AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health c...AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health checkup program including abdominal ultrasonography.This study involved 11 714 apparently healthy Japanese men and women,18 to 83 years of age.NAFLD was defined by abdominal ultrasonography without an alcohol intake of more than 20 g/d,known liver disease,or current use of medication.The revised criteria of the National Cholesterol Education Program Adult Treatment PanelⅢ were used to characterize the metabolic syndrome.RESULTS:NAFLD was detected in 32.2%(95%CI:31.0%-33.5%)of men(n=1874 of 5811)and in 8.7%(95%CI:8.0%-9.5%)of women(n=514 of 5903).Among obese people,the prevalence of NAFLD was as high as 67.3%(95%CI:64.8%-69.7%)in men and 45.8%(95%CI:41.7%-50.0%)in women.Although NAFLD was thought of as being the liver phenotype of metabolic syndrome,the prevalence of the metabolic syndrome among subjects with NAFLD was low both in men and women.66.8%of men and 70.4%of women with NAFLD were not diagnosed with the metabolic syndrome.48.2%of men with NAFLD and 49.8%of women with NAFLD weren't overweight[body mass index(BMI)≥25 kg/m2].In the same way,68.6%of men with NAFLD and 37.9%of women with NAFLD weren't satisfied with abdominal classification(≥90 cm for men and≥80 cm for women).Next,authors defined it as positive at screening for NAFLD when participants satisfied at least one criterion of metabolic syndrome.The sensitivity of the definition"at least 1 criterion"was as good as 84.8%in men and 86.6%in women.Separating subjects by BMI,the sensitivity was higher in obese men and women than in non-obese men and women(92.3%vs 76.8%in men,96.1%vs 77.0%in women,respectively).CONCLUSION:Authors could determine NAFLD effectively in epidemiological study by modifying the usage of the criteria for metabolic syndrome.展开更多
In this paper,Support Vector Machine(SVM)and K-Nearest Neighbor(KNN)based methods are to be applied on fault diagnosis in a robot manipulator.A comparative study between the two classifiers in terms of successfully det...In this paper,Support Vector Machine(SVM)and K-Nearest Neighbor(KNN)based methods are to be applied on fault diagnosis in a robot manipulator.A comparative study between the two classifiers in terms of successfully detecting and isolating the seven classes of sensor faults is considered in this work.For both classifiers,the torque,the position and the speed of the manipulator have been employed as the input vector.However,it is to mention that a large database is needed and used for the training and testing phases.The SVM method used in this paper is based on the Gaussian kernel with the parametersγand the penalty margin parameter“C”,which were adjusted via the PSO algorithm to achieve a maximum accuracy diagnosis.Simulations were carried out on the model of a Selective Compliance Assembly Robot Arm(SCARA)robot manipulator,and the results showed that the Particle Swarm Optimization(PSO)increased the per-formance of the SVM algorithm with the 96.95%accuracy while the KNN algo-rithm achieved a correlation up to 94.62%.These results showed that the SVM algorithm with PSO was more precise than the KNN algorithm when was used in fault diagnosis on a robot manipulator.展开更多
The effects of high magnetic field armealihng on the morphology and texture of pulsed-electrodeposited Co-Ni-P films were investigated by field emission scanning electronic microscopy(FE-SEM),atomic force microscopy(A...The effects of high magnetic field armealihng on the morphology and texture of pulsed-electrodeposited Co-Ni-P films were investigated by field emission scanning electronic microscopy(FE-SEM),atomic force microscopy(AFM) and X-ray diffraction(XRD).The as-deposited film with cluster structural on a rough surface changed into non-uniform and bigger nanocrystalline during the no-field annealing due to a recrystallization process.Post-deposition annealing under a magnetic field favored to form a more homogeneous surface with smaller grain size and lower roughness.The magneto-induced a mixed phase structure including fcc-Ni,hcp-Co and fcc-CoNiP appeared in the case of the films annealed at a 9T magnetic field.The possible overlapping effects such as diffusion and recrystallization obtained by the magnetic field annealing on the morphology evolution and on the phase transformation in the films were interpreted.展开更多
The present study reports on the growth of calcium phosphate coatings on Ti6Al4V substrate by electrodeposition under high magnetic field.The electrodeposition is conducted by potentiostatic method on horizontal elect...The present study reports on the growth of calcium phosphate coatings on Ti6Al4V substrate by electrodeposition under high magnetic field.The electrodeposition is conducted by potentiostatic method on horizontal electrode whose roughness was modified to reach a value of 3μm.The coatings are obtained from an electrolyte containing calcium nitrate as the Ca^(2+) source and ammonium phosphate as the P source with a Ca/P ratio equal to two.The LNCMI high field continuous magnet in a 170 mm bore with homogeneity of 600.10~6 in I cm^3 has been used.The magnetic field with a magnitude up to 12 T is applied perpendicularly to the electrode surface.The surface morphology and chemical composition of the obtained coatings were characterized by 3D digital microscope and scanning electron microscopy associated with X-ray microanalysis(SEM-EDX).The phase composition was analyzed by X-Ray diffraction.The presence of several crystalline phases comprising octacalcium phosphate and hydroxyapatite is obtained and magnetic field seems to change the relative importance of these phases.The coating morphology changes from belt shape crystallites to needle shape crystallites with high magnetic field superimposition without important modification of Ca/P ratio in the deposit.On the other hand formation of volcano-like structures due to the presence of hydrogen bubbles during deposition is considerably reduced in the presence of magnetic field.展开更多
In this study,the possibility of obtaining micro and nano-scaled Co/Ni bi-layered films by use of the electrochemical method was investigated.The electrodeposition process was performed with presence and absence of a ...In this study,the possibility of obtaining micro and nano-scaled Co/Ni bi-layered films by use of the electrochemical method was investigated.The electrodeposition process was performed with presence and absence of a uniform external magnetic field up to 1T to examine its influence on structure and morphology of the obtained thin films. Afterwards,each sample was annealed under high magnetic field with strength up to 12 T at 623 K,what allowed compare and determine the changes in morphology and structure,before and after heat treatment.The Co/Ni bi-layered thin films were deposited onto an indium-doped tin oxide(ITO)-coated conducting glass substrate from sulfate baths with boric acid as an additive.The results show drastic changes in the morphology between macro and nano-scaled films which were strongly affected by an introduction of the magnetic field to the electrodeposition process.The annealing process allowed to determine the nucleus transition and showed that under the high temperature treatment it is possible to control the growth mode as well as the phase composition changes.展开更多
The aim of this study is to show the interest of the mechanical and dynamical properties of glass-flax hybrid composites.Therefore,various staking sequences of glass-flax hybrid composites were manufactured and tested...The aim of this study is to show the interest of the mechanical and dynamical properties of glass-flax hybrid composites.Therefore,various staking sequences of glass-flax hybrid composites were manufactured and tested in free vibrations.The damping coefficients were identified by fitting the experimental responses of free-free bending vibrations.The obtained results show that the staking sequences and the position of flax fiber layers in the hybrid composites changed the properties,so a classification of different stacking sequences was established.In fact,the hybrid laminate made of two glass external layers placed on both sides of four flax layers is very interesting in term of its mechanical and damping properties.Indeed,it showed better specific bending modulus and loss factor than glass composites with proportions of 31 and 39%,respectively.A study of a structure of this composite has been made to validate the obtained results.展开更多
This work aims at studying the effect of hygrothermal and UV cyclic aging on the tensile properties and esthetic characteristics of non-woven composites.The composite materials were thermo-compressed from non-woven ma...This work aims at studying the effect of hygrothermal and UV cyclic aging on the tensile properties and esthetic characteristics of non-woven composites.The composite materials were thermo-compressed from non-woven mats made up of PP and flax or kenaf fibers.This works included evaluating the change in color appearance and analyzing the variations in tensile properties and damage mechanisms,depending on the aging time.The presence of the UV protection film on the composite surface showed its effectiveness against aging.From visual observations and measurement of colorimetric parameters,it has been proved effective in the reduction of the bleaching and yellowing of the composites.As regards the tensile tests,the UV protection film enabled to stabilize the Young’s modulus after 1-week aging for Kenaf/PP and after 3-weeks for Flax/PP.After 4-weeks aging,it halved the number of acoustic emission events related to interfacial decohesion and fiber slippage/pull out for Flax/PP and Kenaf/PP composites.展开更多
Using a linked-parameter technique of level-fitting calculations in a multi configuration basis, a parametric analysis of fine structure (fs) for even-parity levels of V II, involving six configurations, has been perf...Using a linked-parameter technique of level-fitting calculations in a multi configuration basis, a parametric analysis of fine structure (fs) for even-parity levels of V II, involving six configurations, has been performed. This led us to exchange the assignments of two triplets, 3d3(2F)4s c 3F and 3d4 d 3F, reported in earlier analyses as being located at 30,300 cm-1 and 30,600 cm-1, respectively. This is confirmed by experimental hyperfine structure (hfs) A constants, used as fingerprints. Moreover, the current singlet 3d24s2 1D2 position is likely too high. The fs parameters, magnetic Landé g-factors, and the percentage of leading eigenvectors of levels are calculated. We present also predicted singlet, triplet and quintet positions for missing experimental levels up to 100,000 cm-1. The single-electron hfs parameters are determined in their entirety for 51V II for the model space (3d + 4s)4 with good accuracy. For the model space (3d + 4s)4 of 51V II the single-electron hfs parameters are computed;furthermore, our achieved theoretical evaluations of the single-electron hfs parameters, thanks to the use of ab initio calculations, reinforce the validity of these hfs parameter values, deduced from experimental data.展开更多
The 3d34p, 3d35p and 3d24s4p odd configurations of the V II spectrum have been reanalysed and three 3d24s4p triplets are assigned higher energies than previously proposed. We have determined the fine structure paramet...The 3d34p, 3d35p and 3d24s4p odd configurations of the V II spectrum have been reanalysed and three 3d24s4p triplets are assigned higher energies than previously proposed. We have determined the fine structure parameters, the largest and next largest eigenvector percentages of levels, their calculated Landé gJ-factors and predicted positions for missing experimental levels up to 100,000 cm-1 for the 3d24s4p configuration. Furthermore for the first time a hyperfine structure (HFS) parametric treatment, involving levels of these two configurations has been carried out. The deduced single-electron HFS parameter values are successfully checked with those obtained by means of ab initio calculations.展开更多
Gram‐negative bacteria are particularly prone to developing antimicrobial resistance(AMR),as evidenced by the WHO's ESKAPEE list of high‐priority pathogens.One strategy that has increased is the use of antibioti...Gram‐negative bacteria are particularly prone to developing antimicrobial resistance(AMR),as evidenced by the WHO's ESKAPEE list of high‐priority pathogens.One strategy that has increased is the use of antibiotic enhancers,which can reempower abandoned or poorly active antibiotics against the resistant strain of interest.In this study,the polyamino‐isoprenyl antibiotic enhancer,NV716,was tested in combination with two families of multi‐target Ser/Cys‐based enzyme inhibitors,the oxadiazolone derivatives(OX)and the Cyclipostins and Cyclophostin analogs(CyC),which are inactive against Gram‐negative ESKAPEE bacteria,to potentiate their antibacterial activity and thus make them active against these bacteria.We demonstrated that NV716 potentiates some OX and CyC compounds by permeabilizing the outer membrane and thus by increasing the inhibitor accumulation,as shown by fluorescence microscopy.By using the click‐chemistry activity‐based protein profiling(ABPP)approach coupled with proteomic analysis,we also confirmed the multi‐target nature of the best OX and CyC inhibitors by identifying their target proteins on a bacterial culture of Enterobacter cloacae.Remarkably,a large set of these identified proteins had already been captured in previous ABPP experiments conducted on Mycobacterium tuberculosis and/or Mycobacterium abscessus culture.Furthermore,we showed that five of the identified target proteins were present in a total lysate of Pseudomonas aeruginosa.Importantly,these latter enzymes are highly conserved among Gram‐negative bacteria,with two of them annotated as essential for bacterial survival.These results provide proof of concept that both OX and CyC,if successfully potentiated,could be used against ESKAPEE Gram‐negative bacteria.展开更多
Soft robotics is a breakthrough technology to support human-robot interactions.The soft structure of a soft robot can increase safety during human and robot interactions.One of the promising soft actuators for soft ro...Soft robotics is a breakthrough technology to support human-robot interactions.The soft structure of a soft robot can increase safety during human and robot interactions.One of the promising soft actuators for soft robotics is dielectric elastomer actuators(DEAs).DEAs can operate silently and have an excellent energy density.The simple structure of DEAs leads to the easy fabrication of soft actuators.The simplicity combined with silent operation and high energy density make DEAs interesting for soft robotics researchers.DEAs actuation follows the Maxwell-pressure principle.The pressure produced in the DEAs actuation depends much on the voltage applied.Common DEAs requires high voltage to gain an actuation.Since the power consumption of DEAs is in the milli-Watt range,the current needed to operate the DEAs can be neglected.Several commercially available DC-DC converters can convert the volt range to the kV range.In order to get a voltage in the 2-3 kV range,the reliable DC-DC converter can be pricy for each device.This problem hinders the education of soft actuators,especially for a newcomer laboratory that works in soft electric actuators.This paper introduces an entirely do-it-yourself(DIY)Ultrahigh voltage amplifier(UHV-Amp)for education in soft robotics.UHV-Amp can amplify 12 V to at a maximum of 4 kV DC.As a demonstration,we used this UHV-Amp to test a single layer of powdered-based DEAs.The strategy to build this educational type UHV-Amp was utilizing a Cockcroft-Walton circuit structure to amplify the voltage range to the kV range.In its current state,the UHV-Amp has the potential to achieve approximately 4 kV.We created a simple platform to control the UHV-Amp from a personal computer.In near future,we expect this easy control of the UHV-Amp can contribute to the education of soft electric actuators.展开更多
The conventional electrohydrodynamic(EHD)pump is limited to pumping functional and dielectric liquids,which restricts its applications in fields like microfluidics,food safety,and materials production.In this study,we...The conventional electrohydrodynamic(EHD)pump is limited to pumping functional and dielectric liquids,which restricts its applications in fields like microfluidics,food safety,and materials production.In this study,we present a flexible water pump driven by EHD fluid,achieved by integrating valveless elements into the fluidic channel.Our approach leverages the water–EHD interface to propel the immiscible aqueous liquid and reciprocate this process using the nozzle–diffuser system.All components of the water pump are digitally fabricated and assembled.The valveless parts are created using a laser cutting machine.Additionally,we develop a model for the EHD pump and nozzle-diffuser system to predict the generated flow rate,considering factors such as the asymmetrical performance of the EHD pump,pulse frequency,applied voltage,and structural parameters.Finally,we experimentally characterize the flow rates of both the EHD pump and water pump and apply the newly developed device to air bubble manipulation and droplet generation.This research broadens the range of specialized liquids pumped by EHD pumps to include other aqueous liquids or mixtures.展开更多
Flexible electrohydrodynamic(EHD)pumps have been developed and applied in many fields due to no transmission structure,no wear,easy manipulation,and no noise.Physical simulation is often used to predict the output per...Flexible electrohydrodynamic(EHD)pumps have been developed and applied in many fields due to no transmission structure,no wear,easy manipulation,and no noise.Physical simulation is often used to predict the output performance of flexible EHD pumps.However,this method neglects fluid–solid interaction and energy loss caused by flexible materials,which are both difficult to calculate when the flexible pumps deform.Therefore,this study proposes a flexible pump output performance prediction using machine learning algorithms.We used three different types of machine learning:random forest regression,ridge regression,and neural network to predict the critical parameters(pressure,flow rate,and power)of the flexible EHD pump.Voltage,angle,gap,overlap,and channel height are selected as five input data of the neural network.In addition,we optimized essential parameters in the three networks.Finally,we adopt the best predictive model and evaluate the significance of five input parameters to the output performance of the flexible EHD pumps.Among the three methods,the MLP model has exceptionally high accuracy in predicting pressure and flow.Our work is beneficial for the design process of fluid sources in flexible soft actuators and soft hydraulic sources in microfluidic chips.展开更多
基金Supported by Young Scientists(B)(23790791)from Japan Society for the Promotion of Science
文摘AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health checkup program including abdominal ultrasonography.This study involved 11 714 apparently healthy Japanese men and women,18 to 83 years of age.NAFLD was defined by abdominal ultrasonography without an alcohol intake of more than 20 g/d,known liver disease,or current use of medication.The revised criteria of the National Cholesterol Education Program Adult Treatment PanelⅢ were used to characterize the metabolic syndrome.RESULTS:NAFLD was detected in 32.2%(95%CI:31.0%-33.5%)of men(n=1874 of 5811)and in 8.7%(95%CI:8.0%-9.5%)of women(n=514 of 5903).Among obese people,the prevalence of NAFLD was as high as 67.3%(95%CI:64.8%-69.7%)in men and 45.8%(95%CI:41.7%-50.0%)in women.Although NAFLD was thought of as being the liver phenotype of metabolic syndrome,the prevalence of the metabolic syndrome among subjects with NAFLD was low both in men and women.66.8%of men and 70.4%of women with NAFLD were not diagnosed with the metabolic syndrome.48.2%of men with NAFLD and 49.8%of women with NAFLD weren't overweight[body mass index(BMI)≥25 kg/m2].In the same way,68.6%of men with NAFLD and 37.9%of women with NAFLD weren't satisfied with abdominal classification(≥90 cm for men and≥80 cm for women).Next,authors defined it as positive at screening for NAFLD when participants satisfied at least one criterion of metabolic syndrome.The sensitivity of the definition"at least 1 criterion"was as good as 84.8%in men and 86.6%in women.Separating subjects by BMI,the sensitivity was higher in obese men and women than in non-obese men and women(92.3%vs 76.8%in men,96.1%vs 77.0%in women,respectively).CONCLUSION:Authors could determine NAFLD effectively in epidemiological study by modifying the usage of the criteria for metabolic syndrome.
基金supported by Taif University Researchers Supporting Project(Number TURSP-2020/122),Taif University,Taif,Saudi Arabia.
文摘In this paper,Support Vector Machine(SVM)and K-Nearest Neighbor(KNN)based methods are to be applied on fault diagnosis in a robot manipulator.A comparative study between the two classifiers in terms of successfully detecting and isolating the seven classes of sensor faults is considered in this work.For both classifiers,the torque,the position and the speed of the manipulator have been employed as the input vector.However,it is to mention that a large database is needed and used for the training and testing phases.The SVM method used in this paper is based on the Gaussian kernel with the parametersγand the penalty margin parameter“C”,which were adjusted via the PSO algorithm to achieve a maximum accuracy diagnosis.Simulations were carried out on the model of a Selective Compliance Assembly Robot Arm(SCARA)robot manipulator,and the results showed that the Particle Swarm Optimization(PSO)increased the per-formance of the SVM algorithm with the 96.95%accuracy while the KNN algo-rithm achieved a correlation up to 94.62%.These results showed that the SVM algorithm with PSO was more precise than the KNN algorithm when was used in fault diagnosis on a robot manipulator.
基金Item Sponsored by National Natural Science Foundation of China[No.51061130557,51101032]Agence Nationale de la Recherche France[No.2010-INTB-903-01]
文摘The effects of high magnetic field armealihng on the morphology and texture of pulsed-electrodeposited Co-Ni-P films were investigated by field emission scanning electronic microscopy(FE-SEM),atomic force microscopy(AFM) and X-ray diffraction(XRD).The as-deposited film with cluster structural on a rough surface changed into non-uniform and bigger nanocrystalline during the no-field annealing due to a recrystallization process.Post-deposition annealing under a magnetic field favored to form a more homogeneous surface with smaller grain size and lower roughness.The magneto-induced a mixed phase structure including fcc-Ni,hcp-Co and fcc-CoNiP appeared in the case of the films annealed at a 9T magnetic field.The possible overlapping effects such as diffusion and recrystallization obtained by the magnetic field annealing on the morphology evolution and on the phase transformation in the films were interpreted.
文摘The present study reports on the growth of calcium phosphate coatings on Ti6Al4V substrate by electrodeposition under high magnetic field.The electrodeposition is conducted by potentiostatic method on horizontal electrode whose roughness was modified to reach a value of 3μm.The coatings are obtained from an electrolyte containing calcium nitrate as the Ca^(2+) source and ammonium phosphate as the P source with a Ca/P ratio equal to two.The LNCMI high field continuous magnet in a 170 mm bore with homogeneity of 600.10~6 in I cm^3 has been used.The magnetic field with a magnitude up to 12 T is applied perpendicularly to the electrode surface.The surface morphology and chemical composition of the obtained coatings were characterized by 3D digital microscope and scanning electron microscopy associated with X-ray microanalysis(SEM-EDX).The phase composition was analyzed by X-Ray diffraction.The presence of several crystalline phases comprising octacalcium phosphate and hydroxyapatite is obtained and magnetic field seems to change the relative importance of these phases.The coating morphology changes from belt shape crystallites to needle shape crystallites with high magnetic field superimposition without important modification of Ca/P ratio in the deposit.On the other hand formation of volcano-like structures due to the presence of hydrogen bubbles during deposition is considerably reduced in the presence of magnetic field.
基金Item Sponsored by National Natural Science Foundation of China(51061130557,51101032)French ANR,Champagne-Ardenne Region Council and Pole MATERALIA(Programme COMAGNET,Grant No.2010-INTB-903-01)
文摘In this study,the possibility of obtaining micro and nano-scaled Co/Ni bi-layered films by use of the electrochemical method was investigated.The electrodeposition process was performed with presence and absence of a uniform external magnetic field up to 1T to examine its influence on structure and morphology of the obtained thin films. Afterwards,each sample was annealed under high magnetic field with strength up to 12 T at 623 K,what allowed compare and determine the changes in morphology and structure,before and after heat treatment.The Co/Ni bi-layered thin films were deposited onto an indium-doped tin oxide(ITO)-coated conducting glass substrate from sulfate baths with boric acid as an additive.The results show drastic changes in the morphology between macro and nano-scaled films which were strongly affected by an introduction of the magnetic field to the electrodeposition process.The annealing process allowed to determine the nucleus transition and showed that under the high temperature treatment it is possible to control the growth mode as well as the phase composition changes.
文摘The aim of this study is to show the interest of the mechanical and dynamical properties of glass-flax hybrid composites.Therefore,various staking sequences of glass-flax hybrid composites were manufactured and tested in free vibrations.The damping coefficients were identified by fitting the experimental responses of free-free bending vibrations.The obtained results show that the staking sequences and the position of flax fiber layers in the hybrid composites changed the properties,so a classification of different stacking sequences was established.In fact,the hybrid laminate made of two glass external layers placed on both sides of four flax layers is very interesting in term of its mechanical and damping properties.Indeed,it showed better specific bending modulus and loss factor than glass composites with proportions of 31 and 39%,respectively.A study of a structure of this composite has been made to validate the obtained results.
文摘This work aims at studying the effect of hygrothermal and UV cyclic aging on the tensile properties and esthetic characteristics of non-woven composites.The composite materials were thermo-compressed from non-woven mats made up of PP and flax or kenaf fibers.This works included evaluating the change in color appearance and analyzing the variations in tensile properties and damage mechanisms,depending on the aging time.The presence of the UV protection film on the composite surface showed its effectiveness against aging.From visual observations and measurement of colorimetric parameters,it has been proved effective in the reduction of the bleaching and yellowing of the composites.As regards the tensile tests,the UV protection film enabled to stabilize the Young’s modulus after 1-week aging for Kenaf/PP and after 3-weeks for Flax/PP.After 4-weeks aging,it halved the number of acoustic emission events related to interfacial decohesion and fiber slippage/pull out for Flax/PP and Kenaf/PP composites.
文摘Using a linked-parameter technique of level-fitting calculations in a multi configuration basis, a parametric analysis of fine structure (fs) for even-parity levels of V II, involving six configurations, has been performed. This led us to exchange the assignments of two triplets, 3d3(2F)4s c 3F and 3d4 d 3F, reported in earlier analyses as being located at 30,300 cm-1 and 30,600 cm-1, respectively. This is confirmed by experimental hyperfine structure (hfs) A constants, used as fingerprints. Moreover, the current singlet 3d24s2 1D2 position is likely too high. The fs parameters, magnetic Landé g-factors, and the percentage of leading eigenvectors of levels are calculated. We present also predicted singlet, triplet and quintet positions for missing experimental levels up to 100,000 cm-1. The single-electron hfs parameters are determined in their entirety for 51V II for the model space (3d + 4s)4 with good accuracy. For the model space (3d + 4s)4 of 51V II the single-electron hfs parameters are computed;furthermore, our achieved theoretical evaluations of the single-electron hfs parameters, thanks to the use of ab initio calculations, reinforce the validity of these hfs parameter values, deduced from experimental data.
文摘The 3d34p, 3d35p and 3d24s4p odd configurations of the V II spectrum have been reanalysed and three 3d24s4p triplets are assigned higher energies than previously proposed. We have determined the fine structure parameters, the largest and next largest eigenvector percentages of levels, their calculated Landé gJ-factors and predicted positions for missing experimental levels up to 100,000 cm-1 for the 3d24s4p configuration. Furthermore for the first time a hyperfine structure (HFS) parametric treatment, involving levels of these two configurations has been carried out. The deduced single-electron HFS parameter values are successfully checked with those obtained by means of ab initio calculations.
基金supported by the CNRS,INSERM,and Aix Marseille University.Proteomics analyses were carried out using the mass spectrometry facility of Marseille Proteomics(marseille‐proteomique.univ‐amu.fr)supported by IBISAthe Cancéropôle PACA,the Provence‐Alpes‐Côte d'Azur Region,the Institut Paoli‐Calmettes,and Fonds Européen de Développement Regional(FEDER)+1 种基金Emma Forest PhD fellowship is supported by the Ministère de l'Enseignement Supérieur et de la RechercheThe authors would like to thank Pierre Santucci(LISM UMR7255 CNRS)for his help with Biorender.
文摘Gram‐negative bacteria are particularly prone to developing antimicrobial resistance(AMR),as evidenced by the WHO's ESKAPEE list of high‐priority pathogens.One strategy that has increased is the use of antibiotic enhancers,which can reempower abandoned or poorly active antibiotics against the resistant strain of interest.In this study,the polyamino‐isoprenyl antibiotic enhancer,NV716,was tested in combination with two families of multi‐target Ser/Cys‐based enzyme inhibitors,the oxadiazolone derivatives(OX)and the Cyclipostins and Cyclophostin analogs(CyC),which are inactive against Gram‐negative ESKAPEE bacteria,to potentiate their antibacterial activity and thus make them active against these bacteria.We demonstrated that NV716 potentiates some OX and CyC compounds by permeabilizing the outer membrane and thus by increasing the inhibitor accumulation,as shown by fluorescence microscopy.By using the click‐chemistry activity‐based protein profiling(ABPP)approach coupled with proteomic analysis,we also confirmed the multi‐target nature of the best OX and CyC inhibitors by identifying their target proteins on a bacterial culture of Enterobacter cloacae.Remarkably,a large set of these identified proteins had already been captured in previous ABPP experiments conducted on Mycobacterium tuberculosis and/or Mycobacterium abscessus culture.Furthermore,we showed that five of the identified target proteins were present in a total lysate of Pseudomonas aeruginosa.Importantly,these latter enzymes are highly conserved among Gram‐negative bacteria,with two of them annotated as essential for bacterial survival.These results provide proof of concept that both OX and CyC,if successfully potentiated,could be used against ESKAPEE Gram‐negative bacteria.
基金This work was supported by Japan Society for the Promotion of Science,Japan for their support under Grants-in-Aid for Scientific Research on Innovative Areas(18H05473)the JSPS,Japan KAKENHI(21J15489 and 23K13290).
文摘Soft robotics is a breakthrough technology to support human-robot interactions.The soft structure of a soft robot can increase safety during human and robot interactions.One of the promising soft actuators for soft robotics is dielectric elastomer actuators(DEAs).DEAs can operate silently and have an excellent energy density.The simple structure of DEAs leads to the easy fabrication of soft actuators.The simplicity combined with silent operation and high energy density make DEAs interesting for soft robotics researchers.DEAs actuation follows the Maxwell-pressure principle.The pressure produced in the DEAs actuation depends much on the voltage applied.Common DEAs requires high voltage to gain an actuation.Since the power consumption of DEAs is in the milli-Watt range,the current needed to operate the DEAs can be neglected.Several commercially available DC-DC converters can convert the volt range to the kV range.In order to get a voltage in the 2-3 kV range,the reliable DC-DC converter can be pricy for each device.This problem hinders the education of soft actuators,especially for a newcomer laboratory that works in soft electric actuators.This paper introduces an entirely do-it-yourself(DIY)Ultrahigh voltage amplifier(UHV-Amp)for education in soft robotics.UHV-Amp can amplify 12 V to at a maximum of 4 kV DC.As a demonstration,we used this UHV-Amp to test a single layer of powdered-based DEAs.The strategy to build this educational type UHV-Amp was utilizing a Cockcroft-Walton circuit structure to amplify the voltage range to the kV range.In its current state,the UHV-Amp has the potential to achieve approximately 4 kV.We created a simple platform to control the UHV-Amp from a personal computer.In near future,we expect this easy control of the UHV-Amp can contribute to the education of soft electric actuators.
基金supported by the Hirose Foundation(https://hirose-isf.or.jp/)Grant-in-Aid for Scientific Research on Innovative Areas(Research in a proposed research area)from the Japan Society for the Promotion of Science(Grant Nos.18H05473 and 23K13290)JRPs(Stretchable Electrohydrodynamic).
文摘The conventional electrohydrodynamic(EHD)pump is limited to pumping functional and dielectric liquids,which restricts its applications in fields like microfluidics,food safety,and materials production.In this study,we present a flexible water pump driven by EHD fluid,achieved by integrating valveless elements into the fluidic channel.Our approach leverages the water–EHD interface to propel the immiscible aqueous liquid and reciprocate this process using the nozzle–diffuser system.All components of the water pump are digitally fabricated and assembled.The valveless parts are created using a laser cutting machine.Additionally,we develop a model for the EHD pump and nozzle-diffuser system to predict the generated flow rate,considering factors such as the asymmetrical performance of the EHD pump,pulse frequency,applied voltage,and structural parameters.Finally,we experimentally characterize the flow rates of both the EHD pump and water pump and apply the newly developed device to air bubble manipulation and droplet generation.This research broadens the range of specialized liquids pumped by EHD pumps to include other aqueous liquids or mixtures.
基金supported by Grant-in-Aid for Early-Career Scientists from the Japan Society for the Promotion of Science(23K13290),Japan.
文摘Flexible electrohydrodynamic(EHD)pumps have been developed and applied in many fields due to no transmission structure,no wear,easy manipulation,and no noise.Physical simulation is often used to predict the output performance of flexible EHD pumps.However,this method neglects fluid–solid interaction and energy loss caused by flexible materials,which are both difficult to calculate when the flexible pumps deform.Therefore,this study proposes a flexible pump output performance prediction using machine learning algorithms.We used three different types of machine learning:random forest regression,ridge regression,and neural network to predict the critical parameters(pressure,flow rate,and power)of the flexible EHD pump.Voltage,angle,gap,overlap,and channel height are selected as five input data of the neural network.In addition,we optimized essential parameters in the three networks.Finally,we adopt the best predictive model and evaluate the significance of five input parameters to the output performance of the flexible EHD pumps.Among the three methods,the MLP model has exceptionally high accuracy in predicting pressure and flow.Our work is beneficial for the design process of fluid sources in flexible soft actuators and soft hydraulic sources in microfluidic chips.
