According to the analysis on the characteristics of historic earthquakes in Jiangsu Province and South Huanghai Sea region, the historical earthquakes in the studied area are divided into two kinds of comparatively sa...According to the analysis on the characteristics of historic earthquakes in Jiangsu Province and South Huanghai Sea region, the historical earthquakes in the studied area are divided into two kinds of comparatively safe class and comparatively dangerous class. Then the statistical result of earthquake class, the characteristics of geo-graphical distribution and geological structures are studied. The study shows: a) In Jiangsu Province and South Huanghai Sea region, the majority of historical strong earthquakes belong to comparatively safe class, only 13.8% belong to comparatively dangerous class; b) Most historical earthquakes belong to comparatively safe class in the land area of Jiangsu, eastern sea area of Yangtze River mouth and northern depression of South Huanghai Sea region. However, along the coast of middle Jiangsu Province and in the sea area of South Huanghai Sea, the distribution of historical earthquake classes is complex and the earthquake series of comparatively dan-gerous class and comparatively safe class are equivalent in number; c) In the studied area, the statistical results of historical earthquake classes and the characteristics of spatial distribution accord very well with the real case of present-day earthquake series. It shows that the seismic activity in the region has the characteristic of succession, and the result from this study can be used as a reference for early postseismic judgment in the earthquake emer-gency work in Jiangsu Province.展开更多
According to the analysis on the characteristics of historic earthquakes in Jiangsu Province and South Huanghai Sea region, the historical earthquakes in the studied area are divided into two kinds of comparatively sa...According to the analysis on the characteristics of historic earthquakes in Jiangsu Province and South Huanghai Sea region, the historical earthquakes in the studied area are divided into two kinds of comparatively safe class and comparatively dangerous class. Then the statistical result of earthquake class, the characteristics of geo-graphical distribution and geological structures are studied. The study shows: a) In Jiangsu Province and South Huanghai Sea region, the majority of historical strong earthquakes belong to comparatively safe class, only 13.8% belong to comparatively dangerous class; b) Most historical earthquakes belong to comparatively safe class in the land area of Jiangsu, eastern sea area of Yangtze River mouth and northern depression of South Huanghai Sea region. However, along the coast of middle Jiangsu Province and in the sea area of South Huanghai Sea, the distribution of historical earthquake classes is complex and the earthquake series of comparatively dan-gerous class and comparatively safe class are equivalent in number; c) In the studied area, the statistical results of historical earthquake classes and the characteristics of spatial distribution accord very well with the real case of present-day earthquake series. It shows that the seismic activity in the region has the characteristic of succession, and the result from this study can be used as a reference for early postseismic judgment in the earthquake emer-gency work in Jiangsu Province.展开更多
Along the north bank of the Xuxi River, the sand-intercalated-muddy gravel layer from -3.7 - -5.8 m in the borehole 7508 at the East Dam and the middle, coarse and fine sand layer with a thickness of 4.5 m at the lowe...Along the north bank of the Xuxi River, the sand-intercalated-muddy gravel layer from -3.7 - -5.8 m in the borehole 7508 at the East Dam and the middle, coarse and fine sand layer with a thickness of 4.5 m at the lower part of the borehole 8179 between the East Dam and the West Dam indicate that a large natural river was here before the Kingdom of Wu excavated the Xuxi Canal. The existence of Neolithic sites such as Xuecheng, Chaoduntou and Xiajiadang along the Xuxi River and the silt layer with dozens of meters archived under the earth＇s surface within a range of 1 km along both banks are the even more important evidences for the existence of the ancient Zhongjiang River. The floodgate of the East Dam nowadays makes against the communication between the Shuiyangjiang River and the Taihu Lake. The authors suggest the canal between Wuhu and Taihu Lake should be excavated as soon as possible, namely, the navigation channel from Wuhu through Guchenghu Lake, Xuxi River, East Dam, Liyang, Yixing to Taihu Lake should be further widen and the deposits composed of slope wash on the watershed between Shuiyangjiang River and Taihu Lake should be dredged away. Then, the channel journey can be shortened, the boats in ship transportation on the Yangtze River can be shunted to ensure the security of shipping, the resources of sand and gravel in the old river channel can be exploited and the dike of the Yangtze River can be reinforced. So, the problems of irrigation, flood diversion, pollution abatement and drainage of flooded fields in the lower Yangtze River will be resolved. Then, the above methods can impel the sustainable development of the Xuxi River and Taihu Lake area.展开更多
[ Objective] The study aimed to analyze and predict the suitable period of laver along the coastal areas of Jiangsu Province. [ Method ] TO enhance the ability of meteorology to service laver culture, using the modern...[ Objective] The study aimed to analyze and predict the suitable period of laver along the coastal areas of Jiangsu Province. [ Method ] TO enhance the ability of meteorology to service laver culture, using the modern weather forecast technology, agricultural weather prediction was de- veloped according to the demands for meteorological conditions during laver production. [ Result] From south to north, there were certain differ- ences in the suitable periods of laver culture, breeding and harvesting, with slight variations. The forecast of the first and last days of certain water temperature could provide scientific references for the meteorological service of laver culture, and the service effect became better after it was modi- fied with the aid of the medium-term and long-term weather prediction. [ Conclusion] The research can offer theoretical bases for the culture of laver along the coastal areas of Jiangsu Province.展开更多
Soil organic carbon (SOC) plays a key role in the global carbon cycle.In this study,we used statistical and geostatistical methods to characterize and compare the spatial heterogeneity of SOC in soils of Jiangsu Provi...Soil organic carbon (SOC) plays a key role in the global carbon cycle.In this study,we used statistical and geostatistical methods to characterize and compare the spatial heterogeneity of SOC in soils of Jiangsu Province,China,and investigate the factors that influence it,such as topography,soil type,and land use.Our study was based on 24 186 soil samples obtained from the surface soil layer (0-0.2 m) and covering the entire area of the province.Interpolated values of SOC density in the surface layer,obtained by kriging based on a spherical model,ranged between 3.25 and 32.43 kg m 3.The highest SOC densities tended to occur in the Taihu Plain,Lixia River Plain,along the Yangtze River,and in high-elevation hilly areas such as those in northern and southwest Jiangsu,while the lowest values were found in the coastal plain.Elevation,slope,soil type,and land use type significantly affected SOC densities.Steeper slope tended to result in SOC decline.Correlation between elevation and SOC densities was positive in the hill areas but negative in the low plain areas,probably due to the effect of different land cover types,temperature,and soil fertility.High SOC densities were usually found in limestone and paddy soils and low densities in coastal saline soils and alluvial soils,indicating that high clay and silt contents in the soils could lead to an increase,and high sand content to a decrease in the accumulation of SOC.SOC densities were sensitive to land use and usually increased in towns,woodland,paddy land,and shallow water areas,which were strongly affected by industrial and human activities,covered with highly productive vegetation,or subject to long-term use of organic fertilizers or flooding conditions.展开更多
AIM： To study the main environmental and lifestyle factors that account for the regional differences in esophageal cancer （EC） risk in low- and high-risk areas of Jiangsu Province, China. METHODS： Since 2003, a po...AIM： To study the main environmental and lifestyle factors that account for the regional differences in esophageal cancer （EC） risk in low- and high-risk areas of Jiangsu Province, China. METHODS： Since 2003, a population-based casecontrol study has been conducted simultaneously in lowrisk （Ganyu County） and high-risk （Dafeng County） areas of Jiangsu Province, China. Using identical protocols and pre-tested standardized questionnaire, following written informed consent, eligible subjects were inquired about their detail information on potential determinants of EC, including demographic information, socio-economic status, living conditions, disease history, family cancer history, smoking, alcohol drinking, dietary habits, frequency, amount of food intake, etc. Conditional logistic regression with maximum likelihood estimation was used to obtain Odds ratio （OR） and 95 % confidence interval （95% CI）, after adjustment for potential confounders. RESULTS： In the preliminary analysis of the ongoing study, we recruited 291 pairs of cases and controls in Dafeng and 240 pairs of cases and controls in Ganyu, respectively. In both low-risk and high-risk areas, EC was inversely associated with socio-economic status, such as level of education, past economic status and body mass index. However, this disease was more frequent among those who had a family history of cancer or encountered misfortune in the past 10 years. EC was also more frequent among smokers, alcohol drinkers and fast eaters. Furthermore, there was a geographic variation of the associations between smoking, alcohol drinking and EC risk despite the similar prevalence of these risk factors in both low-risk and high-risk areas. The dose-response relationship of smoking and smoking related variables, such as age of the first smoking, duration and amount were apparent only in high-risk areas. On the contrary, a dose-response relationship on the effect of alcohol drinking on EC was observed only in low-risk areas. CONCLUSION： The environmental risk factors, together with genetic factors and gene-environmental interactions might be the main reason for this high-risk gradient in .liangsu Province, China.展开更多
This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence cou...This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence course.Then the paper presents a weighted Markov chain,a method which is used to predict the future incidence state.This method assumes the standardized self-coefficients as weights based on the special characteristics of infectious disease incidence being a dependent stochastic variable.It also analyzes the characteristics of infectious diseases incidence via the Markov chain Monte Carlo method to make the long-term benefit of decision optimal.Our method is successfully validated using existing incidents data of infectious diseases in Jiangsu Province.In summation,this paper proposes ways to improve the accuracy of the weighted Markov chain,specifically in the field of infection epidemiology.展开更多
We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to exam...We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group（24.35±3.14 years,P = 0.000）.The mean maternal body mass index（BMI） at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group（21.76±2.59 kg/m 2,P = 0.000）.About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group（P = 0.000）.Compared with women with normal weight（BMI：18.5-23.9 kg/m 2）,women who were overweight（BMI：24-27.9 kg/m 2） or obese（BMI ≥ 28 kg/m 2）,respectively,had a 1.69-fold（P = 0.000） and a 1.49-fold（P = 0.000） increased risks of having a neonate with macrosomia,while light weight（BMI〈18.5 kg/m 2） women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years（P = 0.001 and P = 0.000）.Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood.展开更多
The genes for 5-1ipoxygenase activating protein （ALOX5AP） and phosphodiesterase 4D （PDE4D） have been demonstrated as susceptibility genes for lacunar in the Icelandic and Pakistani populations, but little is known...The genes for 5-1ipoxygenase activating protein （ALOX5AP） and phosphodiesterase 4D （PDE4D） have been demonstrated as susceptibility genes for lacunar in the Icelandic and Pakistani populations, but little is known about the role of these genes in Chinese populations. The present study utilized polymerase chain reaction and ligase detection reaction to detect single nucleotide polymorphisms （SNPs） in 280 consecutive stroke patients and 258 unrelated population-based controls from Nanjing, Jiangsu Province, China. The allele frequency, genotypes, and haplotypes of the two SNPs （rs456009 and rs966221） in PDE4D were similar between the two groups. However, A allele frequency of rs4073259 （A/G） and rs4769055 （A/C） in the ALOX5AP gene exhibited differences in two groups, and especially the haplotype of the SNP was significantly different between the two groups. Results suggested that the ALOX5AP gene might be involved in lacunar infarct, while PDE4D gene was not a risk factor for lacunar infarct in individuals from Jiangsu Province, China.展开更多
Paralytic shellfish toxins(PSTs) are notorious neurotoxins that threaten public health and food safety worldwide.Although PST monitoring programs have recently been established throughout China, the profiles and varia...Paralytic shellfish toxins(PSTs) are notorious neurotoxins that threaten public health and food safety worldwide.Although PST monitoring programs have recently been established throughout China, the profiles and variation of PSTs in important commercial clams(e.g., Mactra veneriformis, Ruditapes philippinarum, and Meretrix meretrix) along the Jiangsu Province coastline remain largely unexplored. In this study, a validated hydrophilic interaction liquid chromatography–tandem mass spectrometry(HILIC-MS/MS) method was used to examine PST profiles and levels in 540 clam samples from natural production areas along Jiangsu Province coastline during2014–2016. Although the PST levels(≤6.38 μg saxitotoxin equivalents(eq)/kg) were consistently below European Union regulatory limits(≤800 μg saxitotoxin eq/kg) during this time period, saxitotoxin, decarbamoylsaxitotoxin,and gonyautoxins 1 and 4 were detected, and nearly 40% of the samples were saxitotoxin-positive. The PST levels also varied significantly by seasons, with peak values observed in May during 2014–2016. This is the first systematic report of PSTs in clams from Jiangsu Province, and additional research and protective measures are needed to ensure the safety of clams harvested in this area.展开更多
BACKGROUND： Many international studies have shown that plasminogen activator inhibitor-1 （PAl-l） 4G/5G promoter polymorphism does not increase the risk for cerebral infarction. OBJECTIVE： Using PCR methodology and...BACKGROUND： Many international studies have shown that plasminogen activator inhibitor-1 （PAl-l） 4G/5G promoter polymorphism does not increase the risk for cerebral infarction. OBJECTIVE： Using PCR methodology and agarose electrophoresis to detect PAI-1 4G/5G promoter polymorphism in patients with recurrent cerebral infarction in the North Jiangsu Province of China, and to compare results with healthy subjects and patients with first-occurrence cerebral infarction in the same region. DESIGN, TIME AND SETTING： Non-randomized, concurrent, control trial. A total of 122 cerebral infarction patients were admitted to Xuzhou Medical College Hospital＇s Department of Neurology and Xuzhou Central Hospital＇s Department of Neurology between July 2003 and August 2006. PARTICIPANTS： The patients consisted of 63 males and 59 females, aged （62 ± 10） years. They were divided into first-occurrence （n = 58） and recurrence （n = 64） groups. In addition, 50 healthy subjects that underwent physical examination in the outpatient department, including 26 males and 24 females, aged （60 ±12） years, were selected as controls. METHODS AND MAIN OUTCOME MEASURES： PAl-1 4G/5G promoter polymorphism was detected and analyzed using PCR methodology and agarose electrophoresis. RESULTS： Significant differences were determined in terms of genotypic frequency and allele frequency of PAI-1 4G/5G promoter polymorphism, in patients with first-occurrence or recurrent cerebral infarction, when compared with healthy subjects （P 〈 0.05）. There was, however, no significant difference between the first-occurrence and recurrence groups （P 〉 0.05）. CONCLUSION： PAl- 1 4G/5G promoter polymorphism is genetic risk factor for cerebral infarction in China. However, it may be associated with recurrence of cerebral infarction in patients from the North Jiangsu Province of China.展开更多
OBJECTIVE Lung function and grip strength(GS)are associated with cardiovascular disease(CVD),but whether these risk factors interact to affect CVD is unknown.This study aimed to explore the interactions between lung f...OBJECTIVE Lung function and grip strength(GS)are associated with cardiovascular disease(CVD),but whether these risk factors interact to affect CVD is unknown.This study aimed to explore the interactions between lung function and GS with major CVD(defined as fatal/non-fatal myocardial infarction,stroke,and heart failure)incidence.METHODS We conducted a prospective cohort study on the Chinese population in Jiangsu Province.Cox proportional haz-ards models were used to explore the associations between GS,lung function,and major CVD incidence.RESULTS A total of 5967 participants were included in our study;among them,182 participants developed major CVD.Parti-cipants with low forced vital capacity(FVC)had a higher risk of major CVD(hazard ratio(HR)=1.45;95%confidence interval(CI):1.05-2.01;P<0.05)compared with normal FVC.The risk of major CVD incidence(HR=0.54;95%CI:0.35-0.83;P<0.01)was significantly lower in participants with high GS than in individuals with low GS.The interaction between FVC and GS for major CVD incidence(P=0.006)was statistically significant.Compared with normal FVC participants with high GS,low FVC parti-cipants with low GS had the highest risk of major CVD incidence(HR=2.50;95%CI:1.43-4.36;P<0.01).CONCLUSION Among people with low FVC,the risk of major CVD is lower with high GS.Participants with low FVC and low GS have the highest risk of major CVD.Therefore,more attention should be paid to the incidence of major CVD in individu-als with low FVC,especially those who have lower GS.展开更多
Co-seismic water-level and temperature changes of the 2008 magnitude - 8.0 Wenchuan and the 2011 magnitude-9.0 Japan earthquakes recorded at 10 observation wells in Jiangsu province are presented and analyzed. The dat...Co-seismic water-level and temperature changes of the 2008 magnitude - 8.0 Wenchuan and the 2011 magnitude-9.0 Japan earthquakes recorded at 10 observation wells in Jiangsu province are presented and analyzed. The data show that water level responded more regularly with earthquake magnitude and dis- tance than water temperature. The response was different for wells located in different tectonic units, being weaker in central and northern plain, which has a relatively thick surface layer of loess, than southern Jiangsu, which is hilly.展开更多
This thesis discusses the earthquake reflecting ability of the observation well pattern system of Jiangsu Province,China,which has been digitally renovated,and probes into the cause of the major differences in the ear...This thesis discusses the earthquake reflecting ability of the observation well pattern system of Jiangsu Province,China,which has been digitally renovated,and probes into the cause of the major differences in the earthquake reflecting abilities of well holes at different measurement points.This is achieved through the analysis of the co-seismic responses to the Wenchuan(2008;Ms8.0,China)and Tohoku(2011;Ms9.0,Japan)earthquakes.We found that the co-seismic response of water level from regional well holes in Jiangsu Province was stronger than that of water temperature.The water-level co-seismic response follows a consistent law and is closely related to the earthquake magnitude.The co-seismic response of water temperature strongly varied among well points,and was more often manifested as a slow restorative change.The co-seismic responses also varied based on tectonic elements.The response in central and northern Jiangsu was weaker than that of southern Jiangsu,possibly due to the thicker loess cover layer in central Jiangsu which makes it less effective at capturing the micro-changes of stress-strain states relative to the hilly land in the south.The more complicated geological structure in southern Jiangsu makes it contribute to greater changes in the state of underground water after a minor disturbance.展开更多
This paper systematically analyzed 36 earthquake swarms in and around Jiangsu Province, summarized their characteristics and discussed the relationship between earthquske swarms and subsequent strong earthquakes. It a...This paper systematically analyzed 36 earthquake swarms in and around Jiangsu Province, summarized their characteristics and discussed the relationship between earthquske swarms and subsequent strong earthquakes. It also analyzed the judgment criteria for precursory earthquake swarms. Earthquake swarms in Jiangsu Province are concentrated in several areas. Most of them were of magnitude ML2.0～3.9. For most earthquake swarms, the number of earthquakes was less than 30. Time duration for about 55% of earthquake swarms was less than 15 days. The biggest magnitude of one earthquake swarm was not proportional to the number of earthquakes and time duration. There are 78% of earthquake swarms corresponded to the forthcoming earthquakes of M>4.6 in which there're 57% occured in one year, This shows a medium-and short-term criterion. Distance between earthquake swarm and future earthquake was distributed dispersedly. There were no earthquakes occurring in the same location as earthquake swarms. There was no good correlation between the magnitude and the corresponding rate of future earthquakes and the intensity of earthquake swarms. There was also no good correlation between the number of earthquakes in an earthquake swarm and the corresponding rate. The study also shows that it's better to use U-p or whole-combination to determine the type of earthquake swarm.展开更多
Based on the network monitoring data and field investigations,the basic characteristics of the M S4.9 earthquake at the juncture of Gaoyou and Baoying in Jiangsu Province on July20,2012 have been introduced,and the fo...Based on the network monitoring data and field investigations,the basic characteristics of the M S4.9 earthquake at the juncture of Gaoyou and Baoying in Jiangsu Province on July20,2012 have been introduced,and the focal mechanism solutions have also been obtained.According to the regional tectonic features and site macroscopic survey,the occurrence of the earthquake was probably related to the Yangchacang-Sangshutou fault.Based on site survey data,both the evaluation criterion of seismic intensity of this region and the seismic intensity maps have been proposed.According to the damage characteristics of brick-concrete structure and brick-wood structure,the main reasons of serious damage for buildings are poor foundation conditions,low seismic bearing capacity,poor quality of construction and disrepair.Considering the differences of earthquake damage in the different regions,advice on accelerating the new rural construction,improving the resistance against earthquake disasters of rural residential areas and strengthening the seismogenic research on strong and moderate size earthquake is proposed,which will be possibly helpful for earthquake damage survey,prediction and prevention.展开更多
Integrated geophysical technology is a necessary and effective means for geothermal exploration.However,integration of geophysical technology for large‐scale surveys with those for geothermal reservoir localization i...Integrated geophysical technology is a necessary and effective means for geothermal exploration.However,integration of geophysical technology for large‐scale surveys with those for geothermal reservoir localization is still in development.This study used the controlled source audio‐frequency magnetotelluric method technology for large‐scale exploration to obtain underground electrical structure information and micromotion detection technology to obtain underground wave velocity structure information.The combination of two detection technologies was used for local identification of geothermal reservoirs.Further,auxiliary correction and inversion constraint were implemented through the audio magnetotelluric sounding technology for maximum authenticity restoration of the near‐and transition‐field data.Through these technology improvements,a geothermal geological model was established for the Binhai County of Jiangsu Province in China and potential geothermal well locations were identified.On this basis,a geothermal well was drilled nearly 3000m deep,with a daily water volume of over 2000m3/day and a geothermal water temperature of 51°C at the well head.It is found that predictions using the above integrated geophysical exploration technology are in good agreement with the well geological formation data.This integrated geophysical technology can be effectively applied for geothermal exploration with high precision and reliability.展开更多
[Objective] This study aimed to investigate the genetic relationship among waxberry （Myrica rubra Bieb. et Zucc） cultivars in Jiangsu Province. [ Method] Eighteen waxberry cultivars （lines） in Jiangsu Province wer...[Objective] This study aimed to investigate the genetic relationship among waxberry （Myrica rubra Bieb. et Zucc） cultivars in Jiangsu Province. [ Method] Eighteen waxberry cultivars （lines） in Jiangsu Province were analyzed using ISSR-PCR method, and molecular phylogenetic tree was constructed using UPGNA method. [ Result ~ A total of 70 DNA fragments were amplified with nine screened primers, including 43 polymorphic fragments, accounting for 61.4% of the total number of amplified fragments; 18 waxberry cultivars （lines） were clustered into 6 categories with the genetic distance of 0. 14, indicating that there is partial isolation on the basis of gene exchange between waxberry cultivars （lines） in Jiangsu Province. [ Conclusion] This study provided scientific basis for the protection and utilization of waxberry germplasm resources and cultivation of new varieties.展开更多
Introduction:Rabies vaccination compliance and safety are critical for post-exposure prophylaxis.This study compared the freeze-dried human rabies vaccine(Vero cell)under 4-dose(Zagreb)and 5-dose(Essen)regimens in rea...Introduction:Rabies vaccination compliance and safety are critical for post-exposure prophylaxis.This study compared the freeze-dried human rabies vaccine(Vero cell)under 4-dose(Zagreb)and 5-dose(Essen)regimens in real-world settings.Methods:In this open-label,randomized trial across Jiangsu Province,China between 2023 and 2024,2,000 participants received Zagreb(n=999)or Essen(n=1,001)regimens.Active mobile-app surveillance monitored adverse reactions for 28 days postvaccination.Compliance was assessed through dropout(discontinuation)and out-of-window administration(delayed dosing).Safety and compliance differences were analyzed using the chi-squared or Fisher’s exact tests.Results:Overall adverse reaction rates were comparable(Zagreb:2.10%;Essen:2.70%;P=0.385).Solicited local adverse reactions(pain,induration,swelling,and itching)occurred at rates of 1.50%for Zagreb and 2.10%for Essen.Solicited systemic adverse reactions(fever,diarrhea,and vomiting)were 0.60%for both.Dropout rates were statistically similar(8.51%vs.8.69%;P=0.884),but Zagreb had significantly fewer out-of-window administrations(8.41%vs.16.38%;P<0.001).Compliance factors differed:Zagreb was associated with age/marital status/exposure level;Essen additionally involved education and perceived convenience.Conclusion:Both regimens demonstrated comparable safety profiles.The Zagreb regimen showed significantly superior schedule adherence through reduced out-ofwindow administrations while maintaining similar dropout rates to the Essen regimen.展开更多
Introduction:Non-suicidal self-injury(NSSI)has become increasingly prevalent among adolescents,representing a significant public health concern with profound impacts on both physical and mental wellbeing.This study ai...Introduction:Non-suicidal self-injury(NSSI)has become increasingly prevalent among adolescents,representing a significant public health concern with profound impacts on both physical and mental wellbeing.This study aims to determine the prevalence of NSSI among adolescents in Jiangsu Province and develop a prediction model to facilitate early identification and intervention.Methods:This study is based on the“School-based Evaluation and Response to Child Health(SEARCH)”project.A cross-sectional survey was conducted among students from 11 schools in Jiangsu Province,China in 2023.Following data cleaning,11,427 students were included in the analysis.Machine learning methods were employed to establish a risk prediction model for NSSI among adolescents.Results:The prevalence of NSSI among adolescents aged 10–18 was 12.72%.Eight key predictors of NSSI were identified:insomnia,emotional symptoms,cohesion of family environment,history of drinking alcohol,gender,conflict of family environment,conduct problems,and academic level.The XGBoost model demonstrated an area under the curve(AUC)of 0.800[95%confidence interval(CI):0.776,0.823]and an accuracy(ACC)of 0.886 in the testing set.Conclusions:This study underscores the importance of personalized prevention strategies for NSSI and highlights the necessity of implementing comprehensive behavioral interventions,including mental health support,sleep quality enhancement,and cultivation of supportive family environments.展开更多
基金Scientific and Technological Project of Social Development of Jiangsu Province (BS2002068).
文摘According to the analysis on the characteristics of historic earthquakes in Jiangsu Province and South Huanghai Sea region, the historical earthquakes in the studied area are divided into two kinds of comparatively safe class and comparatively dangerous class. Then the statistical result of earthquake class, the characteristics of geo-graphical distribution and geological structures are studied. The study shows: a) In Jiangsu Province and South Huanghai Sea region, the majority of historical strong earthquakes belong to comparatively safe class, only 13.8% belong to comparatively dangerous class; b) Most historical earthquakes belong to comparatively safe class in the land area of Jiangsu, eastern sea area of Yangtze River mouth and northern depression of South Huanghai Sea region. However, along the coast of middle Jiangsu Province and in the sea area of South Huanghai Sea, the distribution of historical earthquake classes is complex and the earthquake series of comparatively dan-gerous class and comparatively safe class are equivalent in number; c) In the studied area, the statistical results of historical earthquake classes and the characteristics of spatial distribution accord very well with the real case of present-day earthquake series. It shows that the seismic activity in the region has the characteristic of succession, and the result from this study can be used as a reference for early postseismic judgment in the earthquake emer-gency work in Jiangsu Province.
文摘According to the analysis on the characteristics of historic earthquakes in Jiangsu Province and South Huanghai Sea region, the historical earthquakes in the studied area are divided into two kinds of comparatively safe class and comparatively dangerous class. Then the statistical result of earthquake class, the characteristics of geo-graphical distribution and geological structures are studied. The study shows: a) In Jiangsu Province and South Huanghai Sea region, the majority of historical strong earthquakes belong to comparatively safe class, only 13.8% belong to comparatively dangerous class; b) Most historical earthquakes belong to comparatively safe class in the land area of Jiangsu, eastern sea area of Yangtze River mouth and northern depression of South Huanghai Sea region. However, along the coast of middle Jiangsu Province and in the sea area of South Huanghai Sea, the distribution of historical earthquake classes is complex and the earthquake series of comparatively dan-gerous class and comparatively safe class are equivalent in number; c) In the studied area, the statistical results of historical earthquake classes and the characteristics of spatial distribution accord very well with the real case of present-day earthquake series. It shows that the seismic activity in the region has the characteristic of succession, and the result from this study can be used as a reference for early postseismic judgment in the earthquake emer-gency work in Jiangsu Province.
基金N ationalN aturalScience Foundation ofChina,N o.40271103K ey Fundam entalA dvance Research Foundation ofN anjing U niversity Subject Construction of Physical G eography during "985" and Testing Fund of N anjingU niversity
文摘Along the north bank of the Xuxi River, the sand-intercalated-muddy gravel layer from -3.7 - -5.8 m in the borehole 7508 at the East Dam and the middle, coarse and fine sand layer with a thickness of 4.5 m at the lower part of the borehole 8179 between the East Dam and the West Dam indicate that a large natural river was here before the Kingdom of Wu excavated the Xuxi Canal. The existence of Neolithic sites such as Xuecheng, Chaoduntou and Xiajiadang along the Xuxi River and the silt layer with dozens of meters archived under the earth＇s surface within a range of 1 km along both banks are the even more important evidences for the existence of the ancient Zhongjiang River. The floodgate of the East Dam nowadays makes against the communication between the Shuiyangjiang River and the Taihu Lake. The authors suggest the canal between Wuhu and Taihu Lake should be excavated as soon as possible, namely, the navigation channel from Wuhu through Guchenghu Lake, Xuxi River, East Dam, Liyang, Yixing to Taihu Lake should be further widen and the deposits composed of slope wash on the watershed between Shuiyangjiang River and Taihu Lake should be dredged away. Then, the channel journey can be shortened, the boats in ship transportation on the Yangtze River can be shunted to ensure the security of shipping, the resources of sand and gravel in the old river channel can be exploited and the dike of the Yangtze River can be reinforced. So, the problems of irrigation, flood diversion, pollution abatement and drainage of flooded fields in the lower Yangtze River will be resolved. Then, the above methods can impel the sustainable development of the Xuxi River and Taihu Lake area.
基金Supported by National Research Fund for Public Welfare (Meteorology) of China (GYHY201006029)Meteorological Scientific Research Open Fund of Jiangsu Province,China (ZD201108)
文摘[ Objective] The study aimed to analyze and predict the suitable period of laver along the coastal areas of Jiangsu Province. [ Method ] TO enhance the ability of meteorology to service laver culture, using the modern weather forecast technology, agricultural weather prediction was de- veloped according to the demands for meteorological conditions during laver production. [ Result] From south to north, there were certain differ- ences in the suitable periods of laver culture, breeding and harvesting, with slight variations. The forecast of the first and last days of certain water temperature could provide scientific references for the meteorological service of laver culture, and the service effect became better after it was modi- fied with the aid of the medium-term and long-term weather prediction. [ Conclusion] The research can offer theoretical bases for the culture of laver along the coastal areas of Jiangsu Province.
基金Supported by the National Social Science Foundation of China (Nos. 10ZD & M030)the Non-Profit Industry Financial Program of the Ministry of Land and Resources of China (No. 200811033)+1 种基金the Foundation of Philosophy and Social Sciences Research of Jiangsu Higher Education Institutions,China (No. 2010ZDAXM008)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,China
文摘Soil organic carbon (SOC) plays a key role in the global carbon cycle.In this study,we used statistical and geostatistical methods to characterize and compare the spatial heterogeneity of SOC in soils of Jiangsu Province,China,and investigate the factors that influence it,such as topography,soil type,and land use.Our study was based on 24 186 soil samples obtained from the surface soil layer (0-0.2 m) and covering the entire area of the province.Interpolated values of SOC density in the surface layer,obtained by kriging based on a spherical model,ranged between 3.25 and 32.43 kg m 3.The highest SOC densities tended to occur in the Taihu Plain,Lixia River Plain,along the Yangtze River,and in high-elevation hilly areas such as those in northern and southwest Jiangsu,while the lowest values were found in the coastal plain.Elevation,slope,soil type,and land use type significantly affected SOC densities.Steeper slope tended to result in SOC decline.Correlation between elevation and SOC densities was positive in the hill areas but negative in the low plain areas,probably due to the effect of different land cover types,temperature,and soil fertility.High SOC densities were usually found in limestone and paddy soils and low densities in coastal saline soils and alluvial soils,indicating that high clay and silt contents in the soils could lead to an increase,and high sand content to a decrease in the accumulation of SOC.SOC densities were sensitive to land use and usually increased in towns,woodland,paddy land,and shallow water areas,which were strongly affected by industrial and human activities,covered with highly productive vegetation,or subject to long-term use of organic fertilizers or flooding conditions.
基金Supported by Jiangsu Provincial Health Department No. RC 2003090
文摘AIM： To study the main environmental and lifestyle factors that account for the regional differences in esophageal cancer （EC） risk in low- and high-risk areas of Jiangsu Province, China. METHODS： Since 2003, a population-based casecontrol study has been conducted simultaneously in lowrisk （Ganyu County） and high-risk （Dafeng County） areas of Jiangsu Province, China. Using identical protocols and pre-tested standardized questionnaire, following written informed consent, eligible subjects were inquired about their detail information on potential determinants of EC, including demographic information, socio-economic status, living conditions, disease history, family cancer history, smoking, alcohol drinking, dietary habits, frequency, amount of food intake, etc. Conditional logistic regression with maximum likelihood estimation was used to obtain Odds ratio （OR） and 95 % confidence interval （95% CI）, after adjustment for potential confounders. RESULTS： In the preliminary analysis of the ongoing study, we recruited 291 pairs of cases and controls in Dafeng and 240 pairs of cases and controls in Ganyu, respectively. In both low-risk and high-risk areas, EC was inversely associated with socio-economic status, such as level of education, past economic status and body mass index. However, this disease was more frequent among those who had a family history of cancer or encountered misfortune in the past 10 years. EC was also more frequent among smokers, alcohol drinkers and fast eaters. Furthermore, there was a geographic variation of the associations between smoking, alcohol drinking and EC risk despite the similar prevalence of these risk factors in both low-risk and high-risk areas. The dose-response relationship of smoking and smoking related variables, such as age of the first smoking, duration and amount were apparent only in high-risk areas. On the contrary, a dose-response relationship on the effect of alcohol drinking on EC was observed only in low-risk areas. CONCLUSION： The environmental risk factors, together with genetic factors and gene-environmental interactions might be the main reason for this high-risk gradient in .liangsu Province, China.
基金supported in part by"National S&T Major Project Foundation of China"(2009ZX10004-904)Universities Natural Science Foundation of Jiangsu Province(09KJB330004),National Science Foundation Grant DMS-9971405National Institutes of Health Contract N01-HV-28183
文摘This paper first applies the sequential cluster method to set up the classification standard of infectious disease incidence state based on the fact that there are many uncertainty characteristics in the incidence course.Then the paper presents a weighted Markov chain,a method which is used to predict the future incidence state.This method assumes the standardized self-coefficients as weights based on the special characteristics of infectious disease incidence being a dependent stochastic variable.It also analyzes the characteristics of infectious diseases incidence via the Markov chain Monte Carlo method to make the long-term benefit of decision optimal.Our method is successfully validated using existing incidents data of infectious diseases in Jiangsu Province.In summation,this paper proposes ways to improve the accuracy of the weighted Markov chain,specifically in the field of infection epidemiology.
基金supported by grants from the Jiangsu Birth Defects Intervention Program(No.JS200302)the Natural Science Foundation of Jiangsu Province(No.BK2008501)
文摘We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence of infant macrosomia at the age of 7 years.A prospective population based cohort study was designed to examine the associations between maternal and perinatal characteristics and the risk of macrosomia.A nested case-control study was conducted to explore the long-term health consequence of infant macrosomia.The mean maternal age of the macrosomia group was 24.74±3.32 years,which is slightly older than that in the control group（24.35±3.14 years,P = 0.000）.The mean maternal body mass index（BMI） at early pregnancy was 22.75±2.81 kg/m 2,which was also higher than that in the control group（21.76±2.59 kg/m 2,P = 0.000）.About 64.6% of macrosomic neonates were males,compared with 51.0% in the control group（P = 0.000）.Compared with women with normal weight（BMI：18.5-23.9 kg/m 2）,women who were overweight（BMI：24-27.9 kg/m 2） or obese（BMI ≥ 28 kg/m 2）,respectively,had a 1.69-fold（P = 0.000） and a 1.49-fold（P = 0.000） increased risks of having a neonate with macrosomia,while light weight（BMI〈18.5 kg/m 2） women had an approximately 50% reduction of the risk.Furthermore,macrosomia infant had a 1.52-fold and 1.50-fold risk,respectively,of developing overweight or obesity at the age of 7 years（P = 0.001 and P = 0.000）.Older maternal age,higher maternal BMI at early pregnancy and male gender were independent risk factors of macrosomia.Macrosomic infant was associated with an increased predisposition to develop overweight or obesity at the beginning of their childhood.
基金the General Program of National Natural Science Foundation of China,No.30870125
文摘The genes for 5-1ipoxygenase activating protein （ALOX5AP） and phosphodiesterase 4D （PDE4D） have been demonstrated as susceptibility genes for lacunar in the Icelandic and Pakistani populations, but little is known about the role of these genes in Chinese populations. The present study utilized polymerase chain reaction and ligase detection reaction to detect single nucleotide polymorphisms （SNPs） in 280 consecutive stroke patients and 258 unrelated population-based controls from Nanjing, Jiangsu Province, China. The allele frequency, genotypes, and haplotypes of the two SNPs （rs456009 and rs966221） in PDE4D were similar between the two groups. However, A allele frequency of rs4073259 （A/G） and rs4769055 （A/C） in the ALOX5AP gene exhibited differences in two groups, and especially the haplotype of the SNP was significantly different between the two groups. Results suggested that the ALOX5AP gene might be involved in lacunar infarct, while PDE4D gene was not a risk factor for lacunar infarct in individuals from Jiangsu Province, China.
基金The Public Science and Technology Research Funds Projects of Ocean under contract Nos 201305007 and 201405017
文摘Paralytic shellfish toxins(PSTs) are notorious neurotoxins that threaten public health and food safety worldwide.Although PST monitoring programs have recently been established throughout China, the profiles and variation of PSTs in important commercial clams(e.g., Mactra veneriformis, Ruditapes philippinarum, and Meretrix meretrix) along the Jiangsu Province coastline remain largely unexplored. In this study, a validated hydrophilic interaction liquid chromatography–tandem mass spectrometry(HILIC-MS/MS) method was used to examine PST profiles and levels in 540 clam samples from natural production areas along Jiangsu Province coastline during2014–2016. Although the PST levels(≤6.38 μg saxitotoxin equivalents(eq)/kg) were consistently below European Union regulatory limits(≤800 μg saxitotoxin eq/kg) during this time period, saxitotoxin, decarbamoylsaxitotoxin,and gonyautoxins 1 and 4 were detected, and nearly 40% of the samples were saxitotoxin-positive. The PST levels also varied significantly by seasons, with peak values observed in May during 2014–2016. This is the first systematic report of PSTs in clams from Jiangsu Province, and additional research and protective measures are needed to ensure the safety of clams harvested in this area.
基金the Xuzhou Social Development Foundation of Jiangsu Province, No. 2006046
文摘BACKGROUND： Many international studies have shown that plasminogen activator inhibitor-1 （PAl-l） 4G/5G promoter polymorphism does not increase the risk for cerebral infarction. OBJECTIVE： Using PCR methodology and agarose electrophoresis to detect PAI-1 4G/5G promoter polymorphism in patients with recurrent cerebral infarction in the North Jiangsu Province of China, and to compare results with healthy subjects and patients with first-occurrence cerebral infarction in the same region. DESIGN, TIME AND SETTING： Non-randomized, concurrent, control trial. A total of 122 cerebral infarction patients were admitted to Xuzhou Medical College Hospital＇s Department of Neurology and Xuzhou Central Hospital＇s Department of Neurology between July 2003 and August 2006. PARTICIPANTS： The patients consisted of 63 males and 59 females, aged （62 ± 10） years. They were divided into first-occurrence （n = 58） and recurrence （n = 64） groups. In addition, 50 healthy subjects that underwent physical examination in the outpatient department, including 26 males and 24 females, aged （60 ±12） years, were selected as controls. METHODS AND MAIN OUTCOME MEASURES： PAl-1 4G/5G promoter polymorphism was detected and analyzed using PCR methodology and agarose electrophoresis. RESULTS： Significant differences were determined in terms of genotypic frequency and allele frequency of PAI-1 4G/5G promoter polymorphism, in patients with first-occurrence or recurrent cerebral infarction, when compared with healthy subjects （P 〈 0.05）. There was, however, no significant difference between the first-occurrence and recurrence groups （P 〉 0.05）. CONCLUSION： PAl- 1 4G/5G promoter polymorphism is genetic risk factor for cerebral infarction in China. However, it may be associated with recurrence of cerebral infarction in patients from the North Jiangsu Province of China.
基金This work was supported by the Natural Science Foundations of China(81973005)the Natural Science Foundation of Jiangsu Province(BK20151593).
文摘OBJECTIVE Lung function and grip strength(GS)are associated with cardiovascular disease(CVD),but whether these risk factors interact to affect CVD is unknown.This study aimed to explore the interactions between lung function and GS with major CVD(defined as fatal/non-fatal myocardial infarction,stroke,and heart failure)incidence.METHODS We conducted a prospective cohort study on the Chinese population in Jiangsu Province.Cox proportional haz-ards models were used to explore the associations between GS,lung function,and major CVD incidence.RESULTS A total of 5967 participants were included in our study;among them,182 participants developed major CVD.Parti-cipants with low forced vital capacity(FVC)had a higher risk of major CVD(hazard ratio(HR)=1.45;95%confidence interval(CI):1.05-2.01;P<0.05)compared with normal FVC.The risk of major CVD incidence(HR=0.54;95%CI:0.35-0.83;P<0.01)was significantly lower in participants with high GS than in individuals with low GS.The interaction between FVC and GS for major CVD incidence(P=0.006)was statistically significant.Compared with normal FVC participants with high GS,low FVC parti-cipants with low GS had the highest risk of major CVD incidence(HR=2.50;95%CI:1.43-4.36;P<0.01).CONCLUSION Among people with low FVC,the risk of major CVD is lower with high GS.Participants with low FVC and low GS have the highest risk of major CVD.Therefore,more attention should be paid to the incidence of major CVD in individu-als with low FVC,especially those who have lower GS.
文摘Co-seismic water-level and temperature changes of the 2008 magnitude - 8.0 Wenchuan and the 2011 magnitude-9.0 Japan earthquakes recorded at 10 observation wells in Jiangsu province are presented and analyzed. The data show that water level responded more regularly with earthquake magnitude and dis- tance than water temperature. The response was different for wells located in different tectonic units, being weaker in central and northern plain, which has a relatively thick surface layer of loess, than southern Jiangsu, which is hilly.
基金supported by the Scientific and Technological Support Project of Jiangsu Province(No.BS2007084)Seismic Technology Spark Project(No.XH12020)
文摘This thesis discusses the earthquake reflecting ability of the observation well pattern system of Jiangsu Province,China,which has been digitally renovated,and probes into the cause of the major differences in the earthquake reflecting abilities of well holes at different measurement points.This is achieved through the analysis of the co-seismic responses to the Wenchuan(2008;Ms8.0,China)and Tohoku(2011;Ms9.0,Japan)earthquakes.We found that the co-seismic response of water level from regional well holes in Jiangsu Province was stronger than that of water temperature.The water-level co-seismic response follows a consistent law and is closely related to the earthquake magnitude.The co-seismic response of water temperature strongly varied among well points,and was more often manifested as a slow restorative change.The co-seismic responses also varied based on tectonic elements.The response in central and northern Jiangsu was weaker than that of southern Jiangsu,possibly due to the thicker loess cover layer in central Jiangsu which makes it less effective at capturing the micro-changes of stress-strain states relative to the hilly land in the south.The more complicated geological structure in southern Jiangsu makes it contribute to greater changes in the state of underground water after a minor disturbance.
基金funded by the Social Development Program of Jiangsu Province(Grant No.BS2007084)
文摘This paper systematically analyzed 36 earthquake swarms in and around Jiangsu Province, summarized their characteristics and discussed the relationship between earthquske swarms and subsequent strong earthquakes. It also analyzed the judgment criteria for precursory earthquake swarms. Earthquake swarms in Jiangsu Province are concentrated in several areas. Most of them were of magnitude ML2.0～3.9. For most earthquake swarms, the number of earthquakes was less than 30. Time duration for about 55% of earthquake swarms was less than 15 days. The biggest magnitude of one earthquake swarm was not proportional to the number of earthquakes and time duration. There are 78% of earthquake swarms corresponded to the forthcoming earthquakes of M>4.6 in which there're 57% occured in one year, This shows a medium-and short-term criterion. Distance between earthquake swarm and future earthquake was distributed dispersedly. There were no earthquakes occurring in the same location as earthquake swarms. There was no good correlation between the magnitude and the corresponding rate of future earthquakes and the intensity of earthquake swarms. There was also no good correlation between the number of earthquakes in an earthquake swarm and the corresponding rate. The study also shows that it's better to use U-p or whole-combination to determine the type of earthquake swarm.
基金Supported by Key Project of Suzhou Municipal Government,China(No.2009-191)Key Project of Xuzhou Municipal Government,China(T(2009)009)
文摘Based on the network monitoring data and field investigations,the basic characteristics of the M S4.9 earthquake at the juncture of Gaoyou and Baoying in Jiangsu Province on July20,2012 have been introduced,and the focal mechanism solutions have also been obtained.According to the regional tectonic features and site macroscopic survey,the occurrence of the earthquake was probably related to the Yangchacang-Sangshutou fault.Based on site survey data,both the evaluation criterion of seismic intensity of this region and the seismic intensity maps have been proposed.According to the damage characteristics of brick-concrete structure and brick-wood structure,the main reasons of serious damage for buildings are poor foundation conditions,low seismic bearing capacity,poor quality of construction and disrepair.Considering the differences of earthquake damage in the different regions,advice on accelerating the new rural construction,improving the resistance against earthquake disasters of rural residential areas and strengthening the seismogenic research on strong and moderate size earthquake is proposed,which will be possibly helpful for earthquake damage survey,prediction and prevention.
基金Geological and Mineral Resources Survey of Metallogenic Belt in the Middle and Lower Reaches of Yangtze River,Grant/Award Number:1212011220540Jiangsu 1:50000 Dingsanwei,Kaishan Island,Yangqiao,Chenjiagang,New Huaihe Estuary,Xiangshui Estuary,Dayou,Xiaojie,DayuJian District,Grant/Award Numbers:Base[2012]02‐014‐009,Base[2013]01‐019‐002,Base[2014]01‐021‐003。
文摘Integrated geophysical technology is a necessary and effective means for geothermal exploration.However,integration of geophysical technology for large‐scale surveys with those for geothermal reservoir localization is still in development.This study used the controlled source audio‐frequency magnetotelluric method technology for large‐scale exploration to obtain underground electrical structure information and micromotion detection technology to obtain underground wave velocity structure information.The combination of two detection technologies was used for local identification of geothermal reservoirs.Further,auxiliary correction and inversion constraint were implemented through the audio magnetotelluric sounding technology for maximum authenticity restoration of the near‐and transition‐field data.Through these technology improvements,a geothermal geological model was established for the Binhai County of Jiangsu Province in China and potential geothermal well locations were identified.On this basis,a geothermal well was drilled nearly 3000m deep,with a daily water volume of over 2000m3/day and a geothermal water temperature of 51°C at the well head.It is found that predictions using the above integrated geophysical exploration technology are in good agreement with the well geological formation data.This integrated geophysical technology can be effectively applied for geothermal exploration with high precision and reliability.
基金Supported by Special Fund for National Public Service Sectors (Agriculture) Research of China(20120389)Scientific and Technological Support Project of Suzhou City (SN201008)+3 种基金Public Technology Service Platform for Characteristic Fruit Industry of Suzhou City(SZP201011)Natural Science Research Project from Suzhou Polytechnic Institute of Agriculture(NS1101)Jiangsu Agricultural Science and Technology Innovation Fund[CX(12)2011]Jiangsu Provincial Science&Technology Support (Agriculture) Program(BE2012361)
文摘[Objective] This study aimed to investigate the genetic relationship among waxberry （Myrica rubra Bieb. et Zucc） cultivars in Jiangsu Province. [ Method] Eighteen waxberry cultivars （lines） in Jiangsu Province were analyzed using ISSR-PCR method, and molecular phylogenetic tree was constructed using UPGNA method. [ Result ~ A total of 70 DNA fragments were amplified with nine screened primers, including 43 polymorphic fragments, accounting for 61.4% of the total number of amplified fragments; 18 waxberry cultivars （lines） were clustered into 6 categories with the genetic distance of 0. 14, indicating that there is partial isolation on the basis of gene exchange between waxberry cultivars （lines） in Jiangsu Province. [ Conclusion] This study provided scientific basis for the protection and utilization of waxberry germplasm resources and cultivation of new varieties.
文摘Introduction:Rabies vaccination compliance and safety are critical for post-exposure prophylaxis.This study compared the freeze-dried human rabies vaccine(Vero cell)under 4-dose(Zagreb)and 5-dose(Essen)regimens in real-world settings.Methods:In this open-label,randomized trial across Jiangsu Province,China between 2023 and 2024,2,000 participants received Zagreb(n=999)or Essen(n=1,001)regimens.Active mobile-app surveillance monitored adverse reactions for 28 days postvaccination.Compliance was assessed through dropout(discontinuation)and out-of-window administration(delayed dosing).Safety and compliance differences were analyzed using the chi-squared or Fisher’s exact tests.Results:Overall adverse reaction rates were comparable(Zagreb:2.10%;Essen:2.70%;P=0.385).Solicited local adverse reactions(pain,induration,swelling,and itching)occurred at rates of 1.50%for Zagreb and 2.10%for Essen.Solicited systemic adverse reactions(fever,diarrhea,and vomiting)were 0.60%for both.Dropout rates were statistically similar(8.51%vs.8.69%;P=0.884),but Zagreb had significantly fewer out-of-window administrations(8.41%vs.16.38%;P<0.001).Compliance factors differed:Zagreb was associated with age/marital status/exposure level;Essen additionally involved education and perceived convenience.Conclusion:Both regimens demonstrated comparable safety profiles.The Zagreb regimen showed significantly superior schedule adherence through reduced out-ofwindow administrations while maintaining similar dropout rates to the Essen regimen.
基金Supported by the Jiangsu Provincial Key Research and Development Program(BE2021617).
文摘Introduction:Non-suicidal self-injury(NSSI)has become increasingly prevalent among adolescents,representing a significant public health concern with profound impacts on both physical and mental wellbeing.This study aims to determine the prevalence of NSSI among adolescents in Jiangsu Province and develop a prediction model to facilitate early identification and intervention.Methods:This study is based on the“School-based Evaluation and Response to Child Health(SEARCH)”project.A cross-sectional survey was conducted among students from 11 schools in Jiangsu Province,China in 2023.Following data cleaning,11,427 students were included in the analysis.Machine learning methods were employed to establish a risk prediction model for NSSI among adolescents.Results:The prevalence of NSSI among adolescents aged 10–18 was 12.72%.Eight key predictors of NSSI were identified:insomnia,emotional symptoms,cohesion of family environment,history of drinking alcohol,gender,conflict of family environment,conduct problems,and academic level.The XGBoost model demonstrated an area under the curve(AUC)of 0.800[95%confidence interval(CI):0.776,0.823]and an accuracy(ACC)of 0.886 in the testing set.Conclusions:This study underscores the importance of personalized prevention strategies for NSSI and highlights the necessity of implementing comprehensive behavioral interventions,including mental health support,sleep quality enhancement,and cultivation of supportive family environments.
