Electron–hole(e–h)recombination is a fundamental process that governs energy dissipation and device efficiency in semiconductors.In two-dimensional(2D)materials,the formation of tightly bound excitons makes exciton-...Electron–hole(e–h)recombination is a fundamental process that governs energy dissipation and device efficiency in semiconductors.In two-dimensional(2D)materials,the formation of tightly bound excitons makes exciton-mediated e–h recombination the dominant decay pathway.In this work,nonradiative e–h recombination within excitons in monolayer MoS2 is investigated using first-principles simulations that combine nonadiabatic molecular dynamics with𝐺𝑊and real-time Bethe–Salpeter equation(BSE)propagation.A two-step process is identified:rapid intervalley redistribution induced by exchange interaction,followed by slower phonon-assisted recombination facilitated by exciton binding.By selectively removing the screened Coulomb and exchange terms from the BSE Hamiltonian,their respective contributions are disentangled—exchange interaction is found to increase the number of accessible recombination pathways,while binding reduces the excitation energy and enhances nonradiative decay.A reduction in recombination lifetime by over an order of magnitude is observed due to the excitonic many-body effects.These findings provide microscopic insights for understanding and tuning exciton lifetimes in 2D transition-metal dichalcogenides.展开更多
Initial success has been achieved in Hong Kong in controlling primary air pollutants,but ambient ozone levels kept increasing during the past three decades.Volatile organic compounds(VOCs)are important for mitigating ...Initial success has been achieved in Hong Kong in controlling primary air pollutants,but ambient ozone levels kept increasing during the past three decades.Volatile organic compounds(VOCs)are important for mitigating ozone pollution as its major precursors.This study analyzed VOC characteristics of roadside,suburban,and rural sites in Hong Kong to investigate their compositions,concentrations,and source contributions.Herewe showthat the TVOC concentrations were 23.05±13.24,12.68±15.36,and 5.16±5.48 ppbv for roadside,suburban,and rural sites between May 2015 to June 2019,respectively.By using Positive Matrix Factorization(PMF)model,six sources were identified at the roadside site over five years:Liquefied petroleum gas(LPG)usage(33%–46%),gasoline evaporation(8%–31%),aged air mass(11%–28%),gasoline exhaust(5%–16%),diesel exhaust(2%–16%)and fuel filling(75–9%).Similarly,six sources were distinguished at the suburban site,including LPG usage(30%–33%),solvent usage(20%–26%),diesel exhaust(14%–26%),gasoline evaporation(8%–16%),aged air mass(4%–11%),and biogenic emissions(2%–5%).At the rural site,four sources were identified,including aged airmass(33%–51%),solvent usage(25%–30%),vehicular emissions(11%–28%),and biogenic emissions(6%–12%).The analysis further revealed that fuel filling and LPG usage were the primary contributors to OFP and OH reactivity at the roadside site,while solvent usage and biogenic emissions accounted for almost half of OFP and OH reactivity at the suburban and rural sites,respectively.These findings highlight the importance of identifying and characterizing VOC sources at different sites to help policymakers develop targeted measures for pollution mitigation in specific areas.展开更多
This study explores the impact of a host community’s level of cultural diversity on the integration ability and mental health of Syrian refugees resettling into two U.S.States:California and Idaho.This paper addresse...This study explores the impact of a host community’s level of cultural diversity on the integration ability and mental health of Syrian refugees resettling into two U.S.States:California and Idaho.This paper addresses the need for effective integration strategies,mainly due to their impact on mental health,given the current pressing conflicts in the Middle East and the global refugee crisis.This paper uses a comparative analysis of existing literature to examine how refugees hosted in more culturally diverse communities,such as California,experience better means of integration and thus have improved mental health than those hosted in culturally homogenous communities,such as Idaho.Additionally,the study concluded that refugees who can assimilate into a community experience fewer mental health issues.The findings provide valuable insight and information for policymakers seeking to improve refugee integration through nuanced strategies.The study suggests further primary research to discover additional impacts of a community’s cultural diversity on refugees’integration ability.展开更多
BACKGROUND Vitamin D deficiency has been associated with prostate cancer,particularly in ethnic minorities.Patients with prostate cancer may still be deficient even in areas of high sun exposure.Although androgen depr...BACKGROUND Vitamin D deficiency has been associated with prostate cancer,particularly in ethnic minorities.Patients with prostate cancer may still be deficient even in areas of high sun exposure.Although androgen deprivation therapy(ADT)is well documented to affect bone health,its impact on vitamin D levels is still uncertain.This study investigates the subgroups of prostate cancer patients most associated with vitamin D deficiency and ADT’s relation to this.AIM To examine how prevalent vitamin D deficiency is among prostate cancer patients in a sun-rich environment,with focus on differences by race and disease stage.It also assessed whether ADT is associated with changes in vitamin D levels.METHODS Prostate cancer patients treated at Chao Family Comprehensive Cancer Center between 2014-2024 were retrospectively studied with regards to vitamin D levels across racial groups,disease stages,and ADT exposure.Changes in vitamin D levels pre-and post-ADT over 24 months were assessed by statistical methods including paired t-tests.RESULTS Among 120 patients(mean age:74 years,mean body mass index:27.6 kg/m^(2)),African American(33.3%)and Hispanic(31.8%)patients had the greatest prevalence of vitamin D deficiency(<20 ng/mL).With a 28.6%deficit rate,metastatic castration-resistant prostate cancer had the highest prevalence rates of deficiency.There was no significant difference between pre-and post-ADT vitamin D levels(P=0.45).CONCLUSION Vitamin D deficiency is common in prostate cancer patients,especially racial minorities and those with advanced disease,despite residing in an area with high sun exposure.ADT does not significantly impact vitamin D levels in the short term.Routine screening and supplementation should be considered in these high-risk groups.展开更多
Dear Editor,Irreversible retinal damage can occur due to retinal degenerative(RD)diseases as well as injuries caused by accidents or devices.Laser devices can inflict permanent damage to the retina,leading to the loss...Dear Editor,Irreversible retinal damage can occur due to retinal degenerative(RD)diseases as well as injuries caused by accidents or devices.Laser devices can inflict permanent damage to the retina,leading to the loss of photoreceptors(PRs)and underlying retinal pigment epithelium(RPE),culminating in vision impairment.Since there is no effective treatment for permanent retinal injuries,replacing damaged PRs and RPE with corresponding healthy cells can be a suitable therapeutic approach.展开更多
Endometrial cancer is the most common gynecologic cancer diagnosed in the United States and mortality is on the rise.Advanced and recurrent endometrial cancer represents a treatment challenge as historically there hav...Endometrial cancer is the most common gynecologic cancer diagnosed in the United States and mortality is on the rise.Advanced and recurrent endometrial cancer represents a treatment challenge as historically there have been limited therapeutic options for patients.In the last several years,multiple practice-changing clinical trials have led to significant improvements in the treatment landscape.This review will cover updates in the treatment and management of advanced and recurrent endometrial cancer with a focus on novel therapeutics,such as anti-PD-L1 and PD-1 inhibitors,poly ADP-ribose polymerase(PARP)inhibitors,antibody-drug conjugates,and hormonal therapy.展开更多
Alcohol-associated liver disease(ALD)is a rapidly increasing indication for liver transplantation(LT)globally with a significant rise in transplants for ALD with limited sobriety including patients with alcohol-associ...Alcohol-associated liver disease(ALD)is a rapidly increasing indication for liver transplantation(LT)globally with a significant rise in transplants for ALD with limited sobriety including patients with alcohol-associated hepatitis(AH).This evolution challenges the older paradigm that mandates prolonged periods of alcohol abstinence prior to LT.Due to the limited armamentarium of effective pharmacotherapy to treat severe AH,the mortality rates are significantly higher when LT is not available.In the patients who are transplanted for ALD with limited sobriety including AH,patient and graft survival are equivalent,if not better,compared to patients transplanted for other etiologies.However,due to the risk of alcohol relapse and other psychosocial factors,public opinion regarding early LT may continue to impact how the field moves forward particularly regarding organ stewardship and the need for equitable allocation of organs.Numerous tools for psychosocial evaluations have been developed to assist liver transplant teams to identify appropriate patients in a more uniform manner.In this review,we aim to assess the available evidence to support early LT for alcohol AH and propose directions for the future as the field continues to evolve.展开更多
The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions a...The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's disease.Beyond these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain.Understanding these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect cognition.This review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.展开更多
Spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)is a promising high-voltage cathode material for the next generation lithium metal batteries because of its high operating voltage plateau(4.7 V vs.Li+/Li),high theoretical specific...Spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)is a promising high-voltage cathode material for the next generation lithium metal batteries because of its high operating voltage plateau(4.7 V vs.Li+/Li),high theoretical specific capacity(147 mAh/g),relatively low cost and environmentally benign properties.Despite promising,the commercialization of LNMO cathodes is hindered by its electrochemical instability using conventional carbonate electrolytes,resulting in lower Coulombic efficiency and poor cycling stability.Herein,we adopt an all-fluorinated electrolyte(AFE)with a wide electrochemical stability window for Li//LNMO cells.Compared to conventional carbonate electrolytes,AFE significantly improves the discharge capacity and rate performance of Li//LNMO cells at various cut-off voltages and temperatures,attributed to the formation of a robust cathode-electrolyte interphase(CEI)layer.Specifically,the resultant Li//AFE//LNMO cells deliver a discharge capacity of 131.7 mAh/g with 84.1%capacity retention after 250 cycles at a charge cut-off voltage of 4.9 V,while it sustains only 114.8 mAh/g with 81.9%capacity retention for the cell using a conventional carbonate electrolyte.The influence of charge/discharge rate and temperature on the performance is also evaluated.Overall,this study presents a facile approach to promote the commercialization of high-voltage LNMO cathodes.展开更多
Gastric cancer(GC)remains a leading cause of cancer mortality.While the extent of nodal involvement is a well-known prognostic factor,the specific entity of swollen lymph node metastasis(SLNM),bulky nodal tumor deposi...Gastric cancer(GC)remains a leading cause of cancer mortality.While the extent of nodal involvement is a well-known prognostic factor,the specific entity of swollen lymph node metastasis(SLNM),bulky nodal tumor deposits detectable radiologically or pathologically,has received little attention in staging.Recent data from a study by Cui et al demonstrated that SLNM is an independent predictor of very poor survival in GC.Through robust data and rigorous propensitymatched analyses,SLNM emerged not merely as an anatomical finding but as an independent predictor of poor prognosis,even among patients undergoing curative resection.As precision oncology advances,the findings by Cui et al urge a fundamental rethinking of how SLNM is incorporated into clinical decisionmaking for GC management.In this editorial,we critically examine the prognostic significance of SLNM,challenge its omission from traditional staging frameworks,and advocate for its formal integration into preoperative risk stratification and treatment planning.Recognizing SLNM at diagnosis could unlock intensified neoadjuvant therapy strategies and optimize outcomes for a historically high-risk patient subgroup.展开更多
Objective:Acupuncture has demonstrated efficacy as a treatment for fibromyalgia;however,predictors of short-and long-term analgesic response in this population are not well understood.Methods:This manuscript describes...Objective:Acupuncture has demonstrated efficacy as a treatment for fibromyalgia;however,predictors of short-and long-term analgesic response in this population are not well understood.Methods:This manuscript describes a secondary analysis of a single-center,blinded,sham-controlled,randomized longitudinal acupuncture clinical trial in fibromyalgia.Baseline characterization included pressure pain threshold and pain interference,while residualized change in pain intensity from baseline to follow-up served as the primary outcome measure.Participants were randomized into groups that received verum(n=36)or sham(n=29)acupuncture treatment over a 12-week period(18 treatments)and were followed for 37 weeks from the initiation of treatment.Results:Lower pressure pain thresholds at baseline were associated with greater analgesia only in the sham treatment group immediately following treatment,while those with higher pressure pain thresholds had greater analgesia with verum treatment(B=–13.43,P=0.001).Additionally,greater perceived impact of pain at baseline was predictive of greater short-term analgesia irrespective of treatment.Pressure pain threshold was not found to be predictive of long-term differential treatment response(B=–1.71,P=0.66).There was a significant difference in the relationship between perceived impact of pain at baseline and subsequent long-term analgesia between groups where those with greater perceived impact of pain displayed improved long-term analgesia for verum acupuncture compared to the sham group(B=–11.37,P=0.004).Conclusion:Our results support the use of a self-reported pain outcome in predicting long-term analgesia following acupuncture in fibromyalgia.展开更多
Gastric carcinoma is a leading cause of cancer-related mortality worldwide,yet reliable noninvasive biomarkers for its early detection remain limited.As research continues to elucidate the inflammatory underpinnings o...Gastric carcinoma is a leading cause of cancer-related mortality worldwide,yet reliable noninvasive biomarkers for its early detection remain limited.As research continues to elucidate the inflammatory underpinnings of tumor initiation and progression,it has become increasingly clear that pro-inflammatory cytokines may hold promise as diagnostic adjuncts.Serum cytokines such as interleukin(IL)-1β,IL-6,IL-8,and interferon-gamma have been frequently reported as elevated in gastric cancer patients compared to healthy individuals.These molecules,known for their roles in modulating tumor-promoting inflammation,angiogenesis,and immune evasion,may serve as accessible indicators of disease presence or progression.Several studies have shown that individual cytokines,particularly IL-6 and IL-8,can achieve receiver operating characteristic curves and area under the curve values exceeding 0.70,suggesting reasonable diagnostic utility.We assess the comparative utility of individual cytokines versus multiplex panels,evaluate their roles in tumor biology and treatment resistance,and situate these findings within the broader inflammatory biomarker landscape.Limitations of the current literature,including small sample sizes,heterogeneity in study design,and lack of specificity,are critically discussed.We advocate for prospective,multicenter validation studies and highlight the promise of integrating inflammatory cytokine profiling into diagnostic algorithms.Composite cytokine panels may better reflect the complex immunobiology of tumor progression and offer a scalable,accessible adjunct to current gastric cancer screening strategies.展开更多
BACKGROUND Normothermic liver machine perfusion(NMP)is a novel technology used to preserve and evaluate the function of liver allografts.AIM To assess NMP utilization in liver transplant(LT)practices.METHODS All adult...BACKGROUND Normothermic liver machine perfusion(NMP)is a novel technology used to preserve and evaluate the function of liver allografts.AIM To assess NMP utilization in liver transplant(LT)practices.METHODS All adult deceased-donor LT recipients between January 2021 and September 2023 in the United States were analyzed.Outcomes including discard rates,survival,preservation time and timing of surgery were compared between two groups:NMP vs non-NMP.RESULTS Between 2021 and 2023,NMP was utilized in 1493(6.3%)of all LTs in the United States.Compared to non-NMP group,NMP group had lower allograft discard rate(6.5%vs 10%,P<0.001),older recipients’age(median:47 vs 42 years,P<0.001),and higher utilization of donors from donation after circulatory death(DCD)(55%vs 11%,P<0.001).NMP group also had longer distances between recipient and donor hospitals(median:156 vs 138 miles,P<0.001),longer preser-vation time(median:12.2 vs 5.8 hours,P<0.001),and more daytime reperfusion(74%vs 55%,P<0.001).Post-transplant survival outcomes were comparable between the two groups.In a subgroup analysis of NMP,recipients in the long preservation time(≥8 hours)group had higher daytime reperfusion(78%vs 55%,P<0.001)and similar post-transplant survival when compared to the short preservation time(<8 hours)group.CONCLUSION The utilization of NMP is associated with lower discard rates and increased DCD organs for LT.NMP allows for prolonging the preservation time and increased occurrence of daytime LT,without any impact on the survival outcomes.展开更多
Ferroelectric topological insulators realized in heterostructures of two topologically trivial two-dimensional materials have recently attracted significant interest. Using first-principles calculations combined with ...Ferroelectric topological insulators realized in heterostructures of two topologically trivial two-dimensional materials have recently attracted significant interest. Using first-principles calculations combined with topological quantum chemistry, we investigate bilayer α-In_(2) Se_(3)(2 L-In_(2) Se_(3)) in van der Waals heterostructures with XSe(X = Ga, In, Tl) substrates within space group P 3m1(No. 156). We show that the emergence of ferroelectricity-driven topological phase transitions in these systems is dictated by fundamental symmetry principles rather than material-specific effects. The band bending at the XSe/2 L-In_(2) Se_(3) interface enables topological band inversions, with higher-electron-affinity substrates such as GaSe and TlSe favoring the transition. Remarkably, GaSe/2 L-In_(2) Se_(3) exhibits a reversible transition between topological and trivial insulating phases upon polarization switching, while TlSe/2 L-In_(2) Se_(3) undergoes sequential transitions from a topological insulator to a trivial insulator and eventually to a metallic state. This multistate manipulation highlights a viable route for designing tunable, low-power, multi-functional electronic devices.展开更多
BACKGROUND Old donor allografts in liver transplantation(LT)account for 25%of all allografts,and their utilization is projected to increase with the aging general population.Older allografts are associated with higher...BACKGROUND Old donor allografts in liver transplantation(LT)account for 25%of all allografts,and their utilization is projected to increase with the aging general population.Older allografts are associated with higher rates of all-cause mortality and graft failure;however,there is limited literature exploring the specific phenotypic changes(e.g.,functional status,cause-specific mortality)observed in different donor:recipient age pairs.AIM To investigate differences in functional impairment and cause-specific mortality between different donor:recipient age pairs.METHODS This was a retrospective analysis of LT patients from the Scientific Registry of Transplant Recipients from 2002 to 2022.Donors were categorized into younger age donors,≤45-years(YAD),middle-aged donors,46-69-years(MAD),and older age donors,≥70-years(OAD).Recipients were categorized into younger age recipients,≤55-years(YAR)and older age recipients,>55-years(OAR)age recipients.Multivariate Fine-Gray competing risk and logistic regression analyses identified independent risk factors for cause-specific mortality and improvements in functional status,respectively.RESULTS Overall,126185 patients were included in the analysis:YAD:YAR(32.7%), YAD:OAR (25.2%), MAD:YAR (17.5%), MAD:OAR (20.7%), OAD:YAR (1.3%), and OAD:OAR (2.7%). Compared toYAD:YAR, OAD pairs had the lowest likelihoods of improved functional status 5 years post-LT (OAD:YAR oddsratio 0.53, 95% confidence interval 0.42-0.67, P < 0.001;OAD:OAR odds ratio 0.67, 95% confidence interval 0.51-0.89, P = 0.006). Donor:recipient age pairs with older donors had higher rates of graft- and infection-relatedmortality compared to those with younger donors (P < 0.001). Meanwhile, donor:recipient age pairs with olderrecipients had higher cardioneurovascular- or malignancy-related deaths compared to those with youngerrecipients (P < 0.001).CONCLUSIONDonor:recipient age mismatch was associated with differences in cause-specific mortality and functional status.These insights could potentially inform age-matched organ allocation strategies, though future work is warranted.展开更多
Introduction:Holmium Laser Enucleation of the Prostate(HoLEP)is a size-independent,endoscopic management option for benign prostatic hyperplasia(BPH).HoLEP offers a distinct advantage for patients who are at high-risk...Introduction:Holmium Laser Enucleation of the Prostate(HoLEP)is a size-independent,endoscopic management option for benign prostatic hyperplasia(BPH).HoLEP offers a distinct advantage for patients who are at high-risk for bleeding whilst preserving prostatic tissue for pathology analysis,unlike photoselective vaporization.Further,HoLEP avoids the need for cystotomy,unlike simple open and robotic prostatectomy,by using intravesical morcellation.We report our experience with the first 1000 HoLEP procedures at our institution.Materials and Methods:We performed a retrospective review of all HoLEP procedures performed at our institution from 2013–2021 to capture patient demographics,procedure details,and outcomes.Unpaired two sample ttestswere used to compare outcomes,p<0.05 considered statistically significant.Results:The average patient age and BMI were 71.1 y(±8.1 y)and 27.9 kg/m^(2)(±4.9 kg/m^(2)),respectively.69.4%of patients were on an alpha blocker and 33.3%of patients were on a 5-alpha reductase inhibitor preoperatively.11.2%of cases were redo outlet procedures including after prior Urolift.Average prostate volume was 108.0 mL(±66.5 mL)and average enucleation time was 119.7 min(±56 min).On average,65 g(±53.2 g)prostate tissue was resected.Pre-operative and postoperative flow,post-void residual(PVR),AUAsymptom score(AUA-SS),and quality of life(QoL)score showed notable improvement.Complication rates remained low,with the most common including blood transfusion(2.8%),urethral stricture(1.9%),and persistent stress urinary incontinence(1.3%).Conclusions:HoLEP is emerging as the new surgical gold standard for BPH.A steep learning curve remains for urologists.Nonetheless,this procedure holds great promise in improving patient experiences with BPH.展开更多
Objectives:Positive family functioning(FF)is critical for adolescent development,yet only a few studies have examined this developmental trajectory pathway.This study aimed to identify different types of FF developmen...Objectives:Positive family functioning(FF)is critical for adolescent development,yet only a few studies have examined this developmental trajectory pathway.This study aimed to identify different types of FF development trajectories during junior high school students,investigate their influence on social avoidance(SA),and further examine the mediating role of preference for solitude(PS)between them.Methods:A three-wave longitudinal study was used with six-month intervals.Questionnaire data were collected from 436 junior high school students in Jiangxi Province,China.Participants ranged in age from 11 to 14 years old(Mean=12.89 years,SD=1.08;50.2%male).Results:Four heterogeneous types of FF trajectories were identified:(1)a high and increasing group(14.7%);(2)a consistently high group(36.24%);(3)a consistently moderate group(45.86%);and(4)a rapid growth group(3.2%).The developmental trajectories of FF among junior high students significantly varied in their levels of SA(F(3,432)=32.03,p<0.001).Compared to the high and increasing groups,the consistently high,consistently medium,and rapid growth groups exhibited higher levels of SA.PS mediated the association between the developmental trajectory of FF and SA.Conclusion:There was a close relationship between the developmental trajectory of FF and SA.Interventions focusing on family system optimization and solitary preference management could effectively mitigate SA behaviors.These findings are important for promoting healthy socialization in adolescents.展开更多
Using exact diagonalization of the Hamiltonian and transition matrix in the energy eigenbasis,we perform model calculations of the magnetic relaxation rate in single-molecule magnets.A careful examination of the trans...Using exact diagonalization of the Hamiltonian and transition matrix in the energy eigenbasis,we perform model calculations of the magnetic relaxation rate in single-molecule magnets.A careful examination of the transition matrix reveals that resonant tunneling does not enhance transitions between the nearly degenerate states;rather,it suppresses them.Instead,transitions from one state in the degenerate pair to neighboring states of the other are significantly enhanced.We conduct a detailed analysis of the transition rates to clearly demonstrate how resonant tunneling modulates these processes.This work provides a substantial reinterpretation of the resonant magnetic relaxation in single-molecule magnets and clearly identifies the dominant relaxation pathways.展开更多
Altermagnetism,a recently identified class of collinear magnetism,combines key features of antiferromagnets and ferromagnets.Despite having zero net magnetization,altermagnetic materials exhibit anomalous transport ef...Altermagnetism,a recently identified class of collinear magnetism,combines key features of antiferromagnets and ferromagnets.Despite having zero net magnetization,altermagnetic materials exhibit anomalous transport effects,including the anomalous Hall,Nernst,and thermal Hall effects,as well as magneto-optical Kerr and Faraday effects.These phenomena,previously thought unique to ferromagnets,are dictated by symmetry,as confirmed by density functional theory(DFT)calculations.However,an effective model-based approach to verify these symmetry constraints remains unavailable.In this Letter,we construct a k·ρ model for d-wave altermagnets CuX_(2)(X=F,Cl)using spin space group representations and apply it to calculate the anomalous Hall effect.The symmetry-imposed transport properties predicted by the model are in agreement with the DFT results,providing a foundation for further investigation into symmetry-restricted transport phenomena in altermagnetic materials.展开更多
基金supported by the National Key Research and Development Program of China (Grant Nos.2024YFA1409800 for J.Z.and2024YFA1408603 for Q.Z.)the National Natural Science Foundation of China (Grant Nos.12125408,12334004for J.Z.,and 12174363 for Q.Z.)+1 种基金the Innovation Program for Quantum Science and Technology (Grant No.2021ZD0303306 for J.Z.)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0450101 for J.Z.)。
文摘Electron–hole(e–h)recombination is a fundamental process that governs energy dissipation and device efficiency in semiconductors.In two-dimensional(2D)materials,the formation of tightly bound excitons makes exciton-mediated e–h recombination the dominant decay pathway.In this work,nonradiative e–h recombination within excitons in monolayer MoS2 is investigated using first-principles simulations that combine nonadiabatic molecular dynamics with𝐺𝑊and real-time Bethe–Salpeter equation(BSE)propagation.A two-step process is identified:rapid intervalley redistribution induced by exchange interaction,followed by slower phonon-assisted recombination facilitated by exciton binding.By selectively removing the screened Coulomb and exchange terms from the BSE Hamiltonian,their respective contributions are disentangled—exchange interaction is found to increase the number of accessible recombination pathways,while binding reduces the excitation energy and enhances nonradiative decay.A reduction in recombination lifetime by over an order of magnitude is observed due to the excitonic many-body effects.These findings provide microscopic insights for understanding and tuning exciton lifetimes in 2D transition-metal dichalcogenides.
基金supported by Hong Kong Environment Protection Department(Quotation Ref.18-06532)Hong Kong Innovation and Technology Fund(ITS/193/20FP)Hong Kong Research Grants Council(No.26304921).
文摘Initial success has been achieved in Hong Kong in controlling primary air pollutants,but ambient ozone levels kept increasing during the past three decades.Volatile organic compounds(VOCs)are important for mitigating ozone pollution as its major precursors.This study analyzed VOC characteristics of roadside,suburban,and rural sites in Hong Kong to investigate their compositions,concentrations,and source contributions.Herewe showthat the TVOC concentrations were 23.05±13.24,12.68±15.36,and 5.16±5.48 ppbv for roadside,suburban,and rural sites between May 2015 to June 2019,respectively.By using Positive Matrix Factorization(PMF)model,six sources were identified at the roadside site over five years:Liquefied petroleum gas(LPG)usage(33%–46%),gasoline evaporation(8%–31%),aged air mass(11%–28%),gasoline exhaust(5%–16%),diesel exhaust(2%–16%)and fuel filling(75–9%).Similarly,six sources were distinguished at the suburban site,including LPG usage(30%–33%),solvent usage(20%–26%),diesel exhaust(14%–26%),gasoline evaporation(8%–16%),aged air mass(4%–11%),and biogenic emissions(2%–5%).At the rural site,four sources were identified,including aged airmass(33%–51%),solvent usage(25%–30%),vehicular emissions(11%–28%),and biogenic emissions(6%–12%).The analysis further revealed that fuel filling and LPG usage were the primary contributors to OFP and OH reactivity at the roadside site,while solvent usage and biogenic emissions accounted for almost half of OFP and OH reactivity at the suburban and rural sites,respectively.These findings highlight the importance of identifying and characterizing VOC sources at different sites to help policymakers develop targeted measures for pollution mitigation in specific areas.
文摘This study explores the impact of a host community’s level of cultural diversity on the integration ability and mental health of Syrian refugees resettling into two U.S.States:California and Idaho.This paper addresses the need for effective integration strategies,mainly due to their impact on mental health,given the current pressing conflicts in the Middle East and the global refugee crisis.This paper uses a comparative analysis of existing literature to examine how refugees hosted in more culturally diverse communities,such as California,experience better means of integration and thus have improved mental health than those hosted in culturally homogenous communities,such as Idaho.Additionally,the study concluded that refugees who can assimilate into a community experience fewer mental health issues.The findings provide valuable insight and information for policymakers seeking to improve refugee integration through nuanced strategies.The study suggests further primary research to discover additional impacts of a community’s cultural diversity on refugees’integration ability.
文摘BACKGROUND Vitamin D deficiency has been associated with prostate cancer,particularly in ethnic minorities.Patients with prostate cancer may still be deficient even in areas of high sun exposure.Although androgen deprivation therapy(ADT)is well documented to affect bone health,its impact on vitamin D levels is still uncertain.This study investigates the subgroups of prostate cancer patients most associated with vitamin D deficiency and ADT’s relation to this.AIM To examine how prevalent vitamin D deficiency is among prostate cancer patients in a sun-rich environment,with focus on differences by race and disease stage.It also assessed whether ADT is associated with changes in vitamin D levels.METHODS Prostate cancer patients treated at Chao Family Comprehensive Cancer Center between 2014-2024 were retrospectively studied with regards to vitamin D levels across racial groups,disease stages,and ADT exposure.Changes in vitamin D levels pre-and post-ADT over 24 months were assessed by statistical methods including paired t-tests.RESULTS Among 120 patients(mean age:74 years,mean body mass index:27.6 kg/m^(2)),African American(33.3%)and Hispanic(31.8%)patients had the greatest prevalence of vitamin D deficiency(<20 ng/mL).With a 28.6%deficit rate,metastatic castration-resistant prostate cancer had the highest prevalence rates of deficiency.There was no significant difference between pre-and post-ADT vitamin D levels(P=0.45).CONCLUSION Vitamin D deficiency is common in prostate cancer patients,especially racial minorities and those with advanced disease,despite residing in an area with high sun exposure.ADT does not significantly impact vitamin D levels in the short term.Routine screening and supplementation should be considered in these high-risk groups.
基金supported by the National Eye Institute,National Institute of Health,Bethesda,Maryland,USA[CIRM DISC1-09912(BBT),NIH EY031144(BBT),R01 EY031834,EY-017337]the USC Ophthalmology Core(NIH P30EY029220,an unrestricted grant to the USC Department of Ophthalmology from RPB)+1 种基金the BrightFocus Foundation(M2016186,BBT)support from a Research to Prevent Blindness(RPB,New York,NY,USA)unrestricted grant to the UCI Department of Ophthalmology.
文摘Dear Editor,Irreversible retinal damage can occur due to retinal degenerative(RD)diseases as well as injuries caused by accidents or devices.Laser devices can inflict permanent damage to the retina,leading to the loss of photoreceptors(PRs)and underlying retinal pigment epithelium(RPE),culminating in vision impairment.Since there is no effective treatment for permanent retinal injuries,replacing damaged PRs and RPE with corresponding healthy cells can be a suitable therapeutic approach.
文摘Endometrial cancer is the most common gynecologic cancer diagnosed in the United States and mortality is on the rise.Advanced and recurrent endometrial cancer represents a treatment challenge as historically there have been limited therapeutic options for patients.In the last several years,multiple practice-changing clinical trials have led to significant improvements in the treatment landscape.This review will cover updates in the treatment and management of advanced and recurrent endometrial cancer with a focus on novel therapeutics,such as anti-PD-L1 and PD-1 inhibitors,poly ADP-ribose polymerase(PARP)inhibitors,antibody-drug conjugates,and hormonal therapy.
文摘Alcohol-associated liver disease(ALD)is a rapidly increasing indication for liver transplantation(LT)globally with a significant rise in transplants for ALD with limited sobriety including patients with alcohol-associated hepatitis(AH).This evolution challenges the older paradigm that mandates prolonged periods of alcohol abstinence prior to LT.Due to the limited armamentarium of effective pharmacotherapy to treat severe AH,the mortality rates are significantly higher when LT is not available.In the patients who are transplanted for ALD with limited sobriety including AH,patient and graft survival are equivalent,if not better,compared to patients transplanted for other etiologies.However,due to the risk of alcohol relapse and other psychosocial factors,public opinion regarding early LT may continue to impact how the field moves forward particularly regarding organ stewardship and the need for equitable allocation of organs.Numerous tools for psychosocial evaluations have been developed to assist liver transplant teams to identify appropriate patients in a more uniform manner.In this review,we aim to assess the available evidence to support early LT for alcohol AH and propose directions for the future as the field continues to evolve.
文摘The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's disease.Beyond these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain.Understanding these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect cognition.This review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.
基金supported by the startup funding of HLX provided by UC Irvine.
文摘Spinel LiNi_(0.5)Mn_(1.5)O_(4)(LNMO)is a promising high-voltage cathode material for the next generation lithium metal batteries because of its high operating voltage plateau(4.7 V vs.Li+/Li),high theoretical specific capacity(147 mAh/g),relatively low cost and environmentally benign properties.Despite promising,the commercialization of LNMO cathodes is hindered by its electrochemical instability using conventional carbonate electrolytes,resulting in lower Coulombic efficiency and poor cycling stability.Herein,we adopt an all-fluorinated electrolyte(AFE)with a wide electrochemical stability window for Li//LNMO cells.Compared to conventional carbonate electrolytes,AFE significantly improves the discharge capacity and rate performance of Li//LNMO cells at various cut-off voltages and temperatures,attributed to the formation of a robust cathode-electrolyte interphase(CEI)layer.Specifically,the resultant Li//AFE//LNMO cells deliver a discharge capacity of 131.7 mAh/g with 84.1%capacity retention after 250 cycles at a charge cut-off voltage of 4.9 V,while it sustains only 114.8 mAh/g with 81.9%capacity retention for the cell using a conventional carbonate electrolyte.The influence of charge/discharge rate and temperature on the performance is also evaluated.Overall,this study presents a facile approach to promote the commercialization of high-voltage LNMO cathodes.
文摘Gastric cancer(GC)remains a leading cause of cancer mortality.While the extent of nodal involvement is a well-known prognostic factor,the specific entity of swollen lymph node metastasis(SLNM),bulky nodal tumor deposits detectable radiologically or pathologically,has received little attention in staging.Recent data from a study by Cui et al demonstrated that SLNM is an independent predictor of very poor survival in GC.Through robust data and rigorous propensitymatched analyses,SLNM emerged not merely as an anatomical finding but as an independent predictor of poor prognosis,even among patients undergoing curative resection.As precision oncology advances,the findings by Cui et al urge a fundamental rethinking of how SLNM is incorporated into clinical decisionmaking for GC management.In this editorial,we critically examine the prognostic significance of SLNM,challenge its omission from traditional staging frameworks,and advocate for its formal integration into preoperative risk stratification and treatment planning.Recognizing SLNM at diagnosis could unlock intensified neoadjuvant therapy strategies and optimize outcomes for a historically high-risk patient subgroup.
基金supported by National Institutes of Health(NCCAM)grant R01 AT00004Department of Defense DAMD-17002-0018+1 种基金Georgetown University GCRC grant 98-186supported by National Institutes of Health(NCCAM)K01AT01111-01 and National Institutes of Health grant R01-AT-00755。
文摘Objective:Acupuncture has demonstrated efficacy as a treatment for fibromyalgia;however,predictors of short-and long-term analgesic response in this population are not well understood.Methods:This manuscript describes a secondary analysis of a single-center,blinded,sham-controlled,randomized longitudinal acupuncture clinical trial in fibromyalgia.Baseline characterization included pressure pain threshold and pain interference,while residualized change in pain intensity from baseline to follow-up served as the primary outcome measure.Participants were randomized into groups that received verum(n=36)or sham(n=29)acupuncture treatment over a 12-week period(18 treatments)and were followed for 37 weeks from the initiation of treatment.Results:Lower pressure pain thresholds at baseline were associated with greater analgesia only in the sham treatment group immediately following treatment,while those with higher pressure pain thresholds had greater analgesia with verum treatment(B=–13.43,P=0.001).Additionally,greater perceived impact of pain at baseline was predictive of greater short-term analgesia irrespective of treatment.Pressure pain threshold was not found to be predictive of long-term differential treatment response(B=–1.71,P=0.66).There was a significant difference in the relationship between perceived impact of pain at baseline and subsequent long-term analgesia between groups where those with greater perceived impact of pain displayed improved long-term analgesia for verum acupuncture compared to the sham group(B=–11.37,P=0.004).Conclusion:Our results support the use of a self-reported pain outcome in predicting long-term analgesia following acupuncture in fibromyalgia.
文摘Gastric carcinoma is a leading cause of cancer-related mortality worldwide,yet reliable noninvasive biomarkers for its early detection remain limited.As research continues to elucidate the inflammatory underpinnings of tumor initiation and progression,it has become increasingly clear that pro-inflammatory cytokines may hold promise as diagnostic adjuncts.Serum cytokines such as interleukin(IL)-1β,IL-6,IL-8,and interferon-gamma have been frequently reported as elevated in gastric cancer patients compared to healthy individuals.These molecules,known for their roles in modulating tumor-promoting inflammation,angiogenesis,and immune evasion,may serve as accessible indicators of disease presence or progression.Several studies have shown that individual cytokines,particularly IL-6 and IL-8,can achieve receiver operating characteristic curves and area under the curve values exceeding 0.70,suggesting reasonable diagnostic utility.We assess the comparative utility of individual cytokines versus multiplex panels,evaluate their roles in tumor biology and treatment resistance,and situate these findings within the broader inflammatory biomarker landscape.Limitations of the current literature,including small sample sizes,heterogeneity in study design,and lack of specificity,are critically discussed.We advocate for prospective,multicenter validation studies and highlight the promise of integrating inflammatory cytokine profiling into diagnostic algorithms.Composite cytokine panels may better reflect the complex immunobiology of tumor progression and offer a scalable,accessible adjunct to current gastric cancer screening strategies.
文摘BACKGROUND Normothermic liver machine perfusion(NMP)is a novel technology used to preserve and evaluate the function of liver allografts.AIM To assess NMP utilization in liver transplant(LT)practices.METHODS All adult deceased-donor LT recipients between January 2021 and September 2023 in the United States were analyzed.Outcomes including discard rates,survival,preservation time and timing of surgery were compared between two groups:NMP vs non-NMP.RESULTS Between 2021 and 2023,NMP was utilized in 1493(6.3%)of all LTs in the United States.Compared to non-NMP group,NMP group had lower allograft discard rate(6.5%vs 10%,P<0.001),older recipients’age(median:47 vs 42 years,P<0.001),and higher utilization of donors from donation after circulatory death(DCD)(55%vs 11%,P<0.001).NMP group also had longer distances between recipient and donor hospitals(median:156 vs 138 miles,P<0.001),longer preser-vation time(median:12.2 vs 5.8 hours,P<0.001),and more daytime reperfusion(74%vs 55%,P<0.001).Post-transplant survival outcomes were comparable between the two groups.In a subgroup analysis of NMP,recipients in the long preservation time(≥8 hours)group had higher daytime reperfusion(78%vs 55%,P<0.001)and similar post-transplant survival when compared to the short preservation time(<8 hours)group.CONCLUSION The utilization of NMP is associated with lower discard rates and increased DCD organs for LT.NMP allows for prolonging the preservation time and increased occurrence of daytime LT,without any impact on the survival outcomes.
基金supported by the National Natural Science Foundation of China (Grant Nos.11874141,12174059,and 11604134)。
文摘Ferroelectric topological insulators realized in heterostructures of two topologically trivial two-dimensional materials have recently attracted significant interest. Using first-principles calculations combined with topological quantum chemistry, we investigate bilayer α-In_(2) Se_(3)(2 L-In_(2) Se_(3)) in van der Waals heterostructures with XSe(X = Ga, In, Tl) substrates within space group P 3m1(No. 156). We show that the emergence of ferroelectricity-driven topological phase transitions in these systems is dictated by fundamental symmetry principles rather than material-specific effects. The band bending at the XSe/2 L-In_(2) Se_(3) interface enables topological band inversions, with higher-electron-affinity substrates such as GaSe and TlSe favoring the transition. Remarkably, GaSe/2 L-In_(2) Se_(3) exhibits a reversible transition between topological and trivial insulating phases upon polarization switching, while TlSe/2 L-In_(2) Se_(3) undergoes sequential transitions from a topological insulator to a trivial insulator and eventually to a metallic state. This multistate manipulation highlights a viable route for designing tunable, low-power, multi-functional electronic devices.
文摘BACKGROUND Old donor allografts in liver transplantation(LT)account for 25%of all allografts,and their utilization is projected to increase with the aging general population.Older allografts are associated with higher rates of all-cause mortality and graft failure;however,there is limited literature exploring the specific phenotypic changes(e.g.,functional status,cause-specific mortality)observed in different donor:recipient age pairs.AIM To investigate differences in functional impairment and cause-specific mortality between different donor:recipient age pairs.METHODS This was a retrospective analysis of LT patients from the Scientific Registry of Transplant Recipients from 2002 to 2022.Donors were categorized into younger age donors,≤45-years(YAD),middle-aged donors,46-69-years(MAD),and older age donors,≥70-years(OAD).Recipients were categorized into younger age recipients,≤55-years(YAR)and older age recipients,>55-years(OAR)age recipients.Multivariate Fine-Gray competing risk and logistic regression analyses identified independent risk factors for cause-specific mortality and improvements in functional status,respectively.RESULTS Overall,126185 patients were included in the analysis:YAD:YAR(32.7%), YAD:OAR (25.2%), MAD:YAR (17.5%), MAD:OAR (20.7%), OAD:YAR (1.3%), and OAD:OAR (2.7%). Compared toYAD:YAR, OAD pairs had the lowest likelihoods of improved functional status 5 years post-LT (OAD:YAR oddsratio 0.53, 95% confidence interval 0.42-0.67, P < 0.001;OAD:OAR odds ratio 0.67, 95% confidence interval 0.51-0.89, P = 0.006). Donor:recipient age pairs with older donors had higher rates of graft- and infection-relatedmortality compared to those with younger donors (P < 0.001). Meanwhile, donor:recipient age pairs with olderrecipients had higher cardioneurovascular- or malignancy-related deaths compared to those with youngerrecipients (P < 0.001).CONCLUSIONDonor:recipient age mismatch was associated with differences in cause-specific mortality and functional status.These insights could potentially inform age-matched organ allocation strategies, though future work is warranted.
文摘Introduction:Holmium Laser Enucleation of the Prostate(HoLEP)is a size-independent,endoscopic management option for benign prostatic hyperplasia(BPH).HoLEP offers a distinct advantage for patients who are at high-risk for bleeding whilst preserving prostatic tissue for pathology analysis,unlike photoselective vaporization.Further,HoLEP avoids the need for cystotomy,unlike simple open and robotic prostatectomy,by using intravesical morcellation.We report our experience with the first 1000 HoLEP procedures at our institution.Materials and Methods:We performed a retrospective review of all HoLEP procedures performed at our institution from 2013–2021 to capture patient demographics,procedure details,and outcomes.Unpaired two sample ttestswere used to compare outcomes,p<0.05 considered statistically significant.Results:The average patient age and BMI were 71.1 y(±8.1 y)and 27.9 kg/m^(2)(±4.9 kg/m^(2)),respectively.69.4%of patients were on an alpha blocker and 33.3%of patients were on a 5-alpha reductase inhibitor preoperatively.11.2%of cases were redo outlet procedures including after prior Urolift.Average prostate volume was 108.0 mL(±66.5 mL)and average enucleation time was 119.7 min(±56 min).On average,65 g(±53.2 g)prostate tissue was resected.Pre-operative and postoperative flow,post-void residual(PVR),AUAsymptom score(AUA-SS),and quality of life(QoL)score showed notable improvement.Complication rates remained low,with the most common including blood transfusion(2.8%),urethral stricture(1.9%),and persistent stress urinary incontinence(1.3%).Conclusions:HoLEP is emerging as the new surgical gold standard for BPH.A steep learning curve remains for urologists.Nonetheless,this procedure holds great promise in improving patient experiences with BPH.
基金supported by the National Natural Science Foundation of China(72164018)National Social Science Fund Project(BFA200065)Jiangxi Social Science Foundation Project(21JY13).
文摘Objectives:Positive family functioning(FF)is critical for adolescent development,yet only a few studies have examined this developmental trajectory pathway.This study aimed to identify different types of FF development trajectories during junior high school students,investigate their influence on social avoidance(SA),and further examine the mediating role of preference for solitude(PS)between them.Methods:A three-wave longitudinal study was used with six-month intervals.Questionnaire data were collected from 436 junior high school students in Jiangxi Province,China.Participants ranged in age from 11 to 14 years old(Mean=12.89 years,SD=1.08;50.2%male).Results:Four heterogeneous types of FF trajectories were identified:(1)a high and increasing group(14.7%);(2)a consistently high group(36.24%);(3)a consistently moderate group(45.86%);and(4)a rapid growth group(3.2%).The developmental trajectories of FF among junior high students significantly varied in their levels of SA(F(3,432)=32.03,p<0.001).Compared to the high and increasing groups,the consistently high,consistently medium,and rapid growth groups exhibited higher levels of SA.PS mediated the association between the developmental trajectory of FF and SA.Conclusion:There was a close relationship between the developmental trajectory of FF and SA.Interventions focusing on family system optimization and solitary preference management could effectively mitigate SA behaviors.These findings are important for promoting healthy socialization in adolescents.
基金supported by the National Natural Science Foundation of China(Grant Nos.12404085,12474122,52171188,51771127,and 52111530143)the Fund from DOE-BES(Grant No.DE-FG02-05ER46237)the Central Government Funds of Guiding Local Scientific and Technological Development for Sichuan Province,China(Grant No.2021ZYD0025)。
文摘Using exact diagonalization of the Hamiltonian and transition matrix in the energy eigenbasis,we perform model calculations of the magnetic relaxation rate in single-molecule magnets.A careful examination of the transition matrix reveals that resonant tunneling does not enhance transitions between the nearly degenerate states;rather,it suppresses them.Instead,transitions from one state in the degenerate pair to neighboring states of the other are significantly enhanced.We conduct a detailed analysis of the transition rates to clearly demonstrate how resonant tunneling modulates these processes.This work provides a substantial reinterpretation of the resonant magnetic relaxation in single-molecule magnets and clearly identifies the dominant relaxation pathways.
基金supported by the National Natural Science Foundation of China(Grant No.12274117)the Natural Science Foundation of Henan(Grant No.242300421214)+4 种基金the Program for Innovative Research Team(in Science and Technology)in the University of Henan Province(Grant No.24IRTSTHN025)the Open Fund of Guangdong Provincial Key Laboratory of Nanophotonic Manipulation(No.202502)Guangdong S&T Program(No.2023B1212010008)the High-Performance Computing Center of Henan Normal Universitysupported by the U.S.DOE,Office of Science(Grant No.DE-FG02-05ER46237)。
文摘Altermagnetism,a recently identified class of collinear magnetism,combines key features of antiferromagnets and ferromagnets.Despite having zero net magnetization,altermagnetic materials exhibit anomalous transport effects,including the anomalous Hall,Nernst,and thermal Hall effects,as well as magneto-optical Kerr and Faraday effects.These phenomena,previously thought unique to ferromagnets,are dictated by symmetry,as confirmed by density functional theory(DFT)calculations.However,an effective model-based approach to verify these symmetry constraints remains unavailable.In this Letter,we construct a k·ρ model for d-wave altermagnets CuX_(2)(X=F,Cl)using spin space group representations and apply it to calculate the anomalous Hall effect.The symmetry-imposed transport properties predicted by the model are in agreement with the DFT results,providing a foundation for further investigation into symmetry-restricted transport phenomena in altermagnetic materials.
