Dear Editor,Diabetic macular edema(DME)is a major cause of visual loss in diabetic patients,which is mainly caused by disruption of the blood-retinal barrier and loss of pericytes and endothelial cells,resulting in th...Dear Editor,Diabetic macular edema(DME)is a major cause of visual loss in diabetic patients,which is mainly caused by disruption of the blood-retinal barrier and loss of pericytes and endothelial cells,resulting in the leakage of plasma and lipids[1].Nowadays,laser photocoagulation,intravitreal injections of anti-vascular endothelial growth factor(anti-VEGF)drugs and dexamethasone implant.展开更多
The Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） has released more than two million spectra, which provide the opportunity to search for double-peaked narrow emission line （NEL） galaxies and ...The Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） has released more than two million spectra, which provide the opportunity to search for double-peaked narrow emission line （NEL） galaxies and active galactic nuclei （AGNs）. The double-peaked narrow-line profiles can be well modeled by two velocity components, respectively blueshifted and redshifted with respect to the sys- temic recession velocity. This paper presents 20 double-peaked NEL galaxies and AGNs found from LAMOST DR1 using a search method based on a multi-Gaussian fit of the narrow emission lines. Among them, ten have already been published by other authors, either listed as genuine double-peaked NEL objects or as asymmetric NEL objects, and the remaining ten are original discoveries. We discuss some pos- sible origins for the double-peaked narrow-line features, such as interaction between jet and narrow line regions, interaction with companion galaxies, and black hole bina- ries. Spatially resolved optical imaging and/or follow-up observations in other spectral bands are needed to further discuss the physical mechanisms at work.展开更多
AIM:To evaluate the efficacy of the Tecnis Symfony ZXR00 lens in achieving optimal visual outcomes for cataract surgery patients with axial length(AL)shorter than 24 mm.METHODS:A total of 21 subjects(37 eyes)were subm...AIM:To evaluate the efficacy of the Tecnis Symfony ZXR00 lens in achieving optimal visual outcomes for cataract surgery patients with axial length(AL)shorter than 24 mm.METHODS:A total of 21 subjects(37 eyes)were submitted to cataract surgery and implantation of Tecnis Symfony ZXR00 lens(Johnson&Johnson Vision)was assessed.Patients were examined at 5 m,80 cm,and 40 cm for uncorrected distance visual acuity(UCDVA)and corrected distance visual acuity(CDVA),uncorrected intermediate(UCIVA),and uncorrected near visual acuity(UCNVA).Further,based on the optimal distance correction,the monocular defocusing curve in the range of+0.5 to-3.5 D was investigated.A simple patient-reported spectacle independence questionnaire(PRSIQ)was used to evaluate subjects’subjective feelings about their dependence on glasses at various distances.Multiple linear regression was employed to examine the association amony intraocular lenses(IOLs)diopter,AL,corneal curvature,anterior chamber depth,mean manifest refractive spherical equivalent,pupil,pupil/scan,target refraction,and near vision(logMAR).RESULTS:The study demonstrated enhanced UCNVA alongside comparable distant vision and UCIVA outcomes in eyes with AL shorter than 24 mm.Mean post-operative UCDVA significantly improved from preoperative levels 0.530±0.406(P=0.000).Notably,83.3%of eyes achieved 0.01 logMAR in UCNVA.Five unilateral cases with blended IOL implantation also showed satisfactory visual acuity and satisfaction.The 90.5%(19/21)achieved spectacle independence.The average score for self-reported spectacle-independence on the PRSIQ was 3.52 with a standard deviation of 0.98.The results of the regression analysis revealed that one predictor,the pupil/scan accounted for 27.6%of the variation in near vision[logMAR;F(1,35)=13.33,P<0.01].CONCLUSION:The results affirm the effectiveness of the Tecnis Symfony ZXR00 lens in enhancing visual outcomes for cataract surgery patients with AL shorter than 24 mm.Additionally,the pupil/scan emerges as a critical factor influencing postoperative near vision.展开更多
Mg alloys have the defects of low stiffness,low strength,and high coefficient of thermal expansion(CTE).The composites strategy and its architecture design are effective approaches to improve the comprehensive perform...Mg alloys have the defects of low stiffness,low strength,and high coefficient of thermal expansion(CTE).The composites strategy and its architecture design are effective approaches to improve the comprehensive performance of materials,but the processing difficulty,especially in ceramics forming,limits the control and innovation of material architecture.Here,combined with 3D printing and squeeze infiltration technology,two precisely controllable architectures of AZ91/Al_(2)O_(3)interpenetrating phase composites(IPC)with ceramic scaffold were prepared.The interface,properties and impact of different architecture on IPC performance were studied by experiments and finite element simulation.The metallurgical bonding of the interface was realized with the formation of MgAl_(2)O_(4)reaction layer.The IPC with 1 mm circular hole scaffold(1C-IPC)exhibited significantly improved elastic modulus of 164 GPa,high compressive strength of 680 MPa,and good CTE of 12.91×10^(-6)K^(−1),which were 3.64 times,1.98 times and 55%of the Mg matrix,respectively.Their elastic modulus,compressive strength,and CTE were superior to the vast majority of Mg alloys and Mg based composites.The reinforcement and matrix were bicontinuous and interpenetrating each other,which played a critical role in ensuring the potent strengthening effect of the Al_(2)O_(3)reinforcement by efficient load transfer.Under the same volume fraction of reinforcements,compared to IPC with 1 mm hexagonal hole scaffold(1H-IPC),the elastic modulus and compressive strength of 1C-IPC increased by 15%and 28%,respectively,which was due to the reduced stress concentration and more uniform stress distribution of 1C-IPC.It shows great potential of architecture design in improving the performance of composites.This study provides architectural design strategy and feasible preparation method for the development of high performance materials.展开更多
Based on the Google Earth Engine cloud computing data platform,this study employed three algorithms including Support Vector Machine,Random Forest,and Classification and Regression Tree to classify the current status ...Based on the Google Earth Engine cloud computing data platform,this study employed three algorithms including Support Vector Machine,Random Forest,and Classification and Regression Tree to classify the current status of land covers in Hung Yen province of Vietnam using Landsat 8 OLI satellite images,a free data source with reasonable spatial and temporal resolution.The results of the study show that all three algorithms presented good classification for five basic types of land cover including Rice land,Water bodies,Perennial vegetation,Annual vegetation,Built-up areas as their overall accuracy and Kappa coefficient were greater than 80%and 0.8,respectively.Among the three algorithms,SVM achieved the highest accuracy as its overall accuracy was 86%and the Kappa coefficient was 0.88.Land cover classification based on the SVM algorithm shows that Built-up areas cover the largest area with nearly 31,495 ha,accounting for more than 33.8%of the total natural area,followed by Rice land and Perennial vegetation which cover an area of over 30,767 ha(33%)and 15,637 ha(16.8%),respectively.Water bodies and Annual vegetation cover the smallest areas with 8,820(9.5%)ha and 6,302 ha(6.8%),respectively.The results of this study can be used for land use management and planning as well as other natural resource and environmental management purposes in the province.展开更多
Background:With the rapid development of artificial intelligence(AI),large language models(LLMs)have emerged as a potent tool for invigorating ophthalmology across clinical,educational,and research fields.Their accura...Background:With the rapid development of artificial intelligence(AI),large language models(LLMs)have emerged as a potent tool for invigorating ophthalmology across clinical,educational,and research fields.Their accuracy and reliability have undergone tested.This bibliometric analysis aims to provide an overview of research on LLMs in ophthalmology from both thematic and geographical perspectives.Methods:All existing and highly cited LLM-related ophthalmology research papers published in English up to 24th April 2025 were sourced from Scopus,PubMed,and Web of Science.The characteristics of these publications,including publication output,authors,journals,countries,institutions,citations,and research domains,were analyzed using Biblioshiny and VOSviewer software.Results:A total of 277 articles from 1,459 authors and 89 journals were included in this study.Although relevant publications began to appear in 2019,there was a significant increase starting from 2023.He M and Shi D are the most prolific authors,while Investigative Ophthalmology&Visual Science stands out as the most prominent journal.Most of the top-publishing countries are high-income economies,with the USA taking the lead,and the University of California is the leading institution.VOSviewer identified 5 clusters in the keyword co-occurrence analysis,indicating that current research focuses on the clinical applications of LLMs,particularly in diagnosis and patient education.Conclusions:While LLMs have demonstrated effectiveness in retaining knowledge,their accuracy in image-based diagnosis remains limited.Therefore,future research should investigate fine-tuning strategies and domain-specific adaptations to close this gap.Although research on the applications of LLMs in ophthalmology is still in its early stages,it holds significant potential for advancing the field.展开更多
As the main component of electronic products,plastics contain complex and diverse metal additives.Recycling process is not conducive to stable existence of metal additives in electronic plastics.Once the e-waste plast...As the main component of electronic products,plastics contain complex and diverse metal additives.Recycling process is not conducive to stable existence of metal additives in electronic plastics.Once the e-waste plastics enter the environment,they will continue to release harmful metals into environment after aging,causing serious hazards.This study delved into the analysis and comparison of metal content of e-waste plastics,elucidating aging process and metal leaching behavior over a 112-day natural light exposure period.The findings underscored that metal content in recycled plastics surpassed that in their new counterparts.Specifically,Ti content in new plastics remained below 100 mg/kg,while recycled plastics exhibited Ti content surpassing 100 mg/kg threshold.Throughout prolonged natural light exposure,metals such as Zn,Ba and Sb demonstrated a heightened likelihood of release from electronic plastics in comparison to other metals.The aging process during light exposure led to fragmentation of electronic plastics,accompanied by a reduction in particle size.Notably,the particle size reduction was more pronounced in poly acrylonitrile butadiene styrene(ABS)and recycled ABS,experiencing reductions of 40µm and 85µm,respectively.This phenomenon was attributed to the presence of polybutadiene structural units,which proved more susceptible to aging.Along with the breaking of plastics,the ABS plastics released metal species such as Pb,Cd,Ni,Al that had not been detected in other plastics solutions.The collective evidence from this study suggested that ABS and recycled ABS electronic plastics might pose a heightened potential environmental risk compared to other electronic plastics.展开更多
Rapid industrial growth,urbanization,and agricultural activities have led to the discharge of large volumes of pollutants into coastal environments,raising levels of metals such as arsenic(As),cadmium(Cd),and mercury(...Rapid industrial growth,urbanization,and agricultural activities have led to the discharge of large volumes of pollutants into coastal environments,raising levels of metals such as arsenic(As),cadmium(Cd),and mercury(Hg)in water and sediments.Bivalve molluscs,such as Meretrix lyrata and Saccostrea glomerata can accumulate high amounts of toxic heavy metals in their tissues that pose potential risks to human health.They are frequently used as bioindicators due to their filter-feeding behavior and high accumulation potential.This study evaluates heavy metal accumulation in bivalve molluscs from Northeastern Vietnam,including Quang Ninh Province and Hai Phong City.In this study,a systematic literature review was conducted,combined with a bibliometric analysis,to synthesize and evaluate data on heavy metal accumulation in bivalve molluscs from Northeastern Vietnam.The analysis results showed bio-concentration factors exceeding 1,000 for As,Cd,and Hg in certain species,particularly in samples from Quang Ninh Province.Meanwhile,sediment accumulation factors(BSAF)were lower,suggesting that waterborne pathways predominantly contribute to heavy metal uptake.These findings highlight significant food safety risks due to toxic metal accumulation in seafood resources,emphasizing the urgent need for continuous monitoring and the establishment of local safety standards.The study provides important scientific evidence to support marine environmental management and public health protection.展开更多
AIM:To investigate the effects and the underlying mechanism(s)of conbercept on the phagocytosis of hard exudates(HEs)by Müller glia in diabetic retinopathy(DR).METHODS:Twenty-one eyes from 17 patients with diabet...AIM:To investigate the effects and the underlying mechanism(s)of conbercept on the phagocytosis of hard exudates(HEs)by Müller glia in diabetic retinopathy(DR).METHODS:Twenty-one eyes from 17 patients with diabetic macular edema(DME)underwent optical coherence tomography(OCT)imaging to examine the changes of HEs before and after intravitreal conbercept injection(IVC).In vitro,rat retinal Müller cell line(rMC-1)was cultured under high glucose and treated with oxidized low-density lipoprotein(Ox-LDL)with or without conbercept.Phagocytosis was analysed with immunofluorescence,flow cytometry,and Western blot.Expressions of scavenger receptors(LOX-1,CD36)were analyzed by quantitative real-time polymerase chain reaction(qRT-PCR).Conbercept’s effects on vascular endothelial growth factor A(VEGF-A),VEGFR2,inflammation(NF-κB,IL-6,iNOS),and oxidative stress(ROS)were evaluated with Western blot and immunofluorescence.RESULTS:The area of HEs showed minimal change after the first IVC(1.39±1.41 to 1.38±1.3 mm2,P=0.938),but significantly decreased after the third IVC(0.45±0.66 mm2,P=0.002).In vitro,conbercept enhanced the phagocytosis of Ox-LDL by rMC-1 cells under high glucose condition.Conbercept reduced ROS and inflammation(NF-κB,IL-6,iNOS)in high glucose-treated rMC-1 cells by suppression of VEGF/VEGFR2 pathway.The inhibition of NF-κB by conbercept further activated PPARγ-CD36 axis,increasing CD36 expression and promoting Ox-LDL uptake,thereby facilitating the clearance of HEs.CONCLUSION:Conbercept reduces HEs in DR by enhancing Müller glia phagocytosis possibly through activating PPARγ-CD36 axis,which is mediated by inhibition of VEGF signaling.Modulation of Müller glia phagocytic capacity might provide a novel therapeutic strategy to treat DR and DME.展开更多
Early multiwavelength observations offer crucial insights into the nature of the relativistic jets responsible for gamma-ray bursts and their interaction with the surrounding medium.We present data of GRB 240825A from...Early multiwavelength observations offer crucial insights into the nature of the relativistic jets responsible for gamma-ray bursts and their interaction with the surrounding medium.We present data of GRB 240825A from 17 space-and ground-based telescopes/instruments,covering wavelengths from NIR/optical to X-ray and GeV,and spanning from the prompt emission to the afterglow phase triggered by Swift and Fermi.The early afterglow observations were carried out by SVOM/C-GFT,and spectroscopic observations of the afterglow by GTC,VLT,and TNG determined the redshift of the burst(z=0.659)later.A comprehensive analysis of the prompt emission spectrum observed by Swift-BAT and Fermi-GBM/LAT reveals a rare and significant high-energy cutoff at 76 MeV.Assuming this cutoff is due toγγabsorption allows us to place an upper limit on the initial Lorentz factor,Γ_(0)<245.The optical/NIR and GeV afterglow light curves can be described by the standard external shock model,with early-time emission dominated by a reverse shock(RS)and a subsequent transition to forward shock(FS)emission.Our afterglow modeling yields a consistent estimate of the initial Lorentz factor(Γ_(0)∼234).Furthermore,the RS-to-FS magnetic field ratio(R 302B)indicates that the RS region is significantly more magnetized than the FS region.An isotropic-equivalent kinetic energy of E_(k,iso)=5.25×10^(54) erg is derived,and the correspondingγ-ray radiation efficiency is estimated to beη_(γ)=3.1%.On the other hand,the standard afterglow model cannot reproduce the X-ray light curve of GRB 240825A,calling for improved models to characterize all multiwavelength data.展开更多
Linking meteorology and air pollutants is a key challenge.The study investigated meteorological effects on PM_(2.5)concentration using the advanced convergent cross mapping method,utilizing hourly PM_(2.5)concentratio...Linking meteorology and air pollutants is a key challenge.The study investigated meteorological effects on PM_(2.5)concentration using the advanced convergent cross mapping method,utilizing hourly PM_(2.5)concentration and six meteorological factors across eight provinces and cities in Vietnam.Results demonstrated that temperature(ρ=0.30)and radiation(ρ=0.30)produced the highest effects,followed by humidity(ρ=0.28)and wind speed(ρ=0.24),while pressure(ρ=0.22)and wind direction(ρ=0.17)produced the weakest effects on PM_(2.5)concentration.Comparing theρvalues showed that temperature,wind speed,and wind direction had greater impacts on PM_(2.5)concentration during the dry season whereas radiation had a more influence during the wet season;Southern stations experienced larger meteorological effects.Temperature,humidity,pressure,and wind direction had both positive and negative influences on PM_(2.5)concentration,while radiation and wind speed mostly had negative influences.During PM_(2.5)pollution episodes,there wasmore contribution ofmeteorological effects on PM_(2.5)concentration indicated byρvalues.At contaminated levels,humidity(ρ=0.45)was the most dominant factor affecting PM_(2.5)concentration,followed by temperature(ρ=0.41)and radiation(ρ=0.40).Pollution episodes were pointed out to be more prevalent under higher humidity,higher pressure,lower temperature,lower radiation,and lower wind speed.Theρcalculation also revealed that lower temperature,lower radiation,and higher humidity greatly accelerated each other under pollution episodes,further enhancing PM_(2.5)concentration.The findings contributed to the literature on meteorology and air pollution interaction.展开更多
To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique ph...To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique physiology and procedure-related sequelae present an increasingly relevant challenge in hepatic surgery.We hereby reported a series of patients suffering from hepatocellular carcinoma(HCC)who successfully underwent open and laparoscopic hepatectomy.展开更多
To the Editor : Barcelona Clinic Liver Cancer(BCLC) Stage C hepatocellular carcinoma(HCC) with vascular invasion has been considered unresectable. However, the curative rate from systemic treatment is rather dismal. E...To the Editor : Barcelona Clinic Liver Cancer(BCLC) Stage C hepatocellular carcinoma(HCC) with vascular invasion has been considered unresectable. However, the curative rate from systemic treatment is rather dismal. Even with the use of immunotherapy, complete remission is less than 10% [ 1 ]. On the contrary, recent advances in transplant oncology, especially in the application of liver transplant-related surgical techniques in complex liver resections, make the operation possible for patients with locally advanced HCC who were previously considered to be unresectable [ 2 ]. We hereby present the surgical management of a patient with giant HCC in right liver lobe with inferior vena cava(IVC) invasion.展开更多
Some refractory linings that protect metallic vessels from the hot temperature of the products they contain are made of masonries with or without mortar.The joints play an important role,reducing the stresses in the m...Some refractory linings that protect metallic vessels from the hot temperature of the products they contain are made of masonries with or without mortar.The joints play an important role,reducing the stresses in the masonries during heating.Furthermore,the presence of these joints makes the behaviour of the masonry nonlinear and orthotropic.To perform a thermomechanical simulation using a finite element method of an industrial vessel that contains hundreds or thousands of bricks and joints,microscopic models are not suitable due to the high computational time and the management of the behaviour of the joints(opening/closing)which affects the convergence.To overcome these problems,it is proposed to replace the masonry by a homogeneous material that has a behaviour equivalent to the set of bricks and joints,using a periodic homogenization technique.Since the joints can be closed or open,the equivalent material will have a different behaviour according to the joint state.Furthermore,refractory materials have an elastic-viscoplastic behaviour at high temperatures.So,the equivalent material will have an orthotropic elastic-viscoplastic behaviour,requiring a nonlinear homogenisation technique.An overview of this approach developed at University of Orléans is presented with two industrial applications(blast-furnace and steel ladle).展开更多
Alcohol abuse induces various neurological disorders including motor learning deficits,possibly by affecting neuronal and astrocytic activity.Physical exercise is one effective approach to remediate synaptic loss and ...Alcohol abuse induces various neurological disorders including motor learning deficits,possibly by affecting neuronal and astrocytic activity.Physical exercise is one effective approach to remediate synaptic loss and motor deficits as shown by our previous works.In this study,we unrevealed the role of exercise training in the recovery of cortical neuronal and astrocytic functions.Using a chronic alcohol injection mouse model,we found the hyperreactivity of astrocytes along with dendritic spine loss plus lower neuronal activity in the primary motor cortex.Persistent treadmill exercise training,on the other hand,improved neural spine formation and inhibited reactive astrocytes,alleviating motor learning deficits induced by alcohol exposure.These data collectively support the potency of endurance exercise in the rehabilitation of motor functions under alcohol abuse.展开更多
The informativeness of environmental,social,and governance(ESG)scores and their actual impact on firms remains understudied.To address this gap in the literature,we make theoretical predictions and conduct empirical r...The informativeness of environmental,social,and governance(ESG)scores and their actual impact on firms remains understudied.To address this gap in the literature,we make theoretical predictions and conduct empirical research revealing that a high ESG score is associated with a lower probability of ESG scandals and lower stock returns during a scandal event.Our results suggest that ESG scores are heterogeneous but informative,and that a strong ESG reputation may have both positive and negative consequences for firms.Drawing on our findings,we develop a model and showcase that firms face an optimization problem when determining optimal ESG investment levels.Two equilibria may exist based on the trade-off between ESG scandal losses and ESG adjustment costs.Our model explains why certain firms make heterogeneous ESG decisions.展开更多
Environmental pollution,such as water contamination,is a critical issue that must be absolutely addressed.Here,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3...Environmental pollution,such as water contamination,is a critical issue that must be absolutely addressed.Here,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple hydrothermal method by changing the solvents(H_(2)O,DMF,aqueous HCl solution).The as-prepared nanocatalysts have excellent thermal stability,large porosity,and high hydrophilicity.The results show all materials have good photocatalytic activity in aqueous media,with WO_(3)/WS_(2)nanorods(NRs)having the best activity in the photodegradation of bisphenol A(BPA)under visible-light irradiation.This may originate from increased migration of charge carriers and effective prevention of electron–hole recombination in WO_(3)/WS_(2)NRs,whereby this photocatalyst is able to generate more reactive·OH and·O_(2)^(–)species,leading to greater photocatalytic activity.About 99.6% of BPA is photodegraded within 60 min when using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at pH 7.0.Additionally,the optimal conditions(pH,catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately investigated.These rod-like heterostructures are expressed as potential catalysts with excellent photostability,efficient reusability,and highly active effectivity in different types of water.In particular,the removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reaches 89.1%in contaminated lake water.This study provides promising insights for the nearly complete removal of BPA from wastewater or different water resources,which is advantageous to various applications in environmental remediation.展开更多
Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in animals.Nevertheless,the dynamic nature of chemical-carrying media,such as wate...Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in animals.Nevertheless,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal subject.Moreover,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain imaging.Additionally,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much needed.This is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.展开更多
基金Supported by National Natural Science Foundation of China(No.82171062No.82301222)Zhejiang Provincial Natural Science Foundation of China(No.LY20H120002).
文摘Dear Editor,Diabetic macular edema(DME)is a major cause of visual loss in diabetic patients,which is mainly caused by disruption of the blood-retinal barrier and loss of pericytes and endothelial cells,resulting in the leakage of plasma and lipids[1].Nowadays,laser photocoagulation,intravitreal injections of anti-vascular endothelial growth factor(anti-VEGF)drugs and dexamethasone implant.
基金Supported by the National Natural Science Foundation of China
文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） has released more than two million spectra, which provide the opportunity to search for double-peaked narrow emission line （NEL） galaxies and active galactic nuclei （AGNs）. The double-peaked narrow-line profiles can be well modeled by two velocity components, respectively blueshifted and redshifted with respect to the sys- temic recession velocity. This paper presents 20 double-peaked NEL galaxies and AGNs found from LAMOST DR1 using a search method based on a multi-Gaussian fit of the narrow emission lines. Among them, ten have already been published by other authors, either listed as genuine double-peaked NEL objects or as asymmetric NEL objects, and the remaining ten are original discoveries. We discuss some pos- sible origins for the double-peaked narrow-line features, such as interaction between jet and narrow line regions, interaction with companion galaxies, and black hole bina- ries. Spatially resolved optical imaging and/or follow-up observations in other spectral bands are needed to further discuss the physical mechanisms at work.
文摘AIM:To evaluate the efficacy of the Tecnis Symfony ZXR00 lens in achieving optimal visual outcomes for cataract surgery patients with axial length(AL)shorter than 24 mm.METHODS:A total of 21 subjects(37 eyes)were submitted to cataract surgery and implantation of Tecnis Symfony ZXR00 lens(Johnson&Johnson Vision)was assessed.Patients were examined at 5 m,80 cm,and 40 cm for uncorrected distance visual acuity(UCDVA)and corrected distance visual acuity(CDVA),uncorrected intermediate(UCIVA),and uncorrected near visual acuity(UCNVA).Further,based on the optimal distance correction,the monocular defocusing curve in the range of+0.5 to-3.5 D was investigated.A simple patient-reported spectacle independence questionnaire(PRSIQ)was used to evaluate subjects’subjective feelings about their dependence on glasses at various distances.Multiple linear regression was employed to examine the association amony intraocular lenses(IOLs)diopter,AL,corneal curvature,anterior chamber depth,mean manifest refractive spherical equivalent,pupil,pupil/scan,target refraction,and near vision(logMAR).RESULTS:The study demonstrated enhanced UCNVA alongside comparable distant vision and UCIVA outcomes in eyes with AL shorter than 24 mm.Mean post-operative UCDVA significantly improved from preoperative levels 0.530±0.406(P=0.000).Notably,83.3%of eyes achieved 0.01 logMAR in UCNVA.Five unilateral cases with blended IOL implantation also showed satisfactory visual acuity and satisfaction.The 90.5%(19/21)achieved spectacle independence.The average score for self-reported spectacle-independence on the PRSIQ was 3.52 with a standard deviation of 0.98.The results of the regression analysis revealed that one predictor,the pupil/scan accounted for 27.6%of the variation in near vision[logMAR;F(1,35)=13.33,P<0.01].CONCLUSION:The results affirm the effectiveness of the Tecnis Symfony ZXR00 lens in enhancing visual outcomes for cataract surgery patients with AL shorter than 24 mm.Additionally,the pupil/scan emerges as a critical factor influencing postoperative near vision.
基金supported by the National Key Research and Development Program of China(No.2022YFB3708400)the National Natural Science Foundation of China(No.52305158)+1 种基金the Young Elite Scientists Sponsorship Program by CAST(No.2022QNRC001)the Science Innovation Foundation of Shanghai Academy of Spaceflight Technology(No.USCAST2021-18).
文摘Mg alloys have the defects of low stiffness,low strength,and high coefficient of thermal expansion(CTE).The composites strategy and its architecture design are effective approaches to improve the comprehensive performance of materials,but the processing difficulty,especially in ceramics forming,limits the control and innovation of material architecture.Here,combined with 3D printing and squeeze infiltration technology,two precisely controllable architectures of AZ91/Al_(2)O_(3)interpenetrating phase composites(IPC)with ceramic scaffold were prepared.The interface,properties and impact of different architecture on IPC performance were studied by experiments and finite element simulation.The metallurgical bonding of the interface was realized with the formation of MgAl_(2)O_(4)reaction layer.The IPC with 1 mm circular hole scaffold(1C-IPC)exhibited significantly improved elastic modulus of 164 GPa,high compressive strength of 680 MPa,and good CTE of 12.91×10^(-6)K^(−1),which were 3.64 times,1.98 times and 55%of the Mg matrix,respectively.Their elastic modulus,compressive strength,and CTE were superior to the vast majority of Mg alloys and Mg based composites.The reinforcement and matrix were bicontinuous and interpenetrating each other,which played a critical role in ensuring the potent strengthening effect of the Al_(2)O_(3)reinforcement by efficient load transfer.Under the same volume fraction of reinforcements,compared to IPC with 1 mm hexagonal hole scaffold(1H-IPC),the elastic modulus and compressive strength of 1C-IPC increased by 15%and 28%,respectively,which was due to the reduced stress concentration and more uniform stress distribution of 1C-IPC.It shows great potential of architecture design in improving the performance of composites.This study provides architectural design strategy and feasible preparation method for the development of high performance materials.
文摘Based on the Google Earth Engine cloud computing data platform,this study employed three algorithms including Support Vector Machine,Random Forest,and Classification and Regression Tree to classify the current status of land covers in Hung Yen province of Vietnam using Landsat 8 OLI satellite images,a free data source with reasonable spatial and temporal resolution.The results of the study show that all three algorithms presented good classification for five basic types of land cover including Rice land,Water bodies,Perennial vegetation,Annual vegetation,Built-up areas as their overall accuracy and Kappa coefficient were greater than 80%and 0.8,respectively.Among the three algorithms,SVM achieved the highest accuracy as its overall accuracy was 86%and the Kappa coefficient was 0.88.Land cover classification based on the SVM algorithm shows that Built-up areas cover the largest area with nearly 31,495 ha,accounting for more than 33.8%of the total natural area,followed by Rice land and Perennial vegetation which cover an area of over 30,767 ha(33%)and 15,637 ha(16.8%),respectively.Water bodies and Annual vegetation cover the smallest areas with 8,820(9.5%)ha and 6,302 ha(6.8%),respectively.The results of this study can be used for land use management and planning as well as other natural resource and environmental management purposes in the province.
基金supported by Health and Medical Research Fund,Hong Kong(11220386,12230246).
文摘Background:With the rapid development of artificial intelligence(AI),large language models(LLMs)have emerged as a potent tool for invigorating ophthalmology across clinical,educational,and research fields.Their accuracy and reliability have undergone tested.This bibliometric analysis aims to provide an overview of research on LLMs in ophthalmology from both thematic and geographical perspectives.Methods:All existing and highly cited LLM-related ophthalmology research papers published in English up to 24th April 2025 were sourced from Scopus,PubMed,and Web of Science.The characteristics of these publications,including publication output,authors,journals,countries,institutions,citations,and research domains,were analyzed using Biblioshiny and VOSviewer software.Results:A total of 277 articles from 1,459 authors and 89 journals were included in this study.Although relevant publications began to appear in 2019,there was a significant increase starting from 2023.He M and Shi D are the most prolific authors,while Investigative Ophthalmology&Visual Science stands out as the most prominent journal.Most of the top-publishing countries are high-income economies,with the USA taking the lead,and the University of California is the leading institution.VOSviewer identified 5 clusters in the keyword co-occurrence analysis,indicating that current research focuses on the clinical applications of LLMs,particularly in diagnosis and patient education.Conclusions:While LLMs have demonstrated effectiveness in retaining knowledge,their accuracy in image-based diagnosis remains limited.Therefore,future research should investigate fine-tuning strategies and domain-specific adaptations to close this gap.Although research on the applications of LLMs in ophthalmology is still in its early stages,it holds significant potential for advancing the field.
基金the Natural Science Foundation of Guangdong Province(No.2021B1515020041)the National Natural Science Foundation of China(No.42277403)+4 种基金the Projects of International Cooperation and Exchange of the National Natural Science Foundation of China(NSFC-UNEP)(No:32261143459)the Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control(No.2023B1212060002)the Guangdong Major Project of Basic and Applied Basic Research(No.2023B0303000024)the High-level University Special Fund(No.G03050K001)the Research Projects of the General Administration of Customs(No.2022HK060)for financial support.
文摘As the main component of electronic products,plastics contain complex and diverse metal additives.Recycling process is not conducive to stable existence of metal additives in electronic plastics.Once the e-waste plastics enter the environment,they will continue to release harmful metals into environment after aging,causing serious hazards.This study delved into the analysis and comparison of metal content of e-waste plastics,elucidating aging process and metal leaching behavior over a 112-day natural light exposure period.The findings underscored that metal content in recycled plastics surpassed that in their new counterparts.Specifically,Ti content in new plastics remained below 100 mg/kg,while recycled plastics exhibited Ti content surpassing 100 mg/kg threshold.Throughout prolonged natural light exposure,metals such as Zn,Ba and Sb demonstrated a heightened likelihood of release from electronic plastics in comparison to other metals.The aging process during light exposure led to fragmentation of electronic plastics,accompanied by a reduction in particle size.Notably,the particle size reduction was more pronounced in poly acrylonitrile butadiene styrene(ABS)and recycled ABS,experiencing reductions of 40µm and 85µm,respectively.This phenomenon was attributed to the presence of polybutadiene structural units,which proved more susceptible to aging.Along with the breaking of plastics,the ABS plastics released metal species such as Pb,Cd,Ni,Al that had not been detected in other plastics solutions.The collective evidence from this study suggested that ABS and recycled ABS electronic plastics might pose a heightened potential environmental risk compared to other electronic plastics.
文摘Rapid industrial growth,urbanization,and agricultural activities have led to the discharge of large volumes of pollutants into coastal environments,raising levels of metals such as arsenic(As),cadmium(Cd),and mercury(Hg)in water and sediments.Bivalve molluscs,such as Meretrix lyrata and Saccostrea glomerata can accumulate high amounts of toxic heavy metals in their tissues that pose potential risks to human health.They are frequently used as bioindicators due to their filter-feeding behavior and high accumulation potential.This study evaluates heavy metal accumulation in bivalve molluscs from Northeastern Vietnam,including Quang Ninh Province and Hai Phong City.In this study,a systematic literature review was conducted,combined with a bibliometric analysis,to synthesize and evaluate data on heavy metal accumulation in bivalve molluscs from Northeastern Vietnam.The analysis results showed bio-concentration factors exceeding 1,000 for As,Cd,and Hg in certain species,particularly in samples from Quang Ninh Province.Meanwhile,sediment accumulation factors(BSAF)were lower,suggesting that waterborne pathways predominantly contribute to heavy metal uptake.These findings highlight significant food safety risks due to toxic metal accumulation in seafood resources,emphasizing the urgent need for continuous monitoring and the establishment of local safety standards.The study provides important scientific evidence to support marine environmental management and public health protection.
基金Supported by the National Natural Science Foundation of China(No.82171062,No.82301222,No.32201244).
文摘AIM:To investigate the effects and the underlying mechanism(s)of conbercept on the phagocytosis of hard exudates(HEs)by Müller glia in diabetic retinopathy(DR).METHODS:Twenty-one eyes from 17 patients with diabetic macular edema(DME)underwent optical coherence tomography(OCT)imaging to examine the changes of HEs before and after intravitreal conbercept injection(IVC).In vitro,rat retinal Müller cell line(rMC-1)was cultured under high glucose and treated with oxidized low-density lipoprotein(Ox-LDL)with or without conbercept.Phagocytosis was analysed with immunofluorescence,flow cytometry,and Western blot.Expressions of scavenger receptors(LOX-1,CD36)were analyzed by quantitative real-time polymerase chain reaction(qRT-PCR).Conbercept’s effects on vascular endothelial growth factor A(VEGF-A),VEGFR2,inflammation(NF-κB,IL-6,iNOS),and oxidative stress(ROS)were evaluated with Western blot and immunofluorescence.RESULTS:The area of HEs showed minimal change after the first IVC(1.39±1.41 to 1.38±1.3 mm2,P=0.938),but significantly decreased after the third IVC(0.45±0.66 mm2,P=0.002).In vitro,conbercept enhanced the phagocytosis of Ox-LDL by rMC-1 cells under high glucose condition.Conbercept reduced ROS and inflammation(NF-κB,IL-6,iNOS)in high glucose-treated rMC-1 cells by suppression of VEGF/VEGFR2 pathway.The inhibition of NF-κB by conbercept further activated PPARγ-CD36 axis,increasing CD36 expression and promoting Ox-LDL uptake,thereby facilitating the clearance of HEs.CONCLUSION:Conbercept reduces HEs in DR by enhancing Müller glia phagocytosis possibly through activating PPARγ-CD36 axis,which is mediated by inhibition of VEGF signaling.Modulation of Müller glia phagocytic capacity might provide a novel therapeutic strategy to treat DR and DME.
基金supported by the National Key R&D Program of China(grant No.2024YFA1611600)the SVOM project(a mission under the Strategic Priority Program on Space Science of the Chinese Academy of Sciences)+23 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB0550401)the National Natural Science Foundation of China(NSFC,grant No.12494573)partly supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region(grant No.2024D01D32)Tianshan Talent Training Program(grant No.2023TSYCLJ0053)Tianshan Innovation Team Program(grant No.2024D14015)supported by the Jiangsu Funding Program for Excellent Postdoctoral Talent(grant No.2024ZB110)the Postdoctoral Fellowship Program(grant No.GZC20241916)the General Fund(grant No.2024M763531)of the China Postdoctoral Science Foundationsupported by a Royal Society Dorothy Hodgkin Fellowship(grant Nos.DHF-R1-221175 and DHF-ERE-221005)support by a postdoctoral fellowship from the CNESsupported by the National Key R&D Program of China(grant No.2024YFA1611702)the Strategic Priority Research Program of the Chinese Academy of Sciences(grant No.XDB0550101)the support of the French Agence Nationale de la Recherche(ANR),under grant ANR-23-CE31-0011(project PEGaSUS)financial support from the GRAWITA Large Program Grant(PI P.D’Avanzo)financial support from the Italian Space Agency,contract ASI/INAF No.I/004/11/6support from the INAF project Premiale Supporto Arizona&Italiasupported by the National Natural Science Foundation of China(NSFC,grant No.12133003)supported by the National Natural Science Foundation of China(NSFC,grant No.12373042)the Bagui Scholars Program(No.GXR-6BG2424001)funded by the European Union(ERC,HEAVYMETAL,101071865,Views and opinions expressed are,however,those of the authors only and do not necessarily reflect those of the European Union or the European Research Council Neither the European Union nor the granting authority can be held responsible for them)the Cosmic Dawn Center(DAWN)is funded by the Danish National Research Foundation under grant No.DNRF140supported by the National Natural Science Foundation of China(NSFC,grant Nos.12225305 and 12321003)supported by the National Natural Science Foundation of China(NSFC,grant No.12473049)supported by the General Fund(grant No.2024M763530)of the China Postdoctoral Science Foundation。
文摘Early multiwavelength observations offer crucial insights into the nature of the relativistic jets responsible for gamma-ray bursts and their interaction with the surrounding medium.We present data of GRB 240825A from 17 space-and ground-based telescopes/instruments,covering wavelengths from NIR/optical to X-ray and GeV,and spanning from the prompt emission to the afterglow phase triggered by Swift and Fermi.The early afterglow observations were carried out by SVOM/C-GFT,and spectroscopic observations of the afterglow by GTC,VLT,and TNG determined the redshift of the burst(z=0.659)later.A comprehensive analysis of the prompt emission spectrum observed by Swift-BAT and Fermi-GBM/LAT reveals a rare and significant high-energy cutoff at 76 MeV.Assuming this cutoff is due toγγabsorption allows us to place an upper limit on the initial Lorentz factor,Γ_(0)<245.The optical/NIR and GeV afterglow light curves can be described by the standard external shock model,with early-time emission dominated by a reverse shock(RS)and a subsequent transition to forward shock(FS)emission.Our afterglow modeling yields a consistent estimate of the initial Lorentz factor(Γ_(0)∼234).Furthermore,the RS-to-FS magnetic field ratio(R 302B)indicates that the RS region is significantly more magnetized than the FS region.An isotropic-equivalent kinetic energy of E_(k,iso)=5.25×10^(54) erg is derived,and the correspondingγ-ray radiation efficiency is estimated to beη_(γ)=3.1%.On the other hand,the standard afterglow model cannot reproduce the X-ray light curve of GRB 240825A,calling for improved models to characterize all multiwavelength data.
文摘Linking meteorology and air pollutants is a key challenge.The study investigated meteorological effects on PM_(2.5)concentration using the advanced convergent cross mapping method,utilizing hourly PM_(2.5)concentration and six meteorological factors across eight provinces and cities in Vietnam.Results demonstrated that temperature(ρ=0.30)and radiation(ρ=0.30)produced the highest effects,followed by humidity(ρ=0.28)and wind speed(ρ=0.24),while pressure(ρ=0.22)and wind direction(ρ=0.17)produced the weakest effects on PM_(2.5)concentration.Comparing theρvalues showed that temperature,wind speed,and wind direction had greater impacts on PM_(2.5)concentration during the dry season whereas radiation had a more influence during the wet season;Southern stations experienced larger meteorological effects.Temperature,humidity,pressure,and wind direction had both positive and negative influences on PM_(2.5)concentration,while radiation and wind speed mostly had negative influences.During PM_(2.5)pollution episodes,there wasmore contribution ofmeteorological effects on PM_(2.5)concentration indicated byρvalues.At contaminated levels,humidity(ρ=0.45)was the most dominant factor affecting PM_(2.5)concentration,followed by temperature(ρ=0.41)and radiation(ρ=0.40).Pollution episodes were pointed out to be more prevalent under higher humidity,higher pressure,lower temperature,lower radiation,and lower wind speed.Theρcalculation also revealed that lower temperature,lower radiation,and higher humidity greatly accelerated each other under pollution episodes,further enhancing PM_(2.5)concentration.The findings contributed to the literature on meteorology and air pollution interaction.
文摘To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique physiology and procedure-related sequelae present an increasingly relevant challenge in hepatic surgery.We hereby reported a series of patients suffering from hepatocellular carcinoma(HCC)who successfully underwent open and laparoscopic hepatectomy.
文摘To the Editor : Barcelona Clinic Liver Cancer(BCLC) Stage C hepatocellular carcinoma(HCC) with vascular invasion has been considered unresectable. However, the curative rate from systemic treatment is rather dismal. Even with the use of immunotherapy, complete remission is less than 10% [ 1 ]. On the contrary, recent advances in transplant oncology, especially in the application of liver transplant-related surgical techniques in complex liver resections, make the operation possible for patients with locally advanced HCC who were previously considered to be unresectable [ 2 ]. We hereby present the surgical management of a patient with giant HCC in right liver lobe with inferior vena cava(IVC) invasion.
基金the PhD students(M.Ali,J.Brulin,M.Landreau,T.M.H Nguyen)who have participated to this study,the different compagnies(CPM,RHI-Magnesita,Saint-Gobain,and Tata Steel),the European Commission(ATHOR project,764987 Grant)the Federation for International Refractory Research and Education which have funded it.
文摘Some refractory linings that protect metallic vessels from the hot temperature of the products they contain are made of masonries with or without mortar.The joints play an important role,reducing the stresses in the masonries during heating.Furthermore,the presence of these joints makes the behaviour of the masonry nonlinear and orthotropic.To perform a thermomechanical simulation using a finite element method of an industrial vessel that contains hundreds or thousands of bricks and joints,microscopic models are not suitable due to the high computational time and the management of the behaviour of the joints(opening/closing)which affects the convergence.To overcome these problems,it is proposed to replace the masonry by a homogeneous material that has a behaviour equivalent to the set of bricks and joints,using a periodic homogenization technique.Since the joints can be closed or open,the equivalent material will have a different behaviour according to the joint state.Furthermore,refractory materials have an elastic-viscoplastic behaviour at high temperatures.So,the equivalent material will have an orthotropic elastic-viscoplastic behaviour,requiring a nonlinear homogenisation technique.An overview of this approach developed at University of Orléans is presented with two industrial applications(blast-furnace and steel ladle).
基金STI2030-Major Projects(2022ZD0207600)National Key Research and Development Program of China(2020YFA0113600)+2 种基金National Natural Science Foundation of China(U22A20301,32070955)Key Research and Development Plan of Ningxia(2022BEG01004)Guangdong Basic and Applied Basic Research Foundation(2023B1515040015).
文摘Alcohol abuse induces various neurological disorders including motor learning deficits,possibly by affecting neuronal and astrocytic activity.Physical exercise is one effective approach to remediate synaptic loss and motor deficits as shown by our previous works.In this study,we unrevealed the role of exercise training in the recovery of cortical neuronal and astrocytic functions.Using a chronic alcohol injection mouse model,we found the hyperreactivity of astrocytes along with dendritic spine loss plus lower neuronal activity in the primary motor cortex.Persistent treadmill exercise training,on the other hand,improved neural spine formation and inhibited reactive astrocytes,alleviating motor learning deficits induced by alcohol exposure.These data collectively support the potency of endurance exercise in the rehabilitation of motor functions under alcohol abuse.
基金funded by Hong Kong Polytechnic University under grand number P0047740.
文摘The informativeness of environmental,social,and governance(ESG)scores and their actual impact on firms remains understudied.To address this gap in the literature,we make theoretical predictions and conduct empirical research revealing that a high ESG score is associated with a lower probability of ESG scandals and lower stock returns during a scandal event.Our results suggest that ESG scores are heterogeneous but informative,and that a strong ESG reputation may have both positive and negative consequences for firms.Drawing on our findings,we develop a model and showcase that firms face an optimization problem when determining optimal ESG investment levels.Two equilibria may exist based on the trade-off between ESG scandal losses and ESG adjustment costs.Our model explains why certain firms make heterogeneous ESG decisions.
基金The Vietnam National Foundation for Science and Technology Development(NAFOSTED)and the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(Grant No.NRF-2022R1A2C1012996)。
文摘Environmental pollution,such as water contamination,is a critical issue that must be absolutely addressed.Here,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple hydrothermal method by changing the solvents(H_(2)O,DMF,aqueous HCl solution).The as-prepared nanocatalysts have excellent thermal stability,large porosity,and high hydrophilicity.The results show all materials have good photocatalytic activity in aqueous media,with WO_(3)/WS_(2)nanorods(NRs)having the best activity in the photodegradation of bisphenol A(BPA)under visible-light irradiation.This may originate from increased migration of charge carriers and effective prevention of electron–hole recombination in WO_(3)/WS_(2)NRs,whereby this photocatalyst is able to generate more reactive·OH and·O_(2)^(–)species,leading to greater photocatalytic activity.About 99.6% of BPA is photodegraded within 60 min when using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at pH 7.0.Additionally,the optimal conditions(pH,catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately investigated.These rod-like heterostructures are expressed as potential catalysts with excellent photostability,efficient reusability,and highly active effectivity in different types of water.In particular,the removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reaches 89.1%in contaminated lake water.This study provides promising insights for the nearly complete removal of BPA from wastewater or different water resources,which is advantageous to various applications in environmental remediation.
基金funded by a Croucher Innovation Award(CIA20CU01)from the Croucher Foundationthe General Research Fund(14100122)+4 种基金the Collaborative Research Fund(C6027-19GF&C7074-21GF)the Area of Excellence Scheme(AoE/M-604/16)of the Research Grants Councilthe University Grants Committee of Hong Kong,Chinathe Excellent Young Scientists Fund(Hong Kong and Macao,China)(82122001)from the National Natural Science Foundation of Chinathe Lo’s Family Charity Fund Limited(all to HK).
文摘Precise chemical cue presentation alongside advanced brainwide imaging techniques is important to the study of chemosensory processing in animals.Nevertheless,the dynamic nature of chemical-carrying media,such as water or air,poses a significant challenge for delivering highly-controlled chemical flow to an animal subject.Moreover,contact-based cue manipulation and delivery easily shift the position of the animal subject,which is often undesirable for high-quality brain imaging.Additionally,more advanced interfacing tools that align with the diverse range of body part sizes of an animal,ranging from micrometer-scale neurons to meter-long limbs,are much needed.This is particularly crucial when dealing with dimensions that are beyond the reach of conventional experimental tools.
