Objective To determine the prevalence of lumbar spondylolysis(LS)and the proportion of spondylolytic spondylolisthesis(SS)in China,and to evaluate the musculoskeletal status of patients with LS and SS.Methods Spine Co...Objective To determine the prevalence of lumbar spondylolysis(LS)and the proportion of spondylolytic spondylolisthesis(SS)in China,and to evaluate the musculoskeletal status of patients with LS and SS.Methods Spine Computed Tomography(CT)images were collected from community populations aged 40 and above in a nationwide multi-center project.LS was diagnosed,and SS was graded by an experienced radiologist.Bone mineral density(BMD)and paraspinal muscle parameters were quantified based on CT images.Results One hundred and seventeen patients of a total of 3,317 individuals were diagnosed with LS,corresponding to a prevalence rate of 3.53%.63 of the 1,214 males(5.18%)and 54 of the 2,103 females(2.57%)were diagnosed with LS.SS occurred in 64/121 vertebrae(52.89%).BMD was not associated with LS(P=0.341).The L5 extensor paraspinal muscle density was higher in the LS group than in the non-LS group.In the LS group,patients with SS had a smaller L5 paraspinal extensor muscle cross-sectional area than those without SS(P=0.003).Conclusion The prevalence of LS in Chinese adults was 3.53%,with prevalence rates of 5.18%in males and 2.57%in females.Patients with LS have higher muscle density,whereas those with SS have smaller muscle cross-sectional areas at the L5 level.展开更多
With the advancements of the next-generation communication networking and Internet ofThings(IoT)technologies,a variety of computation-intensive applications(e.g.,autonomous driving and face recognition)have emerged.Th...With the advancements of the next-generation communication networking and Internet ofThings(IoT)technologies,a variety of computation-intensive applications(e.g.,autonomous driving and face recognition)have emerged.The execution of these IoT applications demands a lot of computing resources.Nevertheless,terminal devices(TDs)usually do not have sufficient computing resources to process these applications.Offloading IoT applications to be processed by mobile edge computing(MEC)servers with more computing resources provides a promising way to address this issue.While a significant number of works have studied task offloading,only a few of them have considered the security issue.This study investigates the problem of spectrum allocation and security-sensitive task offloading in an MEC system.Dynamic voltage scaling(DVS)technology is applied by TDs to reduce energy consumption and computing time.To guarantee data security during task offloading,we use AES cryptographic technique.The studied problem is formulated as an optimization problem and solved by our proposed efficient offloading scheme.The simulation results show that the proposed scheme can reduce system cost while guaranteeing data security.展开更多
The manipulation of nanometric objects,encompassing both non-biological and biological objects,offers a transformative avenue for breakthroughs in diverse fields,such as chemistry,biology,chemical and biomedical engin...The manipulation of nanometric objects,encompassing both non-biological and biological objects,offers a transformative avenue for breakthroughs in diverse fields,such as chemistry,biology,chemical and biomedical engineering,materials and mechanical engineering,and various industrial applications.However,achieving accuracy,precision,and high throughput in the manipulation of nanometric objects,whether on the scale of a single nanometric entity or molecule,is a formidable challenge because of the extremely small dimensions involved.Nanofluidics has already demonstrated unique capabilities for transporting the mass of ions and small molecules at the nanoscale.We posit that chip-based nanofluidic devices provide potent strategies for the precise,accurate,and high-throughput manipulation of single nanometric entities and molecules,benefiting from their dimensions,which are comparable to those of nanometric objects.This article offers an overview of the current progress in nanofluidic manipulation of single nanometric objects.It also discusses the challenges in the development of nanofluidic manipulation technologies.Furthermore,the article explores future opportunities in the field,highlighting possible solutions to the challenges,and aims to contribute to the ongoing discourse on nanofluidic manipulation,thus propelling the field to overcome its current limitations.展开更多
Polythiophenes(PTs)with flexible backbones possess inherent polymer behaviors,including molecular wire effects and dynamic structural changes inπ-conjugated systems.The chemical sensing at the functionalized side cha...Polythiophenes(PTs)with flexible backbones possess inherent polymer behaviors,including molecular wire effects and dynamic structural changes inπ-conjugated systems.The chemical sensing at the functionalized side chains can manipulate such polymer characteristics,resulting in various optical patterns depending on the analyte structures and their concentrations.The unique optical patterns derived from polymer properties contribute to group categorization over a wide concentration range for pattern recognition.This review aims to provide a concise overview of the potential of PT chemosensor arrays using actual sensing examples in environmental monitoring,medical diagnostics,and food analysis.Furthermore,this review summarizes the methodologies that use polymer gels to realize practical chemosensor array chips for onsite analysis.展开更多
In this study, we introduced the temperaturedependent formation phases and crystallographic parameters of hot-pressed silver gallium telluride AgGaTe2 and copper gallium telluride CuGaTe2 with chalcopyrite structure f...In this study, we introduced the temperaturedependent formation phases and crystallographic parameters of hot-pressed silver gallium telluride AgGaTe2 and copper gallium telluride CuGaTe2 with chalcopyrite structure from 300 to 800 K. These two compounds are potential thermoelectric materials in the intermediate temperature range; however, the temperature-dependent formation phases and crystallographic parameters of hotpressed samples have not yet been analyzed in detail. The crystal structure analysis based on synchrotron X-ray diffraction （SXRD） measurements clarifies that impurity phases such as Te and Ag2Te in the AgGaTe2 matrix and Te and CuTe in the CuGaTe2 matrix appear at some temperature regions above 300 K. The existence of such impurity phases could be correlated with the increases of the electrical resistivity and Seebeck coefficient of the samples after multiple measurement cycles of the temperature-dependent transport properties from 300 to 800 K. The tetragonal lattice parameters a and c, tetragonal lattice volume, thermal expansion coefficients, tetragonal distortion, anion displacement parameter, and isotropic displacement parameter of the hot-pressed AgGaTe2 and CuGaTe2 were also analyzed. These crystallographic parameters are expected to substantially affect the thermoelectric properties of AgGaTe2 and CuGaTe2. Our results provide prospect of the long-term high-temperature stability and clues of the detailed analysis on the transport properties of hot-pressed AgGaTe2 and CuGaTe2, which should aid their development for thermoelectric applications.展开更多
Nanostructured carbon materials, including carbon nanotubes, graphene and nanoporous carbon, show promise for expanding renewable energy. In particular, the configuration and electronic properties of graphene edges in...Nanostructured carbon materials, including carbon nanotubes, graphene and nanoporous carbon, show promise for expanding renewable energy. In particular, the configuration and electronic properties of graphene edges in relation with their electrochemical activity have become a major issue in carbon-based energy storage devices. Here, we review recent results concerning the important roles of graphene edges as the gateway for lithium ion intercalation in the anode of lithium-ion batteries, as promoters of high capacitance in carbon-based supercapacitors, and as anchoring sites for Pt nanoparticles in fuel cells. We envisage that the controlled synthesis of a specific, clean, and stable edge configuration could be achieved to maximize the electrochemical performance of nanostructured carbon-based energy storage devices.展开更多
A large number of 3D models are created on computers and available for networks. Some content-based retrieval technologies are indispensable to find out particular data from such anonymous datasets. Though several sha...A large number of 3D models are created on computers and available for networks. Some content-based retrieval technologies are indispensable to find out particular data from such anonymous datasets. Though several shape retrieval technologies have been developed, little attention has been given to the points on human＇s sense and impression （as known as Kansei） in the conventional techniques, In this paper, the authors propose a novel method of shape retrieval based on shape impression of human＇s Kansei. The key to the method is the Gaussian curvature distribution from 3D models as features for shape retrieval. Then it classifies the 3D models by extracted feature and measures similarity among models in storage.展开更多
Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain.However,compared with the expression and function of bioactive mature domain,the biological ro...Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain.However,compared with the expression and function of bioactive mature domain,the biological role of the pro-domain is poorly understood.Unexpectedly,we found that the pro-domain（or pro-peptide）of brain-derived neurotrophic factor（BDNF）,which is well-known neurotrophic factor in brain,has a potential ability to facilitate hippocampal long-term depression.Furthermore,a BDNF polymorphism Val66Met,which substitute valine into methionine at 66 amino acid,impacted the biological activity of the BDNF pro-peptide.We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.展开更多
F-actins are semi-flexible polyelectrolytes and can be assembled into large polymer-actin complex with polymorphism through electrostatic interaction with polycations. This study investigates the structural phase beha...F-actins are semi-flexible polyelectrolytes and can be assembled into large polymer-actin complex with polymorphism through electrostatic interaction with polycations. This study investigates the structural phase behavior and the growth of polymer-actin complexes in terms of its longitudinal and lateral sizes. Our results show that formation of polymer-actin complexes is cooperative, and morphology and growth of polymer-actin complexes depend on polycation species and concentrations of polycation and salt in a constant actin concentration. We found that the longitudinal growth and lateral growth of polymer-actin complexes are dominated by different factors. This induces the structural polymorphism of polymer-actin complexes. Major factors to influence the polymorphism of polymer-actin complexes in polyelectrolytc system have been discussed. Our results indicate that the semi-flexible polyelectrolyte nature of F-actins is important for controlling the morphology and growth ofactin architectures in cell.展开更多
Fluorescence imaging can provide valuable information on the expression,distribution,and activity of drug target proteins.Chemical probes are useful small-molecule tools for fluorescence imaging with high structural f...Fluorescence imaging can provide valuable information on the expression,distribution,and activity of drug target proteins.Chemical probes are useful small-molecule tools for fluorescence imaging with high structural flexibility and biocompatibility.In this review,we briefly introduce two classes of fluorescent probes for the visualization of drug target proteins.Enzymatically activatable probes make use of the specific enzymatic transformations that generally produce a fluorogenic response upon reacting with target enzymes.Alternatively,specific imaging can be conferred with a ligand that drives the probes to target proteins,where the labeling relies on noncovalent binding,covalent inhibition,or traceless labeling by ligand-directed chemistry.展开更多
AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treat...AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, "NAT2*4", was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity.展开更多
基金Funding National Key R&D Program of China(2021YFC2501701,2021YFC2501703)Beijing Jishuitan Hospital Scientific Research Fund(QN202404)+1 种基金Beijing Municipal Health Commission(BJRITO-RDP-2023)Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes(JYY2023-8).
文摘Objective To determine the prevalence of lumbar spondylolysis(LS)and the proportion of spondylolytic spondylolisthesis(SS)in China,and to evaluate the musculoskeletal status of patients with LS and SS.Methods Spine Computed Tomography(CT)images were collected from community populations aged 40 and above in a nationwide multi-center project.LS was diagnosed,and SS was graded by an experienced radiologist.Bone mineral density(BMD)and paraspinal muscle parameters were quantified based on CT images.Results One hundred and seventeen patients of a total of 3,317 individuals were diagnosed with LS,corresponding to a prevalence rate of 3.53%.63 of the 1,214 males(5.18%)and 54 of the 2,103 females(2.57%)were diagnosed with LS.SS occurred in 64/121 vertebrae(52.89%).BMD was not associated with LS(P=0.341).The L5 extensor paraspinal muscle density was higher in the LS group than in the non-LS group.In the LS group,patients with SS had a smaller L5 paraspinal extensor muscle cross-sectional area than those without SS(P=0.003).Conclusion The prevalence of LS in Chinese adults was 3.53%,with prevalence rates of 5.18%in males and 2.57%in females.Patients with LS have higher muscle density,whereas those with SS have smaller muscle cross-sectional areas at the L5 level.
基金supported in part by Key Scientific Research Projects of Colleges and Universities in Anhui Province(2022AH051921)Science Research Project of Bengbu University(2024YYX47pj,2024YYX48pj)+8 种基金Anhui Province Excellent Research and Innovation Team in Intelligent Manufacturing and Information Technology(2023AH052938)Big Data and Machine Learning Research Team(BBXYKYTDxj05)Funding Project for the Cultivation of Outstanding Talents in Colleges and Universities(gxyqZD2021135)the Key Scientific Research Projects of Anhui Provincial Department of Education(2022AH051376)Start Up Funds for Scientific Research of High-Level Talents of Bengbu University(BBXY2020KYQD02)Scientific Research and Development Fund of Suzhou University(2021fzjj29)Research on Grain Logistics Data Processing and Safety Issues(ALAQ202401017)the Open Fund of State Key Laboratory of Tea Plant Biology and Utilization(SKLTOF20220131)funded by the Ongoing Research Funding Program(ORF-2025-102),King Saud University,Riyadh,Saudi Arabia.
文摘With the advancements of the next-generation communication networking and Internet ofThings(IoT)technologies,a variety of computation-intensive applications(e.g.,autonomous driving and face recognition)have emerged.The execution of these IoT applications demands a lot of computing resources.Nevertheless,terminal devices(TDs)usually do not have sufficient computing resources to process these applications.Offloading IoT applications to be processed by mobile edge computing(MEC)servers with more computing resources provides a promising way to address this issue.While a significant number of works have studied task offloading,only a few of them have considered the security issue.This study investigates the problem of spectrum allocation and security-sensitive task offloading in an MEC system.Dynamic voltage scaling(DVS)technology is applied by TDs to reduce energy consumption and computing time.To guarantee data security during task offloading,we use AES cryptographic technique.The studied problem is formulated as an optimization problem and solved by our proposed efficient offloading scheme.The simulation results show that the proposed scheme can reduce system cost while guaranteeing data security.
基金partially supported by Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research(JSPS KAKENHI)(JP21H04640,JP23KF0274,JP24KF0160,JP19KK0129,JP20H00497,JP18H01848,JP16K13653,JP26706010,and JP26630403)Ministry of Education,Culture,Sports,Science and Technology Grants-in-Aid for Scientific Research(MEXT KAKENHI)(JP21H05231,JP19H04678,JP17H05468,and JP26107714)+4 种基金Japan Science and Technology Agency Precursory Research for Embryonic Science and Technology(JST PRESTO)(JPMJPR18H5)Core Research for Evolutionary Science and Technology(CREST)(JPMJCR18H2)the Asahi Glass Foundation,Japanthe support received from the Japan Society for the Promotion of Science(JSPS)(P23374)the Development and Promotion of the Science and Technology Talents Project of Thailand(DPST532133)。
文摘The manipulation of nanometric objects,encompassing both non-biological and biological objects,offers a transformative avenue for breakthroughs in diverse fields,such as chemistry,biology,chemical and biomedical engineering,materials and mechanical engineering,and various industrial applications.However,achieving accuracy,precision,and high throughput in the manipulation of nanometric objects,whether on the scale of a single nanometric entity or molecule,is a formidable challenge because of the extremely small dimensions involved.Nanofluidics has already demonstrated unique capabilities for transporting the mass of ions and small molecules at the nanoscale.We posit that chip-based nanofluidic devices provide potent strategies for the precise,accurate,and high-throughput manipulation of single nanometric entities and molecules,benefiting from their dimensions,which are comparable to those of nanometric objects.This article offers an overview of the current progress in nanofluidic manipulation of single nanometric objects.It also discusses the challenges in the development of nanofluidic manipulation technologies.Furthermore,the article explores future opportunities in the field,highlighting possible solutions to the challenges,and aims to contribute to the ongoing discourse on nanofluidic manipulation,thus propelling the field to overcome its current limitations.
基金support from the Japan Society for the Promotion of Science(JSPS)KAKENHI(Grant Nos.JP23H03864 and JP24K01315)JST CREST(Grant No.JPMJCR2011)+1 种基金Y.Sasaki thanks JSPS KAKENHI(Grant No.JP24K17667)JST PRESTO(JPMJPR23H2).
文摘Polythiophenes(PTs)with flexible backbones possess inherent polymer behaviors,including molecular wire effects and dynamic structural changes inπ-conjugated systems.The chemical sensing at the functionalized side chains can manipulate such polymer characteristics,resulting in various optical patterns depending on the analyte structures and their concentrations.The unique optical patterns derived from polymer properties contribute to group categorization over a wide concentration range for pattern recognition.This review aims to provide a concise overview of the potential of PT chemosensor arrays using actual sensing examples in environmental monitoring,medical diagnostics,and food analysis.Furthermore,this review summarizes the methodologies that use polymer gels to realize practical chemosensor array chips for onsite analysis.
基金financially supported by a Grantin-Aid for Young Scientists (A) (No. 15H05548) of JapanJST PRESTO of Japan (No. JPMJPR17R4)the Program to Support Research Activities of Female Researchers in Osaka Prefecture University in Japan
文摘In this study, we introduced the temperaturedependent formation phases and crystallographic parameters of hot-pressed silver gallium telluride AgGaTe2 and copper gallium telluride CuGaTe2 with chalcopyrite structure from 300 to 800 K. These two compounds are potential thermoelectric materials in the intermediate temperature range; however, the temperature-dependent formation phases and crystallographic parameters of hotpressed samples have not yet been analyzed in detail. The crystal structure analysis based on synchrotron X-ray diffraction （SXRD） measurements clarifies that impurity phases such as Te and Ag2Te in the AgGaTe2 matrix and Te and CuTe in the CuGaTe2 matrix appear at some temperature regions above 300 K. The existence of such impurity phases could be correlated with the increases of the electrical resistivity and Seebeck coefficient of the samples after multiple measurement cycles of the temperature-dependent transport properties from 300 to 800 K. The tetragonal lattice parameters a and c, tetragonal lattice volume, thermal expansion coefficients, tetragonal distortion, anion displacement parameter, and isotropic displacement parameter of the hot-pressed AgGaTe2 and CuGaTe2 were also analyzed. These crystallographic parameters are expected to substantially affect the thermoelectric properties of AgGaTe2 and CuGaTe2. Our results provide prospect of the long-term high-temperature stability and clues of the detailed analysis on the transport properties of hot-pressed AgGaTe2 and CuGaTe2, which should aid their development for thermoelectric applications.
基金supported by the grant No. 24310088 from the Ministry of Education, Culture, Sports, Science and Technology, Japansupport from the Research Center for Exotic NanoCarbon Project, Japan Regional Innovation Strategy Program by the Excellence
文摘Nanostructured carbon materials, including carbon nanotubes, graphene and nanoporous carbon, show promise for expanding renewable energy. In particular, the configuration and electronic properties of graphene edges in relation with their electrochemical activity have become a major issue in carbon-based energy storage devices. Here, we review recent results concerning the important roles of graphene edges as the gateway for lithium ion intercalation in the anode of lithium-ion batteries, as promoters of high capacitance in carbon-based supercapacitors, and as anchoring sites for Pt nanoparticles in fuel cells. We envisage that the controlled synthesis of a specific, clean, and stable edge configuration could be achieved to maximize the electrochemical performance of nanostructured carbon-based energy storage devices.
文摘A large number of 3D models are created on computers and available for networks. Some content-based retrieval technologies are indispensable to find out particular data from such anonymous datasets. Though several shape retrieval technologies have been developed, little attention has been given to the points on human＇s sense and impression （as known as Kansei） in the conventional techniques, In this paper, the authors propose a novel method of shape retrieval based on shape impression of human＇s Kansei. The key to the method is the Gaussian curvature distribution from 3D models as features for shape retrieval. Then it classifies the 3D models by extracted feature and measures similarity among models in storage.
基金supported by a Grant-in-Aid for Scientific Research on Priority Areas(Elucidation of neural network function in the brain)from the Ministry of Education,Culture,Sports,Science and Technology of Japan:KAKENHI Grant-in-Aid for Scientific Research(17K07073 and 22500305)(MK)Japan Science and Technology AgencyCore Research for Evolutional Science and Technology(MK)
文摘Most growth factors are initially synthesized as precursors and it was cleaved into bioactive mature domain and pro-domain.However,compared with the expression and function of bioactive mature domain,the biological role of the pro-domain is poorly understood.Unexpectedly,we found that the pro-domain（or pro-peptide）of brain-derived neurotrophic factor（BDNF）,which is well-known neurotrophic factor in brain,has a potential ability to facilitate hippocampal long-term depression.Furthermore,a BDNF polymorphism Val66Met,which substitute valine into methionine at 66 amino acid,impacted the biological activity of the BDNF pro-peptide.We lastly discuss the possible roles of BDNF and its pro-peptide in the generation of neural stem cells and progress of ischemia.
基金This research is financially supported by SORST, JST and the Ministry of Education, Science, Sports, and Culture, Japan (Grant-in-Aid of Creative Scientific Research).
文摘F-actins are semi-flexible polyelectrolytes and can be assembled into large polymer-actin complex with polymorphism through electrostatic interaction with polycations. This study investigates the structural phase behavior and the growth of polymer-actin complexes in terms of its longitudinal and lateral sizes. Our results show that formation of polymer-actin complexes is cooperative, and morphology and growth of polymer-actin complexes depend on polycation species and concentrations of polycation and salt in a constant actin concentration. We found that the longitudinal growth and lateral growth of polymer-actin complexes are dominated by different factors. This induces the structural polymorphism of polymer-actin complexes. Major factors to influence the polymorphism of polymer-actin complexes in polyelectrolytc system have been discussed. Our results indicate that the semi-flexible polyelectrolyte nature of F-actins is important for controlling the morphology and growth ofactin architectures in cell.
基金This work was funded by Japan Science and Technology Agency(JST)ERATO Grant JPMJER1802 and a Grant-in-Aid for Scientific Research on Innovative Areas“Chemistry for Multimolecular Crowding Biosystems”(17H06348).
文摘Fluorescence imaging can provide valuable information on the expression,distribution,and activity of drug target proteins.Chemical probes are useful small-molecule tools for fluorescence imaging with high structural flexibility and biocompatibility.In this review,we briefly introduce two classes of fluorescent probes for the visualization of drug target proteins.Enzymatically activatable probes make use of the specific enzymatic transformations that generally produce a fluorogenic response upon reacting with target enzymes.Alternatively,specific imaging can be conferred with a ligand that drives the probes to target proteins,where the labeling relies on noncovalent binding,covalent inhibition,or traceless labeling by ligand-directed chemistry.
基金by Grant-in-Aid for Scientif ic Research (Category B, No. 18390168) for K Tsukamoto by the Ministry of Education, Culture, Sports, Science and Technology of Japan
文摘AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, "NAT2*4", was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity.
