Moving from the most recent results on Foxg1 biology,we first summarize the available information on some special pleiotropic effectors of neurodevelopmental interest,involved in controlling both transcription and pos...Moving from the most recent results on Foxg1 biology,we first summarize the available information on some special pleiotropic effectors of neurodevelopmental interest,involved in controlling both transcription and post-transcriptional steps of gene expression.Then,after further analysis of the literature,we report evidence that,not strictly limited to neurodevelopmental effectors,such pleiotropy also applies to other transcription factors,involved in physiology and homeostasis.Furthermore,through the systematic analysis of a major public protein-protein interaction database,we gather strong evidence that the involvement of“canonical”transcription factors in post-transcriptional control of gene expression could be a pervasive phenomenon,characterizing hundreds of effectors.Finally,we discuss the biological significance of these findings and propose three evolutionary mechanisms that may have contributed to such an unexpected scenario.展开更多
Generation of astrocytes within the murine developing cerebral cortex mainly takes place during the first postnatal week, after neuronogenesis and prior to the bulk of oligogenesis. This process involves a great varie...Generation of astrocytes within the murine developing cerebral cortex mainly takes place during the first postnatal week, after neuronogenesis and prior to the bulk of oligogenesis. This process involves a great variety of highly complex regulatory mechanisms. Astrocytic outputs depend on two primary factors： progressive commitment of multipotent precursors to astroglial fates and proper tuning of proliferation of astrocyte-committed progenitors. To date, several regulatory mechanisms have been identified for the former process, while very little is known about modulation of astroblast proliferation （reviewed in Mallamaci,展开更多
基金supported by SISSA(intramural funding to AM)International FOXG1 Research Foundation(Grant to AM)+1 种基金Italian Ministery of University and Research(Grant PRIN222022M95RC7 to AM)Fondazione Telethon(Grant GMR22T2018 to AM).
文摘Moving from the most recent results on Foxg1 biology,we first summarize the available information on some special pleiotropic effectors of neurodevelopmental interest,involved in controlling both transcription and post-transcriptional steps of gene expression.Then,after further analysis of the literature,we report evidence that,not strictly limited to neurodevelopmental effectors,such pleiotropy also applies to other transcription factors,involved in physiology and homeostasis.Furthermore,through the systematic analysis of a major public protein-protein interaction database,we gather strong evidence that the involvement of“canonical”transcription factors in post-transcriptional control of gene expression could be a pervasive phenomenon,characterizing hundreds of effectors.Finally,we discuss the biological significance of these findings and propose three evolutionary mechanisms that may have contributed to such an unexpected scenario.
文摘Generation of astrocytes within the murine developing cerebral cortex mainly takes place during the first postnatal week, after neuronogenesis and prior to the bulk of oligogenesis. This process involves a great variety of highly complex regulatory mechanisms. Astrocytic outputs depend on two primary factors： progressive commitment of multipotent precursors to astroglial fates and proper tuning of proliferation of astrocyte-committed progenitors. To date, several regulatory mechanisms have been identified for the former process, while very little is known about modulation of astroblast proliferation （reviewed in Mallamaci,
