OBJECTIVE: To investigate the effects of Maixuekang Capsules combined with edaravone on serum matrix metalloproteinase-9(MMP-9), S-100β protein levels and neurological functions in patients with hemorrhagic cerebral ...OBJECTIVE: To investigate the effects of Maixuekang Capsules combined with edaravone on serum matrix metalloproteinase-9(MMP-9), S-100β protein levels and neurological functions in patients with hemorrhagic cerebral infarction. METHOSDS: A total of 76 patients with hemorrhagic cerebral infarction treated in the First Affiliated Hospital of Henan University of Science and Technology from January 2017 to May 2018 were selected and were randomly divided into treatment group and control group, with 38 patients in each group. The control group was given edaravone, and the treatment group was given Maixuekang Capsules on the basis of the control group. The clinical efficacy, serum MMP-9 and S-100β protein levels, neurological function recovery, activity of daily living and incidence rate of adverse reactions were compared between the 2 groups. RESULTS: The total effective rate of the treatment group was 92.11%, which was higher than 71.05% of the control group(P < 0.05); the National Institutes of Health Stroke Scale(NIHSS) score in the 2 groups decreased(P < 0.05), and the Activity of Daily Living Scale(ADL) score increased(P < 0.05), the improvement of the above 2 scores in the treatment group were better than those in the control group(P < 0.05); the level of MMP-9 was gradually decreasing in the 2 groups, on the 7th day, 14 th day after treatment, and the levels of MMP-9 decreased significantly(P < 0.05), and the treatment group was lower than the control group at all time points(P < 0.05); on the 3rd day after treatment, the levels of S-100β protein in the 2 groups increased significantly(P < 0.05); on the 7th day, 14 th day after treatment, the levels of S-100β protein in the two groups decreased significantly(P < 0.05), and the treatment group was significantly lower than the control group(P < 0.05); there was no significant difference in incidence rate of adverse reactions between 7.89% in the control group and 5.26% in the treatment group(P > 0.05). CONCLUSION: The combination of Maixuekang Capsules and edaravone is effective in treating hemorrhagic cerebral infarction, and it can significantly improve neurological function defect and daily living ability, reduce serum MMP-9 and S-100β protein levels, and has higher safety.展开更多
Electric power plays an important role in people's daily life and can have an important impact. The safe and stable operation of distribution lines has also attracted widespread attention in various industries and...Electric power plays an important role in people's daily life and can have an important impact. The safe and stable operation of distribution lines has also attracted widespread attention in various industries and fields. In order to ensure the good operation of the circuit, meet the power demand of all aspects, and improve the power generation quality and safety as much as possible, it is necessary to continuously improve the operation and maintenance of distribution equipment in distribution lines, so as to promote the good development of China's power grid.展开更多
The operation and maintenance of substation is highly technical, involving more operation and maintenance management equipment, covering a wide range of fields, and is easily affected by the external natural environme...The operation and maintenance of substation is highly technical, involving more operation and maintenance management equipment, covering a wide range of fields, and is easily affected by the external natural environment in the actual operation and maintenance process, which easily leads to a variety of dangerous points in the operation and maintenance process of substation. Once these dangerous points occur, it will not only affect the normal operation of substation power system and shorten the service life of substation equipment. At the same time, it also poses a serious threat to the personal safety of operation and maintenance personnel. Therefore, it is necessary to actively explore effective countermeasures to prevent the occurrence of these dangerous points, so as to ensure the personal safety of operation and maintenance personnel and promote the smooth operation of substation power system.展开更多
In the process of power supply of power system, the development of primary equipment overhaul of substation is facing many challenges. Further analysis of the current status of power and electrical equipment maintenan...In the process of power supply of power system, the development of primary equipment overhaul of substation is facing many challenges. Further analysis of the current status of power and electrical equipment maintenance and repair, so as to formulate targeted improvement strategies, is the fundamental measure to comprehensively improve the level of power and electrical equipment maintenance and maintenance of normal operation of the equipment.展开更多
By the end of 2021,the proportion of people participating in normalized physical exercise in China has reached up to 37.2%,contributing to the transformation of competitive sports into national sports.This has signifi...By the end of 2021,the proportion of people participating in normalized physical exercise in China has reached up to 37.2%,contributing to the transformation of competitive sports into national sports.This has significantly affected the teaching quality of physical education in primary and secondary schools.In the critical period of the“14th Five-Year Plan”construction,it is necessary to deepen the physical education work in primary and secondary schools concertedly with high-quality development goals.Taking this as the starting point,the paper outlines the basic content and main influence of national sports as well as analyzes the new demands of physical education in primary and secondary schools under the background of national sports.On this basis,several targeted teaching strategies are put forward from three aspects:teaching concept,information technology,and teaching goals.展开更多
Ganoderma lucidum,a medicinal mushroom renowned for its production of a diverse array of compounds,accounts for the pharmacological effects including anti-infammatory,antioxidant,immunomodulatory,and anticancer charac...Ganoderma lucidum,a medicinal mushroom renowned for its production of a diverse array of compounds,accounts for the pharmacological effects including anti-infammatory,antioxidant,immunomodulatory,and anticancer characteristics.Thus,it is recognized as a valuable species of interest in the pharmaceutical and nutraceutical industries due to its important medicinal properties.Recent advances in omics technologies such as genomes,transcriptomics,proteomics,and metabolomics have considerably increased our understanding of the bioactives in G.lucidum.This review explores the application of molecular breeding techniques to enhance both the yield and quality of G.lucidum across the food,pharmaceutical,and industrial sectors.The article discusses the current state of research on the use of contemporary omics technologies which studies and highlights future research directions that may increase the production of bioactive compounds for their therapeutic potential.Additionally,predictive methods with computational studies have recently emerged as effective tools for investigating bioactive constituents in G.lucidum,providing an organized and cost-effective strategy for understanding their bioactivity,interactions,and possible therapeutic uses.Omics and machine learning techniques can be applied to identify the candidates for pharmaceutical applications and to enhance the production of bioactive compounds in G.lucidum.The quantifcation and production of the bioactive compounds can be streamlined by the integrating computational study of bioactive compounds with non-destructive predictive machine learning models of the same.Synergistically,these techniques have the potential to be a promising approach for the future prediction of the bioactive constituents,without compromising the integrity of the fungal organism.展开更多
Emerging engineering strategies of colloidal metal-semiconductor nanorod hybrid nanostructures spanning from type,size,dimension,and location of both metal nanoparticles and semiconductors,co-catalyst,band gap structu...Emerging engineering strategies of colloidal metal-semiconductor nanorod hybrid nanostructures spanning from type,size,dimension,and location of both metal nanoparticles and semiconductors,co-catalyst,band gap structure,surface ligand to hole scavenger are elaborated symmetrically to rationalize the design of this type of intriguing materials for efficient photocatalytic applications.展开更多
To the Editor:Takayasu arteritis(TA),a non-specific large-vessel vasculitis characterized by granulomatous inflammation of vascular walls,[1] has been reported the main cause for 53% of aortitis.[2] TA with aortitis,i...To the Editor:Takayasu arteritis(TA),a non-specific large-vessel vasculitis characterized by granulomatous inflammation of vascular walls,[1] has been reported the main cause for 53% of aortitis.[2] TA with aortitis,involving aorta,aortic root(ring and sinus),and valves,may lead to heart failure and mortality attributed to aortic stenosis or dilation,aneurysm or dissection,aortic valve insufficiency,perivalvular leakage,and so on.展开更多
文摘OBJECTIVE: To investigate the effects of Maixuekang Capsules combined with edaravone on serum matrix metalloproteinase-9(MMP-9), S-100β protein levels and neurological functions in patients with hemorrhagic cerebral infarction. METHOSDS: A total of 76 patients with hemorrhagic cerebral infarction treated in the First Affiliated Hospital of Henan University of Science and Technology from January 2017 to May 2018 were selected and were randomly divided into treatment group and control group, with 38 patients in each group. The control group was given edaravone, and the treatment group was given Maixuekang Capsules on the basis of the control group. The clinical efficacy, serum MMP-9 and S-100β protein levels, neurological function recovery, activity of daily living and incidence rate of adverse reactions were compared between the 2 groups. RESULTS: The total effective rate of the treatment group was 92.11%, which was higher than 71.05% of the control group(P < 0.05); the National Institutes of Health Stroke Scale(NIHSS) score in the 2 groups decreased(P < 0.05), and the Activity of Daily Living Scale(ADL) score increased(P < 0.05), the improvement of the above 2 scores in the treatment group were better than those in the control group(P < 0.05); the level of MMP-9 was gradually decreasing in the 2 groups, on the 7th day, 14 th day after treatment, and the levels of MMP-9 decreased significantly(P < 0.05), and the treatment group was lower than the control group at all time points(P < 0.05); on the 3rd day after treatment, the levels of S-100β protein in the 2 groups increased significantly(P < 0.05); on the 7th day, 14 th day after treatment, the levels of S-100β protein in the two groups decreased significantly(P < 0.05), and the treatment group was significantly lower than the control group(P < 0.05); there was no significant difference in incidence rate of adverse reactions between 7.89% in the control group and 5.26% in the treatment group(P > 0.05). CONCLUSION: The combination of Maixuekang Capsules and edaravone is effective in treating hemorrhagic cerebral infarction, and it can significantly improve neurological function defect and daily living ability, reduce serum MMP-9 and S-100β protein levels, and has higher safety.
文摘Electric power plays an important role in people's daily life and can have an important impact. The safe and stable operation of distribution lines has also attracted widespread attention in various industries and fields. In order to ensure the good operation of the circuit, meet the power demand of all aspects, and improve the power generation quality and safety as much as possible, it is necessary to continuously improve the operation and maintenance of distribution equipment in distribution lines, so as to promote the good development of China's power grid.
文摘The operation and maintenance of substation is highly technical, involving more operation and maintenance management equipment, covering a wide range of fields, and is easily affected by the external natural environment in the actual operation and maintenance process, which easily leads to a variety of dangerous points in the operation and maintenance process of substation. Once these dangerous points occur, it will not only affect the normal operation of substation power system and shorten the service life of substation equipment. At the same time, it also poses a serious threat to the personal safety of operation and maintenance personnel. Therefore, it is necessary to actively explore effective countermeasures to prevent the occurrence of these dangerous points, so as to ensure the personal safety of operation and maintenance personnel and promote the smooth operation of substation power system.
文摘In the process of power supply of power system, the development of primary equipment overhaul of substation is facing many challenges. Further analysis of the current status of power and electrical equipment maintenance and repair, so as to formulate targeted improvement strategies, is the fundamental measure to comprehensively improve the level of power and electrical equipment maintenance and maintenance of normal operation of the equipment.
文摘By the end of 2021,the proportion of people participating in normalized physical exercise in China has reached up to 37.2%,contributing to the transformation of competitive sports into national sports.This has significantly affected the teaching quality of physical education in primary and secondary schools.In the critical period of the“14th Five-Year Plan”construction,it is necessary to deepen the physical education work in primary and secondary schools concertedly with high-quality development goals.Taking this as the starting point,the paper outlines the basic content and main influence of national sports as well as analyzes the new demands of physical education in primary and secondary schools under the background of national sports.On this basis,several targeted teaching strategies are put forward from three aspects:teaching concept,information technology,and teaching goals.
基金funded by DST-SERB,Govt.of India under the CRG project vide sanction order number CRG/2021/001815the financial support of the European Union under the REFRESH–Research Excellence for region Sustainability and High-tech Industries(No.CZ.10.03.01/00/22_003/0000048)via the operational Programme Just Transitionpartially carried out at the Jet Propulsion Laboratory,California Institute of Technology,under a contract with the National Aeronautics and Space Administration(No.80NM0018D0004)。
文摘Ganoderma lucidum,a medicinal mushroom renowned for its production of a diverse array of compounds,accounts for the pharmacological effects including anti-infammatory,antioxidant,immunomodulatory,and anticancer characteristics.Thus,it is recognized as a valuable species of interest in the pharmaceutical and nutraceutical industries due to its important medicinal properties.Recent advances in omics technologies such as genomes,transcriptomics,proteomics,and metabolomics have considerably increased our understanding of the bioactives in G.lucidum.This review explores the application of molecular breeding techniques to enhance both the yield and quality of G.lucidum across the food,pharmaceutical,and industrial sectors.The article discusses the current state of research on the use of contemporary omics technologies which studies and highlights future research directions that may increase the production of bioactive compounds for their therapeutic potential.Additionally,predictive methods with computational studies have recently emerged as effective tools for investigating bioactive constituents in G.lucidum,providing an organized and cost-effective strategy for understanding their bioactivity,interactions,and possible therapeutic uses.Omics and machine learning techniques can be applied to identify the candidates for pharmaceutical applications and to enhance the production of bioactive compounds in G.lucidum.The quantifcation and production of the bioactive compounds can be streamlined by the integrating computational study of bioactive compounds with non-destructive predictive machine learning models of the same.Synergistically,these techniques have the potential to be a promising approach for the future prediction of the bioactive constituents,without compromising the integrity of the fungal organism.
基金supported by the Australian Research Council(ARC)Future Fellowship Scheme(FT210100509)ARC Discovery Project(DP220101959)+2 种基金the Hebrew University of Jerusalem--Zelman Cowen Academic Initiatives(zCAl)Joint Projects 2021,the Innovation and Technology Commission(grant no.MHP/104/21)Shenzhen Science Technology and Innovation Commission(grant no.20210324125612035)City University of Hong Kong(grant no.9360140).
文摘Emerging engineering strategies of colloidal metal-semiconductor nanorod hybrid nanostructures spanning from type,size,dimension,and location of both metal nanoparticles and semiconductors,co-catalyst,band gap structure,surface ligand to hole scavenger are elaborated symmetrically to rationalize the design of this type of intriguing materials for efficient photocatalytic applications.
基金This work was supported by a grant from the National Natural Science Foundation of China(No.81771730).
文摘To the Editor:Takayasu arteritis(TA),a non-specific large-vessel vasculitis characterized by granulomatous inflammation of vascular walls,[1] has been reported the main cause for 53% of aortitis.[2] TA with aortitis,involving aorta,aortic root(ring and sinus),and valves,may lead to heart failure and mortality attributed to aortic stenosis or dilation,aneurysm or dissection,aortic valve insufficiency,perivalvular leakage,and so on.
