Dear Editor,The incidence of rectal cancer has increased in patients younger than 50 years old during the last decade.It is well established that young age at cancer onset is a hallmark of hereditary cancer.The preval...Dear Editor,The incidence of rectal cancer has increased in patients younger than 50 years old during the last decade.It is well established that young age at cancer onset is a hallmark of hereditary cancer.The prevalence of germline variants among early-onset rectal cancer(EORC)patients is largely unexplored.Here,we aimed to determine the spectrum of germline variants and their clinical impact in EORC patients diagnosed at age 40 or younger.We investigated 71 EORC patients(Supplementary Table S1),one of the largest cohorts to date,using a customized panel with 93 genes(Supplementary Table S2).展开更多
基金This study was supported by grants from the Region of Southern Denmark Research Fund,Denmark,and the National Institute of Science and Technology in Oncogenomics(INCITO,FAPESP#2008/57887-9 and CNPq#573589/08-9)Brazil.Caroline Moraes Beltrami received a fellowship from the National Council for Scientific and Technological Development(CNPq#371497/2013-2)Luisa Matos do Canto received a fellowship from the Sao Paulo Research Foundation(FAPESP#2014/06323-9 and#2015/25803-4).
文摘Dear Editor,The incidence of rectal cancer has increased in patients younger than 50 years old during the last decade.It is well established that young age at cancer onset is a hallmark of hereditary cancer.The prevalence of germline variants among early-onset rectal cancer(EORC)patients is largely unexplored.Here,we aimed to determine the spectrum of germline variants and their clinical impact in EORC patients diagnosed at age 40 or younger.We investigated 71 EORC patients(Supplementary Table S1),one of the largest cohorts to date,using a customized panel with 93 genes(Supplementary Table S2).
