To evaluate the treatment safety of Tenghuangjiangu tablet on osteoarthritis,3365 osteoarthritis patients whose prescription included Tenghuangjiangu tablet from 15 hospitals were involved in the prospective and multi...To evaluate the treatment safety of Tenghuangjiangu tablet on osteoarthritis,3365 osteoarthritis patients whose prescription included Tenghuangjiangu tablet from 15 hospitals were involved in the prospective and multi-center clinical trial.Tenghuangjiangu tablet dosage was decided by instruction or doctors’experience.The course of treatment and observation was 4 weeks.The adverse drug reactions were observed in the treatment process.Results showed male and female patients were 1018(30.25%)and 2347(69.75%),respectively,and 528 patients had allergic history.The patients’average age was 58.30±8.99 years,and the average disease course was 33.29±37.40 months.The average score of WOMAC scale was 95.07±42.42,which indicated the light conditions.2275 patients were treated with combined drug regimen.There were two adverse drug reactions in this research.One reaction was skin rashes with itching and the interventions were stopped original drugs and give antianaphylactic treatment.The other reaction was stomach discomfort with disgusting and the intervention was stopped the original drugs temporarily,then continued to take two drugs after 3 days and the reaction didn’t appear.The accident rate of adverse drug reaction was 0.059%.The safety of Tenghuangjiangu tablet clinical application was good,and the mechanism of adverse drug reaction should be researched in-depth.展开更多
The year 2017 marks the 15th anniversary of Joumal of Integrative Agriculture （JIA）, an official journal of the Chinese Academy of Agricultural Sciences （CAAS）. JIA has experi- enced a successful journey during th...The year 2017 marks the 15th anniversary of Joumal of Integrative Agriculture （JIA）, an official journal of the Chinese Academy of Agricultural Sciences （CAAS）. JIA has experi- enced a successful journey during the past 15 years. The 21 st century began with great challenges in global climate change, food safety, resource scarcity, and other key issues which are closely related to the agriculture sciences. Effec- tive solutions for agricultural problems require an internation- al exchange of experience via platforms such as academic journals. To contribute to these forums, the agriculture community in China sought to establish a scholarly journal published in English. In Jan. 2002, an agriculture journal in English was launched by CAAS and the first issue of the journal Agricultural Sciences in China was published. From the start, it has emphasized global concerns in multi-disci- plinary agricultural fields of crop science, horticulture, plant protection, animal science, veterinary medicine, agro-eco- system and environment science, food science and etc. And it is a peer-reviewed international journal published monthly in English. The first Editor-in-Chief was ZHAI Huqu, the president of CAAS at that time.展开更多
Background:Immune-mediated inflammatory disease(IMID)and cancer share underlying mechanisms.We aimed to comprehensively evaluate the associations between IMIDs and cancers from global,population and genetic perspectiv...Background:Immune-mediated inflammatory disease(IMID)and cancer share underlying mechanisms.We aimed to comprehensively evaluate the associations between IMIDs and cancers from global,population and genetic perspectives.Methods:A triangulation framework was employed to assess the association between IMIDs and cancers,using the Global Burden of Disease Study(2012-2021)to analyse six IMIDs and 33 cancers.The UK Biobank(UKBB)prospective cohort was subsequently used to validate these associations,with hazard ratios(HRs)and 95%confidence intervals(CIs)estimated by Cox proportional hazards models.Causal inference based on genetic instruments was performed in the FinnGen and UKBB to assess the potential causal effects between IMIDs and cancers.Results:IMIDs were positively associated with the occurrence of cancers from a global perspective.Moreover,170 specific IMID-cancer pairs revealed statistically significant associations.A total of 20 pairs of specific IMID-cancer associations were further confirmed in the UKBB cohort.Among these,the five most pronounced associations included atopic dermatitis with Hodgkin lymphoma(HR=12.56,95%CI:1.76-89.59),with ovarian cancer(HR=5.65,95%CI:1.41-22.65)and with non-Hodgkin lymphoma(HR=5.11,95%CI:1.91-13.63);rheumatoid arthritis with Hodgkin lymphoma(HR=3.85,95%CI:1.11-13.32);and psoriasis with Hodgkin lymphoma(HR=3.43,95%CI:1.69-6.96).Additionally,a positive causal association between rheumatoid arthritis and Hodgkin lymphoma(inverse variance weighted OR=1.31,95%CI:1.10-1.57)was observed.Conclusions:This study provides comprehensive evidence of the relationships between IMIDs and cancers from global,population and genetic perspectives and identifies 20 pairs of specific IMID-cancer associations,thereby contributing to advancements in cancer prevention and control.展开更多
文摘To evaluate the treatment safety of Tenghuangjiangu tablet on osteoarthritis,3365 osteoarthritis patients whose prescription included Tenghuangjiangu tablet from 15 hospitals were involved in the prospective and multi-center clinical trial.Tenghuangjiangu tablet dosage was decided by instruction or doctors’experience.The course of treatment and observation was 4 weeks.The adverse drug reactions were observed in the treatment process.Results showed male and female patients were 1018(30.25%)and 2347(69.75%),respectively,and 528 patients had allergic history.The patients’average age was 58.30±8.99 years,and the average disease course was 33.29±37.40 months.The average score of WOMAC scale was 95.07±42.42,which indicated the light conditions.2275 patients were treated with combined drug regimen.There were two adverse drug reactions in this research.One reaction was skin rashes with itching and the interventions were stopped original drugs and give antianaphylactic treatment.The other reaction was stomach discomfort with disgusting and the intervention was stopped the original drugs temporarily,then continued to take two drugs after 3 days and the reaction didn’t appear.The accident rate of adverse drug reaction was 0.059%.The safety of Tenghuangjiangu tablet clinical application was good,and the mechanism of adverse drug reaction should be researched in-depth.
文摘The year 2017 marks the 15th anniversary of Joumal of Integrative Agriculture （JIA）, an official journal of the Chinese Academy of Agricultural Sciences （CAAS）. JIA has experi- enced a successful journey during the past 15 years. The 21 st century began with great challenges in global climate change, food safety, resource scarcity, and other key issues which are closely related to the agriculture sciences. Effec- tive solutions for agricultural problems require an internation- al exchange of experience via platforms such as academic journals. To contribute to these forums, the agriculture community in China sought to establish a scholarly journal published in English. In Jan. 2002, an agriculture journal in English was launched by CAAS and the first issue of the journal Agricultural Sciences in China was published. From the start, it has emphasized global concerns in multi-disci- plinary agricultural fields of crop science, horticulture, plant protection, animal science, veterinary medicine, agro-eco- system and environment science, food science and etc. And it is a peer-reviewed international journal published monthly in English. The first Editor-in-Chief was ZHAI Huqu, the president of CAAS at that time.
基金National Natural Science Foundation of China,Grant/Award Numbers:82404340,82273722,82373685,82204143CAMS Innovation Fund for Medical Science,Grant/Award Number:2021-I2M-1-067Open Research Fund Programme of Changzhou Institute for Advanced Study of Public Health,Nanjing Medical University,Grant/Award Number:CPHM202301。
文摘Background:Immune-mediated inflammatory disease(IMID)and cancer share underlying mechanisms.We aimed to comprehensively evaluate the associations between IMIDs and cancers from global,population and genetic perspectives.Methods:A triangulation framework was employed to assess the association between IMIDs and cancers,using the Global Burden of Disease Study(2012-2021)to analyse six IMIDs and 33 cancers.The UK Biobank(UKBB)prospective cohort was subsequently used to validate these associations,with hazard ratios(HRs)and 95%confidence intervals(CIs)estimated by Cox proportional hazards models.Causal inference based on genetic instruments was performed in the FinnGen and UKBB to assess the potential causal effects between IMIDs and cancers.Results:IMIDs were positively associated with the occurrence of cancers from a global perspective.Moreover,170 specific IMID-cancer pairs revealed statistically significant associations.A total of 20 pairs of specific IMID-cancer associations were further confirmed in the UKBB cohort.Among these,the five most pronounced associations included atopic dermatitis with Hodgkin lymphoma(HR=12.56,95%CI:1.76-89.59),with ovarian cancer(HR=5.65,95%CI:1.41-22.65)and with non-Hodgkin lymphoma(HR=5.11,95%CI:1.91-13.63);rheumatoid arthritis with Hodgkin lymphoma(HR=3.85,95%CI:1.11-13.32);and psoriasis with Hodgkin lymphoma(HR=3.43,95%CI:1.69-6.96).Additionally,a positive causal association between rheumatoid arthritis and Hodgkin lymphoma(inverse variance weighted OR=1.31,95%CI:1.10-1.57)was observed.Conclusions:This study provides comprehensive evidence of the relationships between IMIDs and cancers from global,population and genetic perspectives and identifies 20 pairs of specific IMID-cancer associations,thereby contributing to advancements in cancer prevention and control.
