Introduction: Primary cardiac myxofibrosarcoma (MFS) is a rare and aggressive malignancy, with limited treatment options and a high recurrence rate. Multimodal imaging is critical for diagnosis, and surgery remains th...Introduction: Primary cardiac myxofibrosarcoma (MFS) is a rare and aggressive malignancy, with limited treatment options and a high recurrence rate. Multimodal imaging is critical for diagnosis, and surgery remains the primary treatment, though recurrence is common. Case Presentation: We present the case of a 41-year-old male with history of intermittent chest pain and palpitations. Initial work-up revealed a left atrial mass, which after thorough evaluation with multimodal imaging and histopathological assessment, was diagnosed as a primary cardiac myxofibrosarcoma. Despite complete surgical resection and low-grade histology, recurrence ensued, prompting reintervention and adjuvant radiotherapy. Discussion: Cardiac MFS poses significant diagnostic challenges. Multimodal imaging and immunohistochemistry are key to diagnosis. While surgery is the mainstay of treatment, high recurrence rates necessitate consideration of adjuvant therapies and long-term monitoring. Conclusion: This case highlights the importance of differential diagnosis of intracardiac masses, as well as reaching a consensus regarding the approach for malignant cardiac tumors.展开更多
Cardiac amyloidosis is a disease characterized by the deposition of misfolded proteins in the myocardium,leading to restrictive cardiomyopathy.It com-prises two subtypes:immunoglobulin light chain cardiac amyloidosis(...Cardiac amyloidosis is a disease characterized by the deposition of misfolded proteins in the myocardium,leading to restrictive cardiomyopathy.It com-prises two subtypes:immunoglobulin light chain cardiac amyloidosis(AL)and transthyretin cardiac amyloidosis(ATTR).ATTR is classified as wild-type(wtATTR)and hereditary(hATTR),depending on the presence or absence of a transthyretin(TTR)genetic mutation.The diagnosis of cardiac amyloidosis is challenging due to nonspecific symptoms with other cardiac conditions,of-ten resulting in misdiagnosis.This mini review provides an in-depth analysis of cardiac amyloidosis,focusing on its subtypes,clinical manifestations,diag-nostic multimodal imaging,and recent therapeutic advancements.展开更多
文摘Introduction: Primary cardiac myxofibrosarcoma (MFS) is a rare and aggressive malignancy, with limited treatment options and a high recurrence rate. Multimodal imaging is critical for diagnosis, and surgery remains the primary treatment, though recurrence is common. Case Presentation: We present the case of a 41-year-old male with history of intermittent chest pain and palpitations. Initial work-up revealed a left atrial mass, which after thorough evaluation with multimodal imaging and histopathological assessment, was diagnosed as a primary cardiac myxofibrosarcoma. Despite complete surgical resection and low-grade histology, recurrence ensued, prompting reintervention and adjuvant radiotherapy. Discussion: Cardiac MFS poses significant diagnostic challenges. Multimodal imaging and immunohistochemistry are key to diagnosis. While surgery is the mainstay of treatment, high recurrence rates necessitate consideration of adjuvant therapies and long-term monitoring. Conclusion: This case highlights the importance of differential diagnosis of intracardiac masses, as well as reaching a consensus regarding the approach for malignant cardiac tumors.
文摘Cardiac amyloidosis is a disease characterized by the deposition of misfolded proteins in the myocardium,leading to restrictive cardiomyopathy.It com-prises two subtypes:immunoglobulin light chain cardiac amyloidosis(AL)and transthyretin cardiac amyloidosis(ATTR).ATTR is classified as wild-type(wtATTR)and hereditary(hATTR),depending on the presence or absence of a transthyretin(TTR)genetic mutation.The diagnosis of cardiac amyloidosis is challenging due to nonspecific symptoms with other cardiac conditions,of-ten resulting in misdiagnosis.This mini review provides an in-depth analysis of cardiac amyloidosis,focusing on its subtypes,clinical manifestations,diag-nostic multimodal imaging,and recent therapeutic advancements.
