Biomacromolecules form membraneless organelles through liquid-liquid phase separation in order to regulate the efficiency of particular biochemical reactions.Dysregulation of phase separation might result in pathologi...Biomacromolecules form membraneless organelles through liquid-liquid phase separation in order to regulate the efficiency of particular biochemical reactions.Dysregulation of phase separation might result in pathological condensation or sequestration of biomolecules,leading to diseases.Thus,phase separation and phase separating factors may serve as drug targets for disease treatment.Nevertheless,such associations have not yet been integrated into phase separation-related databases.Therefore,based on MloDisDB,a database for membraneless organelle factor-disease associations previously developed by our lab,we constructed PhaSeDis,the phase separation-disease association database.We increased the number of phase separation entries from 52 to 185,and supplemented the evidence provided by the original articles verifying the phase separation nature of the factors.Moreover,we included the information of interacting small molecules with low-throughput or high-throughput evidence that might serve as potential drugs for phase separation entries.PhaSeDis strives to offer comprehensive descriptions of each entry,elucidating how phase separating factors induce pathological conditions via phase separation and the mechanisms by which small molecules intervene.We believe that PhaSeDis would be very important in the application of phase separation regulation in treating relateddiseases.PhaSeDis is availableathttp:/mlodis.phasep.pro.展开更多
基金supported by the National Key R&D Program of China(Grant No.2023YFF1204703)the Beijing Natural Science Foundation,China(Grant No.Z230014)the National Natural Science Foundation of China(Grant Nos.T2325003 and 31000609).
文摘Biomacromolecules form membraneless organelles through liquid-liquid phase separation in order to regulate the efficiency of particular biochemical reactions.Dysregulation of phase separation might result in pathological condensation or sequestration of biomolecules,leading to diseases.Thus,phase separation and phase separating factors may serve as drug targets for disease treatment.Nevertheless,such associations have not yet been integrated into phase separation-related databases.Therefore,based on MloDisDB,a database for membraneless organelle factor-disease associations previously developed by our lab,we constructed PhaSeDis,the phase separation-disease association database.We increased the number of phase separation entries from 52 to 185,and supplemented the evidence provided by the original articles verifying the phase separation nature of the factors.Moreover,we included the information of interacting small molecules with low-throughput or high-throughput evidence that might serve as potential drugs for phase separation entries.PhaSeDis strives to offer comprehensive descriptions of each entry,elucidating how phase separating factors induce pathological conditions via phase separation and the mechanisms by which small molecules intervene.We believe that PhaSeDis would be very important in the application of phase separation regulation in treating relateddiseases.PhaSeDis is availableathttp:/mlodis.phasep.pro.
