The open science movement has gained significant momentum within the last few years.This comes along with the need to store and share research artefacts,such as publications and research data.For this purpose,research...The open science movement has gained significant momentum within the last few years.This comes along with the need to store and share research artefacts,such as publications and research data.For this purpose,research repositories need to be established.A variety of solutions exist for implementing such repositories,covering diverse features,ranging from custom depositing workflows to social media-like functions.In this article,we introduce the FAIREST principles,a framework inspired by the well-known FAIR principles,but designed to provide a set of metrics for assessing and selecting solutions for creating digital repositories for research artefacts.The goal is to support decision makers in choosing such a solution when planning for a repository,especially at an institutional level.The metrics included are therefore based on two pillars:(1)an analysis of established features and functionalities,drawn from existing dedicated,general purpose and commonly used solutions,and(2)a literature review on general requirements for digital repositories for research artefacts and related systems.We further describe an assessment of 11 widespread solutions,with the goal to provide an overview of the current landscape of research data repository solutions,identifying gaps and research challenges to be addressed.展开更多
The number of patients with Alzheimer’s disease(AD)is increasing worldwide due to extended life expectancy,with AD being the most common cause of dementia.AD pathological hallmarks consist of brain depositions of agg...The number of patients with Alzheimer’s disease(AD)is increasing worldwide due to extended life expectancy,with AD being the most common cause of dementia.AD pathological hallmarks consist of brain depositions of aggregated amyloid beta(Aβ)into neuritic plaques and neurofibrillary tangles of hyperphosphorylated tau,lead-ing to synaptic dysfunction and neuronal loss[1].Prot-eomic studies of cerebrospinal fluid(CSF)have shown that several biological processes are dysregulated in AD,such as the innate immune system,inflammatory response,hemostasis,lipid processing,oxidative stress response and synaptic functioning[2].展开更多
基金supported by the Fundacao para a Ciencia e a Tecnologia through the LASIGE Research DB/00408/2020,UIDP/00408/2020supported by the Federal Ministry of Education and Research of Germany(BMBF)un no.16Dll128("Deutsches Internet-Institut").
文摘The open science movement has gained significant momentum within the last few years.This comes along with the need to store and share research artefacts,such as publications and research data.For this purpose,research repositories need to be established.A variety of solutions exist for implementing such repositories,covering diverse features,ranging from custom depositing workflows to social media-like functions.In this article,we introduce the FAIREST principles,a framework inspired by the well-known FAIR principles,but designed to provide a set of metrics for assessing and selecting solutions for creating digital repositories for research artefacts.The goal is to support decision makers in choosing such a solution when planning for a repository,especially at an institutional level.The metrics included are therefore based on two pillars:(1)an analysis of established features and functionalities,drawn from existing dedicated,general purpose and commonly used solutions,and(2)a literature review on general requirements for digital repositories for research artefacts and related systems.We further describe an assessment of 11 widespread solutions,with the goal to provide an overview of the current landscape of research data repository solutions,identifying gaps and research challenges to be addressed.
基金funded by the Portuguese Science and Technology Foundation(FCT)Beyond Beta Amyloid:Deciphering Early Pathogenic Changes in Alzheimer’s disease project PTDC/MED-NEU/27946/2017,by The National Mass Spectrometry Network(POCI-01–0145-FEDER-402–022125 Ref.ROTEIRO/0028/2013),UIDB/04539/2020,UIDP/04539/2020,through funding of LASIGE Research Unit(UIDB/00408/2020 and UIDP/00408/2020).
文摘The number of patients with Alzheimer’s disease(AD)is increasing worldwide due to extended life expectancy,with AD being the most common cause of dementia.AD pathological hallmarks consist of brain depositions of aggregated amyloid beta(Aβ)into neuritic plaques and neurofibrillary tangles of hyperphosphorylated tau,lead-ing to synaptic dysfunction and neuronal loss[1].Prot-eomic studies of cerebrospinal fluid(CSF)have shown that several biological processes are dysregulated in AD,such as the innate immune system,inflammatory response,hemostasis,lipid processing,oxidative stress response and synaptic functioning[2].
