. A dynamic threshold mechanism enables the algorithm to adapt to varying network conditions, while its fragmentation awareness effectively mitigates spectrum fragmentation. Simulation results on NSFNET and COST 239 topologies demonstrate that DT-RSAF significantly outperforms methods such as K-Shortest Path Routing and Spectrum Allocation (KSP-RSA), Load Balanced and Fragmentation-Aware (LBFA), and the Invasive Weed Optimization-based RSA (IWO-RSA). Under heavy traffic, DT-RSAF reduces the blocking probability by up to 15% and achieves lower Bandwidth Fragmentation Ratios (BFR), ranging from 74% to 75%, compared to 77% - 80% for KSP-RSA, 75% - 77% for LBFA, and approximately 76% for IWO-RSA. DT-RSAF also demonstrated reasonable computation times compared to KSP-RSA, LBFA, and IWO-RSA. On a small-sized network, its computation time was 8710 times faster than that of Integer Linear Programming (ILP) on the same network topology. Additionally, it achieved a similar execution time to LBFA and outperformed IWO-RSA in terms of efficiency. These results highlight DT-RSAF’s capability to maintain large contiguous frequency blocks, making it highly effective for accommodating high-bandwidth requests in EONs while maintaining reasonable execution times.展开更多
Objective:Breast cancer in India is growing at an alarming rate,and the fact that it is currently being detected more frequently in the younger age groups is even more concerning.In India,a woman dies of breast cancer...Objective:Breast cancer in India is growing at an alarming rate,and the fact that it is currently being detected more frequently in the younger age groups is even more concerning.In India,a woman dies of breast cancer every 8 min,which is a terrible situation.Breast cancer claims one life for every two women who are diagnosed with it.However,the morbidity level is gradually increasing due to advanced medical treatment,but we need to be aware and alert.Methods:The research has been structured as a randomized controlled trial.A total of 180 breast cancer patients were taken from Acharya Vinoba Bhave Rural Hospital(AVBRH),Cancer Center Sawangi Meghe for the study as per inclusion and exclusion criteria.With intervention,the period of the study was 11 months.A signed consent form was taken from each participant and based on the answers before,during,and after the trial the data were analyzed using IBM SPSS v29.Results:The investigator believes that the Buerger-Allen exercise and Epsom salt foot bath will improve the symptoms in the symptomatic group of breast cancer patients and will prevent or delay the occurrence of peripheral neuropathy symptoms among the asymptomatic group as well as improve the overall quality of life(QoL).However,during the trial,if any of the study participants developed any side effects,they would be identified early and prompt treatment would be initiated.Conclusions:This study protocol aims to evaluate and compare the non-pharmacological treatment options for chemotherapy-induced peripheral neuropathy(CIPN)and to develop a new treatment option that will pave the way to lead a new non-pharmacological cost-effective treatment option for breast cancer patients which also could improve the QoL.展开更多
BACKGROUND Chronic neuropathic pain and depression are common and debilitating conditions in cancer patients,significantly impacting their quality of life.Pregabalin,an anticonvulsant medication,is used for neuropathi...BACKGROUND Chronic neuropathic pain and depression are common and debilitating conditions in cancer patients,significantly impacting their quality of life.Pregabalin,an anticonvulsant medication,is used for neuropathic pain and may also influence depressive symptoms.This study evaluates the efficacy and safety of pregabalin on pain intensity,depression severity,and side effects in cancer patients with chronic neuropathic pain and depression.AIM To evaluate the impact of pregabalin on pain intensity,depression severity,and the safety profile in cancer patients with chronic neuropathic pain and depression.METHODS This observational case series included 10 cancer patients experiencing chronic neuropathic pain and depression.Pregabalin was administered at a starting dose of 150 mg twice daily,with adjustments based on patient tolerance and pain response up to 300 mg twice daily.Pain intensity and depression severity were assessed using the brief pain inventory(BPI)and the Hamilton depression rating scale(HDRS)at baseline,4 weeks,and 8 weeks.Side effects were monitored using a self-reported side effect questionnaire.RESULTS Pregabalin led to a significant reduction in pain intensity and depression severity.The mean BPI score decreased from 7.8(SD=1.2)at baseline to 5.2(SD=1.4)at 4 weeks and 4.1(SD=1.5)at 8 weeks,representing reductions of 33.3%and 47.4%,respectively.The mean HDRS score decreased from 18.5(SD=4.0)at baseline to 13.2(SD=4.1)at 4 weeks and 9.8(SD=3.6)at 8 weeks,showing reductions of 28.4%and 47.0%,respectively.Side effects included dizziness(50%),drowsiness(40%),weight gain(30%),and dry mouth(20%).No severe adverse effects were reported.All patients completed the study,with 30%requiring dose adjustments.CONCLUSION Pregabalin significantly alleviates both chronic neuropathic pain and depression in cancer patients with a manageable safety profile.These findings support the use of pregabalin in this patient population,though further research with larger samples and controlled designs is warranted.展开更多
In this work,we investigate how activated carbon(AC)derived from olive pomace biomass can be used as an anode material in lithium-ion batteries.The biomass-derived activated carbon has the potential to be highly effic...In this work,we investigate how activated carbon(AC)derived from olive pomace biomass can be used as an anode material in lithium-ion batteries.The biomass-derived activated carbon has the potential to be highly efficient,deliver high performance,sustainable,and cost-effective in LIBs-related production.The activated carbon is prepared by using H3PO4 as a chemical activation agent,and then calcining the obtained product at 500℃ for different controlled atmospheres under(i)air(AC-Atm),(ii)vacuum(AC-Vac),and(iii)argon(ACArg).The different samples were systematically analyzed using scanning electron microscopy(SEM),Highresolution transmission electron microscopy(HRTEM),energy dispersive spectroscopy(EDS),X-ray fluores-cence(XRF),X-ray diffraction(XRD),FT-IR and Raman spectroscopy,and thermogravimetric analysis(TGA)to assess their properties.The electrochemical properties of the carbonaceous materials were studied by galvano-static cycling,cyclic voltammetry(CV),and electrochemical impedance spectroscopy(EIS).The results showed high specific capacity and stable cycling performance,with capacities of 288,184,and 56 mAh g^(-1) at the current density of 25 mA g^(-1) after 70 cycles for AC-Arg,AC-Vac,and AC-Atm respectively.Furthermore,the CE efficiency was nearly 100%from the first cycles.This study opens up interesting prospects and offers promising oppor-tunities for more efficient recovery of unused olive pomace waste,by integrating it into energy storage appli-cations,particularly sustainable lithium-ion batteries.展开更多
We analyse the Diophantine equation of Fermat xp yp = zp with p > 2 a prime, x, y, z positive nonzero integers. We consider the hypothetical solution (a, b, c) of previous equation. We use Fermat main divisors, Dio...We analyse the Diophantine equation of Fermat xp yp = zp with p > 2 a prime, x, y, z positive nonzero integers. We consider the hypothetical solution (a, b, c) of previous equation. We use Fermat main divisors, Diophantine remainders of (a, b, c), an asymptotic approach based on Balzano Weierstrass Analysis Theorem as tools. We construct convergent infinite sequences and establish asymptotic results including the following surprising one. If z y = 1 then there exists a tight bound N such that, for all prime exponents p > N , we have xp yp zp.展开更多
In medical imaging, particularly for analyzing brain tumor MRIs, the expertise of skilled neurosurgeons or radiologists is often essential. However, many developing countries face a significant shortage of these speci...In medical imaging, particularly for analyzing brain tumor MRIs, the expertise of skilled neurosurgeons or radiologists is often essential. However, many developing countries face a significant shortage of these specialists, which impedes the accurate identification and analysis of tumors. This shortage exacerbates the challenge of delivering precise and timely diagnoses and delays the production of comprehensive MRI reports. Such delays can critically affect treatment outcomes, especially for conditions requiring immediate intervention, potentially leading to higher mortality rates. In this study, we introduced an adapted convolutional neural network designed to automate brain tumor diagnosis. Our model features fewer layers, each optimized with carefully selected hyperparameters. As a result, it significantly reduced both execution time and memory usage compared to other models. Specifically, its execution time was 10 times shorter than that of the referenced models, and its memory consumption was 3 times lower than that of ResNet. In terms of accuracy, our model outperformed all other architectures presented in the study, except for ResNet, which showed similar performance with an accuracy of around 90%.展开更多
Intrusion Detection Systems (IDS) are essential for computer security, with various techniques developed over time. However, many of these methods suffer from high false positive rates. To address this, we propose an ...Intrusion Detection Systems (IDS) are essential for computer security, with various techniques developed over time. However, many of these methods suffer from high false positive rates. To address this, we propose an approach utilizing Recurrent Neural Networks (RNN). Our method starts by reducing the dataset’s dimensionality using a Deep Auto-Encoder (DAE), followed by intrusion detection through a Bidirectional Long Short-Term Memory (BiLSTM) network. The proposed DAE-BiLSTM model outperforms Random Forest, AdaBoost, and standard BiLSTM models, achieving an accuracy of 0.97, a recall of 0.95, and an AUC of 0.93. Although BiLSTM is slightly less effective than DAE-BiLSTM, both RNN-based models outperform AdaBoost and Random Forest. ROC curves show that DAE-BiLSTM is the most effective, demonstrating strong detection capabilities with a low false positive rate. While AdaBoost performs well, it is less effective than RNN models but still surpasses Random Forest.展开更多
In the present work,the focus has been shifted to the relationship between the PANI morphology and the physicochemical properties,controlled by the amount of added ionic liquids,of the polymerization medium instead of...In the present work,the focus has been shifted to the relationship between the PANI morphology and the physicochemical properties,controlled by the amount of added ionic liquids,of the polymerization medium instead of focusing on the structure of the ionic liquids as used to be in the litterature.For that reason,PANI has been synthesized in different weight ratio of[Pyrr][PTS]/water following the standard experimental process.The addition of[Pyrr][PTS]into the polymerization medium controls the morphology of PANI without affecting its structure.Moreover,[Pyrr][PTS]promotes a viscous reaction system without the need of an external source.The viscosity of the polymerization system restricts the diffusion of species that leads to the predominance of the homogeneous nucleation mode during the course of polymerization and,thus,nanostructuring of PANI morphology.As for the ionic conductivity,it reflects the mobility of the ions of the polymerization medium and,thus,the way of its interference with the formed PANI that affects the arrangement and the shape of formed PANI fibers.This relationship between PANI morphology and the physicochemical properties,adjusted by adding ionic liquids,of the polymerization medium is prelaminar and promising.The effect of the ionic liquids on the viscosity as well as on the mobility of the polymerization medium have to be taken into consideration to choose the ionic liquids,which lead to the PANI with desired morphology.展开更多
OBJECTIVE:To investigate the effect of acupressure applied to UB60 and K3 acupuncture points in order to relieve the procedural pain caused by heel lancing blood sampling process in the term newborns.METHODS:The data ...OBJECTIVE:To investigate the effect of acupressure applied to UB60 and K3 acupuncture points in order to relieve the procedural pain caused by heel lancing blood sampling process in the term newborns.METHODS:The data were collected by using the Information Form and the Neonatal Infant Pain Scale.Acupressure applied for 3 min before heel lancing blood sampling in the newborns in the experimental group(n=31).No intervention was applied to newborns in the control group(n=32).RESULTS:A significant difference was found between mean scores of the newborns in the control and acupressure group in favor of the acupressure group in terms of heart rate during and after the procedure,oxygen saturation before,during and after the procedure,duration of crying during and after the procedure(P<0.05).It was found that there was a significant difference between groups in terms of Neonatal Infant Pain Scale mean scores during(P=0.001)and after the procedure(P<0.05),and the difference was found to be in favor of the acupressure group.CONCLUSION:As a result,acupressure was found to be an effective method in relieving pain caused by heel lancing blood sampling in newborns.展开更多
Structural,optical and magnetic properties are reported for new synthesized perovskite materials.Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3) compositions were prepared via solid sta...Structural,optical and magnetic properties are reported for new synthesized perovskite materials.Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3) compositions were prepared via solid state reaction.X-ray analysis confirms that both compositions show feature of perovskite structure.Rietveld refinement method was used to confirm the phase formation and investigate the structure and space group.The study demonstrates the formation of orthorhombic structure with Pnma space group for Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) while the composition Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3) structure adopts Pbnm symmetry.UV–vis spectroscopy measurements show very broad and intense UV–visible light absorption,the estimated band gap ranges between 2.07 and 2.15 eV.Magnetic measurements were carried out for the compositions Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3).The hysteresis loops of both samples at 300 and 10 K show a strong ferromagnetic behavior.The temperature dependent magnetization at 0.05 T under field-cooled(FC)and zero field cooled(ZFC)modes shows magnetic frustration or spin glass-like behavior.展开更多
In order to promote the nursing discipline to developindependently and scientifically, nursing practice shouldbe guided by nursing theory instead of intuition andexperience of nurses [1]. Nursing theory can assist nur...In order to promote the nursing discipline to developindependently and scientifically, nursing practice shouldbe guided by nursing theory instead of intuition andexperience of nurses [1]. Nursing theory can assist nursesto deliver individual patient’s care and help to improveobservation and recognition of specific patient need, be itbiological, psychological or social [2]. Nursing theory hasdeveloped quickly and successfully in recent decadesinternationally; however, it is still in the early stage ofdevelopment in China.展开更多
The aims of this work turn towards the valorization of the underutilized Raw Sugar Beet Pulp by-product to produce white Cellulose Microfibers(CMFs),and its potential effect as a reinforcement for the development of H...The aims of this work turn towards the valorization of the underutilized Raw Sugar Beet Pulp by-product to produce white Cellulose Microfibers(CMFs),and its potential effect as a reinforcement for the development of High-Density Polyethylene(HDPE)composites.Pure CMFs were first obtained by subjecting raw SBP to alkali and bleaching treatments.Several characterization techniques were performed to confirm the successful removal of the amorphous compounds from the surface of individual fibers,including SEM,XRD,TGA,and FT-IR analysis.Various CMF loadings(5–10 wt%)were incorporated as bio-fillers into HDPE polymer to evaluate their reinforcing ability in comparison to raw and alkali-treated SBP using twin-screw extrusion followed by injection molding.Styrene–(Ethylene–Butene)–Styrene Three-Block Co-Polymer Grafted with Maleic Anhydride was used as a compatibilizer to improve the interfacial adhesion between fibers and the matrix.Thermal,mechanical,and rheological properties of the produced composite samples were investigated.It was found that the Young’s modulus were gradually increased with increasing of fibers loadings,with a maximum increase of 30%and 26%observed for composite containing 10 wt%of CMFs and raw SBP,respectively,over neat HDPE.While,the use of coupling agent enhances the ductile behavior of the composites.It was also found that all fiber improves the hardness and toughness behavior of all reinforced composites as well as the complex modulus particularly at 10 wt%.The thermal stability slightly increases with the addition of fibers.This study demonstrates a new route for the valorization of SBP by-products.These fibers can be considered as a valuable bio-fillers candidate for the development of composite materials with enhanced properties.展开更多
Household solid waste management is a major public health concern in the community people and closely related to daily human life. Community people can play a pivotal role in managing household solid waste. <strong...Household solid waste management is a major public health concern in the community people and closely related to daily human life. Community people can play a pivotal role in managing household solid waste. <strong>Objectives:</strong> This study was aimed to assess the awareness and practice of household solid waste management among the people living in the Mugda community in Dhaka. <strong>Methods:</strong> A descriptive co-relational study design was used. A total of 112 participants were selected with the convenience sampling technique. The data collection period was from July 2019 to June 2020. The data were collected from the participants by face-to-face interview through the door-to-door survey by using a structured questionnaire. Data were analyzed by using descriptive, Pearson correlation, t-test, and one-way ANOVA statistics. <strong>Results: </strong>Finding of the study shows that the mean awareness regarding household solid waste management was 7.96 (SD = 1.64) and the mean practice was 2.94 (SD = 1.35) respectively. It indicates that the awareness and practice of community people were at a moderate level. In bivariate analysis, it has been shown that training on household solid waste management (“P < 0.001”), and recyclable waste (p = 0.019) were statistically significantly correlated with household solid waste management practice. <strong>Conclusion: </strong>Overall awareness and practice level of household solid waste management were at a moderate level among the community people. Training on household solid waste management and recyclable waste management were statistically significantly correlated with household solid waste management. Policymakers can use this baseline data to make a strategy for increasing awareness among the community people.展开更多
Heart attack is an extremely urgent medical condition which may occur at any time and can affect anybody and means the failure of the pump function of the heart and it represents the condition which brings to death. T...Heart attack is an extremely urgent medical condition which may occur at any time and can affect anybody and means the failure of the pump function of the heart and it represents the condition which brings to death. The aim of this study is the training, which is the acquisition of knowledge, abilities and skills as a result of education and practice in a certain discipline and this project has been created to make as accessible to all as possible the information about the identification and treatment of heart attack. However, the key objective has been involving only laic blind subjects in the trial and theoretical-practical course to support vital functions （BLS （basic life support））, to demonstrate that in a state of emergency, like a heart attack, even a subject affected by visual impairment, if properly trained, can be very helpful and can contribute to save a life. Fifteen partially sighted and sightless executors have participated in this study. In order to evaluate learning objectives of the course, participants have completed a pre-course test to examine these areas： cognitive and emotional, motivational, theoretical-practical; while, at the end of the course, participants have completed a comment card about the course. At the end of this study it can be seen that blind subjects do not present any type of limitation in the learning and in the execution of BLS manoeuvres after an appropriate training.展开更多
Objective： To identify and clarify the existing definitions of quality of life in head and neck cancer survivors. Thisconcept analysis will inform healthcare professionals of promoting nursing care for head and neck ...Objective： To identify and clarify the existing definitions of quality of life in head and neck cancer survivors. Thisconcept analysis will inform healthcare professionals of promoting nursing care for head and neck cancer survivors andeventually improve their quality of life. Method： Concept analysis based on Walker and Avant’s framework. Results：Quality of life is a subjective and personally derived cognitive evaluation of global well-being by perceiving a feeling ofoverall life satisfaction in his/her own value, happiness, and the independence to manage daily activities and lifeexperience. Three defining attributes for quality of life were identified： a feeling of overall life satisfaction in his/hervalue, global personal well-being, and independence. An improvement of quality of life means an improvement ofclinical outcome. However, the variety of instruments for measuring life quality makes it difficult for healthcareprofessionals to select a standard one for head and neck cancer survivors. Conclusion： By proposing a comprehensivedefinition of the concept, this analysis contributes to the advancement of knowledge about quality of life in the context ofhead and neck cancer survivorship. Through a sound understanding of the phenomenon, healthcare professions willrecognize or measure head and neck cancer survivors’ life conditions in a more accurate way and to implementintervention where necessary, eventually, improve patients’ life quality in survivorship.展开更多
Objective： To explore and analyze the concept of intensive care unit （ICU） delirium. Method： Walker and Avant’sstrategy of analysis was adopted to this research. Results： ICU delirium is defined as the presence ...Objective： To explore and analyze the concept of intensive care unit （ICU） delirium. Method： Walker and Avant’sstrategy of analysis was adopted to this research. Results： ICU delirium is defined as the presence of an acute cognitiveimpairment, accompanied by a disturbance of consciousness with fluctuating inattention, and the array of dysfunctionsonly developed for a short period of time in ICU. The antecedents of ICU delirium include （1） the high severity of illness,（2） pain, （3） sedative use, （4） immobilization, （5） sleep deprivation and （6） unpleasant awareness. The consequencesinvolve （1） promoting the risks of self-extubation and unplanned removal of catheters, （2） prolonging the length of ICUstay, （3） increasing the mortality of critical patients and （4） Some different ICU delirium assessment instruments aregathered. Confusion Assessment Method for Intensive Care Unit assessment tool （CAM-ICU） was the most populardiagnostic tool used by nurses. Conclusion： Concept analysis as an extension and development of nursing theory cancreate a linkage between practice and theory. It will create a knowledge foundation of ICU delirium and provide atheoretical basis to construct nursing theory. This study can help ICU nurses to understand and recognize ICU delirium.ICU nurses will be enlightened to develop effective interventions of ICU delirium to improve critical patients’ clinicaloutcomes.展开更多
文摘This paper proposes an efficient strategy for resource utilization in Elastic Optical Networks (EONs) to minimize spectrum fragmentation and reduce connection blocking probability during Routing and Spectrum Allocation (RSA). The proposed method, Dynamic Threshold-Based Routing and Spectrum Allocation with Fragmentation Awareness (DT-RSAF), integrates rerouting and spectrum defragmentation as needed. By leveraging Yen’s shortest path algorithm, DT-RSAF enhances resource utilization while ensuring improved service continuity. A dynamic threshold mechanism enables the algorithm to adapt to varying network conditions, while its fragmentation awareness effectively mitigates spectrum fragmentation. Simulation results on NSFNET and COST 239 topologies demonstrate that DT-RSAF significantly outperforms methods such as K-Shortest Path Routing and Spectrum Allocation (KSP-RSA), Load Balanced and Fragmentation-Aware (LBFA), and the Invasive Weed Optimization-based RSA (IWO-RSA). Under heavy traffic, DT-RSAF reduces the blocking probability by up to 15% and achieves lower Bandwidth Fragmentation Ratios (BFR), ranging from 74% to 75%, compared to 77% - 80% for KSP-RSA, 75% - 77% for LBFA, and approximately 76% for IWO-RSA. DT-RSAF also demonstrated reasonable computation times compared to KSP-RSA, LBFA, and IWO-RSA. On a small-sized network, its computation time was 8710 times faster than that of Integer Linear Programming (ILP) on the same network topology. Additionally, it achieved a similar execution time to LBFA and outperformed IWO-RSA in terms of efficiency. These results highlight DT-RSAF’s capability to maintain large contiguous frequency blocks, making it highly effective for accommodating high-bandwidth requests in EONs while maintaining reasonable execution times.
基金supported by study protocol(No.DMIHER(DU)IEC/2023/22).
文摘Objective:Breast cancer in India is growing at an alarming rate,and the fact that it is currently being detected more frequently in the younger age groups is even more concerning.In India,a woman dies of breast cancer every 8 min,which is a terrible situation.Breast cancer claims one life for every two women who are diagnosed with it.However,the morbidity level is gradually increasing due to advanced medical treatment,but we need to be aware and alert.Methods:The research has been structured as a randomized controlled trial.A total of 180 breast cancer patients were taken from Acharya Vinoba Bhave Rural Hospital(AVBRH),Cancer Center Sawangi Meghe for the study as per inclusion and exclusion criteria.With intervention,the period of the study was 11 months.A signed consent form was taken from each participant and based on the answers before,during,and after the trial the data were analyzed using IBM SPSS v29.Results:The investigator believes that the Buerger-Allen exercise and Epsom salt foot bath will improve the symptoms in the symptomatic group of breast cancer patients and will prevent or delay the occurrence of peripheral neuropathy symptoms among the asymptomatic group as well as improve the overall quality of life(QoL).However,during the trial,if any of the study participants developed any side effects,they would be identified early and prompt treatment would be initiated.Conclusions:This study protocol aims to evaluate and compare the non-pharmacological treatment options for chemotherapy-induced peripheral neuropathy(CIPN)and to develop a new treatment option that will pave the way to lead a new non-pharmacological cost-effective treatment option for breast cancer patients which also could improve the QoL.
文摘BACKGROUND Chronic neuropathic pain and depression are common and debilitating conditions in cancer patients,significantly impacting their quality of life.Pregabalin,an anticonvulsant medication,is used for neuropathic pain and may also influence depressive symptoms.This study evaluates the efficacy and safety of pregabalin on pain intensity,depression severity,and side effects in cancer patients with chronic neuropathic pain and depression.AIM To evaluate the impact of pregabalin on pain intensity,depression severity,and the safety profile in cancer patients with chronic neuropathic pain and depression.METHODS This observational case series included 10 cancer patients experiencing chronic neuropathic pain and depression.Pregabalin was administered at a starting dose of 150 mg twice daily,with adjustments based on patient tolerance and pain response up to 300 mg twice daily.Pain intensity and depression severity were assessed using the brief pain inventory(BPI)and the Hamilton depression rating scale(HDRS)at baseline,4 weeks,and 8 weeks.Side effects were monitored using a self-reported side effect questionnaire.RESULTS Pregabalin led to a significant reduction in pain intensity and depression severity.The mean BPI score decreased from 7.8(SD=1.2)at baseline to 5.2(SD=1.4)at 4 weeks and 4.1(SD=1.5)at 8 weeks,representing reductions of 33.3%and 47.4%,respectively.The mean HDRS score decreased from 18.5(SD=4.0)at baseline to 13.2(SD=4.1)at 4 weeks and 9.8(SD=3.6)at 8 weeks,showing reductions of 28.4%and 47.0%,respectively.Side effects included dizziness(50%),drowsiness(40%),weight gain(30%),and dry mouth(20%).No severe adverse effects were reported.All patients completed the study,with 30%requiring dose adjustments.CONCLUSION Pregabalin significantly alleviates both chronic neuropathic pain and depression in cancer patients with a manageable safety profile.These findings support the use of pregabalin in this patient population,though further research with larger samples and controlled designs is warranted.
文摘In this work,we investigate how activated carbon(AC)derived from olive pomace biomass can be used as an anode material in lithium-ion batteries.The biomass-derived activated carbon has the potential to be highly efficient,deliver high performance,sustainable,and cost-effective in LIBs-related production.The activated carbon is prepared by using H3PO4 as a chemical activation agent,and then calcining the obtained product at 500℃ for different controlled atmospheres under(i)air(AC-Atm),(ii)vacuum(AC-Vac),and(iii)argon(ACArg).The different samples were systematically analyzed using scanning electron microscopy(SEM),Highresolution transmission electron microscopy(HRTEM),energy dispersive spectroscopy(EDS),X-ray fluores-cence(XRF),X-ray diffraction(XRD),FT-IR and Raman spectroscopy,and thermogravimetric analysis(TGA)to assess their properties.The electrochemical properties of the carbonaceous materials were studied by galvano-static cycling,cyclic voltammetry(CV),and electrochemical impedance spectroscopy(EIS).The results showed high specific capacity and stable cycling performance,with capacities of 288,184,and 56 mAh g^(-1) at the current density of 25 mA g^(-1) after 70 cycles for AC-Arg,AC-Vac,and AC-Atm respectively.Furthermore,the CE efficiency was nearly 100%from the first cycles.This study opens up interesting prospects and offers promising oppor-tunities for more efficient recovery of unused olive pomace waste,by integrating it into energy storage appli-cations,particularly sustainable lithium-ion batteries.
文摘We analyse the Diophantine equation of Fermat xp yp = zp with p > 2 a prime, x, y, z positive nonzero integers. We consider the hypothetical solution (a, b, c) of previous equation. We use Fermat main divisors, Diophantine remainders of (a, b, c), an asymptotic approach based on Balzano Weierstrass Analysis Theorem as tools. We construct convergent infinite sequences and establish asymptotic results including the following surprising one. If z y = 1 then there exists a tight bound N such that, for all prime exponents p > N , we have xp yp zp.
文摘In medical imaging, particularly for analyzing brain tumor MRIs, the expertise of skilled neurosurgeons or radiologists is often essential. However, many developing countries face a significant shortage of these specialists, which impedes the accurate identification and analysis of tumors. This shortage exacerbates the challenge of delivering precise and timely diagnoses and delays the production of comprehensive MRI reports. Such delays can critically affect treatment outcomes, especially for conditions requiring immediate intervention, potentially leading to higher mortality rates. In this study, we introduced an adapted convolutional neural network designed to automate brain tumor diagnosis. Our model features fewer layers, each optimized with carefully selected hyperparameters. As a result, it significantly reduced both execution time and memory usage compared to other models. Specifically, its execution time was 10 times shorter than that of the referenced models, and its memory consumption was 3 times lower than that of ResNet. In terms of accuracy, our model outperformed all other architectures presented in the study, except for ResNet, which showed similar performance with an accuracy of around 90%.
文摘Intrusion Detection Systems (IDS) are essential for computer security, with various techniques developed over time. However, many of these methods suffer from high false positive rates. To address this, we propose an approach utilizing Recurrent Neural Networks (RNN). Our method starts by reducing the dataset’s dimensionality using a Deep Auto-Encoder (DAE), followed by intrusion detection through a Bidirectional Long Short-Term Memory (BiLSTM) network. The proposed DAE-BiLSTM model outperforms Random Forest, AdaBoost, and standard BiLSTM models, achieving an accuracy of 0.97, a recall of 0.95, and an AUC of 0.93. Although BiLSTM is slightly less effective than DAE-BiLSTM, both RNN-based models outperform AdaBoost and Random Forest. ROC curves show that DAE-BiLSTM is the most effective, demonstrating strong detection capabilities with a low false positive rate. While AdaBoost performs well, it is less effective than RNN models but still surpasses Random Forest.
基金funded by RESCOLL French society and the Lebanese University。
文摘In the present work,the focus has been shifted to the relationship between the PANI morphology and the physicochemical properties,controlled by the amount of added ionic liquids,of the polymerization medium instead of focusing on the structure of the ionic liquids as used to be in the litterature.For that reason,PANI has been synthesized in different weight ratio of[Pyrr][PTS]/water following the standard experimental process.The addition of[Pyrr][PTS]into the polymerization medium controls the morphology of PANI without affecting its structure.Moreover,[Pyrr][PTS]promotes a viscous reaction system without the need of an external source.The viscosity of the polymerization system restricts the diffusion of species that leads to the predominance of the homogeneous nucleation mode during the course of polymerization and,thus,nanostructuring of PANI morphology.As for the ionic conductivity,it reflects the mobility of the ions of the polymerization medium and,thus,the way of its interference with the formed PANI that affects the arrangement and the shape of formed PANI fibers.This relationship between PANI morphology and the physicochemical properties,adjusted by adding ionic liquids,of the polymerization medium is prelaminar and promising.The effect of the ionic liquids on the viscosity as well as on the mobility of the polymerization medium have to be taken into consideration to choose the ionic liquids,which lead to the PANI with desired morphology.
基金Supported by Canakkale Onsekiz Mart University(COMU)Scientific Research Projects Coordination Unit(SRPCU)grant"TYL 2017/1360"。
文摘OBJECTIVE:To investigate the effect of acupressure applied to UB60 and K3 acupuncture points in order to relieve the procedural pain caused by heel lancing blood sampling process in the term newborns.METHODS:The data were collected by using the Information Form and the Neonatal Infant Pain Scale.Acupressure applied for 3 min before heel lancing blood sampling in the newborns in the experimental group(n=31).No intervention was applied to newborns in the control group(n=32).RESULTS:A significant difference was found between mean scores of the newborns in the control and acupressure group in favor of the acupressure group in terms of heart rate during and after the procedure,oxygen saturation before,during and after the procedure,duration of crying during and after the procedure(P<0.05).It was found that there was a significant difference between groups in terms of Neonatal Infant Pain Scale mean scores during(P=0.001)and after the procedure(P<0.05),and the difference was found to be in favor of the acupressure group.CONCLUSION:As a result,acupressure was found to be an effective method in relieving pain caused by heel lancing blood sampling in newborns.
基金MohammedⅥPolytechnic Universitythe Office Chérifien des Phosphates in the Moroccan Kingdom(OⅥCP group)University Hassan 1st for their support。
文摘Structural,optical and magnetic properties are reported for new synthesized perovskite materials.Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3) compositions were prepared via solid state reaction.X-ray analysis confirms that both compositions show feature of perovskite structure.Rietveld refinement method was used to confirm the phase formation and investigate the structure and space group.The study demonstrates the formation of orthorhombic structure with Pnma space group for Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) while the composition Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3) structure adopts Pbnm symmetry.UV–vis spectroscopy measurements show very broad and intense UV–visible light absorption,the estimated band gap ranges between 2.07 and 2.15 eV.Magnetic measurements were carried out for the compositions Ba_(0.3)La_(0.7)Ti_(0.3)Fe_(0.7)O_(3) and Ba_(0.1)La_(0.9)Ti_(0.1)Fe_(0.9)O_(3).The hysteresis loops of both samples at 300 and 10 K show a strong ferromagnetic behavior.The temperature dependent magnetization at 0.05 T under field-cooled(FC)and zero field cooled(ZFC)modes shows magnetic frustration or spin glass-like behavior.
文摘In order to promote the nursing discipline to developindependently and scientifically, nursing practice shouldbe guided by nursing theory instead of intuition andexperience of nurses [1]. Nursing theory can assist nursesto deliver individual patient’s care and help to improveobservation and recognition of specific patient need, be itbiological, psychological or social [2]. Nursing theory hasdeveloped quickly and successfully in recent decadesinternationally; however, it is still in the early stage ofdevelopment in China.
基金financial assistance of the Moroccan National Center for Scientific and Technical Research(CNRST)toward this research is hereby acknowledgedThanks to Abou El Kacem QAISS from Moroccan Foundation for Advanced Science,Innovation and Research(MAScIR)for his help to elaborate and characterize all our composites.
文摘The aims of this work turn towards the valorization of the underutilized Raw Sugar Beet Pulp by-product to produce white Cellulose Microfibers(CMFs),and its potential effect as a reinforcement for the development of High-Density Polyethylene(HDPE)composites.Pure CMFs were first obtained by subjecting raw SBP to alkali and bleaching treatments.Several characterization techniques were performed to confirm the successful removal of the amorphous compounds from the surface of individual fibers,including SEM,XRD,TGA,and FT-IR analysis.Various CMF loadings(5–10 wt%)were incorporated as bio-fillers into HDPE polymer to evaluate their reinforcing ability in comparison to raw and alkali-treated SBP using twin-screw extrusion followed by injection molding.Styrene–(Ethylene–Butene)–Styrene Three-Block Co-Polymer Grafted with Maleic Anhydride was used as a compatibilizer to improve the interfacial adhesion between fibers and the matrix.Thermal,mechanical,and rheological properties of the produced composite samples were investigated.It was found that the Young’s modulus were gradually increased with increasing of fibers loadings,with a maximum increase of 30%and 26%observed for composite containing 10 wt%of CMFs and raw SBP,respectively,over neat HDPE.While,the use of coupling agent enhances the ductile behavior of the composites.It was also found that all fiber improves the hardness and toughness behavior of all reinforced composites as well as the complex modulus particularly at 10 wt%.The thermal stability slightly increases with the addition of fibers.This study demonstrates a new route for the valorization of SBP by-products.These fibers can be considered as a valuable bio-fillers candidate for the development of composite materials with enhanced properties.
文摘Household solid waste management is a major public health concern in the community people and closely related to daily human life. Community people can play a pivotal role in managing household solid waste. <strong>Objectives:</strong> This study was aimed to assess the awareness and practice of household solid waste management among the people living in the Mugda community in Dhaka. <strong>Methods:</strong> A descriptive co-relational study design was used. A total of 112 participants were selected with the convenience sampling technique. The data collection period was from July 2019 to June 2020. The data were collected from the participants by face-to-face interview through the door-to-door survey by using a structured questionnaire. Data were analyzed by using descriptive, Pearson correlation, t-test, and one-way ANOVA statistics. <strong>Results: </strong>Finding of the study shows that the mean awareness regarding household solid waste management was 7.96 (SD = 1.64) and the mean practice was 2.94 (SD = 1.35) respectively. It indicates that the awareness and practice of community people were at a moderate level. In bivariate analysis, it has been shown that training on household solid waste management (“P < 0.001”), and recyclable waste (p = 0.019) were statistically significantly correlated with household solid waste management practice. <strong>Conclusion: </strong>Overall awareness and practice level of household solid waste management were at a moderate level among the community people. Training on household solid waste management and recyclable waste management were statistically significantly correlated with household solid waste management. Policymakers can use this baseline data to make a strategy for increasing awareness among the community people.
文摘Heart attack is an extremely urgent medical condition which may occur at any time and can affect anybody and means the failure of the pump function of the heart and it represents the condition which brings to death. The aim of this study is the training, which is the acquisition of knowledge, abilities and skills as a result of education and practice in a certain discipline and this project has been created to make as accessible to all as possible the information about the identification and treatment of heart attack. However, the key objective has been involving only laic blind subjects in the trial and theoretical-practical course to support vital functions （BLS （basic life support））, to demonstrate that in a state of emergency, like a heart attack, even a subject affected by visual impairment, if properly trained, can be very helpful and can contribute to save a life. Fifteen partially sighted and sightless executors have participated in this study. In order to evaluate learning objectives of the course, participants have completed a pre-course test to examine these areas： cognitive and emotional, motivational, theoretical-practical; while, at the end of the course, participants have completed a comment card about the course. At the end of this study it can be seen that blind subjects do not present any type of limitation in the learning and in the execution of BLS manoeuvres after an appropriate training.
文摘Objective： To identify and clarify the existing definitions of quality of life in head and neck cancer survivors. Thisconcept analysis will inform healthcare professionals of promoting nursing care for head and neck cancer survivors andeventually improve their quality of life. Method： Concept analysis based on Walker and Avant’s framework. Results：Quality of life is a subjective and personally derived cognitive evaluation of global well-being by perceiving a feeling ofoverall life satisfaction in his/her own value, happiness, and the independence to manage daily activities and lifeexperience. Three defining attributes for quality of life were identified： a feeling of overall life satisfaction in his/hervalue, global personal well-being, and independence. An improvement of quality of life means an improvement ofclinical outcome. However, the variety of instruments for measuring life quality makes it difficult for healthcareprofessionals to select a standard one for head and neck cancer survivors. Conclusion： By proposing a comprehensivedefinition of the concept, this analysis contributes to the advancement of knowledge about quality of life in the context ofhead and neck cancer survivorship. Through a sound understanding of the phenomenon, healthcare professions willrecognize or measure head and neck cancer survivors’ life conditions in a more accurate way and to implementintervention where necessary, eventually, improve patients’ life quality in survivorship.
文摘Objective： To explore and analyze the concept of intensive care unit （ICU） delirium. Method： Walker and Avant’sstrategy of analysis was adopted to this research. Results： ICU delirium is defined as the presence of an acute cognitiveimpairment, accompanied by a disturbance of consciousness with fluctuating inattention, and the array of dysfunctionsonly developed for a short period of time in ICU. The antecedents of ICU delirium include （1） the high severity of illness,（2） pain, （3） sedative use, （4） immobilization, （5） sleep deprivation and （6） unpleasant awareness. The consequencesinvolve （1） promoting the risks of self-extubation and unplanned removal of catheters, （2） prolonging the length of ICUstay, （3） increasing the mortality of critical patients and （4） Some different ICU delirium assessment instruments aregathered. Confusion Assessment Method for Intensive Care Unit assessment tool （CAM-ICU） was the most populardiagnostic tool used by nurses. Conclusion： Concept analysis as an extension and development of nursing theory cancreate a linkage between practice and theory. It will create a knowledge foundation of ICU delirium and provide atheoretical basis to construct nursing theory. This study can help ICU nurses to understand and recognize ICU delirium.ICU nurses will be enlightened to develop effective interventions of ICU delirium to improve critical patients’ clinicaloutcomes.
