Dear Editor,Diabetic macular edema(DME)is a major cause of visual loss in diabetic patients,which is mainly caused by disruption of the blood-retinal barrier and loss of pericytes and endothelial cells,resulting in th...Dear Editor,Diabetic macular edema(DME)is a major cause of visual loss in diabetic patients,which is mainly caused by disruption of the blood-retinal barrier and loss of pericytes and endothelial cells,resulting in the leakage of plasma and lipids[1].Nowadays,laser photocoagulation,intravitreal injections of anti-vascular endothelial growth factor(anti-VEGF)drugs and dexamethasone implant.展开更多
The Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） has released more than two million spectra, which provide the opportunity to search for double-peaked narrow emission line （NEL） galaxies and ...The Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） has released more than two million spectra, which provide the opportunity to search for double-peaked narrow emission line （NEL） galaxies and active galactic nuclei （AGNs）. The double-peaked narrow-line profiles can be well modeled by two velocity components, respectively blueshifted and redshifted with respect to the sys- temic recession velocity. This paper presents 20 double-peaked NEL galaxies and AGNs found from LAMOST DR1 using a search method based on a multi-Gaussian fit of the narrow emission lines. Among them, ten have already been published by other authors, either listed as genuine double-peaked NEL objects or as asymmetric NEL objects, and the remaining ten are original discoveries. We discuss some pos- sible origins for the double-peaked narrow-line features, such as interaction between jet and narrow line regions, interaction with companion galaxies, and black hole bina- ries. Spatially resolved optical imaging and/or follow-up observations in other spectral bands are needed to further discuss the physical mechanisms at work.展开更多
AIM:To evaluate the efficacy of the Tecnis Symfony ZXR00 lens in achieving optimal visual outcomes for cataract surgery patients with axial length(AL)shorter than 24 mm.METHODS:A total of 21 subjects(37 eyes)were subm...AIM:To evaluate the efficacy of the Tecnis Symfony ZXR00 lens in achieving optimal visual outcomes for cataract surgery patients with axial length(AL)shorter than 24 mm.METHODS:A total of 21 subjects(37 eyes)were submitted to cataract surgery and implantation of Tecnis Symfony ZXR00 lens(Johnson&Johnson Vision)was assessed.Patients were examined at 5 m,80 cm,and 40 cm for uncorrected distance visual acuity(UCDVA)and corrected distance visual acuity(CDVA),uncorrected intermediate(UCIVA),and uncorrected near visual acuity(UCNVA).Further,based on the optimal distance correction,the monocular defocusing curve in the range of+0.5 to-3.5 D was investigated.A simple patient-reported spectacle independence questionnaire(PRSIQ)was used to evaluate subjects’subjective feelings about their dependence on glasses at various distances.Multiple linear regression was employed to examine the association amony intraocular lenses(IOLs)diopter,AL,corneal curvature,anterior chamber depth,mean manifest refractive spherical equivalent,pupil,pupil/scan,target refraction,and near vision(logMAR).RESULTS:The study demonstrated enhanced UCNVA alongside comparable distant vision and UCIVA outcomes in eyes with AL shorter than 24 mm.Mean post-operative UCDVA significantly improved from preoperative levels 0.530±0.406(P=0.000).Notably,83.3%of eyes achieved 0.01 logMAR in UCNVA.Five unilateral cases with blended IOL implantation also showed satisfactory visual acuity and satisfaction.The 90.5%(19/21)achieved spectacle independence.The average score for self-reported spectacle-independence on the PRSIQ was 3.52 with a standard deviation of 0.98.The results of the regression analysis revealed that one predictor,the pupil/scan accounted for 27.6%of the variation in near vision[logMAR;F(1,35)=13.33,P<0.01].CONCLUSION:The results affirm the effectiveness of the Tecnis Symfony ZXR00 lens in enhancing visual outcomes for cataract surgery patients with AL shorter than 24 mm.Additionally,the pupil/scan emerges as a critical factor influencing postoperative near vision.展开更多
Mg alloys have the defects of low stiffness,low strength,and high coefficient of thermal expansion(CTE).The composites strategy and its architecture design are effective approaches to improve the comprehensive perform...Mg alloys have the defects of low stiffness,low strength,and high coefficient of thermal expansion(CTE).The composites strategy and its architecture design are effective approaches to improve the comprehensive performance of materials,but the processing difficulty,especially in ceramics forming,limits the control and innovation of material architecture.Here,combined with 3D printing and squeeze infiltration technology,two precisely controllable architectures of AZ91/Al_(2)O_(3)interpenetrating phase composites(IPC)with ceramic scaffold were prepared.The interface,properties and impact of different architecture on IPC performance were studied by experiments and finite element simulation.The metallurgical bonding of the interface was realized with the formation of MgAl_(2)O_(4)reaction layer.The IPC with 1 mm circular hole scaffold(1C-IPC)exhibited significantly improved elastic modulus of 164 GPa,high compressive strength of 680 MPa,and good CTE of 12.91×10^(-6)K^(−1),which were 3.64 times,1.98 times and 55%of the Mg matrix,respectively.Their elastic modulus,compressive strength,and CTE were superior to the vast majority of Mg alloys and Mg based composites.The reinforcement and matrix were bicontinuous and interpenetrating each other,which played a critical role in ensuring the potent strengthening effect of the Al_(2)O_(3)reinforcement by efficient load transfer.Under the same volume fraction of reinforcements,compared to IPC with 1 mm hexagonal hole scaffold(1H-IPC),the elastic modulus and compressive strength of 1C-IPC increased by 15%and 28%,respectively,which was due to the reduced stress concentration and more uniform stress distribution of 1C-IPC.It shows great potential of architecture design in improving the performance of composites.This study provides architectural design strategy and feasible preparation method for the development of high performance materials.展开更多
Based on the Google Earth Engine cloud computing data platform,this study employed three algorithms including Support Vector Machine,Random Forest,and Classification and Regression Tree to classify the current status ...Based on the Google Earth Engine cloud computing data platform,this study employed three algorithms including Support Vector Machine,Random Forest,and Classification and Regression Tree to classify the current status of land covers in Hung Yen province of Vietnam using Landsat 8 OLI satellite images,a free data source with reasonable spatial and temporal resolution.The results of the study show that all three algorithms presented good classification for five basic types of land cover including Rice land,Water bodies,Perennial vegetation,Annual vegetation,Built-up areas as their overall accuracy and Kappa coefficient were greater than 80%and 0.8,respectively.Among the three algorithms,SVM achieved the highest accuracy as its overall accuracy was 86%and the Kappa coefficient was 0.88.Land cover classification based on the SVM algorithm shows that Built-up areas cover the largest area with nearly 31,495 ha,accounting for more than 33.8%of the total natural area,followed by Rice land and Perennial vegetation which cover an area of over 30,767 ha(33%)and 15,637 ha(16.8%),respectively.Water bodies and Annual vegetation cover the smallest areas with 8,820(9.5%)ha and 6,302 ha(6.8%),respectively.The results of this study can be used for land use management and planning as well as other natural resource and environmental management purposes in the province.展开更多
Background:With the rapid development of artificial intelligence(AI),large language models(LLMs)have emerged as a potent tool for invigorating ophthalmology across clinical,educational,and research fields.Their accura...Background:With the rapid development of artificial intelligence(AI),large language models(LLMs)have emerged as a potent tool for invigorating ophthalmology across clinical,educational,and research fields.Their accuracy and reliability have undergone tested.This bibliometric analysis aims to provide an overview of research on LLMs in ophthalmology from both thematic and geographical perspectives.Methods:All existing and highly cited LLM-related ophthalmology research papers published in English up to 24th April 2025 were sourced from Scopus,PubMed,and Web of Science.The characteristics of these publications,including publication output,authors,journals,countries,institutions,citations,and research domains,were analyzed using Biblioshiny and VOSviewer software.Results:A total of 277 articles from 1,459 authors and 89 journals were included in this study.Although relevant publications began to appear in 2019,there was a significant increase starting from 2023.He M and Shi D are the most prolific authors,while Investigative Ophthalmology&Visual Science stands out as the most prominent journal.Most of the top-publishing countries are high-income economies,with the USA taking the lead,and the University of California is the leading institution.VOSviewer identified 5 clusters in the keyword co-occurrence analysis,indicating that current research focuses on the clinical applications of LLMs,particularly in diagnosis and patient education.Conclusions:While LLMs have demonstrated effectiveness in retaining knowledge,their accuracy in image-based diagnosis remains limited.Therefore,future research should investigate fine-tuning strategies and domain-specific adaptations to close this gap.Although research on the applications of LLMs in ophthalmology is still in its early stages,it holds significant potential for advancing the field.展开更多
As the main component of electronic products,plastics contain complex and diverse metal additives.Recycling process is not conducive to stable existence of metal additives in electronic plastics.Once the e-waste plast...As the main component of electronic products,plastics contain complex and diverse metal additives.Recycling process is not conducive to stable existence of metal additives in electronic plastics.Once the e-waste plastics enter the environment,they will continue to release harmful metals into environment after aging,causing serious hazards.This study delved into the analysis and comparison of metal content of e-waste plastics,elucidating aging process and metal leaching behavior over a 112-day natural light exposure period.The findings underscored that metal content in recycled plastics surpassed that in their new counterparts.Specifically,Ti content in new plastics remained below 100 mg/kg,while recycled plastics exhibited Ti content surpassing 100 mg/kg threshold.Throughout prolonged natural light exposure,metals such as Zn,Ba and Sb demonstrated a heightened likelihood of release from electronic plastics in comparison to other metals.The aging process during light exposure led to fragmentation of electronic plastics,accompanied by a reduction in particle size.Notably,the particle size reduction was more pronounced in poly acrylonitrile butadiene styrene(ABS)and recycled ABS,experiencing reductions of 40µm and 85µm,respectively.This phenomenon was attributed to the presence of polybutadiene structural units,which proved more susceptible to aging.Along with the breaking of plastics,the ABS plastics released metal species such as Pb,Cd,Ni,Al that had not been detected in other plastics solutions.The collective evidence from this study suggested that ABS and recycled ABS electronic plastics might pose a heightened potential environmental risk compared to other electronic plastics.展开更多
Rapid industrial growth,urbanization,and agricultural activities have led to the discharge of large volumes of pollutants into coastal environments,raising levels of metals such as arsenic(As),cadmium(Cd),and mercury(...Rapid industrial growth,urbanization,and agricultural activities have led to the discharge of large volumes of pollutants into coastal environments,raising levels of metals such as arsenic(As),cadmium(Cd),and mercury(Hg)in water and sediments.Bivalve molluscs,such as Meretrix lyrata and Saccostrea glomerata can accumulate high amounts of toxic heavy metals in their tissues that pose potential risks to human health.They are frequently used as bioindicators due to their filter-feeding behavior and high accumulation potential.This study evaluates heavy metal accumulation in bivalve molluscs from Northeastern Vietnam,including Quang Ninh Province and Hai Phong City.In this study,a systematic literature review was conducted,combined with a bibliometric analysis,to synthesize and evaluate data on heavy metal accumulation in bivalve molluscs from Northeastern Vietnam.The analysis results showed bio-concentration factors exceeding 1,000 for As,Cd,and Hg in certain species,particularly in samples from Quang Ninh Province.Meanwhile,sediment accumulation factors(BSAF)were lower,suggesting that waterborne pathways predominantly contribute to heavy metal uptake.These findings highlight significant food safety risks due to toxic metal accumulation in seafood resources,emphasizing the urgent need for continuous monitoring and the establishment of local safety standards.The study provides important scientific evidence to support marine environmental management and public health protection.展开更多
AIM:To investigate the effects and the underlying mechanism(s)of conbercept on the phagocytosis of hard exudates(HEs)by Müller glia in diabetic retinopathy(DR).METHODS:Twenty-one eyes from 17 patients with diabet...AIM:To investigate the effects and the underlying mechanism(s)of conbercept on the phagocytosis of hard exudates(HEs)by Müller glia in diabetic retinopathy(DR).METHODS:Twenty-one eyes from 17 patients with diabetic macular edema(DME)underwent optical coherence tomography(OCT)imaging to examine the changes of HEs before and after intravitreal conbercept injection(IVC).In vitro,rat retinal Müller cell line(rMC-1)was cultured under high glucose and treated with oxidized low-density lipoprotein(Ox-LDL)with or without conbercept.Phagocytosis was analysed with immunofluorescence,flow cytometry,and Western blot.Expressions of scavenger receptors(LOX-1,CD36)were analyzed by quantitative real-time polymerase chain reaction(qRT-PCR).Conbercept’s effects on vascular endothelial growth factor A(VEGF-A),VEGFR2,inflammation(NF-κB,IL-6,iNOS),and oxidative stress(ROS)were evaluated with Western blot and immunofluorescence.RESULTS:The area of HEs showed minimal change after the first IVC(1.39±1.41 to 1.38±1.3 mm2,P=0.938),but significantly decreased after the third IVC(0.45±0.66 mm2,P=0.002).In vitro,conbercept enhanced the phagocytosis of Ox-LDL by rMC-1 cells under high glucose condition.Conbercept reduced ROS and inflammation(NF-κB,IL-6,iNOS)in high glucose-treated rMC-1 cells by suppression of VEGF/VEGFR2 pathway.The inhibition of NF-κB by conbercept further activated PPARγ-CD36 axis,increasing CD36 expression and promoting Ox-LDL uptake,thereby facilitating the clearance of HEs.CONCLUSION:Conbercept reduces HEs in DR by enhancing Müller glia phagocytosis possibly through activating PPARγ-CD36 axis,which is mediated by inhibition of VEGF signaling.Modulation of Müller glia phagocytic capacity might provide a novel therapeutic strategy to treat DR and DME.展开更多
Early multiwavelength observations offer crucial insights into the nature of the relativistic jets responsible for gamma-ray bursts and their interaction with the surrounding medium.We present data of GRB 240825A from...Early multiwavelength observations offer crucial insights into the nature of the relativistic jets responsible for gamma-ray bursts and their interaction with the surrounding medium.We present data of GRB 240825A from 17 space-and ground-based telescopes/instruments,covering wavelengths from NIR/optical to X-ray and GeV,and spanning from the prompt emission to the afterglow phase triggered by Swift and Fermi.The early afterglow observations were carried out by SVOM/C-GFT,and spectroscopic observations of the afterglow by GTC,VLT,and TNG determined the redshift of the burst(z=0.659)later.A comprehensive analysis of the prompt emission spectrum observed by Swift-BAT and Fermi-GBM/LAT reveals a rare and significant high-energy cutoff at 76 MeV.Assuming this cutoff is due toγγabsorption allows us to place an upper limit on the initial Lorentz factor,Γ_(0)<245.The optical/NIR and GeV afterglow light curves can be described by the standard external shock model,with early-time emission dominated by a reverse shock(RS)and a subsequent transition to forward shock(FS)emission.Our afterglow modeling yields a consistent estimate of the initial Lorentz factor(Γ_(0)∼234).Furthermore,the RS-to-FS magnetic field ratio(R 302B)indicates that the RS region is significantly more magnetized than the FS region.An isotropic-equivalent kinetic energy of E_(k,iso)=5.25×10^(54) erg is derived,and the correspondingγ-ray radiation efficiency is estimated to beη_(γ)=3.1%.On the other hand,the standard afterglow model cannot reproduce the X-ray light curve of GRB 240825A,calling for improved models to characterize all multiwavelength data.展开更多
中国香港位于热带北缘,其植被在历史上曾遭到大规模破坏,近几十年来逐渐恢复。香港植物标本采集有很长的历史,迄今为止已记录的维管植物超过2 170种,然而新种和新分布仍在不断增加。在最近的野外工作中,作者发现10种在香港新记录到的维...中国香港位于热带北缘,其植被在历史上曾遭到大规模破坏,近几十年来逐渐恢复。香港植物标本采集有很长的历史,迄今为止已记录的维管植物超过2 170种,然而新种和新分布仍在不断增加。在最近的野外工作中,作者发现10种在香港新记录到的维管植物,分别是唇边书带蕨[Haplopteris elongata (Swartz) E. H.Crane]、雷公连[Amydrium sinense (Engl.) H. Li]、百足藤[Pothos repens (Lour.) Druce]、四川轮环藤(Cycleasutchuenensis Gagnep.)、山黑豆(Dumasia truncata Siebold&Zucc.)、倒心叶珊瑚[Aucuba obcordata (Rehder) Fu ex W. K. Hu et Soong]、竹叶榕(Ficus stenophylla Hemsl.)、长叶冠毛榕[F. gasparriniana var. esquirolii (H. Lév.&Vaniot) Corner]、硬叶冬青(Ilex ficifolia C. J. Tseng ex S. K. Chen et Y. X. Feng)、假福王草[Paraprenanthes sororia(Miq.) C. Shih.]。雷公连属(Amydrium Schott)、山黑豆属(Dumasia DC.)和假福王草属(Paraprenanthes C. C.Chang ex C. Shih)为香港的新记录属。以上的发现不仅丰富了香港的植物区系,而且表明保护残存植被非常重要,且极小种群的保护也值得特别关注。展开更多
基金Supported by National Natural Science Foundation of China(No.82171062No.82301222)Zhejiang Provincial Natural Science Foundation of China(No.LY20H120002).
文摘Dear Editor,Diabetic macular edema(DME)is a major cause of visual loss in diabetic patients,which is mainly caused by disruption of the blood-retinal barrier and loss of pericytes and endothelial cells,resulting in the leakage of plasma and lipids[1].Nowadays,laser photocoagulation,intravitreal injections of anti-vascular endothelial growth factor(anti-VEGF)drugs and dexamethasone implant.
基金Supported by the National Natural Science Foundation of China
文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） has released more than two million spectra, which provide the opportunity to search for double-peaked narrow emission line （NEL） galaxies and active galactic nuclei （AGNs）. The double-peaked narrow-line profiles can be well modeled by two velocity components, respectively blueshifted and redshifted with respect to the sys- temic recession velocity. This paper presents 20 double-peaked NEL galaxies and AGNs found from LAMOST DR1 using a search method based on a multi-Gaussian fit of the narrow emission lines. Among them, ten have already been published by other authors, either listed as genuine double-peaked NEL objects or as asymmetric NEL objects, and the remaining ten are original discoveries. We discuss some pos- sible origins for the double-peaked narrow-line features, such as interaction between jet and narrow line regions, interaction with companion galaxies, and black hole bina- ries. Spatially resolved optical imaging and/or follow-up observations in other spectral bands are needed to further discuss the physical mechanisms at work.
文摘AIM:To evaluate the efficacy of the Tecnis Symfony ZXR00 lens in achieving optimal visual outcomes for cataract surgery patients with axial length(AL)shorter than 24 mm.METHODS:A total of 21 subjects(37 eyes)were submitted to cataract surgery and implantation of Tecnis Symfony ZXR00 lens(Johnson&Johnson Vision)was assessed.Patients were examined at 5 m,80 cm,and 40 cm for uncorrected distance visual acuity(UCDVA)and corrected distance visual acuity(CDVA),uncorrected intermediate(UCIVA),and uncorrected near visual acuity(UCNVA).Further,based on the optimal distance correction,the monocular defocusing curve in the range of+0.5 to-3.5 D was investigated.A simple patient-reported spectacle independence questionnaire(PRSIQ)was used to evaluate subjects’subjective feelings about their dependence on glasses at various distances.Multiple linear regression was employed to examine the association amony intraocular lenses(IOLs)diopter,AL,corneal curvature,anterior chamber depth,mean manifest refractive spherical equivalent,pupil,pupil/scan,target refraction,and near vision(logMAR).RESULTS:The study demonstrated enhanced UCNVA alongside comparable distant vision and UCIVA outcomes in eyes with AL shorter than 24 mm.Mean post-operative UCDVA significantly improved from preoperative levels 0.530±0.406(P=0.000).Notably,83.3%of eyes achieved 0.01 logMAR in UCNVA.Five unilateral cases with blended IOL implantation also showed satisfactory visual acuity and satisfaction.The 90.5%(19/21)achieved spectacle independence.The average score for self-reported spectacle-independence on the PRSIQ was 3.52 with a standard deviation of 0.98.The results of the regression analysis revealed that one predictor,the pupil/scan accounted for 27.6%of the variation in near vision[logMAR;F(1,35)=13.33,P<0.01].CONCLUSION:The results affirm the effectiveness of the Tecnis Symfony ZXR00 lens in enhancing visual outcomes for cataract surgery patients with AL shorter than 24 mm.Additionally,the pupil/scan emerges as a critical factor influencing postoperative near vision.
基金supported by the National Key Research and Development Program of China(No.2022YFB3708400)the National Natural Science Foundation of China(No.52305158)+1 种基金the Young Elite Scientists Sponsorship Program by CAST(No.2022QNRC001)the Science Innovation Foundation of Shanghai Academy of Spaceflight Technology(No.USCAST2021-18).
文摘Mg alloys have the defects of low stiffness,low strength,and high coefficient of thermal expansion(CTE).The composites strategy and its architecture design are effective approaches to improve the comprehensive performance of materials,but the processing difficulty,especially in ceramics forming,limits the control and innovation of material architecture.Here,combined with 3D printing and squeeze infiltration technology,two precisely controllable architectures of AZ91/Al_(2)O_(3)interpenetrating phase composites(IPC)with ceramic scaffold were prepared.The interface,properties and impact of different architecture on IPC performance were studied by experiments and finite element simulation.The metallurgical bonding of the interface was realized with the formation of MgAl_(2)O_(4)reaction layer.The IPC with 1 mm circular hole scaffold(1C-IPC)exhibited significantly improved elastic modulus of 164 GPa,high compressive strength of 680 MPa,and good CTE of 12.91×10^(-6)K^(−1),which were 3.64 times,1.98 times and 55%of the Mg matrix,respectively.Their elastic modulus,compressive strength,and CTE were superior to the vast majority of Mg alloys and Mg based composites.The reinforcement and matrix were bicontinuous and interpenetrating each other,which played a critical role in ensuring the potent strengthening effect of the Al_(2)O_(3)reinforcement by efficient load transfer.Under the same volume fraction of reinforcements,compared to IPC with 1 mm hexagonal hole scaffold(1H-IPC),the elastic modulus and compressive strength of 1C-IPC increased by 15%and 28%,respectively,which was due to the reduced stress concentration and more uniform stress distribution of 1C-IPC.It shows great potential of architecture design in improving the performance of composites.This study provides architectural design strategy and feasible preparation method for the development of high performance materials.
文摘Based on the Google Earth Engine cloud computing data platform,this study employed three algorithms including Support Vector Machine,Random Forest,and Classification and Regression Tree to classify the current status of land covers in Hung Yen province of Vietnam using Landsat 8 OLI satellite images,a free data source with reasonable spatial and temporal resolution.The results of the study show that all three algorithms presented good classification for five basic types of land cover including Rice land,Water bodies,Perennial vegetation,Annual vegetation,Built-up areas as their overall accuracy and Kappa coefficient were greater than 80%and 0.8,respectively.Among the three algorithms,SVM achieved the highest accuracy as its overall accuracy was 86%and the Kappa coefficient was 0.88.Land cover classification based on the SVM algorithm shows that Built-up areas cover the largest area with nearly 31,495 ha,accounting for more than 33.8%of the total natural area,followed by Rice land and Perennial vegetation which cover an area of over 30,767 ha(33%)and 15,637 ha(16.8%),respectively.Water bodies and Annual vegetation cover the smallest areas with 8,820(9.5%)ha and 6,302 ha(6.8%),respectively.The results of this study can be used for land use management and planning as well as other natural resource and environmental management purposes in the province.
基金supported by Health and Medical Research Fund,Hong Kong(11220386,12230246).
文摘Background:With the rapid development of artificial intelligence(AI),large language models(LLMs)have emerged as a potent tool for invigorating ophthalmology across clinical,educational,and research fields.Their accuracy and reliability have undergone tested.This bibliometric analysis aims to provide an overview of research on LLMs in ophthalmology from both thematic and geographical perspectives.Methods:All existing and highly cited LLM-related ophthalmology research papers published in English up to 24th April 2025 were sourced from Scopus,PubMed,and Web of Science.The characteristics of these publications,including publication output,authors,journals,countries,institutions,citations,and research domains,were analyzed using Biblioshiny and VOSviewer software.Results:A total of 277 articles from 1,459 authors and 89 journals were included in this study.Although relevant publications began to appear in 2019,there was a significant increase starting from 2023.He M and Shi D are the most prolific authors,while Investigative Ophthalmology&Visual Science stands out as the most prominent journal.Most of the top-publishing countries are high-income economies,with the USA taking the lead,and the University of California is the leading institution.VOSviewer identified 5 clusters in the keyword co-occurrence analysis,indicating that current research focuses on the clinical applications of LLMs,particularly in diagnosis and patient education.Conclusions:While LLMs have demonstrated effectiveness in retaining knowledge,their accuracy in image-based diagnosis remains limited.Therefore,future research should investigate fine-tuning strategies and domain-specific adaptations to close this gap.Although research on the applications of LLMs in ophthalmology is still in its early stages,it holds significant potential for advancing the field.
基金the Natural Science Foundation of Guangdong Province(No.2021B1515020041)the National Natural Science Foundation of China(No.42277403)+4 种基金the Projects of International Cooperation and Exchange of the National Natural Science Foundation of China(NSFC-UNEP)(No:32261143459)the Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control(No.2023B1212060002)the Guangdong Major Project of Basic and Applied Basic Research(No.2023B0303000024)the High-level University Special Fund(No.G03050K001)the Research Projects of the General Administration of Customs(No.2022HK060)for financial support.
文摘As the main component of electronic products,plastics contain complex and diverse metal additives.Recycling process is not conducive to stable existence of metal additives in electronic plastics.Once the e-waste plastics enter the environment,they will continue to release harmful metals into environment after aging,causing serious hazards.This study delved into the analysis and comparison of metal content of e-waste plastics,elucidating aging process and metal leaching behavior over a 112-day natural light exposure period.The findings underscored that metal content in recycled plastics surpassed that in their new counterparts.Specifically,Ti content in new plastics remained below 100 mg/kg,while recycled plastics exhibited Ti content surpassing 100 mg/kg threshold.Throughout prolonged natural light exposure,metals such as Zn,Ba and Sb demonstrated a heightened likelihood of release from electronic plastics in comparison to other metals.The aging process during light exposure led to fragmentation of electronic plastics,accompanied by a reduction in particle size.Notably,the particle size reduction was more pronounced in poly acrylonitrile butadiene styrene(ABS)and recycled ABS,experiencing reductions of 40µm and 85µm,respectively.This phenomenon was attributed to the presence of polybutadiene structural units,which proved more susceptible to aging.Along with the breaking of plastics,the ABS plastics released metal species such as Pb,Cd,Ni,Al that had not been detected in other plastics solutions.The collective evidence from this study suggested that ABS and recycled ABS electronic plastics might pose a heightened potential environmental risk compared to other electronic plastics.
文摘Rapid industrial growth,urbanization,and agricultural activities have led to the discharge of large volumes of pollutants into coastal environments,raising levels of metals such as arsenic(As),cadmium(Cd),and mercury(Hg)in water and sediments.Bivalve molluscs,such as Meretrix lyrata and Saccostrea glomerata can accumulate high amounts of toxic heavy metals in their tissues that pose potential risks to human health.They are frequently used as bioindicators due to their filter-feeding behavior and high accumulation potential.This study evaluates heavy metal accumulation in bivalve molluscs from Northeastern Vietnam,including Quang Ninh Province and Hai Phong City.In this study,a systematic literature review was conducted,combined with a bibliometric analysis,to synthesize and evaluate data on heavy metal accumulation in bivalve molluscs from Northeastern Vietnam.The analysis results showed bio-concentration factors exceeding 1,000 for As,Cd,and Hg in certain species,particularly in samples from Quang Ninh Province.Meanwhile,sediment accumulation factors(BSAF)were lower,suggesting that waterborne pathways predominantly contribute to heavy metal uptake.These findings highlight significant food safety risks due to toxic metal accumulation in seafood resources,emphasizing the urgent need for continuous monitoring and the establishment of local safety standards.The study provides important scientific evidence to support marine environmental management and public health protection.
基金Supported by the National Natural Science Foundation of China(No.82171062,No.82301222,No.32201244).
文摘AIM:To investigate the effects and the underlying mechanism(s)of conbercept on the phagocytosis of hard exudates(HEs)by Müller glia in diabetic retinopathy(DR).METHODS:Twenty-one eyes from 17 patients with diabetic macular edema(DME)underwent optical coherence tomography(OCT)imaging to examine the changes of HEs before and after intravitreal conbercept injection(IVC).In vitro,rat retinal Müller cell line(rMC-1)was cultured under high glucose and treated with oxidized low-density lipoprotein(Ox-LDL)with or without conbercept.Phagocytosis was analysed with immunofluorescence,flow cytometry,and Western blot.Expressions of scavenger receptors(LOX-1,CD36)were analyzed by quantitative real-time polymerase chain reaction(qRT-PCR).Conbercept’s effects on vascular endothelial growth factor A(VEGF-A),VEGFR2,inflammation(NF-κB,IL-6,iNOS),and oxidative stress(ROS)were evaluated with Western blot and immunofluorescence.RESULTS:The area of HEs showed minimal change after the first IVC(1.39±1.41 to 1.38±1.3 mm2,P=0.938),but significantly decreased after the third IVC(0.45±0.66 mm2,P=0.002).In vitro,conbercept enhanced the phagocytosis of Ox-LDL by rMC-1 cells under high glucose condition.Conbercept reduced ROS and inflammation(NF-κB,IL-6,iNOS)in high glucose-treated rMC-1 cells by suppression of VEGF/VEGFR2 pathway.The inhibition of NF-κB by conbercept further activated PPARγ-CD36 axis,increasing CD36 expression and promoting Ox-LDL uptake,thereby facilitating the clearance of HEs.CONCLUSION:Conbercept reduces HEs in DR by enhancing Müller glia phagocytosis possibly through activating PPARγ-CD36 axis,which is mediated by inhibition of VEGF signaling.Modulation of Müller glia phagocytic capacity might provide a novel therapeutic strategy to treat DR and DME.
基金supported by the National Key R&D Program of China(grant No.2024YFA1611600)the SVOM project(a mission under the Strategic Priority Program on Space Science of the Chinese Academy of Sciences)+23 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB0550401)the National Natural Science Foundation of China(NSFC,grant No.12494573)partly supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region(grant No.2024D01D32)Tianshan Talent Training Program(grant No.2023TSYCLJ0053)Tianshan Innovation Team Program(grant No.2024D14015)supported by the Jiangsu Funding Program for Excellent Postdoctoral Talent(grant No.2024ZB110)the Postdoctoral Fellowship Program(grant No.GZC20241916)the General Fund(grant No.2024M763531)of the China Postdoctoral Science Foundationsupported by a Royal Society Dorothy Hodgkin Fellowship(grant Nos.DHF-R1-221175 and DHF-ERE-221005)support by a postdoctoral fellowship from the CNESsupported by the National Key R&D Program of China(grant No.2024YFA1611702)the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB0550101)the support of the French Agence Nationale de la Recherche(ANR),under grant ANR-23-CE31-0011(project PEGaSUS)financial support from the GRAWITA Large Program Grant(PI P.D’Avanzo)financial support from the Italian Space Agency,contract ASI/INAF No.I/004/11/6support from the INAF project Premiale Supporto Arizona&Italiasupported by the National Natural Science Foundation of China(NSFC,grant No.12133003)supported by the National Natural Science Foundation of China(NSFC,grant No.12373042)the Bagui Scholars Program(No.GXR-6BG2424001)funded by the European Union(ERC,HEAVYMETAL,101071865,Views and opinions expressed are,however,those of the authors only and do not necessarily reflect those of the European Union or the European Research Council Neither the European Union nor the granting authority can be held responsible for them)the Cosmic Dawn Center(DAWN)is funded by the Danish National Research Foundation under grant No.DNRF140supported by the National Natural Science Foundation of China(NSFC,grant Nos.12225305 and 12321003)supported by the National Natural Science Foundation of China(NSFC,grant No.12473049)supported by the General Fund(grant No.2024M763530)of the China Postdoctoral Science Foundation。
文摘Early multiwavelength observations offer crucial insights into the nature of the relativistic jets responsible for gamma-ray bursts and their interaction with the surrounding medium.We present data of GRB 240825A from 17 space-and ground-based telescopes/instruments,covering wavelengths from NIR/optical to X-ray and GeV,and spanning from the prompt emission to the afterglow phase triggered by Swift and Fermi.The early afterglow observations were carried out by SVOM/C-GFT,and spectroscopic observations of the afterglow by GTC,VLT,and TNG determined the redshift of the burst(z=0.659)later.A comprehensive analysis of the prompt emission spectrum observed by Swift-BAT and Fermi-GBM/LAT reveals a rare and significant high-energy cutoff at 76 MeV.Assuming this cutoff is due toγγabsorption allows us to place an upper limit on the initial Lorentz factor,Γ_(0)<245.The optical/NIR and GeV afterglow light curves can be described by the standard external shock model,with early-time emission dominated by a reverse shock(RS)and a subsequent transition to forward shock(FS)emission.Our afterglow modeling yields a consistent estimate of the initial Lorentz factor(Γ_(0)∼234).Furthermore,the RS-to-FS magnetic field ratio(R 302B)indicates that the RS region is significantly more magnetized than the FS region.An isotropic-equivalent kinetic energy of E_(k,iso)=5.25×10^(54) erg is derived,and the correspondingγ-ray radiation efficiency is estimated to beη_(γ)=3.1%.On the other hand,the standard afterglow model cannot reproduce the X-ray light curve of GRB 240825A,calling for improved models to characterize all multiwavelength data.
文摘中国香港位于热带北缘,其植被在历史上曾遭到大规模破坏,近几十年来逐渐恢复。香港植物标本采集有很长的历史,迄今为止已记录的维管植物超过2 170种,然而新种和新分布仍在不断增加。在最近的野外工作中,作者发现10种在香港新记录到的维管植物,分别是唇边书带蕨[Haplopteris elongata (Swartz) E. H.Crane]、雷公连[Amydrium sinense (Engl.) H. Li]、百足藤[Pothos repens (Lour.) Druce]、四川轮环藤(Cycleasutchuenensis Gagnep.)、山黑豆(Dumasia truncata Siebold&Zucc.)、倒心叶珊瑚[Aucuba obcordata (Rehder) Fu ex W. K. Hu et Soong]、竹叶榕(Ficus stenophylla Hemsl.)、长叶冠毛榕[F. gasparriniana var. esquirolii (H. Lév.&Vaniot) Corner]、硬叶冬青(Ilex ficifolia C. J. Tseng ex S. K. Chen et Y. X. Feng)、假福王草[Paraprenanthes sororia(Miq.) C. Shih.]。雷公连属(Amydrium Schott)、山黑豆属(Dumasia DC.)和假福王草属(Paraprenanthes C. C.Chang ex C. Shih)为香港的新记录属。以上的发现不仅丰富了香港的植物区系,而且表明保护残存植被非常重要,且极小种群的保护也值得特别关注。
