Objective:To evaluate the effects of Cocos nucifera(C.nucifera)water on the cardiovascular and renal functions of offspring from rat dams fed high fat diet during gestation.Methods:Four groups of pregnant Wistar rats ...Objective:To evaluate the effects of Cocos nucifera(C.nucifera)water on the cardiovascular and renal functions of offspring from rat dams fed high fat diet during gestation.Methods:Four groups of pregnant Wistar rats were treated from gestation day 1 to 21;namely,control(1 mL/100 g distilled water),C.nucifera water(1 mL/100 g C.nucifera water),high fat diet(1 mL/100 g distilled water+30%butter:70%standard rodent diet)and high fat diet+C.nucifera water(1 mL/100 g C.nucifera water+30%butter:70%standard rodent diet).All dams received standard rodent diet from gestation day 22,and offspring were weaned to standard rodent diet on postnatal day 28.On postnatal day 120,serum and cardiac levels of malondialdehyde,interleukin-1βand high sensitivity C-reactive protein were determined in offspring.Serum creatinine and urea levels as well as histology of heart and kidney tissue were assessed.Data were analyzed using One-way ANOVA and P<0.05 was considered statistically significant.Results:Male high fat diet offspring showed significantly increased(P<0.05)serum interleukin-1βcompared with C.nucifera water offspring.The increase in serum high sensitivity C-reactive protein observed in female high fat diet offspring was not present in high fat diet+C.nucifera water offspring.Heart tissues from high fat diet offspring showed scanty fibers and congested myocardium with mild fibrosis.Male high fat diet offspring kidneys showed mesangial cell hyperplasia,fat infiltration and mild tubular necrosis.These were accompanied with alterations in serum urea and creatinine levels in high fat diet+C.nucifera water offspring.Conclusions:C.nucifera water exerts cardioprotective and renoprotective effects on offspring of rat dams fed high fat diet during gestation via an anti-inflammatory mechanism.展开更多
文摘Objective:To evaluate the effects of Cocos nucifera(C.nucifera)water on the cardiovascular and renal functions of offspring from rat dams fed high fat diet during gestation.Methods:Four groups of pregnant Wistar rats were treated from gestation day 1 to 21;namely,control(1 mL/100 g distilled water),C.nucifera water(1 mL/100 g C.nucifera water),high fat diet(1 mL/100 g distilled water+30%butter:70%standard rodent diet)and high fat diet+C.nucifera water(1 mL/100 g C.nucifera water+30%butter:70%standard rodent diet).All dams received standard rodent diet from gestation day 22,and offspring were weaned to standard rodent diet on postnatal day 28.On postnatal day 120,serum and cardiac levels of malondialdehyde,interleukin-1βand high sensitivity C-reactive protein were determined in offspring.Serum creatinine and urea levels as well as histology of heart and kidney tissue were assessed.Data were analyzed using One-way ANOVA and P<0.05 was considered statistically significant.Results:Male high fat diet offspring showed significantly increased(P<0.05)serum interleukin-1βcompared with C.nucifera water offspring.The increase in serum high sensitivity C-reactive protein observed in female high fat diet offspring was not present in high fat diet+C.nucifera water offspring.Heart tissues from high fat diet offspring showed scanty fibers and congested myocardium with mild fibrosis.Male high fat diet offspring kidneys showed mesangial cell hyperplasia,fat infiltration and mild tubular necrosis.These were accompanied with alterations in serum urea and creatinine levels in high fat diet+C.nucifera water offspring.Conclusions:C.nucifera water exerts cardioprotective and renoprotective effects on offspring of rat dams fed high fat diet during gestation via an anti-inflammatory mechanism.
