Schizophrenia is a complex psychiatric disorder marked by positive and negative symptoms,leading to mood disturbances,cognitive impairments,and social withdrawal.While anti-psychotic medications remain the cornerstone...Schizophrenia is a complex psychiatric disorder marked by positive and negative symptoms,leading to mood disturbances,cognitive impairments,and social withdrawal.While anti-psychotic medications remain the cornerstone of treatment,they often fail to fully address certain symptoms.Additionally,treatment-resistant schizophrenia,affecting 30%-40%of patients,remains a substantial clinical challenge.Positive,negative symptoms and cognitive impairments have been linked to disruptions in the glutamatergic,serotonin,GABAergic,and muscarinic pathways in the brain.Recent advances using genome-wide association study and other approaches have uncovered a significant number of new schizophrenia risk genes that uncovered new,and reinforced prior,concepts on the genetic and neurological underpinnings of schizophrenia,including abnormalities in synaptic function,immune processes,and lipid metabolism.Concurrently,new therapeutics targeting different modalities,which are expected to address some of the limitations of anti-psychotic drugs currently being offered to patients,are currently being evaluated.Collectively,these efforts provide new momentum for the next phase of schizophrenia research and treatment.展开更多
This paper presents a simulator model of a marine diesel engine based on physical, semi-physical, mathematical and thermodynamic equations, which allows fast predictive simulations The whole engine system is divided i...This paper presents a simulator model of a marine diesel engine based on physical, semi-physical, mathematical and thermodynamic equations, which allows fast predictive simulations The whole engine system is divided into several functional blocks： cooling, lubrication, air, injection, combustion and emissions. The sub-models and dynamic characteristics of individual blocks are established according to engine working principles equations and experimental data collected from a marine diesel engine test bench for SIMB Company under the reference 6M26SRP1. The overall engine system dynamics is expressed as a set of simultaneous algebraic and differential equations using sub-blocks and S-Functions of Matlab/Simulink. The simulation of this model, implemented on Matlab/Simulink has been validated and can be used to obtain engine performance, pressure, temperature, efficiency, heat release, crank angle, fuel rate, emissions at different sub-blocks. The simulator will be used, in future work, to study the engine performance in faulty conditions, and can be used to assist marine engineers in fault diagnosis and estimation （FDI） as well as designers to predict the behavior of the cooling system, lubrication system, injection system, combustion, emissions, in order to optimize the dimensions of different components. This program is a platform for fault simulator, to investigate the impact on sub-blocks engine＇s output of changing values for faults parameters such as： faulty fuel injector, leaky cylinder, worn fuel pump, broken piston rings, a dirty turbocharger, dirty air filter, dirty air cooler, air leakage, water leakage, oil leakage and contamination, fouling of heat exchanger, pumps wear, failure of injectors （and many others）.展开更多
RSA public key crypto system is a relatively safe technology, which is widely used in today’s secure electronic communication. In this paper, a new implementation method to optimize a 1 024 bit RSA processor was pres...RSA public key crypto system is a relatively safe technology, which is widely used in today’s secure electronic communication. In this paper, a new implementation method to optimize a 1 024 bit RSA processor was presented. Basically, a fast modular multiplication architecture based on Montgomery’s algorithm was proposed. Modular exponentiation algorithm scans encryption from right to left, so two modular multiplications can be processed parallel. The new architecture is also fit for an effective I/O interface. The time to calculate a modular exponentiation is about n 2 clock cycles. The proposed architecture has a data rate of 93.7 kb/s for 1 024 bit work with a 100 MHz clock.展开更多
基金supported by the Ministry of Health National Medical Research Council (to JL)the National University of Singapore (to JJEC)
文摘Schizophrenia is a complex psychiatric disorder marked by positive and negative symptoms,leading to mood disturbances,cognitive impairments,and social withdrawal.While anti-psychotic medications remain the cornerstone of treatment,they often fail to fully address certain symptoms.Additionally,treatment-resistant schizophrenia,affecting 30%-40%of patients,remains a substantial clinical challenge.Positive,negative symptoms and cognitive impairments have been linked to disruptions in the glutamatergic,serotonin,GABAergic,and muscarinic pathways in the brain.Recent advances using genome-wide association study and other approaches have uncovered a significant number of new schizophrenia risk genes that uncovered new,and reinforced prior,concepts on the genetic and neurological underpinnings of schizophrenia,including abnormalities in synaptic function,immune processes,and lipid metabolism.Concurrently,new therapeutics targeting different modalities,which are expected to address some of the limitations of anti-psychotic drugs currently being offered to patients,are currently being evaluated.Collectively,these efforts provide new momentum for the next phase of schizophrenia research and treatment.
文摘This paper presents a simulator model of a marine diesel engine based on physical, semi-physical, mathematical and thermodynamic equations, which allows fast predictive simulations The whole engine system is divided into several functional blocks： cooling, lubrication, air, injection, combustion and emissions. The sub-models and dynamic characteristics of individual blocks are established according to engine working principles equations and experimental data collected from a marine diesel engine test bench for SIMB Company under the reference 6M26SRP1. The overall engine system dynamics is expressed as a set of simultaneous algebraic and differential equations using sub-blocks and S-Functions of Matlab/Simulink. The simulation of this model, implemented on Matlab/Simulink has been validated and can be used to obtain engine performance, pressure, temperature, efficiency, heat release, crank angle, fuel rate, emissions at different sub-blocks. The simulator will be used, in future work, to study the engine performance in faulty conditions, and can be used to assist marine engineers in fault diagnosis and estimation （FDI） as well as designers to predict the behavior of the cooling system, lubrication system, injection system, combustion, emissions, in order to optimize the dimensions of different components. This program is a platform for fault simulator, to investigate the impact on sub-blocks engine＇s output of changing values for faults parameters such as： faulty fuel injector, leaky cylinder, worn fuel pump, broken piston rings, a dirty turbocharger, dirty air filter, dirty air cooler, air leakage, water leakage, oil leakage and contamination, fouling of heat exchanger, pumps wear, failure of injectors （and many others）.
基金NSF of U nited States under Contract 5 978East Asia and Pacific Program(960 2 485 )
文摘RSA public key crypto system is a relatively safe technology, which is widely used in today’s secure electronic communication. In this paper, a new implementation method to optimize a 1 024 bit RSA processor was presented. Basically, a fast modular multiplication architecture based on Montgomery’s algorithm was proposed. Modular exponentiation algorithm scans encryption from right to left, so two modular multiplications can be processed parallel. The new architecture is also fit for an effective I/O interface. The time to calculate a modular exponentiation is about n 2 clock cycles. The proposed architecture has a data rate of 93.7 kb/s for 1 024 bit work with a 100 MHz clock.
