Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for pat...Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), before and during the COVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPCI from December 2018 to July 2021. The COVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the COVID-19 pandemic. Conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the COVID-19 pandemic. Delay times to admission and reperfusion did not differ significantly between before and during the pandemic.展开更多
We synthesized reddish-orange luminescent La_(10)W_(22)O_(81)(LWO):Sm^(3+)microphosphors by hydrothermalassisted solid-state reaction.X-ray diffraction analysis reveals that all the studied phosphors crystallize in an...We synthesized reddish-orange luminescent La_(10)W_(22)O_(81)(LWO):Sm^(3+)microphosphors by hydrothermalassisted solid-state reaction.X-ray diffraction analysis reveals that all the studied phosphors crystallize in an orthorhombic structure in the Pbcn space group(60),Field emission scanning electron microscopy indicates that the LWO:1.5 mol%Sm^(3+)phosphor displays a smooth-surfaced hexagonal rod-like shape,with a closed shape at both ends,and high-resolution transmission electron microscopy demonstrates a robust crystalline structure.The chemical composition and valence states of the phosphor were investigated using X-ray photoelectron spectroscopy.At 403 nm excitation,LWO:1.5 mol%Sm3+exhibits maximum intensity with the strongest band at 596 nm(^(4)G_(5/2)→^(6)H_(7/2))in the reddish-orange region.The intensity of Sm^(3+)emission decreases beyond 1.5 mol%owing to concentration quenching regulated by dipole-quadrupole interaction between Sm^(3+)ions.The optimized microphosphor LWO:1.5 mol%Sm^(3+)exhibits color coordinates(0.5760,0.4207),which is close to that of the Amber LED-NSPAR 70 BS(0.570,0.420),displaying the highest color purity of 99.2%and correlated color temperature of 1694 K.In addition,both breast cancer cells MCF-7 and normal lung fibroblasts WI-38 were tested for toxicity with the optimized microphosphor.It is found that the LWO:1.5 Sm^(3+)microphosphor is extremely toxic to cancer cells,but not to normal cells.Based on these results,LWO:Sm^(3+)microphosphor can serve as a biomedical candidate for the treatment of cancer,as well as a potential multicolor emitting material for w-LEDs.展开更多
Aims: Increasing focus on improvement and optimisation of the treatment in primary care and reduction of healthcare costs emphasize the need to understand which factors determines adherence and non-adherence to clinic...Aims: Increasing focus on improvement and optimisation of the treatment in primary care and reduction of healthcare costs emphasize the need to understand which factors determines adherence and non-adherence to clinical guidelines. In the present study, we examined attitudes towards clinical guidelines in Danish general practitioners (GPs). Methods: We conducted a survey among Danish GPs from all five regions of Denmark. In total, 443 GPs answered the web-based questionnaire that contained questions about attitudes and barriers to clinical guidelines. Results: More than 90% of the GPs reported that they have good knowledge of the guidelines and in general follows the guidelines. A majority of the GPs (81%) found it acceptable that economic considerations are part of the guidelines. The most important factors for non- adherence to guidelines were “need of adjustment to clinical practice” and “lack of confidence in guidelines”. The attitudes to clinical guidelines were not significantly associated with practice characteristics such as gender, years of experience, practice organisation and localisation. Conclusions: Our findings show that clinical guidelines are an integrated or internalised part of everyday practice among GPs in Denmark. Furthermore, the findings indicate that Danish GPs are positive towards applying priority setting in their practice. This is decisive in the light of rising healthcare costs due to development of new expensive technologies and ageing populations that puts pressure on the healthcare system in general and primary healthcare in particular.展开更多
Through the deep data analysis of the cosmetics industry, it can be found that the changes in population structure, differences of consumption habits, and income factors which have led to the intergenerational replace...Through the deep data analysis of the cosmetics industry, it can be found that the changes in population structure, differences of consumption habits, and income factors which have led to the intergenerational replacement of Chinese consumers. Middle-aged crowd in China, their consumption concept tend to be relatively conservative, while for young generations, their income level is becoming higher. The purchasing power and consumption tendency of such young consumer groups are significantly higher than that of middle-aged and elderly people. Relevant data show that the consumption intention and consumer confidence index of the new generation (born in 1995 and beyond) are significantly higher than the overall level of ditferent age groups, and the growth rate are accelerating. In the urban residents’ consumption in 2012, the contribution of the new generation is 15%, and it is expected to reach 35% by 2020, which fully shows that the new generation of consumers has begun to become the mainstream of new generation consumption.展开更多
We studied the influence of surveyed area size on density estimates by means of camera-trapping in a low-density felid population(1-2 individuals/100 km^(2)).We applied non-spatial capture-recapture(CR)and spatial CR(...We studied the influence of surveyed area size on density estimates by means of camera-trapping in a low-density felid population(1-2 individuals/100 km^(2)).We applied non-spatial capture-recapture(CR)and spatial CR(SCR)models for Eurasian lynx during winter 2005/2006 in the northwestern Swiss Alps by sampling an area divided into 5 nested plots ranging from 65 to 760 km^(2).CR model density estimates(95%CI)for models M_(0)and M_(h)decreased from 2.61(1.55-3.68)and 3.6(1.62-5.57)independent lynx/100 km^(2),respectively,in the smallest to 1.20(1.04-1.35)and 1.26(0.89-1.63)independent lynx/100 km^(2),respectively,in the largest area surveyed.SCR model density estimates also decreased with increasing sampling area but not significantly.High individual range overlaps in relatively small areas(the edge effect)is the most plausible reason for this positive bias in the CR models.Our results confirm that SCR models are much more robust to changes in trap array size than CR models,thus avoiding overestimation of density in smaller areas.However,when a study is concerned with monitoring population changes,large spatial efforts(area surveyed≥760 km^(2))are required to obtain reliable and precise density estimates with these population densities and recapture rates.展开更多
We investigate the gravitational wave spectrum originating from the cosmological first-order phase transition.We compare two models:one is a scalar field model without gravitation,while the other is a scalar field mod...We investigate the gravitational wave spectrum originating from the cosmological first-order phase transition.We compare two models:one is a scalar field model without gravitation,while the other is a scalar field model with gravitation.Based on the sensitivity curves of the LISA space-based interferometer on the stochastic gravitational-wave background,we compare the difference between the gravitational wave spectra of the former and the latter cases obtained from the bubble collision process.In particular,we numerically calculate the speed of the bubble wall before collision for the two models.We demonstrate that the difference between the amplitudes of these spectra can clearly distinguish between the two models.We expect that the LISA with Signal to Noise Ratio=10 could observe the spectrum as the fast first-order phase transition.展开更多
文摘Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), before and during the COVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPCI from December 2018 to July 2021. The COVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the COVID-19 pandemic. Conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the COVID-19 pandemic. Delay times to admission and reperfusion did not differ significantly between before and during the pandemic.
基金Project supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2021R1A6A1A03039493)by the Ministry of Science,Information and Communications Technology(ICT)and Future Planning(2022R1A2C1009389)。
文摘We synthesized reddish-orange luminescent La_(10)W_(22)O_(81)(LWO):Sm^(3+)microphosphors by hydrothermalassisted solid-state reaction.X-ray diffraction analysis reveals that all the studied phosphors crystallize in an orthorhombic structure in the Pbcn space group(60),Field emission scanning electron microscopy indicates that the LWO:1.5 mol%Sm^(3+)phosphor displays a smooth-surfaced hexagonal rod-like shape,with a closed shape at both ends,and high-resolution transmission electron microscopy demonstrates a robust crystalline structure.The chemical composition and valence states of the phosphor were investigated using X-ray photoelectron spectroscopy.At 403 nm excitation,LWO:1.5 mol%Sm3+exhibits maximum intensity with the strongest band at 596 nm(^(4)G_(5/2)→^(6)H_(7/2))in the reddish-orange region.The intensity of Sm^(3+)emission decreases beyond 1.5 mol%owing to concentration quenching regulated by dipole-quadrupole interaction between Sm^(3+)ions.The optimized microphosphor LWO:1.5 mol%Sm^(3+)exhibits color coordinates(0.5760,0.4207),which is close to that of the Amber LED-NSPAR 70 BS(0.570,0.420),displaying the highest color purity of 99.2%and correlated color temperature of 1694 K.In addition,both breast cancer cells MCF-7 and normal lung fibroblasts WI-38 were tested for toxicity with the optimized microphosphor.It is found that the LWO:1.5 Sm^(3+)microphosphor is extremely toxic to cancer cells,but not to normal cells.Based on these results,LWO:Sm^(3+)microphosphor can serve as a biomedical candidate for the treatment of cancer,as well as a potential multicolor emitting material for w-LEDs.
文摘Aims: Increasing focus on improvement and optimisation of the treatment in primary care and reduction of healthcare costs emphasize the need to understand which factors determines adherence and non-adherence to clinical guidelines. In the present study, we examined attitudes towards clinical guidelines in Danish general practitioners (GPs). Methods: We conducted a survey among Danish GPs from all five regions of Denmark. In total, 443 GPs answered the web-based questionnaire that contained questions about attitudes and barriers to clinical guidelines. Results: More than 90% of the GPs reported that they have good knowledge of the guidelines and in general follows the guidelines. A majority of the GPs (81%) found it acceptable that economic considerations are part of the guidelines. The most important factors for non- adherence to guidelines were “need of adjustment to clinical practice” and “lack of confidence in guidelines”. The attitudes to clinical guidelines were not significantly associated with practice characteristics such as gender, years of experience, practice organisation and localisation. Conclusions: Our findings show that clinical guidelines are an integrated or internalised part of everyday practice among GPs in Denmark. Furthermore, the findings indicate that Danish GPs are positive towards applying priority setting in their practice. This is decisive in the light of rising healthcare costs due to development of new expensive technologies and ageing populations that puts pressure on the healthcare system in general and primary healthcare in particular.
文摘Through the deep data analysis of the cosmetics industry, it can be found that the changes in population structure, differences of consumption habits, and income factors which have led to the intergenerational replacement of Chinese consumers. Middle-aged crowd in China, their consumption concept tend to be relatively conservative, while for young generations, their income level is becoming higher. The purchasing power and consumption tendency of such young consumer groups are significantly higher than that of middle-aged and elderly people. Relevant data show that the consumption intention and consumer confidence index of the new generation (born in 1995 and beyond) are significantly higher than the overall level of ditferent age groups, and the growth rate are accelerating. In the urban residents’ consumption in 2012, the contribution of the new generation is 15%, and it is expected to reach 35% by 2020, which fully shows that the new generation of consumers has begun to become the mainstream of new generation consumption.
基金supported by the Federal Office for the Environment.
文摘We studied the influence of surveyed area size on density estimates by means of camera-trapping in a low-density felid population(1-2 individuals/100 km^(2)).We applied non-spatial capture-recapture(CR)and spatial CR(SCR)models for Eurasian lynx during winter 2005/2006 in the northwestern Swiss Alps by sampling an area divided into 5 nested plots ranging from 65 to 760 km^(2).CR model density estimates(95%CI)for models M_(0)and M_(h)decreased from 2.61(1.55-3.68)and 3.6(1.62-5.57)independent lynx/100 km^(2),respectively,in the smallest to 1.20(1.04-1.35)and 1.26(0.89-1.63)independent lynx/100 km^(2),respectively,in the largest area surveyed.SCR model density estimates also decreased with increasing sampling area but not significantly.High individual range overlaps in relatively small areas(the edge effect)is the most plausible reason for this positive bias in the CR models.Our results confirm that SCR models are much more robust to changes in trap array size than CR models,thus avoiding overestimation of density in smaller areas.However,when a study is concerned with monitoring population changes,large spatial efforts(area surveyed≥760 km^(2))are required to obtain reliable and precise density estimates with these population densities and recapture rates.
基金BHL(2020R1F1A1075472),DY(2021R1C1C1008622,2021R1A4A5031460)WL(2016R1D1A1B01010234)were supported by the National Research Foundation of KoreaLY was supported by the Basic Science Research Program(2020R1A6A1A03047877)of the National Research Foundation of Korea funded by the Ministry of Education through Center for Quantum Spacetime(CQUeST)of Sogang University。
文摘We investigate the gravitational wave spectrum originating from the cosmological first-order phase transition.We compare two models:one is a scalar field model without gravitation,while the other is a scalar field model with gravitation.Based on the sensitivity curves of the LISA space-based interferometer on the stochastic gravitational-wave background,we compare the difference between the gravitational wave spectra of the former and the latter cases obtained from the bubble collision process.In particular,we numerically calculate the speed of the bubble wall before collision for the two models.We demonstrate that the difference between the amplitudes of these spectra can clearly distinguish between the two models.We expect that the LISA with Signal to Noise Ratio=10 could observe the spectrum as the fast first-order phase transition.
