Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myr...Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myrtus cumini Linn.This review provides an overview of its medicinal value,including taxonomical classification,geographic distribution,cultivation techniques,pharmacognostical aspects,phytochemical constituents,traditional uses,and pharmacological applications.In India,‘Ram Jamun’or‘Raja Jamun’is cultivated in the north,while the‘Paras’variety is grown in central regions.Various components of S.cumini fruits are utilized to enhance the nutritional quality of wines,jellies,jams,and fermented products.Rich in essential nutrients like vitamins,carbohydrates,minerals,antioxidants,and anthocyanins,S.cumini also contains bioactive phytoconstituents such as gallic acid,tannins,and polyphenols,which contribute to its pharmacological properties.Traditionally,black plums have been used as carminatives,diuretics,and remedies for stomach ailments,spleen enlargement,diarrhea,and urinary retention.Additionally,S.cumini has been historically administered to women post-abortion and is recognized for its role in managing diabetes and dysentery.Polyphenolic compounds in Jamun exhibit potential therapeutic benefits against diabetes,arthritis,cancer,asthma,and cardiovascular diseases.Given its promising ethnopharmacological profile,extensive research has been conducted on various plant parts,highlighting their antioxidant,antifungal,antibacterial,antidiabetic,and anticancer properties.This review aims to provide a comprehensive understanding of Syzygium cumini’s traditional and therapeutic significance,serving as a valuable resource for future research.展开更多
Autism Spectrum Disorder(ASD)is a complex neurodevelopmental condition that causes multiple challenges in behavioral and communication activities.In the medical field,the data related to ASD,the security measures are ...Autism Spectrum Disorder(ASD)is a complex neurodevelopmental condition that causes multiple challenges in behavioral and communication activities.In the medical field,the data related to ASD,the security measures are integrated in this research responsibly and effectively to develop the Mobile Neuron Attention Stage-by-Stage Network(MNASNet)model,which is the integration of both Mobile Network(MobileNet)and Neuron Attention Stage-by-Stage.The steps followed to detect ASD with privacy-preserved data are data normalization,data augmentation,and K-Anonymization.The clinical data of individuals are taken initially and preprocessed using the Z-score Normalization.Then,data augmentation is performed using the oversampling technique.Subsequently,K-Anonymization is effectuated by utilizing the Black-winged Kite Algorithm to ensure the privacy of medical data,where the best fitness solution is based on data utility and privacy.Finally,after improving the data privacy,the developed approach MNASNet is implemented for ASD detection,which achieves highly accurate results compared to traditional methods to detect autism behavior.Hence,the final results illustrate that the proposed MNASNet achieves an accuracy of 92.9%,TPR of 95.9%,and TNR of 90.9%at the k-samples of 8.展开更多
BACKGROUND Gallbladder mucocele,also known as gallbladder hydrops,is a rare condition characterized by the distention of the gallbladder due to the accumulation of fluid or mucus within its lumen,primarily attributed ...BACKGROUND Gallbladder mucocele,also known as gallbladder hydrops,is a rare condition characterized by the distention of the gallbladder due to the accumulation of fluid or mucus within its lumen,primarily attributed to obstruction arising from a gallstone in the cystic duct or gallbladder neck.CASE SUMMARY We present a case of a 67-year-old woman with an incidentally discovered gallbladder mucocele,shedding light on the clinical presentation,causes,and histopathological findings.We performed a literature review including an analysis of 27 case reports,revealing the diverse spectrum of causative factors,clinical manifestations,diagnosis,and management.CONCLUSION This study underscores the importance of considering alternative diagnoses and highlights the significance of imaging techniques in narrowing down the differential diagnosis and histopathologic examination for a definitive diagnosis.展开更多
Our study describes the reported rate of the Institutional Review Board(IRB)approval,declaration of Helsinki(DoH),and informed consent in the case reports and case series and investigates factors associated with the e...Our study describes the reported rate of the Institutional Review Board(IRB)approval,declaration of Helsinki(DoH),and informed consent in the case reports and case series and investigates factors associated with the ethical approval report.We searched PubMed for case reports and case series from 2006 to 2017.Annually,we obtained the first 20 articles of a case report cluster from 20 distinct publications.This analysis initially contained at least 2400 papers,with 100 papers each study design and year.Only 26(5.4%)of 480 included studies reported IRB approval,DoH approval,and participant informed consent;58(12.1%)reported two out of three ethical statements(DoH,informed consent,IRB);and 151(31.5%)reported only one,leading to nearly 245 studies(51.0%)did not report any ethical approval item.Both clusters mentioned the DoH the least.Only years,ages,ethical item types,and cluster types were associated with ethical reporting practices.This study found the serious under‐reporting of ethical practices in both case reports and case series.展开更多
背景与目的:华蟾素目前广泛应用于肿瘤的治疗中,由于在80年代上市,未进行临床Ⅰ期研究,无法确定其最大耐受剂量。因此本文旨在观察华蟾素治疗肝细胞癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞癌...背景与目的:华蟾素目前广泛应用于肿瘤的治疗中,由于在80年代上市,未进行临床Ⅰ期研究,无法确定其最大耐受剂量。因此本文旨在观察华蟾素治疗肝细胞癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞癌、非小细胞肺癌和胰腺癌接受华蟾素治疗,采用静脉滴注,连续14 d,21 d为一疗程。如果没有出现剂量限制性毒性,治疗将持续2个疗程。剂量递增的方案为:10、20、40、60、90和120 m l/(m2.d)。结果:入组15例患者(每个剂量组为3例)中,11例为肝癌,2例胰腺癌和2例肺癌。第五剂量组结束时没有发现剂量限制性毒性(DLT)。其中14例患者可评价疗效,6例(42.9%)为SD,8例(57.1%)为PD。在第一剂量组中,1例肝癌患者肿瘤缩小20%并维持11个月。结论:本研究最高剂量达到常规剂量的8倍,尚未出现剂量限制性毒性。部分患者获得了肿瘤缩小或稳定的疗效。展开更多
目的:研究腺病毒介导14-3-3.σ(Ad-14-3-.3σ)对Akt过表达Rat1-Akt细胞成瘤性的作用,并探讨其作用是否通过负调控Akt而实现。方法:通过半体内和体内实验观察Ad-14-3-.3σ转染对Rat1-Akt细胞在裸鼠中成瘤性的影响;采用W estern b lottin...目的:研究腺病毒介导14-3-3.σ(Ad-14-3-.3σ)对Akt过表达Rat1-Akt细胞成瘤性的作用,并探讨其作用是否通过负调控Akt而实现。方法:通过半体内和体内实验观察Ad-14-3-.3σ转染对Rat1-Akt细胞在裸鼠中成瘤性的影响;采用W estern b lotting方法检测转染14-3-.3σ基因后肿瘤组织内14-3-.3σ蛋白及其对Akt蛋白、Akt磷酸化活性和Akt磷酸化底物水平的影响。结果:无论体外用Ad-14-3-3σ处理Rat1-Akt细胞,还是体内经瘤内注射Ad-14-3-3σ,均可见14-3-3.σ可使荷瘤鼠肿瘤体积显著缩小(P<0.05),出现肿瘤的时间推迟,其中以长时间不间断给药疗效最好;转染14-3-.3σ基因治疗组的肿瘤组织中Akt蛋白、Akt-Thr308位点磷酸化活性及Akt磷酸化底物水平低于转染Ad-β-gal或PBS处理的对照组。结论:14-3-3σ可抑制Rat1-Akt细胞在裸鼠中的成瘤性,14-3-3σ通过负性调控Akt蛋白水平和磷酸化活性而抑瘤。展开更多
文摘Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myrtus cumini Linn.This review provides an overview of its medicinal value,including taxonomical classification,geographic distribution,cultivation techniques,pharmacognostical aspects,phytochemical constituents,traditional uses,and pharmacological applications.In India,‘Ram Jamun’or‘Raja Jamun’is cultivated in the north,while the‘Paras’variety is grown in central regions.Various components of S.cumini fruits are utilized to enhance the nutritional quality of wines,jellies,jams,and fermented products.Rich in essential nutrients like vitamins,carbohydrates,minerals,antioxidants,and anthocyanins,S.cumini also contains bioactive phytoconstituents such as gallic acid,tannins,and polyphenols,which contribute to its pharmacological properties.Traditionally,black plums have been used as carminatives,diuretics,and remedies for stomach ailments,spleen enlargement,diarrhea,and urinary retention.Additionally,S.cumini has been historically administered to women post-abortion and is recognized for its role in managing diabetes and dysentery.Polyphenolic compounds in Jamun exhibit potential therapeutic benefits against diabetes,arthritis,cancer,asthma,and cardiovascular diseases.Given its promising ethnopharmacological profile,extensive research has been conducted on various plant parts,highlighting their antioxidant,antifungal,antibacterial,antidiabetic,and anticancer properties.This review aims to provide a comprehensive understanding of Syzygium cumini’s traditional and therapeutic significance,serving as a valuable resource for future research.
文摘Autism Spectrum Disorder(ASD)is a complex neurodevelopmental condition that causes multiple challenges in behavioral and communication activities.In the medical field,the data related to ASD,the security measures are integrated in this research responsibly and effectively to develop the Mobile Neuron Attention Stage-by-Stage Network(MNASNet)model,which is the integration of both Mobile Network(MobileNet)and Neuron Attention Stage-by-Stage.The steps followed to detect ASD with privacy-preserved data are data normalization,data augmentation,and K-Anonymization.The clinical data of individuals are taken initially and preprocessed using the Z-score Normalization.Then,data augmentation is performed using the oversampling technique.Subsequently,K-Anonymization is effectuated by utilizing the Black-winged Kite Algorithm to ensure the privacy of medical data,where the best fitness solution is based on data utility and privacy.Finally,after improving the data privacy,the developed approach MNASNet is implemented for ASD detection,which achieves highly accurate results compared to traditional methods to detect autism behavior.Hence,the final results illustrate that the proposed MNASNet achieves an accuracy of 92.9%,TPR of 95.9%,and TNR of 90.9%at the k-samples of 8.
文摘BACKGROUND Gallbladder mucocele,also known as gallbladder hydrops,is a rare condition characterized by the distention of the gallbladder due to the accumulation of fluid or mucus within its lumen,primarily attributed to obstruction arising from a gallstone in the cystic duct or gallbladder neck.CASE SUMMARY We present a case of a 67-year-old woman with an incidentally discovered gallbladder mucocele,shedding light on the clinical presentation,causes,and histopathological findings.We performed a literature review including an analysis of 27 case reports,revealing the diverse spectrum of causative factors,clinical manifestations,diagnosis,and management.CONCLUSION This study underscores the importance of considering alternative diagnoses and highlights the significance of imaging techniques in narrowing down the differential diagnosis and histopathologic examination for a definitive diagnosis.
文摘Our study describes the reported rate of the Institutional Review Board(IRB)approval,declaration of Helsinki(DoH),and informed consent in the case reports and case series and investigates factors associated with the ethical approval report.We searched PubMed for case reports and case series from 2006 to 2017.Annually,we obtained the first 20 articles of a case report cluster from 20 distinct publications.This analysis initially contained at least 2400 papers,with 100 papers each study design and year.Only 26(5.4%)of 480 included studies reported IRB approval,DoH approval,and participant informed consent;58(12.1%)reported two out of three ethical statements(DoH,informed consent,IRB);and 151(31.5%)reported only one,leading to nearly 245 studies(51.0%)did not report any ethical approval item.Both clusters mentioned the DoH the least.Only years,ages,ethical item types,and cluster types were associated with ethical reporting practices.This study found the serious under‐reporting of ethical practices in both case reports and case series.
文摘背景与目的:华蟾素目前广泛应用于肿瘤的治疗中,由于在80年代上市,未进行临床Ⅰ期研究,无法确定其最大耐受剂量。因此本文旨在观察华蟾素治疗肝细胞癌、肺癌和胰腺癌的最大耐受剂量和不良反应,同时评价治疗疗效。方法:Ⅲ、Ⅳ期肝细胞癌、非小细胞肺癌和胰腺癌接受华蟾素治疗,采用静脉滴注,连续14 d,21 d为一疗程。如果没有出现剂量限制性毒性,治疗将持续2个疗程。剂量递增的方案为:10、20、40、60、90和120 m l/(m2.d)。结果:入组15例患者(每个剂量组为3例)中,11例为肝癌,2例胰腺癌和2例肺癌。第五剂量组结束时没有发现剂量限制性毒性(DLT)。其中14例患者可评价疗效,6例(42.9%)为SD,8例(57.1%)为PD。在第一剂量组中,1例肝癌患者肿瘤缩小20%并维持11个月。结论:本研究最高剂量达到常规剂量的8倍,尚未出现剂量限制性毒性。部分患者获得了肿瘤缩小或稳定的疗效。
文摘目的:研究腺病毒介导14-3-3.σ(Ad-14-3-.3σ)对Akt过表达Rat1-Akt细胞成瘤性的作用,并探讨其作用是否通过负调控Akt而实现。方法:通过半体内和体内实验观察Ad-14-3-.3σ转染对Rat1-Akt细胞在裸鼠中成瘤性的影响;采用W estern b lotting方法检测转染14-3-.3σ基因后肿瘤组织内14-3-.3σ蛋白及其对Akt蛋白、Akt磷酸化活性和Akt磷酸化底物水平的影响。结果:无论体外用Ad-14-3-3σ处理Rat1-Akt细胞,还是体内经瘤内注射Ad-14-3-3σ,均可见14-3-3.σ可使荷瘤鼠肿瘤体积显著缩小(P<0.05),出现肿瘤的时间推迟,其中以长时间不间断给药疗效最好;转染14-3-.3σ基因治疗组的肿瘤组织中Akt蛋白、Akt-Thr308位点磷酸化活性及Akt磷酸化底物水平低于转染Ad-β-gal或PBS处理的对照组。结论:14-3-3σ可抑制Rat1-Akt细胞在裸鼠中的成瘤性,14-3-3σ通过负性调控Akt蛋白水平和磷酸化活性而抑瘤。
