Type 2 diabetes(T2D)is a chronic metabolic disorder marked by insulin resistance and impaired glucose metabolism,often diagnosed at advanced stages[1].Metabolomics offers a promising approach for identifying biomarker...Type 2 diabetes(T2D)is a chronic metabolic disorder marked by insulin resistance and impaired glucose metabolism,often diagnosed at advanced stages[1].Metabolomics offers a promising approach for identifying biomarkers to detect T2D early[2].This longitudinal study uses Korean Genome and Epidemiology Study(KoGES)data,a cohort of 10,300 individuals aged 40-69 years recruited in 2001-2002,with biennial follow-ups.The study included 664 participants from phases 6-8(2012-2016)with complete metabolomic data[3].The aim was to find novel metabolite biomarkers associated with T2D risk.展开更多
Dear Editor,Plant tissue culture involves callus formation and de novo shoot regeneration.First,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-indu...Dear Editor,Plant tissue culture involves callus formation and de novo shoot regeneration.First,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。展开更多
基金supported by the National Research Foundation of Korea(NRF),funded by the Ministry of Education(NRF-2022R1A2C1092497)。
文摘Type 2 diabetes(T2D)is a chronic metabolic disorder marked by insulin resistance and impaired glucose metabolism,often diagnosed at advanced stages[1].Metabolomics offers a promising approach for identifying biomarkers to detect T2D early[2].This longitudinal study uses Korean Genome and Epidemiology Study(KoGES)data,a cohort of 10,300 individuals aged 40-69 years recruited in 2001-2002,with biennial follow-ups.The study included 664 participants from phases 6-8(2012-2016)with complete metabolomic data[3].The aim was to find novel metabolite biomarkers associated with T2D risk.
基金Basic Science Research(NRF-2022R1A2 B5B02001266 to P.J.S.)the New breeding technologies development Program(PJ01653002 to P.J.S.)provided by the Rural Development Administration+1 种基金This work was also supported by Korea Basic Science Institute(C370000 to G.S.H)the Korea Research Institute of Bioscience and Biotechnology(KRIBB)Research Initiative Program(KGM 5282331 to S.W.K.).
文摘Dear Editor,Plant tissue culture involves callus formation and de novo shoot regeneration.First,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。
