Due to the limited effects of current treatments on brain repair and regeneration,stroke continues to be the predominant cause of death and long-term disability on a global scale.In recent years,hydrogel-based biomate...Due to the limited effects of current treatments on brain repair and regeneration,stroke continues to be the predominant cause of death and long-term disability on a global scale.In recent years,hydrogel-based biomaterials combined with stem cells and extracellular vesicles have emerged as promising new treatments to improve brain regeneration after stroke.However,the clinical translation of hydrogel-based biomaterials for the treatment of brain injury is still far from satisfactory.In this review,we first summarise the present status of stroke-related clinical treatments and the advantages provided by hydrogel-based materials in combination with stem cells and extracellular vesicles in preclinical studies.We then focus on the possible causes of the gap between preclinical studies and clinical translation of hydrogel-based biomaterials from the perspective of biocompatibility and safety,the choices of preclinical models,the lack of clinical noninvasive imaging methods,standardisation and quality control,manufacturing scalability,and regulatory compliance.With the progress in the abovementioned areas,we believe that the clinical translation of hydrogel-based biomaterials will greatly improve brain regeneration after stroke and that this improvement will be realised by the general public in the near future.展开更多
基金the National Key R&D Program of China,No.2019YFA0112000(to YT)the National Natural Science Foundation of China(NSFC),Nos.82071284(to YT),82371307(to YT),82172529(to JW),32060184(to HM)+4 种基金Natural Science Foundation of Shanghai,No.21ZR1451700(to HL)Young Leading Scientists Cultivation Plan supported by Shanghai Municipal Education Commission,No.ZXWH1082101(to YT)Interdisciplinary Program of Shanghai Jiao Tong University,No.ZH2018QNA16(to YT)Key Projects of the National Center for Translational Medicine SUITM-202306(to YT)and Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University,No.202101AY070001-044(to HM).
文摘Due to the limited effects of current treatments on brain repair and regeneration,stroke continues to be the predominant cause of death and long-term disability on a global scale.In recent years,hydrogel-based biomaterials combined with stem cells and extracellular vesicles have emerged as promising new treatments to improve brain regeneration after stroke.However,the clinical translation of hydrogel-based biomaterials for the treatment of brain injury is still far from satisfactory.In this review,we first summarise the present status of stroke-related clinical treatments and the advantages provided by hydrogel-based materials in combination with stem cells and extracellular vesicles in preclinical studies.We then focus on the possible causes of the gap between preclinical studies and clinical translation of hydrogel-based biomaterials from the perspective of biocompatibility and safety,the choices of preclinical models,the lack of clinical noninvasive imaging methods,standardisation and quality control,manufacturing scalability,and regulatory compliance.With the progress in the abovementioned areas,we believe that the clinical translation of hydrogel-based biomaterials will greatly improve brain regeneration after stroke and that this improvement will be realised by the general public in the near future.
