The University of Arizona Center for Integrative Medicine （AzCIM） was founded in 1994 with a primary focus of educating physicians in integrative medicine （IM）. Twenty years later, IM has become an internationally...The University of Arizona Center for Integrative Medicine （AzCIM） was founded in 1994 with a primary focus of educating physicians in integrative medicine （IM）. Twenty years later, IM has become an internationally recognized movement in medicine. With 40% of United States＇ medical schools having membership in the Academic Consortium for Integrative Medicine and Health it is foreseeable that all medical students and residents will soon receive training in the principles and practices of IM. The AzCIM has the broadest range and depth of IM educational programs and has had a major influence on integrative medical education in the United States. This review describes the fellowship, residency and medical student programs at AzCIM as well as other significant national drivers of IM education; it also points out the challenges faced in developing IM initiatives. The field of IM has matured with new nationa board certification in IM requiring fellowship training. Allied health professional IM educational courses, as well as integrative health coaching, assure that all members of the health care team can receive training. This review describes the evolution of IM education and will be helpful to academic centers, health care institutions, and countries seeking to introduce IM initiatives.展开更多
Traditional Chinese medicine(TCM)is a well-accepted therapy for atopic dermatitis(AD).However,there are currently no evidence-based guidelines integrating TCM and Western medicine for the treatment of AD,limiting the ...Traditional Chinese medicine(TCM)is a well-accepted therapy for atopic dermatitis(AD).However,there are currently no evidence-based guidelines integrating TCM and Western medicine for the treatment of AD,limiting the clinical application of such combined approaches.Therefore,the China Association of Chinese Medicine initiated the development of the current guideline,focusing on key issues related to the use of TCM in the treatment of AD.This guideline was developed in accordance with the principles of the guideline formulation manual published by the World Health Organization.A comprehensive review of the literature on the combined use of TCM and Western medicine to treat AD was conducted.The findings were extensively discussed by experts in dermatology and pharmacy with expertise in both TCM and Western medicine.This guideline comprises 23 recommendations across seven major areas,including TCM syndrome differentiation and classification of AD,principles and application scenarios of TCM combined with Western medicine for treating AD,outcome indicators for evaluating clinical efficacy of AD treatment,integration of TCM pattern classification and Western medicine across disease stages,daily management of AD,the use of internal TCM therapies and proprietary Chinese medicines,and TCM external treatments.展开更多
“Integration is a hallmark of our era's development and a magic key to solve epochal problems.”“Medicine originated from humanity's initial expression of suffering and the primary desire to alleviate that s...“Integration is a hallmark of our era's development and a magic key to solve epochal problems.”“Medicine originated from humanity's initial expression of suffering and the primary desire to alleviate that suffering.”展开更多
High-Intensity Interval Training(HIIT)has gained prominence as a time-efficient and effective exercise modality to improve cardiovascular(CV)fitness,metabolic health,and physical performance.Therefore,our aim was to s...High-Intensity Interval Training(HIIT)has gained prominence as a time-efficient and effective exercise modality to improve cardiovascular(CV)fitness,metabolic health,and physical performance.Therefore,our aim was to synthesize current clinical research on the effects of HIIT on the Autonomic Nervous System.We conducted the search for studies in the Directory of Open Access Journals,Embase,Virtual Health Library,Pubmed,and Scielo databases,in January of 2024.We included a total of 20 studies in our review.This literature review highlights the potential of HIIT to modulate the Autonomic Nervous System,enhancing CV function and overall health.Despite the promising findings,the interpretation of the results is tempered by the variability in study designs,populations,and methodologies.Future research should address these limitations,aiming for a more nuanced understanding of the relationship between HIIT and Autonomic Nervous System function.The review indicates that standardized protocols need to consider individual characteristics and baseline autonomic states for clinical application.As the body of evidence grows,HIIT may emerge as a cornerstone of exercise prescriptions aimed at optimizing autonomic function and promoting CV health.展开更多
Granulomatosis with polyangiitis(GPA)poses significant therapeutic challenges due to its susceptibility to concurrent infections and frequent relapses.Professor SHI Zaixiang proposed the therapeutic theory of lifting ...Granulomatosis with polyangiitis(GPA)poses significant therapeutic challenges due to its susceptibility to concurrent infections and frequent relapses.Professor SHI Zaixiang proposed the therapeutic theory of lifting depression and removing blood stasis,resolving phlegm and dispelling nodulation for GPA management.He identified the core pathogenesis as“Qi collapse with collateral obstruction and phlegm-stasis intermingling”,establishing the treatment principle of comprehensive intervention through ascending ancestral Qi,activating blood circulation,and resolving phlegm-stasis nodules.In clinical practice,Professor SHI emphasizes maintaining immune homeostasis with herbal medicine to enhance efficiency,while dynamically balancing Qi,blood,Yin,and Yang.Notably,he highlights the critical role of emotional factors in autoimmune disease progression.A representative case was provided to elucidate his clinical reasoning in GPA treatment.展开更多
OBJECTIVE: To compare the efficacy of integrated Chinese and Western Medicine with that of only Western Medicine for the treatment of malignant ascites.METHODS: All randomized controlled trials(January 2004 to March 2...OBJECTIVE: To compare the efficacy of integrated Chinese and Western Medicine with that of only Western Medicine for the treatment of malignant ascites.METHODS: All randomized controlled trials(January 2004 to March 2013) from the China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, and Wanfang Database were searched with keywords. Meta-analysis was conducted by combining the odds ratios of the individual studies. Review Manager 5.0 was used for the analysis.RESULTS: One thousand one hundred and fifty-six patients from 19 randomized controlled trails were included. Of them, 630 patients were treated with integrated Chinese and Western Medicine(the integrative group), and 526 patients were treated with Western Medicine alone(the control group). The Meta-analysis showed that the total effective rate was 78.73% in the integrated group, and 59.13% in the control group. The effective percentage was sig-nificantly higher in the integrative group than that of the control group [OR = 2.85, 95% CI(2.16,3.74),P < 0.01].CONCLUSION: The short-term curative effect in the integrative group was better than that in the control group. Integrative medicine may be beneficial for malignant ascites.展开更多
Objective:Appraisal of treatment outcomes in integrative medicine is a challenge due to a gap between the concepts of Western medicine(WM)disease and traditional Chinese medicine(TCM)syndrome.This study presents an ap...Objective:Appraisal of treatment outcomes in integrative medicine is a challenge due to a gap between the concepts of Western medicine(WM)disease and traditional Chinese medicine(TCM)syndrome.This study presents an approach for the appraisal of integrative medicine that is based on targeted metabolomics.We use non-alcoholic fatty liver disease with spleen deficiency syndrome as a test case.Methods:A patient-reported outcome(PRO)scale was developed based on literature review,Delphi consensus survey,and reliability and validity test,to quantitatively evaluate spleen deficiency syndrome.Then,a metabonomic foundation for the treatment of non-alcoholic fatty liver disease with spleen deficiency syndrome was identified via a longitudinal interventional trial and targeted metabolomics.Finally,an integrated appraisal model was established by identifying metabolites that responded in the treatment of WM disease and TCM syndrome as positive outcomes and using other aspects of the metabonomic foundation as independent variables.Results:Ten symptoms and signs were included in the spleen deficiency PRO scale.The internal reliability,content validity,discriminative validity and structural validity of the scale were all qualified.Based on treatment responses to treatments for WM disease(homeostasis model assessment of insulin resistance)or TCM syndrome(spleen deficiency PRO scale score)from a previous randomized controlled trial,two cohorts comprised of 30 participants each were established for targeted metabolomics detection.Twenty-five metabolites were found to be involved in successful treatment outcomes to both WM and TCM,following quantitative comparison and multivariate analysis.Finally,the model of the integrated appraisal system was exploratively established using binary logistic regression;it included 9 core metabolites and had the prediction probability of 83.3%.Conclusion:This study presented a new and comprehensive research route for integrative appraisal of treatment outcomes for WM disease and TCM syndrome.Critical research techniques used in this research included the development of a TCM syndrome assessment tool,a longitudinal interventional trial with verified TCM treatment,identification of homogeneous metabolites,and statistical modeling.展开更多
Among adolescents,the incidence of type 2 diabetes mellitus(T2 DM)has recently increased.A 12-yearold Chinese boy with a one-year history of hyperphagia presented to our clinic.The patient was diagnosed with T2 DM one...Among adolescents,the incidence of type 2 diabetes mellitus(T2 DM)has recently increased.A 12-yearold Chinese boy with a one-year history of hyperphagia presented to our clinic.The patient was diagnosed with T2 DM one month prior to visiting the clinic and reported undergoing no pharmacologic treatment.Using an integrative medicine approach,including Chinese herbal decoction,berberine hydrochloride tablets,physical exercise and diet control,the patient's fasting blood glucose(FBG)decreased from 8.3 mmol/L to 5.5 mmol/L.Additionally,his glycated haemoglobin decreased from12.9%to 6.1%,indicating that without any Western medicine intervention his diabetes has been reversed after six months of treatment.His FBG remained normal,and nine months after completion of treatment it was 4.9 mmol/L.A potential mechanism in this response may be related to improved insulin resistance and b-cell function,as indicated by observed changes in homeostasis model assessment of insulin resistance and b-cell function.Further,weight loss may also have contributed to the effectiveness of the treatment.This case study is the first to present the innovative approach of integrative medicine to achieve remission of new-onset adolescent T2 DM.展开更多
Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an ine...Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an inevitable choice and path for the medical development in the new era.This article demonstrates ten major propositions for HIM,elaborating on the connotation and extension of HIM from the perspectives of epistemology and methodology,in order to achieve the transformation and adaptive evolution of modernmedicine.展开更多
To meet community demands with optimal Chinese and conventional medical treatment, the University of Hong Kong is promoting integrative medicine by developing Chinese medicine programmes that train students of both We...To meet community demands with optimal Chinese and conventional medical treatment, the University of Hong Kong is promoting integrative medicine by developing Chinese medicine programmes that train students of both Western and Chinese medicine. The programmes emphasize multi-disciplinary training and interaction between the two therapeutic approaches, enabling students to establish reliable, consistent, and respectful mutual cooperation in their future careers.展开更多
Traditional Chinese medicine （TCM） is an important part of the treatment of primary liver cancer （PLC） in China; however, the current instructions for the integrative use of traditional Chinese and Western medicin...Traditional Chinese medicine （TCM） is an important part of the treatment of primary liver cancer （PLC） in China; however, the current instructions for the integrative use of traditional Chinese and Western medicine for PLC are mostly based on expert opinion. There is no evidence-based guideline for clinical prac-tice in this field. Therefore, the Shanghai Association of Chinese Integrative Medicine has established a multidisciplinary working group to develop this guideline, which focuses on the most important questions about the use of TCM during PLC treatment. This guideline was developed following the method- ological process recommended by the World Health Organization Handbook for Guideline Development. Two rounds of questionnaire survey were performed to identify clinical questions; published evidence was searched; the Grading of Recommendations Assessment, Development and Evaluation approach was used to evaluate the body of evidence; and recommendations were formulated by combining the quality of evidence, patient preferences and values, and other risk factors. The guideline was written based on the Reporting Items for Practice Guidelines in Healthcare tool. This guideline contains 10 recommendations related to 8 questions, including recommendations for early treatment by TCM after surgery, TCM combined with transcatheter arterial chemoembolization for advanced PLC, TCM drugs for external use, and acupuncture and moxibustion therapy.展开更多
Purpose: The aim of this study is to develop and validate a scale for perioperative recovery with integrative medicine. Methods: The procedures for developing the scale included a review of both modern and ancient lit...Purpose: The aim of this study is to develop and validate a scale for perioperative recovery with integrative medicine. Methods: The procedures for developing the scale included a review of both modern and ancient literature, other perioperative scales or questionnaire references, an expert consultation, and interviews with patients and surgeons following standard procedures. Primary face and content validity were assessed through a small-scale patient survey of 50 patients. A final evaluation based on the patient survey was conducted among 354 patients (age range 16-75) from the same hospital. This included testing the perioperative recovery scale for integrative medicine (PRSIM) for scaling properties, reliability, validity and responsiveness. Results: The PRSIM, a 20-item scale, was modified from an initial version transcript which included 122 items. The 20 items in the PRSIM covered five domains: direct influence, indirect influence, activity, mental function and general health perceptions. Five factors extracted from an exploratory factor analysis demonstrated a desirable model fit. A confirmatory factor analysis further indicated that the PRSIM had a good fit with the same sample. A data analysis of the PRSIM with 349 patients showed that it had good internal consistency (α> 0.7), test-retest reliability (ICC > 0.4) and split half reliability (α= 0.66). Conclusions: The PRSIM can serve as a valuable instrument for assessing patient perioperative recovery in integrative medicine. It is acceptable for patients in the perioperative period undergoing treatment by either Chinese or integrative medicine, and has good psychometric properties. Registration number: ChiCTR-TRC-09000527.展开更多
Objective: To evaluate the effects of treatment of integrative Chinese and Western medicine (ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS). Methods:The non-random...Objective: To evaluate the effects of treatment of integrative Chinese and Western medicine (ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS). Methods:The non-randomized, controlled trial was conducted on 447 SARS patients treated synchronously with western conventional treatment (WM group, n = 171) alone and ICWM (ICWM group, n = 276). The changes of the cases with normal level (≥95% ) or abnormal level (<95% ) SaO2 were observed dynamically. Results: In the 3rd-14th day of the therapeutic course, the percentage of patients with normal SaO2 in the ICWM group was higher than that in the WM group (OR = 0.5178, P = 0.0038), and this tendency was more evident in patients of the severe type (OR = 0. 18, P = 0. 0001). However, the statistical significance of difference was only shown in patients for whom the ICWM treatment started in the early period after the onset (≤7 days after it, OR = 0.3803, P = 0.006), but not shown in those who received ICWM treatment later in the mid-late period of SARS ( P>0. 05). Conclusion: ICWM treatment, particularly when it is used for intervention in the early stage, is beneficial for maintaining normal SaO2 in SARS patients.展开更多
Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an ine...Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an inevitable choice and path for the medical development in the new era.This article demonstrates ten major propositions for HIM,elaborating on the connotation and extension of HIM fromthe perspectives of epistemology and methodology,in order to achieve the transformation and adaptive evolution of modern medicine.展开更多
At the beginning of this New Year of 2013, we are very pleased to present the English edition of the Journal of Integrative Medicine （JIM）, a PubMed-indexed, peer-reviewed, open-access journal on integrative medicin...At the beginning of this New Year of 2013, we are very pleased to present the English edition of the Journal of Integrative Medicine （JIM）, a PubMed-indexed, peer-reviewed, open-access journal on integrative medicine. The JIM is a continuation of the former Chinese-language journal, the Journal of Chinese Integrative Medicine （JCIM）, established in 2003 and published in Shanghai. Integrative medicine, grounded in patient-centered, evidence-based practice, incorporates the broad spectrum of complementary and alternative medicine （CAM） and includes acupuncture and traditional Chinese medicine, Ayurveda medicine, herbal medicine, homeopathy, nutrition, chiropractic, mind-body medicine, taichi, qigong, and meditation, among other professions. In the past two decades, CAM has become one of the fastest growing branches of health care. CAM now commands attention worldwide and is rapidly being integrated into conventional medicine. China is the country in the world that has great number of scientists doing clinical and research work on integrative medicine. With this new, English-language publication, we are committed to make JIM an international platform for high-quality CAM papers and an open forum in which the different professions and international scholarly communities can exchange views, share research and their clinical experience, discuss CAM education, and confer about issues and problems in our various disciplines and in CAM as a whole in order to promote integrative medicine.展开更多
In September 2015, Nordic Integrative Medicine （NIM）, in partnership with the European Society of Integrative Medicine （ESIM）, convened the 8th European Congress lbr Integrative Medicine （ECIM） 2015 Global Summi...In September 2015, Nordic Integrative Medicine （NIM）, in partnership with the European Society of Integrative Medicine （ESIM）, convened the 8th European Congress lbr Integrative Medicine （ECIM） 2015 Global Summit on Integrative Medicine and Healthcare in Greater Copenhagen, Denmark, to explore the prominent issues that healthcare is facing, globally and the scientific evidence for or against integrative medicine （lM） that includes conventional medicine （CM）, complementary and alternative medicine （CAM）, and traditional medicine （TM）.展开更多
The concept of autonomic regulation （aR） reflects the relevance of the function of different autonomic systems for health, aR can be captured by questionnaires. We differentiate between a trait or constitutional aR ...The concept of autonomic regulation （aR） reflects the relevance of the function of different autonomic systems for health, aR can be captured by questionnaires. We differentiate between a trait or constitutional aR questionnaire version including 12 （short-version） or 18 items, respectively, with three subscales （orthostatic-circulatory, rest/activity and digestive regulation）, and an 18-item state aR questionnaire on the preceding week with four subscales （rest/activity, orthostatic-circulatory, thermo- and digestive regulation）. The validated questionnaires show satisfying to good reliability and robust validity with clear construct validity. In this article, we summarized the actually available literature on aR and the use of aR questionnaires in clinical and observational studies. We described the relationship of high aR with health and in case of low aR or loss of regulation with disease and functional disorder in the three （four） different subscales and functional systems, such as rest/activity, orthostatic-circulatory or digestive regulation （thermoregulation） with the consecutive therapeutJc need. Finally, we gave perspectives of its further application in clinical research.展开更多
More and more evidence show that the targets of traditional Chinese medicine are a resource pool that contributes to the modern medicine. A key aspect of medicine research is to address the issue how to look for a clu...More and more evidence show that the targets of traditional Chinese medicine are a resource pool that contributes to the modern medicine. A key aspect of medicine research is to address the issue how to look for a clue of potential therapeutic molecular targets by interdisciplinary approaches. With the development of high throughput technology, a considerable amount of data has been emerging. The application of these big data is not so efficient as the generation of them. This paper attempts to show that interdisciplinary analysis contributes to the discovery of targets at the initial stage of drug research, indicating that it is necessary to explore the drug research and development with interdisciplinary approaches between integrative medicine and bioinformatics.展开更多
Background: The White-browed Shortwing(Brachypteryx montana) is widespread from the central Himalayas to the southeast Chinese mainland and the island of Taiwan, the Philippines and Indonesia. Multiple subspecies are ...Background: The White-browed Shortwing(Brachypteryx montana) is widespread from the central Himalayas to the southeast Chinese mainland and the island of Taiwan, the Philippines and Indonesia. Multiple subspecies are recognised, and several of these have recently been suggested to be treated as separate species based on differences in morphology and songs.Methods: We here analyse plumage, morphometrics, songs, two mitochondrial and two nuclear markers, and geographical distributions of the two mainland Asian taxa B. m. cruralis and B. m. sinensis and the Taiwan Residents B. m. goodfellowi.Results: We conclude that these differ congruently in morphology, songs and DNA. Male B. m. goodfellowi is the most divergent in plumage(sexually monomorphic, unlike the two others; male similar to female), and B. m. cruralis and B. m. sinensis differ in male plumage maturation. The song of B. m. cruralis is strongly divergent from the others, whereas the songs of B. m. sinensis and B. m. goodfellowi are more similar to each other. Brachypteryx m. sinensis and B. m. goodfellowi are sisters, with an estimated divergence time 4.1 million years ago(mya; 95% highest posterior distribution [HPD] 2.8–5.5 mya), and B. m. cruralis separated from these two 5.8 mya(95% HPD 4.1–7.5 mya). We also report notable range extensions of B. m. sinensis as well as sympatry between this taxon and B. m. cruralis in Sichuan Province, China. Brachypteryx m. montana from Java is found to be more closely related to Lesser Shortwing(B. leucophris) and Rusty-bellied Shortwing(B. hyperythra) than to the mainland Asian and Taiwan Residents taxa.Conclusion: Our data support a recent proposal to treat the three mainland Asian and Taiwan Residents taxa as three species, separate from B. montana sensu stricto: B. cruralis(central Himalayas to south central China and south Vietnam), B. sinensis(north central to southeastern part of China's Mainland) and B. goodfellowi(Taiwan Island).展开更多
文摘The University of Arizona Center for Integrative Medicine （AzCIM） was founded in 1994 with a primary focus of educating physicians in integrative medicine （IM）. Twenty years later, IM has become an internationally recognized movement in medicine. With 40% of United States＇ medical schools having membership in the Academic Consortium for Integrative Medicine and Health it is foreseeable that all medical students and residents will soon receive training in the principles and practices of IM. The AzCIM has the broadest range and depth of IM educational programs and has had a major influence on integrative medical education in the United States. This review describes the fellowship, residency and medical student programs at AzCIM as well as other significant national drivers of IM education; it also points out the challenges faced in developing IM initiatives. The field of IM has matured with new nationa board certification in IM requiring fellowship training. Allied health professional IM educational courses, as well as integrative health coaching, assure that all members of the health care team can receive training. This review describes the evolution of IM education and will be helpful to academic centers, health care institutions, and countries seeking to introduce IM initiatives.
基金Guidelines for the Diagnosis and Treatment of Atopic Dermatitis in Adults with Integrated Traditional Chinese and Western Medicine(No.ZYZB-2023-580)under the High-level Chinese Medicine Key Discipline Construction Project(Integrative Chinese and Western Medicine Clinic)of the National Administration of Traditional Chinese Medicine(No.zyyzdxk-2023065)Support for the Clinical Evidence-Based Capacity Building of High-Level Key Disciplines of Traditional Chinese Medicine in Shanghai in 2024 from the Shanghai Municipal Commission of Science and Technology(No.23Y31920300)the Young Qi Huang Scholar of the National Administration of Traditional Chinese Medicine。
文摘Traditional Chinese medicine(TCM)is a well-accepted therapy for atopic dermatitis(AD).However,there are currently no evidence-based guidelines integrating TCM and Western medicine for the treatment of AD,limiting the clinical application of such combined approaches.Therefore,the China Association of Chinese Medicine initiated the development of the current guideline,focusing on key issues related to the use of TCM in the treatment of AD.This guideline was developed in accordance with the principles of the guideline formulation manual published by the World Health Organization.A comprehensive review of the literature on the combined use of TCM and Western medicine to treat AD was conducted.The findings were extensively discussed by experts in dermatology and pharmacy with expertise in both TCM and Western medicine.This guideline comprises 23 recommendations across seven major areas,including TCM syndrome differentiation and classification of AD,principles and application scenarios of TCM combined with Western medicine for treating AD,outcome indicators for evaluating clinical efficacy of AD treatment,integration of TCM pattern classification and Western medicine across disease stages,daily management of AD,the use of internal TCM therapies and proprietary Chinese medicines,and TCM external treatments.
基金released in Chengdu on June 22,2024,jointly signed and advocated by over 100 academicians from Chinese Academy of Sciences and Chinese Academy of Engineering,and more than 100 presidents from medical universities across China.
文摘“Integration is a hallmark of our era's development and a magic key to solve epochal problems.”“Medicine originated from humanity's initial expression of suffering and the primary desire to alleviate that suffering.”
文摘High-Intensity Interval Training(HIIT)has gained prominence as a time-efficient and effective exercise modality to improve cardiovascular(CV)fitness,metabolic health,and physical performance.Therefore,our aim was to synthesize current clinical research on the effects of HIIT on the Autonomic Nervous System.We conducted the search for studies in the Directory of Open Access Journals,Embase,Virtual Health Library,Pubmed,and Scielo databases,in January of 2024.We included a total of 20 studies in our review.This literature review highlights the potential of HIIT to modulate the Autonomic Nervous System,enhancing CV function and overall health.Despite the promising findings,the interpretation of the results is tempered by the variability in study designs,populations,and methodologies.Future research should address these limitations,aiming for a more nuanced understanding of the relationship between HIIT and Autonomic Nervous System function.The review indicates that standardized protocols need to consider individual characteristics and baseline autonomic states for clinical application.As the body of evidence grows,HIIT may emerge as a cornerstone of exercise prescriptions aimed at optimizing autonomic function and promoting CV health.
基金supported by the Seventh Batch of National Academic Experience Inheritance Project for Senior TCM Experts from the National Administration of Traditional Chinese Medicine(No.GZYRJS[2022]76)the Sixth Batch of Beijing Municipal Academic Experience Inheritance Project for TCM Experts from Beijing Administration of Traditional Chinese Medicine(No.JZYKZ[2019]139).
文摘Granulomatosis with polyangiitis(GPA)poses significant therapeutic challenges due to its susceptibility to concurrent infections and frequent relapses.Professor SHI Zaixiang proposed the therapeutic theory of lifting depression and removing blood stasis,resolving phlegm and dispelling nodulation for GPA management.He identified the core pathogenesis as“Qi collapse with collateral obstruction and phlegm-stasis intermingling”,establishing the treatment principle of comprehensive intervention through ascending ancestral Qi,activating blood circulation,and resolving phlegm-stasis nodules.In clinical practice,Professor SHI emphasizes maintaining immune homeostasis with herbal medicine to enhance efficiency,while dynamically balancing Qi,blood,Yin,and Yang.Notably,he highlights the critical role of emotional factors in autoimmune disease progression.A representative case was provided to elucidate his clinical reasoning in GPA treatment.
基金Supported by Key Projects of Beijing Municipal Science and Technology Commission(No.#D131100002213004)
文摘OBJECTIVE: To compare the efficacy of integrated Chinese and Western Medicine with that of only Western Medicine for the treatment of malignant ascites.METHODS: All randomized controlled trials(January 2004 to March 2013) from the China National Knowledge Infrastructure Database, Chinese Biomedical Literature Database, and Wanfang Database were searched with keywords. Meta-analysis was conducted by combining the odds ratios of the individual studies. Review Manager 5.0 was used for the analysis.RESULTS: One thousand one hundred and fifty-six patients from 19 randomized controlled trails were included. Of them, 630 patients were treated with integrated Chinese and Western Medicine(the integrative group), and 526 patients were treated with Western Medicine alone(the control group). The Meta-analysis showed that the total effective rate was 78.73% in the integrated group, and 59.13% in the control group. The effective percentage was sig-nificantly higher in the integrative group than that of the control group [OR = 2.85, 95% CI(2.16,3.74),P < 0.01].CONCLUSION: The short-term curative effect in the integrative group was better than that in the control group. Integrative medicine may be beneficial for malignant ascites.
基金supported by the Evidence-Based Capacity Building Project for Basic Traditional Chinese MedicineSpecialized Diseases(No.2019XZZX-XH012)Shanghai Municipal Health Commission+1 种基金Three Year Action Plan for InheritanceInnovation and Development of Traditional Chinese Medicine(ZY[2021-2023]-0211)。
文摘Objective:Appraisal of treatment outcomes in integrative medicine is a challenge due to a gap between the concepts of Western medicine(WM)disease and traditional Chinese medicine(TCM)syndrome.This study presents an approach for the appraisal of integrative medicine that is based on targeted metabolomics.We use non-alcoholic fatty liver disease with spleen deficiency syndrome as a test case.Methods:A patient-reported outcome(PRO)scale was developed based on literature review,Delphi consensus survey,and reliability and validity test,to quantitatively evaluate spleen deficiency syndrome.Then,a metabonomic foundation for the treatment of non-alcoholic fatty liver disease with spleen deficiency syndrome was identified via a longitudinal interventional trial and targeted metabolomics.Finally,an integrated appraisal model was established by identifying metabolites that responded in the treatment of WM disease and TCM syndrome as positive outcomes and using other aspects of the metabonomic foundation as independent variables.Results:Ten symptoms and signs were included in the spleen deficiency PRO scale.The internal reliability,content validity,discriminative validity and structural validity of the scale were all qualified.Based on treatment responses to treatments for WM disease(homeostasis model assessment of insulin resistance)or TCM syndrome(spleen deficiency PRO scale score)from a previous randomized controlled trial,two cohorts comprised of 30 participants each were established for targeted metabolomics detection.Twenty-five metabolites were found to be involved in successful treatment outcomes to both WM and TCM,following quantitative comparison and multivariate analysis.Finally,the model of the integrated appraisal system was exploratively established using binary logistic regression;it included 9 core metabolites and had the prediction probability of 83.3%.Conclusion:This study presented a new and comprehensive research route for integrative appraisal of treatment outcomes for WM disease and TCM syndrome.Critical research techniques used in this research included the development of a TCM syndrome assessment tool,a longitudinal interventional trial with verified TCM treatment,identification of homogeneous metabolites,and statistical modeling.
文摘Among adolescents,the incidence of type 2 diabetes mellitus(T2 DM)has recently increased.A 12-yearold Chinese boy with a one-year history of hyperphagia presented to our clinic.The patient was diagnosed with T2 DM one month prior to visiting the clinic and reported undergoing no pharmacologic treatment.Using an integrative medicine approach,including Chinese herbal decoction,berberine hydrochloride tablets,physical exercise and diet control,the patient's fasting blood glucose(FBG)decreased from 8.3 mmol/L to 5.5 mmol/L.Additionally,his glycated haemoglobin decreased from12.9%to 6.1%,indicating that without any Western medicine intervention his diabetes has been reversed after six months of treatment.His FBG remained normal,and nine months after completion of treatment it was 4.9 mmol/L.A potential mechanism in this response may be related to improved insulin resistance and b-cell function,as indicated by observed changes in homeostasis model assessment of insulin resistance and b-cell function.Further,weight loss may also have contributed to the effectiveness of the treatment.This case study is the first to present the innovative approach of integrative medicine to achieve remission of new-onset adolescent T2 DM.
文摘Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an inevitable choice and path for the medical development in the new era.This article demonstrates ten major propositions for HIM,elaborating on the connotation and extension of HIM from the perspectives of epistemology and methodology,in order to achieve the transformation and adaptive evolution of modernmedicine.
文摘To meet community demands with optimal Chinese and conventional medical treatment, the University of Hong Kong is promoting integrative medicine by developing Chinese medicine programmes that train students of both Western and Chinese medicine. The programmes emphasize multi-disciplinary training and interaction between the two therapeutic approaches, enabling students to establish reliable, consistent, and respectful mutual cooperation in their future careers.
基金funded by the Shanghai Municipal Commission of Health and Family Planning(Grant Number ZY3-LCPT-2-1004)National Natural Science Foundation of China(Grant Number81503459)E-Institutes of Shanghai Municipal Education Commission(Grant Number E03008)
文摘Traditional Chinese medicine （TCM） is an important part of the treatment of primary liver cancer （PLC） in China; however, the current instructions for the integrative use of traditional Chinese and Western medicine for PLC are mostly based on expert opinion. There is no evidence-based guideline for clinical prac-tice in this field. Therefore, the Shanghai Association of Chinese Integrative Medicine has established a multidisciplinary working group to develop this guideline, which focuses on the most important questions about the use of TCM during PLC treatment. This guideline was developed following the method- ological process recommended by the World Health Organization Handbook for Guideline Development. Two rounds of questionnaire survey were performed to identify clinical questions; published evidence was searched; the Grading of Recommendations Assessment, Development and Evaluation approach was used to evaluate the body of evidence; and recommendations were formulated by combining the quality of evidence, patient preferences and values, and other risk factors. The guideline was written based on the Reporting Items for Practice Guidelines in Healthcare tool. This guideline contains 10 recommendations related to 8 questions, including recommendations for early treatment by TCM after surgery, TCM combined with transcatheter arterial chemoembolization for advanced PLC, TCM drugs for external use, and acupuncture and moxibustion therapy.
文摘Purpose: The aim of this study is to develop and validate a scale for perioperative recovery with integrative medicine. Methods: The procedures for developing the scale included a review of both modern and ancient literature, other perioperative scales or questionnaire references, an expert consultation, and interviews with patients and surgeons following standard procedures. Primary face and content validity were assessed through a small-scale patient survey of 50 patients. A final evaluation based on the patient survey was conducted among 354 patients (age range 16-75) from the same hospital. This included testing the perioperative recovery scale for integrative medicine (PRSIM) for scaling properties, reliability, validity and responsiveness. Results: The PRSIM, a 20-item scale, was modified from an initial version transcript which included 122 items. The 20 items in the PRSIM covered five domains: direct influence, indirect influence, activity, mental function and general health perceptions. Five factors extracted from an exploratory factor analysis demonstrated a desirable model fit. A confirmatory factor analysis further indicated that the PRSIM had a good fit with the same sample. A data analysis of the PRSIM with 349 patients showed that it had good internal consistency (α> 0.7), test-retest reliability (ICC > 0.4) and split half reliability (α= 0.66). Conclusions: The PRSIM can serve as a valuable instrument for assessing patient perioperative recovery in integrative medicine. It is acceptable for patients in the perioperative period undergoing treatment by either Chinese or integrative medicine, and has good psychometric properties. Registration number: ChiCTR-TRC-09000527.
基金This item is one of the items of State 863 Plan (No.2003AA208101) a special subject of clinical study of State administration of TCM an important item of Beijing Scientific-Technology Plan(No. H020920010031)
文摘Objective: To evaluate the effects of treatment of integrative Chinese and Western medicine (ICWM) on arterial oxygen saturation (SaO2) in patients with severe acute respiratory syndrome (SARS). Methods:The non-randomized, controlled trial was conducted on 447 SARS patients treated synchronously with western conventional treatment (WM group, n = 171) alone and ICWM (ICWM group, n = 276). The changes of the cases with normal level (≥95% ) or abnormal level (<95% ) SaO2 were observed dynamically. Results: In the 3rd-14th day of the therapeutic course, the percentage of patients with normal SaO2 in the ICWM group was higher than that in the WM group (OR = 0.5178, P = 0.0038), and this tendency was more evident in patients of the severe type (OR = 0. 18, P = 0. 0001). However, the statistical significance of difference was only shown in patients for whom the ICWM treatment started in the early period after the onset (≤7 days after it, OR = 0.3803, P = 0.006), but not shown in those who received ICWM treatment later in the mid-late period of SARS ( P>0. 05). Conclusion: ICWM treatment, particularly when it is used for intervention in the early stage, is beneficial for maintaining normal SaO2 in SARS patients.
文摘Holistic integrative medicine,abbreviated as HIM,has been officially proposed since 2012.Its theoretical system has been continuously improved,and its practical methods have become increasingly diverse,becoming an inevitable choice and path for the medical development in the new era.This article demonstrates ten major propositions for HIM,elaborating on the connotation and extension of HIM fromthe perspectives of epistemology and methodology,in order to achieve the transformation and adaptive evolution of modern medicine.
文摘At the beginning of this New Year of 2013, we are very pleased to present the English edition of the Journal of Integrative Medicine （JIM）, a PubMed-indexed, peer-reviewed, open-access journal on integrative medicine. The JIM is a continuation of the former Chinese-language journal, the Journal of Chinese Integrative Medicine （JCIM）, established in 2003 and published in Shanghai. Integrative medicine, grounded in patient-centered, evidence-based practice, incorporates the broad spectrum of complementary and alternative medicine （CAM） and includes acupuncture and traditional Chinese medicine, Ayurveda medicine, herbal medicine, homeopathy, nutrition, chiropractic, mind-body medicine, taichi, qigong, and meditation, among other professions. In the past two decades, CAM has become one of the fastest growing branches of health care. CAM now commands attention worldwide and is rapidly being integrated into conventional medicine. China is the country in the world that has great number of scientists doing clinical and research work on integrative medicine. With this new, English-language publication, we are committed to make JIM an international platform for high-quality CAM papers and an open forum in which the different professions and international scholarly communities can exchange views, share research and their clinical experience, discuss CAM education, and confer about issues and problems in our various disciplines and in CAM as a whole in order to promote integrative medicine.
文摘In September 2015, Nordic Integrative Medicine （NIM）, in partnership with the European Society of Integrative Medicine （ESIM）, convened the 8th European Congress lbr Integrative Medicine （ECIM） 2015 Global Summit on Integrative Medicine and Healthcare in Greater Copenhagen, Denmark, to explore the prominent issues that healthcare is facing, globally and the scientific evidence for or against integrative medicine （lM） that includes conventional medicine （CM）, complementary and alternative medicine （CAM）, and traditional medicine （TM）.
基金financial support by Humanus InstituteBerneburg foundationGyllenberg foundation
文摘The concept of autonomic regulation （aR） reflects the relevance of the function of different autonomic systems for health, aR can be captured by questionnaires. We differentiate between a trait or constitutional aR questionnaire version including 12 （short-version） or 18 items, respectively, with three subscales （orthostatic-circulatory, rest/activity and digestive regulation）, and an 18-item state aR questionnaire on the preceding week with four subscales （rest/activity, orthostatic-circulatory, thermo- and digestive regulation）. The validated questionnaires show satisfying to good reliability and robust validity with clear construct validity. In this article, we summarized the actually available literature on aR and the use of aR questionnaires in clinical and observational studies. We described the relationship of high aR with health and in case of low aR or loss of regulation with disease and functional disorder in the three （four） different subscales and functional systems, such as rest/activity, orthostatic-circulatory or digestive regulation （thermoregulation） with the consecutive therapeutJc need. Finally, we gave perspectives of its further application in clinical research.
基金the grants from National Natural Science Foundation of China (No. 81703871)Doctoral Start-up Foundation of Liaoning Province (No. 20170520408).
文摘More and more evidence show that the targets of traditional Chinese medicine are a resource pool that contributes to the modern medicine. A key aspect of medicine research is to address the issue how to look for a clue of potential therapeutic molecular targets by interdisciplinary approaches. With the development of high throughput technology, a considerable amount of data has been emerging. The application of these big data is not so efficient as the generation of them. This paper attempts to show that interdisciplinary analysis contributes to the discovery of targets at the initial stage of drug research, indicating that it is necessary to explore the drug research and development with interdisciplinary approaches between integrative medicine and bioinformatics.
基金P.A.gratefully acknowledges Jornvall Foundation,Mark and Mo Constantine,and the Chinese Academy of Sciences Visiting Professorship for Senior International Scientists(No.2011T2S04)P.A.and U.O.acknowledge the Swedish Research Council(Grant Nos.2015-04402 and 2015-04651,respectively)
文摘Background: The White-browed Shortwing(Brachypteryx montana) is widespread from the central Himalayas to the southeast Chinese mainland and the island of Taiwan, the Philippines and Indonesia. Multiple subspecies are recognised, and several of these have recently been suggested to be treated as separate species based on differences in morphology and songs.Methods: We here analyse plumage, morphometrics, songs, two mitochondrial and two nuclear markers, and geographical distributions of the two mainland Asian taxa B. m. cruralis and B. m. sinensis and the Taiwan Residents B. m. goodfellowi.Results: We conclude that these differ congruently in morphology, songs and DNA. Male B. m. goodfellowi is the most divergent in plumage(sexually monomorphic, unlike the two others; male similar to female), and B. m. cruralis and B. m. sinensis differ in male plumage maturation. The song of B. m. cruralis is strongly divergent from the others, whereas the songs of B. m. sinensis and B. m. goodfellowi are more similar to each other. Brachypteryx m. sinensis and B. m. goodfellowi are sisters, with an estimated divergence time 4.1 million years ago(mya; 95% highest posterior distribution [HPD] 2.8–5.5 mya), and B. m. cruralis separated from these two 5.8 mya(95% HPD 4.1–7.5 mya). We also report notable range extensions of B. m. sinensis as well as sympatry between this taxon and B. m. cruralis in Sichuan Province, China. Brachypteryx m. montana from Java is found to be more closely related to Lesser Shortwing(B. leucophris) and Rusty-bellied Shortwing(B. hyperythra) than to the mainland Asian and Taiwan Residents taxa.Conclusion: Our data support a recent proposal to treat the three mainland Asian and Taiwan Residents taxa as three species, separate from B. montana sensu stricto: B. cruralis(central Himalayas to south central China and south Vietnam), B. sinensis(north central to southeastern part of China's Mainland) and B. goodfellowi(Taiwan Island).
