1 Introduction Pulmonary hypertension （PH） is a haemodynamic and pathophysiological condition defined as increase in mean pulmonary arterial pressure≥ 25 mmHg at rest as assessed by right heart catheterization （...1 Introduction Pulmonary hypertension （PH） is a haemodynamic and pathophysiological condition defined as increase in mean pulmonary arterial pressure≥ 25 mmHg at rest as assessed by right heart catheterization （RHC）.展开更多
Most of the massive sulfide deposits (VMS) occurring from Precambrian to Cenozoic throughout the world has been subsequently metamorphosed at various grades. Thus, all the original textures have been either completely...Most of the massive sulfide deposits (VMS) occurring from Precambrian to Cenozoic throughout the world has been subsequently metamorphosed at various grades. Thus, all the original textures have been either completely destroyed or strongly modified. However, there are a very few examples, rather younger deposits such as late Cretaceous Turkish VMS deposits and Miocene Kuroko deposits of Japan in which representative and original ore textures are preserved. The Turkish massive sulfide deposits are mainly Cu-Zn-Pb-type and entirely hosted by Late Cretaceous felsic volcanic rocks within a paleoarc geotectonic setting.展开更多
Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive disease characterized by papulonodular skin lesions, gingival hyperplasia, joint contractures, and bone lesions. The skin lesions may consist of multip...Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive disease characterized by papulonodular skin lesions, gingival hyperplasia, joint contractures, and bone lesions. The skin lesions may consist of multiple large tumors, commonly on the scalp and around the neck,and small pearly,pink papules and plaques on the trunk, chin, ears, and around the nostrils. Here, we report a 2-year-old boy with characteristic stiffness of the knees and elbows and pink confluent papules on the paranasal folds, and periauricular and perianal regions. He also had hard nodules all over the scalp and around the mouth, and severe gingival hyperplasia. The lesions were totally excised and clinicopathological diagnosis was JHF.展开更多
The effect of migraine on the prognosis of epilepsy has not been reported. Th e aim of this prospective 5- 10- year follow- up study was to examine some ou tcome measures and the cumulative probability of being seizur...The effect of migraine on the prognosis of epilepsy has not been reported. Th e aim of this prospective 5- 10- year follow- up study was to examine some ou tcome measures and the cumulative probability of being seizure- free in epileps y patients with migraine, and to compare their results with those of epilepsy pa tients without migraine. Fifty- nine patients (40 women; mean age 25 years) wer e diagnosed with both epilepsy and migraine (EM group). The control group consis ted of 56 patients with epilepsy but without migraine (E group). Both groups were recruited and followed up over similar periods. W e compared the outcome variables in the EM group with those in the E group. Kapl an- Meier methods were used to assess the seizurefree curves. The EM group had a significantly lower cumulative probability of being seizure- free over 10 yea rs compared with the E group. The other epilepsy outcome measures at follow- up differed significantly between the groups, with the EM group having a longer du ration of epilepsy, a lower early treatment response, and a higher incidence of intractable epilepsy and achieving remission with polytherapy, and more seizure control and medication problems for at least the last 2 years of followup. Comor bid migraine had a negative effect on the prognosis of epilepsy.展开更多
This study examines the effects of various plant derivative extracts and lactic acid bacteria on yeasts in an attempt to create a prototype of a nutritional bar with antifungal properties.It was done in a series of st...This study examines the effects of various plant derivative extracts and lactic acid bacteria on yeasts in an attempt to create a prototype of a nutritional bar with antifungal properties.It was done in a series of steps by first determining antifungal activity,then developing a food prototype,and finally testing the efficacy of the prototype in mice.The best antifungal activity from plant extracts was noticed in 10%aqueous,and ethanol extracts of garlic(22–34 mm and 16–24 mm inhibition zones respectively),as well as in 10%aqueous and ethanol extracts of goldenseal(16–20 mm inhibition zones for both extracts),and 5%aqueous and ethanol extracts of cinnamon(18–24 mm inhibition zones for both extracts).Lactobacillus plantarum MI-LPI had the widest range of inhibitory effect on pathogenic and spoilage yeasts–it was effective against 10 from 12 strains of yeasts and it was chosen for the development of the nutritional bar.L.plantarum did not decrease significantly during the storage period of 90 days,and>10^(9) CFU/cm^(3) of L.plantarum remained until the end of the experiment.In vivo experiments showed that mice fed with nutritional bars with L.plantarum and C.albicans had 20 times lower counts of C.albicans,compared to mice that were fed nutritional bars with C.albicans alone.Signs of inflammation were also reduced in both small intestine and colon of mice when fed a nutritional bar with lactic acid bacteria.展开更多
文摘1 Introduction Pulmonary hypertension （PH） is a haemodynamic and pathophysiological condition defined as increase in mean pulmonary arterial pressure≥ 25 mmHg at rest as assessed by right heart catheterization （RHC）.
文摘Most of the massive sulfide deposits (VMS) occurring from Precambrian to Cenozoic throughout the world has been subsequently metamorphosed at various grades. Thus, all the original textures have been either completely destroyed or strongly modified. However, there are a very few examples, rather younger deposits such as late Cretaceous Turkish VMS deposits and Miocene Kuroko deposits of Japan in which representative and original ore textures are preserved. The Turkish massive sulfide deposits are mainly Cu-Zn-Pb-type and entirely hosted by Late Cretaceous felsic volcanic rocks within a paleoarc geotectonic setting.
文摘Juvenile hyaline fibromatosis (JHF) is a rare autosomal recessive disease characterized by papulonodular skin lesions, gingival hyperplasia, joint contractures, and bone lesions. The skin lesions may consist of multiple large tumors, commonly on the scalp and around the neck,and small pearly,pink papules and plaques on the trunk, chin, ears, and around the nostrils. Here, we report a 2-year-old boy with characteristic stiffness of the knees and elbows and pink confluent papules on the paranasal folds, and periauricular and perianal regions. He also had hard nodules all over the scalp and around the mouth, and severe gingival hyperplasia. The lesions were totally excised and clinicopathological diagnosis was JHF.
文摘The effect of migraine on the prognosis of epilepsy has not been reported. Th e aim of this prospective 5- 10- year follow- up study was to examine some ou tcome measures and the cumulative probability of being seizure- free in epileps y patients with migraine, and to compare their results with those of epilepsy pa tients without migraine. Fifty- nine patients (40 women; mean age 25 years) wer e diagnosed with both epilepsy and migraine (EM group). The control group consis ted of 56 patients with epilepsy but without migraine (E group). Both groups were recruited and followed up over similar periods. W e compared the outcome variables in the EM group with those in the E group. Kapl an- Meier methods were used to assess the seizurefree curves. The EM group had a significantly lower cumulative probability of being seizure- free over 10 yea rs compared with the E group. The other epilepsy outcome measures at follow- up differed significantly between the groups, with the EM group having a longer du ration of epilepsy, a lower early treatment response, and a higher incidence of intractable epilepsy and achieving remission with polytherapy, and more seizure control and medication problems for at least the last 2 years of followup. Comor bid migraine had a negative effect on the prognosis of epilepsy.
文摘This study examines the effects of various plant derivative extracts and lactic acid bacteria on yeasts in an attempt to create a prototype of a nutritional bar with antifungal properties.It was done in a series of steps by first determining antifungal activity,then developing a food prototype,and finally testing the efficacy of the prototype in mice.The best antifungal activity from plant extracts was noticed in 10%aqueous,and ethanol extracts of garlic(22–34 mm and 16–24 mm inhibition zones respectively),as well as in 10%aqueous and ethanol extracts of goldenseal(16–20 mm inhibition zones for both extracts),and 5%aqueous and ethanol extracts of cinnamon(18–24 mm inhibition zones for both extracts).Lactobacillus plantarum MI-LPI had the widest range of inhibitory effect on pathogenic and spoilage yeasts–it was effective against 10 from 12 strains of yeasts and it was chosen for the development of the nutritional bar.L.plantarum did not decrease significantly during the storage period of 90 days,and>10^(9) CFU/cm^(3) of L.plantarum remained until the end of the experiment.In vivo experiments showed that mice fed with nutritional bars with L.plantarum and C.albicans had 20 times lower counts of C.albicans,compared to mice that were fed nutritional bars with C.albicans alone.Signs of inflammation were also reduced in both small intestine and colon of mice when fed a nutritional bar with lactic acid bacteria.
