In this research work, atomic and molecular orbitals based analysis has been made to see electronic structure of platinum halides (platinum dichloride, platinum dibromide, platinum diiodide and platinum difluride). Th...In this research work, atomic and molecular orbitals based analysis has been made to see electronic structure of platinum halides (platinum dichloride, platinum dibromide, platinum diiodide and platinum difluride). The geometry optimization and three dimensional (3D) modeling of the above mentioned species have been made on CAChe pro software. The results show: (i) The involvement of three p atomic orbitals is negligible as their summation values are very low in comparison to d orbital and considerably low with respect to s orbital. (ii) The study well support the Landis concepts of sdn-hybridation (here n = 1) as bond angle and contributions of s-orbital and d-orbital of Pt(II) are maximum with negligible contribution of p-orbitals. (iii) These halides also support the cloud-expanding effect with experimental data and also follow the nephelauxetic effect. The result is in good agreement with experiment results that covalent character increases in the order: PtI2 > PtBr2 > PtCl2 > PtF2. (iv) And thus the study will help to fine tune the existing complexes of these halides.展开更多
The cloud data centres evolved with an issue of energy management due to the constant increase in size,complexity and enormous consumption of energy.Energy management is a challenging issue that is critical in cloud d...The cloud data centres evolved with an issue of energy management due to the constant increase in size,complexity and enormous consumption of energy.Energy management is a challenging issue that is critical in cloud data centres and an important concern of research for many researchers.In this paper,we proposed a cuckoo search(CS)-based optimisation technique for the virtual machine(VM)selection and a novel placement algorithm considering the different constraints.The energy consumption model and the simulation model have been implemented for the efficient selection of VM.The proposed model CSOA-VM not only lessens the violations at the service level agreement(SLA)level but also minimises the VM migrations.The proposed model also saves energy and the performance analysis shows that energy consumption obtained is 1.35 kWh,SLA violation is 9.2 and VM migration is about 268.Thus,there is an improvement in energy consumption of about 1.8%and a 2.1%improvement(reduction)in violations of SLA in comparison to existing techniques.展开更多
A total of 393 potholes(368 fluvial and 25 marine potholes)were studied at seven different sites in both the fluvial and marine environments.Diverse bedrock properties and large-scale delivery of tools and grinders re...A total of 393 potholes(368 fluvial and 25 marine potholes)were studied at seven different sites in both the fluvial and marine environments.Diverse bedrock properties and large-scale delivery of tools and grinders regulate the dynamic growth,truncation,and amalgamation of potholes.Therefore,the principal objectives of the study are(i)to examine the relationship between the growth of potholes and substrate lithological with structural characteristics(applying geospatial and Schmidt hammer for rock strength analysis)and(ii)to measure the morphology,and size of tools and grinders,processes of truncation and amalgamation in hydro-geomorphic environment using various indices and field techniques.The result showed that large potholes are stretched in the direction of lineament axes and roughly parallel to the river flow direction.Here,the steady growth of pothole depth-diameter is controlled by active bedrock structures,tools,or grinders,and monsoonal high-velocity bank full discharge.Consequently,the deepening and widening of potholes are relatively slow at Bindu,Deuli,and marine beach Neil Island due to fewer structures and little supply of tools or grinders.In small stretches,(Damodar,Subarnarekha,and Rarhu)canyons and gorge-like features(bedrock incision)are formed at Rajrappa,Bhakuyadi,and Guridih sites due to cyclic truncation and amalgamation.Truncation and amalgamation processes restrict the vertical depth threshold value of potholes within 3m,particularly at Rajrappa,Bhakuyadi,and Guridih sites.Scientific study of the pothole's dynamic growth is greatly necessary for the different environmental engineering and river hydraulic projects like excavation,dredging,and dam or barrage construction.Successively,it is essential to compute the cost of rock excavation or dredging,primarily for the mechanical strength of the bedrock river channel and its stability.展开更多
With cloud computing,large chunks of data can be handled at a small cost.However,there are some reservations regarding the security and privacy of cloud data stored.For solving these issues and enhancing cloud computi...With cloud computing,large chunks of data can be handled at a small cost.However,there are some reservations regarding the security and privacy of cloud data stored.For solving these issues and enhancing cloud computing security,this research provides a Three-Layered Security Access model(TLSA)aligned to an intrusion detection mechanism,access control mechanism,and data encryption system.The TLSA underlines the need for the protection of sensitive data.This proposed approach starts with Layer 1 data encryption using the Advanced Encryption Standard(AES).For data transfer and storage,this encryption guarantees the data’s authenticity and secrecy.Surprisingly,the solution employs the AES encryption algorithm to secure essential data before storing them in the Cloud to minimize unauthorized access.Role-based access control(RBAC)implements the second strategic level,which ensures specific personnel access certain data and resources.In RBAC,each user is allowed a specific role and Permission.This implies that permitted users can access some data stored in the Cloud.This layer assists in filtering granular access to data,reducing the risk that undesired data will be discovered during the process.Layer 3 deals with intrusion detection systems(IDS),which detect and quickly deal with malicious actions and intrusion attempts.The proposed TLSA security model of e-commerce includes conventional levels of security,such as encryption and access control,and encloses an insight intrusion detection system.This method offers integrated solutions for most typical security issues of cloud computing,including data secrecy,method of access,and threats.An extensive performance test was carried out to confirm the efficiency of the proposed three-tier security method.Comparisons have been made with state-of-art techniques,including DES,RSA,and DUAL-RSA,keeping into account Accuracy,QILV,F-Measure,Sensitivity,MSE,PSNR,SSIM,and computation time,encryption time,and decryption time.The proposed TLSA method provides an accuracy of 89.23%,F-Measure of 0.876,and SSIM of 0.8564 at a computation time of 5.7 s.A comparison with existing methods shows the better performance of the proposed method,thus confirming the enhanced ability to address security issues in cloud computing.展开更多
During its growth stage,the plant is exposed to various diseases.Detection and early detection of crop diseases is amajor challenge in the horticulture industry.Crop infections can harmtotal crop yield and reduce farm...During its growth stage,the plant is exposed to various diseases.Detection and early detection of crop diseases is amajor challenge in the horticulture industry.Crop infections can harmtotal crop yield and reduce farmers’income if not identified early.Today’s approved method involves a professional plant pathologist to diagnose the disease by visual inspection of the afflicted plant leaves.This is an excellent use case for Community Assessment and Treatment Services(CATS)due to the lengthy manual disease diagnosis process and the accuracy of identification is directly proportional to the skills of pathologists.An alternative to conventional Machine Learning(ML)methods,which require manual identification of parameters for exact results,is to develop a prototype that can be classified without pre-processing.To automatically diagnose tomato leaf disease,this research proposes a hybrid model using the Convolutional Auto-Encoders(CAE)network and the CNN-based deep learning architecture of DenseNet.To date,none of the modern systems described in this paper have a combined model based on DenseNet,CAE,and ConvolutionalNeuralNetwork(CNN)todiagnose the ailments of tomato leaves automatically.Themodelswere trained on a dataset obtained from the Plant Village repository.The dataset consisted of 9920 tomato leaves,and the model-tomodel accuracy ratio was 98.35%.Unlike other approaches discussed in this paper,this hybrid strategy requires fewer training components.Therefore,the training time to classify plant diseases with the trained algorithm,as well as the training time to automatically detect the ailments of tomato leaves,is significantly reduced.展开更多
This review summarizes the breakthrough studies on diabetes management in pregnancy presented at the 84th American Diabetes Association Scientific Sessions,encompassing 31 presentations,categorized into basic science,...This review summarizes the breakthrough studies on diabetes management in pregnancy presented at the 84th American Diabetes Association Scientific Sessions,encompassing 31 presentations,categorized into basic science,clinical studies,therapeutic interventions,and maternal/neonatal outcomes.Basic science investigations reported the enduring impact of gestational diabetes mellitus on offspring adiposity,neurodevelopment,transgenerational metabolic risk,and key insights onβ-cell functioning and islet dysfunctioning.Clinical studies explored novel diagnostic and monitoring approaches,highlighting the potential of continuous glucose monitoring for early detection,risk prediction,and personalized management.Therapeutic interventions demonstrated the efficacy of glucagon-like peptide 1 agonists in preventing cognitive deficits in offspring.Maternal and neonatal health studies emphasized the critical role of optimal glycemic control,early gestational diabetes mellitus intervention,and risk stratification utilizing HbA1c and electronic heart records.展开更多
AIM: To study the role of retrograde terminal ileoscopy in patients suspected to have ileocolonic tuberculosis. METHODS: A retrospective analysis was performed for patients undergoing colonoscopy for suspected ileocol...AIM: To study the role of retrograde terminal ileoscopy in patients suspected to have ileocolonic tuberculosis. METHODS: A retrospective analysis was performed for patients undergoing colonoscopy for suspected ileocolonic tuberculosis between January 2000 and June 2004, in whom retrograde ileoscopy had been performed. Only patients diagnosed with tuberculosis on the basis of histological findings of either a caseating granuloma or those having non-caseating granuloma or a collection of epithelioid cells at a minimum of one endoscopic lesion (either in the colon or the terminal ileum) on histology with good responses to conventional anti-tuberculous drugs were enrolled for the study. RESULTS: Fifty-three patients were included. The terminal ileum was involved in only 11 patients. Eight of these patients had involvement of the cecum too. Two patients had ileal lesions without cecal involvement; however, lesions were noted in the ascending colon. In one patient the whole colon was normal and only the terminal ileum showed nodularity and ulceration. Histological examination of the ileal biopsies obtained from the ileal lesions showed noncaseating granulomas in five, collection of epithelioid cells in four and nonspecific histology in two patients. Mucosal biopsies obtained from the lesion in the terminal ileum, in the patient in whom mucosal abnormality was observed to be confined to the ileum, showed noncaseating granulomas. In two other patients the ileal biopsies alone showed histological evidence of tuberculosis with biopsies from the colonic lesions showing non-specific inflammatory changes only. CONCLUSION: Retrograde ileoscopy should be performed in all patients undergoing colonoscopy for suspected ileocolonic tuberculosis. In some patients only the terminal ileum may be involved and histological examination may reveal evidence of tuberculosis only from the lesions in the terminal ileum. This approach would lead to additional lesions being picked up andincreasing the chances of well-timed diagnosis of tuberculosis.展开更多
Helicobacter pylori (H. pylori) is a gram negative microaerophilic bacterium which resides in the mucous linings of the stomach. It has been implicated in the causation of various gastric disorders including gastric c...Helicobacter pylori (H. pylori) is a gram negative microaerophilic bacterium which resides in the mucous linings of the stomach. It has been implicated in the causation of various gastric disorders including gastric cancer. The geographical distribution and etiology of gastric cancer differ widely in different geographical regions and H. pylori, despite being labeled as a grade I carcinogen, has not been found to be associated with gastric cancer in many areas. Studies in Asian countries such as Thailand, India, Bangladesh, Pakistan, Iran, Saudi Arabian countries, Israel and Malaysia, have reported a high frequency of H. pylori infection co-existing with a low incidence of gastric cancer. In India, a difference in the prevalence of H. pylori infection and gastric cancer has been noted even in different regions of the country leading to a puzzle when attempting to find the causes of these variations. This puzzle of H. pylori distribution and gastric cancer epidemiology is known as the Indian enigma. In this review we have attempted to explain the Indian enigma using evidence from various Indian studies and from around the globe. This review covers aspects of epidemiology, the various biological strains present in different parts of the country and within individuals, the status of different H. pylori-related diseases and the molecular pathogenesis of the bacterium.展开更多
AIM. To assess the causes of ileocecal mass in patients with amebic liver abscess. METHODS： Patients with amebic liver abscess and ileocecal mass were carefully examined and investigated by contrast-enhanced CT scan ...AIM. To assess the causes of ileocecal mass in patients with amebic liver abscess. METHODS： Patients with amebic liver abscess and ileocecal mass were carefully examined and investigated by contrast-enhanced CT scan followed by colonoscopy and histological examination of biopsy materials from lesions during colonoscopy. RESULTS： Ileocecal masses were found in seventeen patients with amebic liver abscess. The cause of the mass was ameboma in 14 patients, cecal tuberculosis in 2 patients and adenocarcinoma of the cecum in 1 patient. Colonic ulcers were noted in five of the six （83%） patients with active diarrhea at presentation. The ileocecal mass in all these patients was ameboma. Ulcers were seen in only one of the 11 （9%） patients without diarrhea. The difference was statistically significant from the group with diarrhea （P〈 0.005）. CONCLUSION： Ileocecal mass is not an uncommon finding in patients with amebic liver abscess. Although, the ileocecal mass is due to ameboma formation in most cases, it should not be assumed that this is the case in all patients. Colonoscopy and histological examination of the target biopsies are mandatory to avoid missing a more sinister lesion.展开更多
Rice bran oil(RBO)is unique among edible vegetable oils because of its unique fatty acid composition,phenolic compound(γ-oryzanol,ferulic acid)and vitamin E(tocopherol and tocotrienol).It has become a great choice of...Rice bran oil(RBO)is unique among edible vegetable oils because of its unique fatty acid composition,phenolic compound(γ-oryzanol,ferulic acid)and vitamin E(tocopherol and tocotrienol).It has become a great choice of cooking oil because of its very high burning point,neutral taste and delicate flavour.Non-conventional methods of RBO extraction are more efficient and environmentally friendly than conventional extraction methods.Advances in RBO extraction using innovative extraction strategies like super/sub-critical CO_(2),microwave-assisted,subcritical H_(2)O,enzyme-assisted aqueous and ultrasoundassisted aqueous extraction methods have proven to significantly improve the yields along with improved nutritional profile of RBO.The compositions and strategies for stabilization of RBO are well discussed.The constituents are present in the RBO contribute to antioxidative,anti-inflammatory,antimicrobial,antidiabetic and anti-cancerous properties to RBO.This has helped RBO to become an important substrate for the application in food(cooking oil,milk product and meat product)and non-food industries(polymer,lubricant,biofuel,structural lipid and cosmetic).This review provided comprehensive information on RBO extraction methods,oil stabilization,existing applications and health benefits.展开更多
AIM： To assess the role of retrograde terminal ileoscopy in hematochezia patients with normal colonoscopy. METHODS： Between January 1997 and March 2005, 39 hematochezia patients （males 36, females 3, mean age 44.7 ...AIM： To assess the role of retrograde terminal ileoscopy in hematochezia patients with normal colonoscopy. METHODS： Between January 1997 and March 2005, 39 hematochezia patients （males 36, females 3, mean age 44.7 years） with a reported normal colonoscopy underwent a repeat colonoscopy. After reaching the cecum, attempt was made to localize the ileocecal valve and intubate the terminal ileum. Any abnormality in the mucosa of the terminal ileum was carefully recorded and biopsies were obtained from suspiciouslooking lesions. RESULTS： During the study period there were 39 patients admitted for hematochezia in whom colonoscopy till cecum did not reveal any abnormality. Fulllength colonoscopy till the cecum could be performed in all the patients. The terminal ileum could be intubated in 36 patients. No abnormality was noted in 31 patients. Ileal ulcers were noted in two patients. Noclularity along with ulceration of the ileal mucosa, a Dieulafoy＇s lesion, and an angiomatous malformation were noted in one patient each. Histological examination of the biopsies obtained from the ulcers revealed typical tuberculous lesion in the patient with nodularity and ulceration. One of the patients had typhoid ulcers and another had non-specific ulcers. CONCLUSION： Retrograde terminal ileoscopy gives limited but valuable information, in patients with hematochezia and should be attempted in all such patients.展开更多
Objective:To evaluate antidiabetic activity of chloroform extracts of Acacia arabica bark, Benincasa hispida fruit,Tinispora cordifolia stem,Ocimum sanctum areal parts and Jatropha curcus leaves.Methods:The chloroform...Objective:To evaluate antidiabetic activity of chloroform extracts of Acacia arabica bark, Benincasa hispida fruit,Tinispora cordifolia stem,Ocimum sanctum areal parts and Jatropha curcus leaves.Methods:The chloroform extracts of Acacia arabica bark,Benincasa hispida fruit,Tinospora cordifolia stem,aerial part of Ocimum sanctum and Jatropha curcus leaves were evaluated at different doses(250 and 500 mg/kg body weight.) for antidiabetic potentials in alloxan induced diabetic albino rats.The extracts were administered for two weeks in different groups whereas tolbutamide(80 mg/kg body weight) was used as reference standard throughout study.Results:The result of present study showed test compounds significantly decreases elevated level of serum glucose and also caused to reverse the cholesterol,triglyceride,HDL and LDL values when compared to untreated diabetic rats.Conclusions:Our finding indicates that different test extracts were able to ameliorate the derangements in lipid metabolism caused by diabetes mellitus in alloxan induced diabetic rats towards normal level.展开更多
Objective:To isolate and characterize antidiabetic component（bioactivity-guided fractionation） from hydro alcoholic extract of Ocimum sanctum（O.sanctum） aerial part.Methods:Ten fractions（F1 - F10） were isolated ...Objective:To isolate and characterize antidiabetic component（bioactivity-guided fractionation） from hydro alcoholic extract of Ocimum sanctum（O.sanctum） aerial part.Methods:Ten fractions（F1 - F10） were isolated from hydro alcoholic extract of O.sanctum aerial part by column chromatography.All the fractions Fl to F10 were screened for antidiabetic activity in alloxan induced diabetic rats by estimating serum glucose level and lipid parameters.The isolated bioactive component was elucidated on the basis of extensive spectroscopic(UV,IR,MS,<sup>1</sup>H and <sup>13</sup>C NMR) data analysis.Results:The bioactive fraction（F5） was found to be potent antidiabetic by ameliorating glucose and lipid parameters（total cholesterol,triglycerides,low and high density lipoprotein cholesterol）.The extensive spectroscopic data analysis reveals that,the isolated bioactive compound elucidated as tetracyclic triterpenoid[16-Hydroxy-4,4,10,13-tetramethyl- 17-（4-methyI-pentyl）-hexadecahydro-cyclopenta[a]phenanthren-3-one].Conclusions:Our present study concluded that,tetracyclic triterpenoid isolated from aerial part of O.sanctum has a great anti-diabetic potential.展开更多
COVID-19,being the virus of fear and anxiety,is one of the most recent and emergent of various respiratory disorders.It is similar to the MERS-COV and SARS-COV,the viruses that affected a large population of different...COVID-19,being the virus of fear and anxiety,is one of the most recent and emergent of various respiratory disorders.It is similar to the MERS-COV and SARS-COV,the viruses that affected a large population of different countries in the year 2012 and 2002,respectively.Various standard models have been used for COVID-19 epidemic prediction but they suffered from low accuracy due to lesser data availability and a high level of uncertainty.The proposed approach used a machine learning-based time-series Facebook NeuralProphet model for prediction of the number of death as well as confirmed cases and compared it with Poisson Distribution,and Random Forest Model.The analysis upon dataset has been performed considering the time duration from January 1st 2020 to16th July 2021.The model has been developed to obtain the forecast values till September 2021.This study aimed to determine the pandemic prediction of COVID-19 in the second wave of coronavirus in India using the latest Time-Series model to observe and predict the coronavirus pandemic situation across the country.In India,the cases are rapidly increasing day-by-day since mid of Feb 2021.The prediction of death rate using the proposed model has a good ability to forecast the COVID-19 dataset essentially in the second wave.To empower the prediction for future validation,the proposed model works effectively.展开更多
文摘In this research work, atomic and molecular orbitals based analysis has been made to see electronic structure of platinum halides (platinum dichloride, platinum dibromide, platinum diiodide and platinum difluride). The geometry optimization and three dimensional (3D) modeling of the above mentioned species have been made on CAChe pro software. The results show: (i) The involvement of three p atomic orbitals is negligible as their summation values are very low in comparison to d orbital and considerably low with respect to s orbital. (ii) The study well support the Landis concepts of sdn-hybridation (here n = 1) as bond angle and contributions of s-orbital and d-orbital of Pt(II) are maximum with negligible contribution of p-orbitals. (iii) These halides also support the cloud-expanding effect with experimental data and also follow the nephelauxetic effect. The result is in good agreement with experiment results that covalent character increases in the order: PtI2 > PtBr2 > PtCl2 > PtF2. (iv) And thus the study will help to fine tune the existing complexes of these halides.
文摘The cloud data centres evolved with an issue of energy management due to the constant increase in size,complexity and enormous consumption of energy.Energy management is a challenging issue that is critical in cloud data centres and an important concern of research for many researchers.In this paper,we proposed a cuckoo search(CS)-based optimisation technique for the virtual machine(VM)selection and a novel placement algorithm considering the different constraints.The energy consumption model and the simulation model have been implemented for the efficient selection of VM.The proposed model CSOA-VM not only lessens the violations at the service level agreement(SLA)level but also minimises the VM migrations.The proposed model also saves energy and the performance analysis shows that energy consumption obtained is 1.35 kWh,SLA violation is 9.2 and VM migration is about 268.Thus,there is an improvement in energy consumption of about 1.8%and a 2.1%improvement(reduction)in violations of SLA in comparison to existing techniques.
文摘A total of 393 potholes(368 fluvial and 25 marine potholes)were studied at seven different sites in both the fluvial and marine environments.Diverse bedrock properties and large-scale delivery of tools and grinders regulate the dynamic growth,truncation,and amalgamation of potholes.Therefore,the principal objectives of the study are(i)to examine the relationship between the growth of potholes and substrate lithological with structural characteristics(applying geospatial and Schmidt hammer for rock strength analysis)and(ii)to measure the morphology,and size of tools and grinders,processes of truncation and amalgamation in hydro-geomorphic environment using various indices and field techniques.The result showed that large potholes are stretched in the direction of lineament axes and roughly parallel to the river flow direction.Here,the steady growth of pothole depth-diameter is controlled by active bedrock structures,tools,or grinders,and monsoonal high-velocity bank full discharge.Consequently,the deepening and widening of potholes are relatively slow at Bindu,Deuli,and marine beach Neil Island due to fewer structures and little supply of tools or grinders.In small stretches,(Damodar,Subarnarekha,and Rarhu)canyons and gorge-like features(bedrock incision)are formed at Rajrappa,Bhakuyadi,and Guridih sites due to cyclic truncation and amalgamation.Truncation and amalgamation processes restrict the vertical depth threshold value of potholes within 3m,particularly at Rajrappa,Bhakuyadi,and Guridih sites.Scientific study of the pothole's dynamic growth is greatly necessary for the different environmental engineering and river hydraulic projects like excavation,dredging,and dam or barrage construction.Successively,it is essential to compute the cost of rock excavation or dredging,primarily for the mechanical strength of the bedrock river channel and its stability.
基金funded by UKRI EPSRC Grant EP/W020408/1 Project SPRITE+2:The Security,Privacy,Identity and Trust Engagement Network plus(phase 2)for this studyThe authors also have been funded by PhD project RS718 on Explainable AI through UKRI EPSRC Grant funded Doctoral Training Centre at Swansea University.
文摘With cloud computing,large chunks of data can be handled at a small cost.However,there are some reservations regarding the security and privacy of cloud data stored.For solving these issues and enhancing cloud computing security,this research provides a Three-Layered Security Access model(TLSA)aligned to an intrusion detection mechanism,access control mechanism,and data encryption system.The TLSA underlines the need for the protection of sensitive data.This proposed approach starts with Layer 1 data encryption using the Advanced Encryption Standard(AES).For data transfer and storage,this encryption guarantees the data’s authenticity and secrecy.Surprisingly,the solution employs the AES encryption algorithm to secure essential data before storing them in the Cloud to minimize unauthorized access.Role-based access control(RBAC)implements the second strategic level,which ensures specific personnel access certain data and resources.In RBAC,each user is allowed a specific role and Permission.This implies that permitted users can access some data stored in the Cloud.This layer assists in filtering granular access to data,reducing the risk that undesired data will be discovered during the process.Layer 3 deals with intrusion detection systems(IDS),which detect and quickly deal with malicious actions and intrusion attempts.The proposed TLSA security model of e-commerce includes conventional levels of security,such as encryption and access control,and encloses an insight intrusion detection system.This method offers integrated solutions for most typical security issues of cloud computing,including data secrecy,method of access,and threats.An extensive performance test was carried out to confirm the efficiency of the proposed three-tier security method.Comparisons have been made with state-of-art techniques,including DES,RSA,and DUAL-RSA,keeping into account Accuracy,QILV,F-Measure,Sensitivity,MSE,PSNR,SSIM,and computation time,encryption time,and decryption time.The proposed TLSA method provides an accuracy of 89.23%,F-Measure of 0.876,and SSIM of 0.8564 at a computation time of 5.7 s.A comparison with existing methods shows the better performance of the proposed method,thus confirming the enhanced ability to address security issues in cloud computing.
基金funded by UKRI EPSRC Grant EP/W020408/1 Project SPRITE+2:The Security,Privacy,Identity,and Trust Engagement Network plus(phase 2)for this studyfunded by PhD project RS718 on Explainable AI through the UKRI EPSRC Grant-funded Doctoral Training Centre at Swansea University.
文摘During its growth stage,the plant is exposed to various diseases.Detection and early detection of crop diseases is amajor challenge in the horticulture industry.Crop infections can harmtotal crop yield and reduce farmers’income if not identified early.Today’s approved method involves a professional plant pathologist to diagnose the disease by visual inspection of the afflicted plant leaves.This is an excellent use case for Community Assessment and Treatment Services(CATS)due to the lengthy manual disease diagnosis process and the accuracy of identification is directly proportional to the skills of pathologists.An alternative to conventional Machine Learning(ML)methods,which require manual identification of parameters for exact results,is to develop a prototype that can be classified without pre-processing.To automatically diagnose tomato leaf disease,this research proposes a hybrid model using the Convolutional Auto-Encoders(CAE)network and the CNN-based deep learning architecture of DenseNet.To date,none of the modern systems described in this paper have a combined model based on DenseNet,CAE,and ConvolutionalNeuralNetwork(CNN)todiagnose the ailments of tomato leaves automatically.Themodelswere trained on a dataset obtained from the Plant Village repository.The dataset consisted of 9920 tomato leaves,and the model-tomodel accuracy ratio was 98.35%.Unlike other approaches discussed in this paper,this hybrid strategy requires fewer training components.Therefore,the training time to classify plant diseases with the trained algorithm,as well as the training time to automatically detect the ailments of tomato leaves,is significantly reduced.
文摘This review summarizes the breakthrough studies on diabetes management in pregnancy presented at the 84th American Diabetes Association Scientific Sessions,encompassing 31 presentations,categorized into basic science,clinical studies,therapeutic interventions,and maternal/neonatal outcomes.Basic science investigations reported the enduring impact of gestational diabetes mellitus on offspring adiposity,neurodevelopment,transgenerational metabolic risk,and key insights onβ-cell functioning and islet dysfunctioning.Clinical studies explored novel diagnostic and monitoring approaches,highlighting the potential of continuous glucose monitoring for early detection,risk prediction,and personalized management.Therapeutic interventions demonstrated the efficacy of glucagon-like peptide 1 agonists in preventing cognitive deficits in offspring.Maternal and neonatal health studies emphasized the critical role of optimal glycemic control,early gestational diabetes mellitus intervention,and risk stratification utilizing HbA1c and electronic heart records.
文摘AIM: To study the role of retrograde terminal ileoscopy in patients suspected to have ileocolonic tuberculosis. METHODS: A retrospective analysis was performed for patients undergoing colonoscopy for suspected ileocolonic tuberculosis between January 2000 and June 2004, in whom retrograde ileoscopy had been performed. Only patients diagnosed with tuberculosis on the basis of histological findings of either a caseating granuloma or those having non-caseating granuloma or a collection of epithelioid cells at a minimum of one endoscopic lesion (either in the colon or the terminal ileum) on histology with good responses to conventional anti-tuberculous drugs were enrolled for the study. RESULTS: Fifty-three patients were included. The terminal ileum was involved in only 11 patients. Eight of these patients had involvement of the cecum too. Two patients had ileal lesions without cecal involvement; however, lesions were noted in the ascending colon. In one patient the whole colon was normal and only the terminal ileum showed nodularity and ulceration. Histological examination of the ileal biopsies obtained from the ileal lesions showed noncaseating granulomas in five, collection of epithelioid cells in four and nonspecific histology in two patients. Mucosal biopsies obtained from the lesion in the terminal ileum, in the patient in whom mucosal abnormality was observed to be confined to the ileum, showed noncaseating granulomas. In two other patients the ileal biopsies alone showed histological evidence of tuberculosis with biopsies from the colonic lesions showing non-specific inflammatory changes only. CONCLUSION: Retrograde ileoscopy should be performed in all patients undergoing colonoscopy for suspected ileocolonic tuberculosis. In some patients only the terminal ileum may be involved and histological examination may reveal evidence of tuberculosis only from the lesions in the terminal ileum. This approach would lead to additional lesions being picked up andincreasing the chances of well-timed diagnosis of tuberculosis.
文摘Helicobacter pylori (H. pylori) is a gram negative microaerophilic bacterium which resides in the mucous linings of the stomach. It has been implicated in the causation of various gastric disorders including gastric cancer. The geographical distribution and etiology of gastric cancer differ widely in different geographical regions and H. pylori, despite being labeled as a grade I carcinogen, has not been found to be associated with gastric cancer in many areas. Studies in Asian countries such as Thailand, India, Bangladesh, Pakistan, Iran, Saudi Arabian countries, Israel and Malaysia, have reported a high frequency of H. pylori infection co-existing with a low incidence of gastric cancer. In India, a difference in the prevalence of H. pylori infection and gastric cancer has been noted even in different regions of the country leading to a puzzle when attempting to find the causes of these variations. This puzzle of H. pylori distribution and gastric cancer epidemiology is known as the Indian enigma. In this review we have attempted to explain the Indian enigma using evidence from various Indian studies and from around the globe. This review covers aspects of epidemiology, the various biological strains present in different parts of the country and within individuals, the status of different H. pylori-related diseases and the molecular pathogenesis of the bacterium.
文摘AIM. To assess the causes of ileocecal mass in patients with amebic liver abscess. METHODS： Patients with amebic liver abscess and ileocecal mass were carefully examined and investigated by contrast-enhanced CT scan followed by colonoscopy and histological examination of biopsy materials from lesions during colonoscopy. RESULTS： Ileocecal masses were found in seventeen patients with amebic liver abscess. The cause of the mass was ameboma in 14 patients, cecal tuberculosis in 2 patients and adenocarcinoma of the cecum in 1 patient. Colonic ulcers were noted in five of the six （83%） patients with active diarrhea at presentation. The ileocecal mass in all these patients was ameboma. Ulcers were seen in only one of the 11 （9%） patients without diarrhea. The difference was statistically significant from the group with diarrhea （P〈 0.005）. CONCLUSION： Ileocecal mass is not an uncommon finding in patients with amebic liver abscess. Although, the ileocecal mass is due to ameboma formation in most cases, it should not be assumed that this is the case in all patients. Colonoscopy and histological examination of the target biopsies are mandatory to avoid missing a more sinister lesion.
文摘Rice bran oil(RBO)is unique among edible vegetable oils because of its unique fatty acid composition,phenolic compound(γ-oryzanol,ferulic acid)and vitamin E(tocopherol and tocotrienol).It has become a great choice of cooking oil because of its very high burning point,neutral taste and delicate flavour.Non-conventional methods of RBO extraction are more efficient and environmentally friendly than conventional extraction methods.Advances in RBO extraction using innovative extraction strategies like super/sub-critical CO_(2),microwave-assisted,subcritical H_(2)O,enzyme-assisted aqueous and ultrasoundassisted aqueous extraction methods have proven to significantly improve the yields along with improved nutritional profile of RBO.The compositions and strategies for stabilization of RBO are well discussed.The constituents are present in the RBO contribute to antioxidative,anti-inflammatory,antimicrobial,antidiabetic and anti-cancerous properties to RBO.This has helped RBO to become an important substrate for the application in food(cooking oil,milk product and meat product)and non-food industries(polymer,lubricant,biofuel,structural lipid and cosmetic).This review provided comprehensive information on RBO extraction methods,oil stabilization,existing applications and health benefits.
文摘AIM： To assess the role of retrograde terminal ileoscopy in hematochezia patients with normal colonoscopy. METHODS： Between January 1997 and March 2005, 39 hematochezia patients （males 36, females 3, mean age 44.7 years） with a reported normal colonoscopy underwent a repeat colonoscopy. After reaching the cecum, attempt was made to localize the ileocecal valve and intubate the terminal ileum. Any abnormality in the mucosa of the terminal ileum was carefully recorded and biopsies were obtained from suspiciouslooking lesions. RESULTS： During the study period there were 39 patients admitted for hematochezia in whom colonoscopy till cecum did not reveal any abnormality. Fulllength colonoscopy till the cecum could be performed in all the patients. The terminal ileum could be intubated in 36 patients. No abnormality was noted in 31 patients. Ileal ulcers were noted in two patients. Noclularity along with ulceration of the ileal mucosa, a Dieulafoy＇s lesion, and an angiomatous malformation were noted in one patient each. Histological examination of the biopsies obtained from the ulcers revealed typical tuberculous lesion in the patient with nodularity and ulceration. One of the patients had typhoid ulcers and another had non-specific ulcers. CONCLUSION： Retrograde terminal ileoscopy gives limited but valuable information, in patients with hematochezia and should be attempted in all such patients.
文摘Objective:To evaluate antidiabetic activity of chloroform extracts of Acacia arabica bark, Benincasa hispida fruit,Tinispora cordifolia stem,Ocimum sanctum areal parts and Jatropha curcus leaves.Methods:The chloroform extracts of Acacia arabica bark,Benincasa hispida fruit,Tinospora cordifolia stem,aerial part of Ocimum sanctum and Jatropha curcus leaves were evaluated at different doses(250 and 500 mg/kg body weight.) for antidiabetic potentials in alloxan induced diabetic albino rats.The extracts were administered for two weeks in different groups whereas tolbutamide(80 mg/kg body weight) was used as reference standard throughout study.Results:The result of present study showed test compounds significantly decreases elevated level of serum glucose and also caused to reverse the cholesterol,triglyceride,HDL and LDL values when compared to untreated diabetic rats.Conclusions:Our finding indicates that different test extracts were able to ameliorate the derangements in lipid metabolism caused by diabetes mellitus in alloxan induced diabetic rats towards normal level.
文摘Objective:To isolate and characterize antidiabetic component（bioactivity-guided fractionation） from hydro alcoholic extract of Ocimum sanctum（O.sanctum） aerial part.Methods:Ten fractions（F1 - F10） were isolated from hydro alcoholic extract of O.sanctum aerial part by column chromatography.All the fractions Fl to F10 were screened for antidiabetic activity in alloxan induced diabetic rats by estimating serum glucose level and lipid parameters.The isolated bioactive component was elucidated on the basis of extensive spectroscopic(UV,IR,MS,<sup>1</sup>H and <sup>13</sup>C NMR) data analysis.Results:The bioactive fraction（F5） was found to be potent antidiabetic by ameliorating glucose and lipid parameters（total cholesterol,triglycerides,low and high density lipoprotein cholesterol）.The extensive spectroscopic data analysis reveals that,the isolated bioactive compound elucidated as tetracyclic triterpenoid[16-Hydroxy-4,4,10,13-tetramethyl- 17-（4-methyI-pentyl）-hexadecahydro-cyclopenta[a]phenanthren-3-one].Conclusions:Our present study concluded that,tetracyclic triterpenoid isolated from aerial part of O.sanctum has a great anti-diabetic potential.
基金This work was supported by the Taif University Researchers supporting Project Number(TURSP-2020/254).
文摘COVID-19,being the virus of fear and anxiety,is one of the most recent and emergent of various respiratory disorders.It is similar to the MERS-COV and SARS-COV,the viruses that affected a large population of different countries in the year 2012 and 2002,respectively.Various standard models have been used for COVID-19 epidemic prediction but they suffered from low accuracy due to lesser data availability and a high level of uncertainty.The proposed approach used a machine learning-based time-series Facebook NeuralProphet model for prediction of the number of death as well as confirmed cases and compared it with Poisson Distribution,and Random Forest Model.The analysis upon dataset has been performed considering the time duration from January 1st 2020 to16th July 2021.The model has been developed to obtain the forecast values till September 2021.This study aimed to determine the pandemic prediction of COVID-19 in the second wave of coronavirus in India using the latest Time-Series model to observe and predict the coronavirus pandemic situation across the country.In India,the cases are rapidly increasing day-by-day since mid of Feb 2021.The prediction of death rate using the proposed model has a good ability to forecast the COVID-19 dataset essentially in the second wave.To empower the prediction for future validation,the proposed model works effectively.
