Strategies for achieving high-energy-density lithium-ion batteries include using high-capacity materials such as high-nickel NCM,increasing the active material content in the electrode by utilizing high-conductivity c...Strategies for achieving high-energy-density lithium-ion batteries include using high-capacity materials such as high-nickel NCM,increasing the active material content in the electrode by utilizing high-conductivity carbon nanotubes(CNT)conductive materials,and electrode thickening.However,these methods are still limited due to the limitation in the capacity of high-nickel NCM,aggregation of CNT conductive materials,and nonuniform material distribution of thick-film electrodes,which ultimately damage the mechanical and electrical integrity of the electrode,leading to a decrease in electrochemical performance.Here,we present an integrated binder-CNT composite dispersion solution to realize a high-solids-content(>77 wt%)slurry for high-mass-loading electrodes and to mitigate the migration of binder and conductive additives.Indeed,the approach reduces solvent usage by approximately 30%and ensures uniform conductive additive-binder domain distribution during electrode manufacturing,resulting in improved coating quality and adhesive strength for high-mass-loading electrodes(>12 mAh cm^(−2)).In terms of various electrode properties,the presented electrode showed low resistance and excellent electrochemical properties despite the low CNT contents of 0.6 wt%compared to the pristine-applied electrode with 0.85 wt%CNT contents.Moreover,our strategy enables faster drying,which increases the coating speed,thereby offering potential energy savings and supporting carbon neutrality in wet-based electrode manufacturing processes.展开更多
This paper describes a method for estimating the continuation of ore bodies at depth based on concentrationvolume(C-V)fractal modeling of the pyrite thermoelectric coefficient in the Pujon gold deposit,Democratic Peo...This paper describes a method for estimating the continuation of ore bodies at depth based on concentrationvolume(C-V)fractal modeling of the pyrite thermoelectric coefficient in the Pujon gold deposit,Democratic People’s Republic of Korea.The method is first established using data in the Kumjomdong area,a well-explored brownfield,and it is then applied to estimate the continuation of ore bodies at depth in the Pyongsandok area,a less-explored greenfield.The methodology consists of four steps:(1)3D modeling of ore bodies using surface geological mapping,mining tunnels in different levels,and a borehole dataset;(2)3D modeling of thermoelectricity coefficients from Au-bearing pyrites based on discrete smooth interpolation and C-V fractal techniques;(3)determination of levels used for calculation of the thermoelectric parameter of pyrite by C-V fractal modeling instead of traditional levels;and(4)determination of the thermoelectric parameter vertical gradient of pyrite reflecting the variation characteristics of pyrite thermoelectricity in the Pujon deposit.The results indicate that(1)pyrites in the Pujon deposit are dominantly P-type,and it is not reasonable to use traditional levels to calculate the thermoelectric parameter of pyrite;(2)thresholds determined by C-V fractal modeling can be used as levels to calculate the thermoelectric parameter of pyrite;(3)the thermoelectric parameter vertical gradient of pyrite ranges from 1 to 2 in the Pujon deposit;and(4)ore body Pyongsan No.9 extends 85 m to 235 m downward from the current borehole location.展开更多
The phenomenological and physically based models,using the true stress–true strain curve data obtained under various hot working conditions of 850–1200°C and 0.001–10 s−1,were developed and improved for AerMet...The phenomenological and physically based models,using the true stress–true strain curve data obtained under various hot working conditions of 850–1200°C and 0.001–10 s−1,were developed and improved for AerMet 100 ultra-high strength steel.The predictability of the developed constitutive models was verified and compared.The determination coefficient and average absolute relative error were 0.9988 and 3.72%for the improved version of the modified Zerilli–Armstrong model,0.9985 and 3.96%for the improved version of the modified Johnson–Cook model,0.9947 and 4.59%for the strain-compensated Arrhenius-type model and 0.9913 and 5.43%for the improved Khan–Huang–Liang model,respectively.The results showed that the improved versions of the modified Zerilli–Armstrong model have the best predictability among the studied constitutive models.Comparing the predictability before and after the improvement,the average absolute relative error was increased by 65.14%for the modified Zerilli–Armstrong model and 58.45%for the modified Johnson–Cook model.This indicates that the phenomenological improvement of physically based constitutive models allows us to develop effectively constitutive equations with high prediction accuracy.展开更多
In this paper,we propose a numerical calculation model of the multigroup neutron diffusion equation in 3D hexagonal geometry using the nodal Green's function method and verified it.We obtained one-dimensional tran...In this paper,we propose a numerical calculation model of the multigroup neutron diffusion equation in 3D hexagonal geometry using the nodal Green's function method and verified it.We obtained one-dimensional transverse integrated equations using the transverse integration procedure over 3D hexagonal geometry and denoted the solutions as a nodal Green's functions under the Neumann boundary condition.By applying a quadratic polynomial expansion of the transverse-averaged quantities,we derived the net neutron current coupling equation,equation for the expansion coefficients of the transverse-averaged neutron flux,and formulas for the coefficient matrix of these equations.We formulated the closed system of equations in correspondence with the boundary conditions.The proposed model was tested by comparing it with the benchmark for the VVER-440 reactor,and the numerical results were in good agreement with the reference solutions.展开更多
In this paper,a meshfree Jacobi point interpolation(MJPI)approach for the dynamic analysis of sandwich laminated conical and cylindrical shells with varying thickness is presented.The theoretical formulations for sand...In this paper,a meshfree Jacobi point interpolation(MJPI)approach for the dynamic analysis of sandwich laminated conical and cylindrical shells with varying thickness is presented.The theoretical formulations for sandwich laminated shells with varying thickness are established using the modified variational principle within the framework of first-order shear deformation theory(FSDT).The displacement components of the sandwich shell are expanded using the MJPI shape function and Fourier series in the meridional and circumferential directions,respectively.The accuracy and reliability of the proposed MJPI shape function are validated against numerical results from published literature and the commercial simulation tool Abaqus.Finally,the effects of different parameters such as thickness gradient,thickness power index and boundary condition on the free vibration and dynamic response of the sandwich laminated shell are investigated.展开更多
Microstructure and surface roughness are two critical factors governing the transparency of transparent ceramics.The manufacturing mechanism of additive manufacturing(AM)layer by layer is destined that the layer thick...Microstructure and surface roughness are two critical factors governing the transparency of transparent ceramics.The manufacturing mechanism of additive manufacturing(AM)layer by layer is destined that the layer thickness has an important influence on the microstructure and surface quality of the printed workpiece.Simultaneously,the occurrence of the stair-stepping phenomenon unavoidably results in a significant surface roughness.Therefore,in this study,yttria(Y_(2)O_(3))transparent ceramics with different printing layer thicknesses were fabricated by AM to investigate the effect of layer thickness on its optical and mechanical properties.The findings indicate that an increase in the layer thickness correlates with a heightened density in the printed green bodies,subsequently leading to enhanced transmittance in the final sintered body.When the layer thickness approximates or falls below the size of large particle agglomerations found in ceramic powders,numerous pores,and voids emerge within the green bodies.Significantly,at a layer thickness of 45µm,the in-line transmittance of Y_(2)O_(3)can reach up to 97.73%of the theoretical limit.In addition,the surface roughness of the Y_(2)O_(3)ceramics decreased as the layer thickness increased.To facilitate the further transition from translucent to transparent 3D Y_(2)O_(3)structures,a vibration-assisted chemical-mechanical polishing technique was developed by replacing water with a colloidal SiO_(2) suspension.This technique resulted in a significant reduction in the surface roughness of the Y_(2)O_(3)ceramics by 95.42%and eliminated the stair-stepping phenomenon caused by AM,thus increasing 66.12%of the in-line transmittance.These enhancements expand their potential applications in laser amplification,optical communications,and other areas requiring high-transparency materials.The method developed in this study can be used for the AM-based fabrication of transparent 3D polycrystalline ceramics.展开更多
Background:With growing concerns about the abuse of prescription and over-the-counter(OTC)medications,such as medications for attention-deficit/hyperactivity disorder(ADHD),diet pills,and sleep aids,among adolescents ...Background:With growing concerns about the abuse of prescription and over-the-counter(OTC)medications,such as medications for attention-deficit/hyperactivity disorder(ADHD),diet pills,and sleep aids,among adolescents in South Korea,this study aimed to investigated how these substances affect key aspects of adolescent well-being,specifically school satisfaction,body image,and sleep quality,and their association with mental health outcomes.Methods:A two-wave longitudinal survey was conducted with Korean female high school students(Wave 1:n=494;Wave 2:n=189).Linear regression analyses were used to evaluate the effects of ADHD medications,diet pills,and sleep aids on changes in school satisfaction,body image,and sleep quality,respectively.We also examined the relationship between these outcomes and mental health indicators,including depression,anxiety,stress,and somatic symptoms.Results:In line with the Self-Medication Hypothesis,which suggests that substances may fail to alleviate stress or improve well-being,the use of ADHD medications was associated with a decrease in school satisfaction,diet pill use was not significantly associated with changes in body image,and sleep aid use was not significantly associated with changes in sleep quality.Poor school satisfaction,body image,and sleep quality were associated with negative mental health outcomes.Conclusion:These findings suggest that ADHD medications,diet pills,and sleep aids may not effectively improve school satisfaction,body image,or sleep quality,and could potentially exacerbate mental health challenges.展开更多
Metal additive manufacturing(MAM)enables near-net shape production of components with minimized waste and excellent mechanical performance based on multi-scale microstructural heterogeneity.Espe-cially,the dislocation...Metal additive manufacturing(MAM)enables near-net shape production of components with minimized waste and excellent mechanical performance based on multi-scale microstructural heterogeneity.Espe-cially,the dislocation cell network that often bears elemental segregation or precipitation of a secondary phase contributes to enhancing the strength of additively manufactured materials.The cell boundaries can also act as active nucleation sites for the formation of precipitates under post-MAM heat treatment,as the chemical heterogeneity and profuse dislocations generate a driving force for precipitation.In this work,we subjected a Co_(18)Cr_(15)Fe_(50)Ni_(10)Mo_(6.5)C_(0.5)(at%)medium-entropy alloy fabricated by laser powder bed fusion(LPBF)to post-LPBF annealing at 900℃for 10 min.Microstructural investigation revealed that the cell boundaries of the as-built sample,which were decorated by Mo segregation,are replaced byμphase andM_(6)C typecarbide precipitatesduringannealingwhile thegrainstructureand sizeremain unaffected,indicating that the post-LPBF annealing delivered the proper amount of heat input to alter only the cell structure.The yield strength slightly decreased with annealing due to a reduction in the strengthening effect by the cell boundaries despite an increased precipitation strengthening effect.How-ever,the post-LPBF annealing improved the strain hardenability and the ultimate tensile strength was enhanced from∼1.02 to∼1.15 GPa owing to reinforced back stress hardening by the increased disloca-tion pile-up at the precipitates.Our results suggest that the cell structure with chemical heterogeneity can be successfully controlled by careful post-MAM heat treatment to tailor the mechanical performance,while also providing insight into alloy design for additive manufacturing.展开更多
BACKGROUND Abnormal gastric acid reflux into the esophagus causes symptoms of gastroeso-phageal reflux disease(GERD)such as heartburn and regurgitation and also leads to mucosal damage.This damage can further lead to ...BACKGROUND Abnormal gastric acid reflux into the esophagus causes symptoms of gastroeso-phageal reflux disease(GERD)such as heartburn and regurgitation and also leads to mucosal damage.This damage can further lead to complications such as Bar-rett’s esophagus and esophagitis.Conventional proton pump inhibitors(PPIs)often fail to reduce nocturnal acid production,leaving patients with unresolved symptoms that worsen at night and decreased satisfaction.Happi ER,a novel dual delayed-release(DDR)formulation of rabeprazole,aims to address these limitations by providing both immediate and prolonged acid suppression.AIM To evaluate the safety and effectiveness of rabeprazole DDR 20 mg capsule in patients with GERD.METHODS This study involved a multicenter,real-world,prospective,observational design over an eight-week period.A total of 1022 GERD patients were treated with rabeprazole DDR 20 mg capsules(Happi ER),as prescribed by their physicians.We included adult patients with confirmed GERD and persistent heartburn symptoms despite prior PPI use.Outcome measures included heartburn severity,frequency of night-time awakenings,use of rescue medications,and overall patient satisfaction.RESULTS Rabeprazole DDR 20 mg capsules(Happi ER)were shown to be highly effective in treating GERD symptoms.At the end of the study,the mean heartburn score improved significantly from 2.46±0.67 at baseline to 0.16±0.39(P<0.0001).The median number of night-time awakenings decreased to 0(P<0.0001).More than 93%of patients rated the therapy as“excellent”or“very good”,reflecting high satisfaction.No significant adverse effects were reported,and the safety profile was comparable to that of traditional PPIs.CONCLUSION By providing both rapid and sustained acid suppression,Happi ER effectively treats GERD,particularly with respect to night-time symptoms.Its safety and efficacy profile make it a viable option for individuals with mild-to-moderate GERD,significantly improving the quality of life and symptom management.展开更多
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.2022M3H4A6A0103720142)the National Research Council of Science&Technology(NST)grant by the Korea government(MSIT)(No.GTL24011-000)+1 种基金the Technology Innovation Program(RS-2024-00404165)through the Korea Planning&Evaluation Institute of Industrial Technology(KEIT)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea)supported by the Samsung SDI Co.Ltd.and the Korea Institute of Science and Technology(KIST)institutional program(2E33942,2E3394B)。
文摘Strategies for achieving high-energy-density lithium-ion batteries include using high-capacity materials such as high-nickel NCM,increasing the active material content in the electrode by utilizing high-conductivity carbon nanotubes(CNT)conductive materials,and electrode thickening.However,these methods are still limited due to the limitation in the capacity of high-nickel NCM,aggregation of CNT conductive materials,and nonuniform material distribution of thick-film electrodes,which ultimately damage the mechanical and electrical integrity of the electrode,leading to a decrease in electrochemical performance.Here,we present an integrated binder-CNT composite dispersion solution to realize a high-solids-content(>77 wt%)slurry for high-mass-loading electrodes and to mitigate the migration of binder and conductive additives.Indeed,the approach reduces solvent usage by approximately 30%and ensures uniform conductive additive-binder domain distribution during electrode manufacturing,resulting in improved coating quality and adhesive strength for high-mass-loading electrodes(>12 mAh cm^(−2)).In terms of various electrode properties,the presented electrode showed low resistance and excellent electrochemical properties despite the low CNT contents of 0.6 wt%compared to the pristine-applied electrode with 0.85 wt%CNT contents.Moreover,our strategy enables faster drying,which increases the coating speed,thereby offering potential energy savings and supporting carbon neutrality in wet-based electrode manufacturing processes.
文摘This paper describes a method for estimating the continuation of ore bodies at depth based on concentrationvolume(C-V)fractal modeling of the pyrite thermoelectric coefficient in the Pujon gold deposit,Democratic People’s Republic of Korea.The method is first established using data in the Kumjomdong area,a well-explored brownfield,and it is then applied to estimate the continuation of ore bodies at depth in the Pyongsandok area,a less-explored greenfield.The methodology consists of four steps:(1)3D modeling of ore bodies using surface geological mapping,mining tunnels in different levels,and a borehole dataset;(2)3D modeling of thermoelectricity coefficients from Au-bearing pyrites based on discrete smooth interpolation and C-V fractal techniques;(3)determination of levels used for calculation of the thermoelectric parameter of pyrite by C-V fractal modeling instead of traditional levels;and(4)determination of the thermoelectric parameter vertical gradient of pyrite reflecting the variation characteristics of pyrite thermoelectricity in the Pujon deposit.The results indicate that(1)pyrites in the Pujon deposit are dominantly P-type,and it is not reasonable to use traditional levels to calculate the thermoelectric parameter of pyrite;(2)thresholds determined by C-V fractal modeling can be used as levels to calculate the thermoelectric parameter of pyrite;(3)the thermoelectric parameter vertical gradient of pyrite ranges from 1 to 2 in the Pujon deposit;and(4)ore body Pyongsan No.9 extends 85 m to 235 m downward from the current borehole location.
基金support from the Central Research Fund of Kim Chaek University of Technology(MIRAE 2023779).
文摘The phenomenological and physically based models,using the true stress–true strain curve data obtained under various hot working conditions of 850–1200°C and 0.001–10 s−1,were developed and improved for AerMet 100 ultra-high strength steel.The predictability of the developed constitutive models was verified and compared.The determination coefficient and average absolute relative error were 0.9988 and 3.72%for the improved version of the modified Zerilli–Armstrong model,0.9985 and 3.96%for the improved version of the modified Johnson–Cook model,0.9947 and 4.59%for the strain-compensated Arrhenius-type model and 0.9913 and 5.43%for the improved Khan–Huang–Liang model,respectively.The results showed that the improved versions of the modified Zerilli–Armstrong model have the best predictability among the studied constitutive models.Comparing the predictability before and after the improvement,the average absolute relative error was increased by 65.14%for the modified Zerilli–Armstrong model and 58.45%for the modified Johnson–Cook model.This indicates that the phenomenological improvement of physically based constitutive models allows us to develop effectively constitutive equations with high prediction accuracy.
文摘In this paper,we propose a numerical calculation model of the multigroup neutron diffusion equation in 3D hexagonal geometry using the nodal Green's function method and verified it.We obtained one-dimensional transverse integrated equations using the transverse integration procedure over 3D hexagonal geometry and denoted the solutions as a nodal Green's functions under the Neumann boundary condition.By applying a quadratic polynomial expansion of the transverse-averaged quantities,we derived the net neutron current coupling equation,equation for the expansion coefficients of the transverse-averaged neutron flux,and formulas for the coefficient matrix of these equations.We formulated the closed system of equations in correspondence with the boundary conditions.The proposed model was tested by comparing it with the benchmark for the VVER-440 reactor,and the numerical results were in good agreement with the reference solutions.
文摘In this paper,a meshfree Jacobi point interpolation(MJPI)approach for the dynamic analysis of sandwich laminated conical and cylindrical shells with varying thickness is presented.The theoretical formulations for sandwich laminated shells with varying thickness are established using the modified variational principle within the framework of first-order shear deformation theory(FSDT).The displacement components of the sandwich shell are expanded using the MJPI shape function and Fourier series in the meridional and circumferential directions,respectively.The accuracy and reliability of the proposed MJPI shape function are validated against numerical results from published literature and the commercial simulation tool Abaqus.Finally,the effects of different parameters such as thickness gradient,thickness power index and boundary condition on the free vibration and dynamic response of the sandwich laminated shell are investigated.
基金financially supported by the Fundamental Research Program of Korea Institute of Materials Science(No.PNK9590).
文摘Microstructure and surface roughness are two critical factors governing the transparency of transparent ceramics.The manufacturing mechanism of additive manufacturing(AM)layer by layer is destined that the layer thickness has an important influence on the microstructure and surface quality of the printed workpiece.Simultaneously,the occurrence of the stair-stepping phenomenon unavoidably results in a significant surface roughness.Therefore,in this study,yttria(Y_(2)O_(3))transparent ceramics with different printing layer thicknesses were fabricated by AM to investigate the effect of layer thickness on its optical and mechanical properties.The findings indicate that an increase in the layer thickness correlates with a heightened density in the printed green bodies,subsequently leading to enhanced transmittance in the final sintered body.When the layer thickness approximates or falls below the size of large particle agglomerations found in ceramic powders,numerous pores,and voids emerge within the green bodies.Significantly,at a layer thickness of 45µm,the in-line transmittance of Y_(2)O_(3)can reach up to 97.73%of the theoretical limit.In addition,the surface roughness of the Y_(2)O_(3)ceramics decreased as the layer thickness increased.To facilitate the further transition from translucent to transparent 3D Y_(2)O_(3)structures,a vibration-assisted chemical-mechanical polishing technique was developed by replacing water with a colloidal SiO_(2) suspension.This technique resulted in a significant reduction in the surface roughness of the Y_(2)O_(3)ceramics by 95.42%and eliminated the stair-stepping phenomenon caused by AM,thus increasing 66.12%of the in-line transmittance.These enhancements expand their potential applications in laser amplification,optical communications,and other areas requiring high-transparency materials.The method developed in this study can be used for the AM-based fabrication of transparent 3D polycrystalline ceramics.
基金supported by the Ministry of Education of the Republic of Korea and the National Research Foundation of Korea(NRF-2024S1A5A2A03040479)。
文摘Background:With growing concerns about the abuse of prescription and over-the-counter(OTC)medications,such as medications for attention-deficit/hyperactivity disorder(ADHD),diet pills,and sleep aids,among adolescents in South Korea,this study aimed to investigated how these substances affect key aspects of adolescent well-being,specifically school satisfaction,body image,and sleep quality,and their association with mental health outcomes.Methods:A two-wave longitudinal survey was conducted with Korean female high school students(Wave 1:n=494;Wave 2:n=189).Linear regression analyses were used to evaluate the effects of ADHD medications,diet pills,and sleep aids on changes in school satisfaction,body image,and sleep quality,respectively.We also examined the relationship between these outcomes and mental health indicators,including depression,anxiety,stress,and somatic symptoms.Results:In line with the Self-Medication Hypothesis,which suggests that substances may fail to alleviate stress or improve well-being,the use of ADHD medications was associated with a decrease in school satisfaction,diet pill use was not significantly associated with changes in body image,and sleep aid use was not significantly associated with changes in sleep quality.Poor school satisfaction,body image,and sleep quality were associated with negative mental health outcomes.Conclusion:These findings suggest that ADHD medications,diet pills,and sleep aids may not effectively improve school satisfaction,body image,or sleep quality,and could potentially exacerbate mental health challenges.
基金supported by the National Research Founda-tion of Korea(NRF)grant funded by the Korean government(MSIT)(Nos.2021R1A2C3006662 and RS-2023-00281246)supported by the Principal R&D project(contract no.PNK9950)of the Korean Institute of Materials Science(KIMS).
文摘Metal additive manufacturing(MAM)enables near-net shape production of components with minimized waste and excellent mechanical performance based on multi-scale microstructural heterogeneity.Espe-cially,the dislocation cell network that often bears elemental segregation or precipitation of a secondary phase contributes to enhancing the strength of additively manufactured materials.The cell boundaries can also act as active nucleation sites for the formation of precipitates under post-MAM heat treatment,as the chemical heterogeneity and profuse dislocations generate a driving force for precipitation.In this work,we subjected a Co_(18)Cr_(15)Fe_(50)Ni_(10)Mo_(6.5)C_(0.5)(at%)medium-entropy alloy fabricated by laser powder bed fusion(LPBF)to post-LPBF annealing at 900℃for 10 min.Microstructural investigation revealed that the cell boundaries of the as-built sample,which were decorated by Mo segregation,are replaced byμphase andM_(6)C typecarbide precipitatesduringannealingwhile thegrainstructureand sizeremain unaffected,indicating that the post-LPBF annealing delivered the proper amount of heat input to alter only the cell structure.The yield strength slightly decreased with annealing due to a reduction in the strengthening effect by the cell boundaries despite an increased precipitation strengthening effect.How-ever,the post-LPBF annealing improved the strain hardenability and the ultimate tensile strength was enhanced from∼1.02 to∼1.15 GPa owing to reinforced back stress hardening by the increased disloca-tion pile-up at the precipitates.Our results suggest that the cell structure with chemical heterogeneity can be successfully controlled by careful post-MAM heat treatment to tailor the mechanical performance,while also providing insight into alloy design for additive manufacturing.
文摘BACKGROUND Abnormal gastric acid reflux into the esophagus causes symptoms of gastroeso-phageal reflux disease(GERD)such as heartburn and regurgitation and also leads to mucosal damage.This damage can further lead to complications such as Bar-rett’s esophagus and esophagitis.Conventional proton pump inhibitors(PPIs)often fail to reduce nocturnal acid production,leaving patients with unresolved symptoms that worsen at night and decreased satisfaction.Happi ER,a novel dual delayed-release(DDR)formulation of rabeprazole,aims to address these limitations by providing both immediate and prolonged acid suppression.AIM To evaluate the safety and effectiveness of rabeprazole DDR 20 mg capsule in patients with GERD.METHODS This study involved a multicenter,real-world,prospective,observational design over an eight-week period.A total of 1022 GERD patients were treated with rabeprazole DDR 20 mg capsules(Happi ER),as prescribed by their physicians.We included adult patients with confirmed GERD and persistent heartburn symptoms despite prior PPI use.Outcome measures included heartburn severity,frequency of night-time awakenings,use of rescue medications,and overall patient satisfaction.RESULTS Rabeprazole DDR 20 mg capsules(Happi ER)were shown to be highly effective in treating GERD symptoms.At the end of the study,the mean heartburn score improved significantly from 2.46±0.67 at baseline to 0.16±0.39(P<0.0001).The median number of night-time awakenings decreased to 0(P<0.0001).More than 93%of patients rated the therapy as“excellent”or“very good”,reflecting high satisfaction.No significant adverse effects were reported,and the safety profile was comparable to that of traditional PPIs.CONCLUSION By providing both rapid and sustained acid suppression,Happi ER effectively treats GERD,particularly with respect to night-time symptoms.Its safety and efficacy profile make it a viable option for individuals with mild-to-moderate GERD,significantly improving the quality of life and symptom management.
