Background The prognostic significance of the affected hemisphere in haemorrhagic stroke remains uncertain.We aimed to determine the relationship between the affected hemisphere(right or left)and differences in non-mo...Background The prognostic significance of the affected hemisphere in haemorrhagic stroke remains uncertain.We aimed to determine the relationship between the affected hemisphere(right or left)and differences in non-motor outcomes,including mood and pain,in patients with acute,supratentorial intracerebral haemorrhage(ICH).These non-motor outcomes are often overlooked in studies following ICH but impact patient recovery and well-being.Methods A secondary prespecified analysis of the Minimally Invasive Surgery with Thrombolysis in Intracerebral Hemorrhage Evacuation(MISTIE)Ⅲ study-a randomised,international,multicentre,placebo-controlled trial of participants with spontaneous,non-traumatic,supratentorial ICH of 30 mL or more that evaluated minimally invasive surgery with thrombolysis compared with standard medical care.Outcomes included EQ-5D three-level version(EQ-5D 3L,composite and individual non-motor components)and modified Rankin scale(mRS)scores at days 30,180 and 365 post-ICH.Results A total of 493 participants were eligible for analysis at day 30 following ICH.In multivariable analyses,patients with right hemispheric ICH were more likely to report problems with pain and discomfort at days 30(β=0.257(95%CI 0.131,0.383)),180(β=0.213(95%CI 0.090,0.336))and 365(β=0.209(95%CI 0.090,0.328))post-ICH.Patients with right hemispheric ICH were also more likely to report problems with anxiety and depression at days 30(β=0.160(95%CI 0.030,0.291))and 180(β=0.171(95%CI 0.049,0.293))following ICH.There were no differences in mRS scores between patients with left or right-sided haemorrhages.Conclusions Right hemispheric lesions were associated with increased reports of mood-related symptoms(depression,anxiety)and pain in patients with acute ICH over time.展开更多
Explicit memory errors may occur when individuals fail to retrieve information about items previously studied (item memory) or about the learning context (source memory). We examined electrophysiological measures duri...Explicit memory errors may occur when individuals fail to retrieve information about items previously studied (item memory) or about the learning context (source memory). We examined electrophysiological measures during recognition failure in order to determine the influence of retrieval orientation for item versus source information. Recognition failure was associated with brain potentials distinct from those associated with success. Furthermore, source-memory failures were associated with earlier-onset brain potentials with a more anterior distribution compared to item-memory failures. Neurocognitive processing was thus modulated by retrieval orientation so as to differentially influence neural correlates of successful versus unsuccessful retrieval.展开更多
Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential deleterious outcomes.Among them,nonsense-mediated mRNA decay(NMD)functions not only as a quality co...Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential deleterious outcomes.Among them,nonsense-mediated mRNA decay(NMD)functions not only as a quality control mechanism targeting aberrant mRNAs containing a premature termination codon but also as a posttranscriptional gene regulation mechanism tar-geting numerous physiological mRNAs.Despite its well-characterized molecular basis,the regulatory scope and biological functions of NMD at an organismal level are incompletely understood.In humans,mutations in genes encoding core NMD factors cause specific developmental and neurological syndromes,suggesting a critical role of NMD in the central nervous system.Here,we review the accumulating biochemical and genetic evidence on the developmental regulation and physiological functions of NMD as well as an emerging role of NMD dysregulation in neurodegenerative diseases.展开更多
文摘Background The prognostic significance of the affected hemisphere in haemorrhagic stroke remains uncertain.We aimed to determine the relationship between the affected hemisphere(right or left)and differences in non-motor outcomes,including mood and pain,in patients with acute,supratentorial intracerebral haemorrhage(ICH).These non-motor outcomes are often overlooked in studies following ICH but impact patient recovery and well-being.Methods A secondary prespecified analysis of the Minimally Invasive Surgery with Thrombolysis in Intracerebral Hemorrhage Evacuation(MISTIE)Ⅲ study-a randomised,international,multicentre,placebo-controlled trial of participants with spontaneous,non-traumatic,supratentorial ICH of 30 mL or more that evaluated minimally invasive surgery with thrombolysis compared with standard medical care.Outcomes included EQ-5D three-level version(EQ-5D 3L,composite and individual non-motor components)and modified Rankin scale(mRS)scores at days 30,180 and 365 post-ICH.Results A total of 493 participants were eligible for analysis at day 30 following ICH.In multivariable analyses,patients with right hemispheric ICH were more likely to report problems with pain and discomfort at days 30(β=0.257(95%CI 0.131,0.383)),180(β=0.213(95%CI 0.090,0.336))and 365(β=0.209(95%CI 0.090,0.328))post-ICH.Patients with right hemispheric ICH were also more likely to report problems with anxiety and depression at days 30(β=0.160(95%CI 0.030,0.291))and 180(β=0.171(95%CI 0.049,0.293))following ICH.There were no differences in mRS scores between patients with left or right-sided haemorrhages.Conclusions Right hemispheric lesions were associated with increased reports of mood-related symptoms(depression,anxiety)and pain in patients with acute ICH over time.
基金supported by the National Natural Science Foundation of China (30570603 and 30870760)the Key Foundation of Beijing Municipal Commission of Education (KZ201010028029)
文摘Explicit memory errors may occur when individuals fail to retrieve information about items previously studied (item memory) or about the learning context (source memory). We examined electrophysiological measures during recognition failure in order to determine the influence of retrieval orientation for item versus source information. Recognition failure was associated with brain potentials distinct from those associated with success. Furthermore, source-memory failures were associated with earlier-onset brain potentials with a more anterior distribution compared to item-memory failures. Neurocognitive processing was thus modulated by retrieval orientation so as to differentially influence neural correlates of successful versus unsuccessful retrieval.
基金Our work is supported by an NIH New Innovator Award(DP2 GM132930)the Muscular Dystrophy Association(MDA602934).J.U.G.is an NARSAD Young Investigator and a Klingenstein-Simons Fellow in NeuroscienceWe thank members of the Guo Lab for discussions。
文摘Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential deleterious outcomes.Among them,nonsense-mediated mRNA decay(NMD)functions not only as a quality control mechanism targeting aberrant mRNAs containing a premature termination codon but also as a posttranscriptional gene regulation mechanism tar-geting numerous physiological mRNAs.Despite its well-characterized molecular basis,the regulatory scope and biological functions of NMD at an organismal level are incompletely understood.In humans,mutations in genes encoding core NMD factors cause specific developmental and neurological syndromes,suggesting a critical role of NMD in the central nervous system.Here,we review the accumulating biochemical and genetic evidence on the developmental regulation and physiological functions of NMD as well as an emerging role of NMD dysregulation in neurodegenerative diseases.
