Objective： Analysis of abstinence rates of smokers per gender at 3, 6, 9 and 12 months in a Smoking Cessation Unit from January 2008 to December 2009. Methods： Descriptive retrospective study. Analysis of socio-demo...Objective： Analysis of abstinence rates of smokers per gender at 3, 6, 9 and 12 months in a Smoking Cessation Unit from January 2008 to December 2009. Methods： Descriptive retrospective study. Analysis of socio-demographic variables, smoking patterns, associated comorbidities, continuous abstinence rates, success, relapses, failure and dropping out. Results： 278 smokers started treatment （33%）; 55.4% males and 44.6% females （mean age of 48.3 and 44.06 years, respectively）. The main associated comorbidities were： psychiatric （38.7%）, cardiovascular （dyslipemia 25%） and respiratory （COPD （chronic obstructive pulmonary disease） 9.7%） in females; cardiovascular （dyslipemia 34.4%）, psychiatric （34.4%） and respiratory （COPD 19.5%） in males. VRN （Varenicline） was prescribed in 40.2% males and 32.2% females; NRT （nicotine replacement therapy） was used in 46.6% and 38.7%, respectively; bupropion was employed in 6.5% and 21.8%, respectively. Psychological counseling was offered only to 7.8% males and 8.1% females. The continuous abstinence rates in males at 3, 6, 9 and 12 months were 51.3%, 37.7%, 32.5% and 30.5%, respectively, and were 45.2%, 29.8%, 25.0% and 24.2% for females. Failure was 9.7% for females and 18.8% for males. Success was more frequent for those on VRN （n = 41 males; n = 12 females）. No relapses were indicated for 42 females and 71 males. The percentage of relapses was higher at 3 months （29.0% females, 19.5% males）. Conclusions： The study observed differences in treating abstinence between genders （in the abstinence rates and failure index）. This implies having to consider incorporating the gender variable into the diagnosis, treatment and prevention of smoking.展开更多
To the Editor:Lung cancer continues to be the most common cause of tumor-related death globally.Screening by low-dose computed tomography(CT)has been proven to greatly reduce the mortality of lung cancer patients.Alth...To the Editor:Lung cancer continues to be the most common cause of tumor-related death globally.Screening by low-dose computed tomography(CT)has been proven to greatly reduce the mortality of lung cancer patients.Although the recommended screened population varies among different guidelines,elderly smokers are always the most important subjects.However,a substantial group of lung cancer patients has been found to be young without tobacco consumptionJ11 Non-smoking lung cancer was even considered to be an independent disease and the seventh leading cause of cancer mortality.展开更多
Background:Current lung cancer screening guidelines recommend annual low-dose computed tomography(LDCT)for high-risk individuals.However,the effectiveness of LDCT in non-high-risk individuals remains inadequately expl...Background:Current lung cancer screening guidelines recommend annual low-dose computed tomography(LDCT)for high-risk individuals.However,the effectiveness of LDCT in non-high-risk individuals remains inadequately explored.With the incidence of lung cancer steadily increasing among non-high-risk individuals,this study aims to assess the risk of lung cancer in non-high-risk individuals and evaluate the potential of thin-section LDCT reconstruction combined with artificial intelligence(LDCT-TRAI)as a screening tool.Methods:A real-world cohort study on lung cancer screening was conducted at the West China Hospital of Sichuan University from January 2010 to July 2021.Participants were screened using either LDCT-TRAI or traditional thick-section LDCT without AI(traditional LDCT).The AI system employed was the uAI-ChestCare software.Lung cancer diagnoses were confirmed through pathological examination.Results:Among the 259121 enrolled non-high-risk participants,87260(33.7%)had positive screening results.Within 1 year,728(0.3%)participants were diagnosed with lung cancer,of whom 87.1%(634/728)were never-smokers,and 92.7%(675/728)presented with stage I disease.Compared with traditional LDCT,LDCT-TRAI demonstrated a higher lung cancer detection rate(0.3%vs.0.2%,P<0.001),particularly for stage I cancers(94.4%vs.83.2%,P<0.001),and was associated with improved survival outcomes(5-year overall survival rate:95.4%vs.81.3%,P<0.0001).Conclusion:These findings highlight the importance of expanding lung cancer screening to non-high-risk populations,especially never-smokers.LDCT-TRAI outperformed traditional LDCT in detecting early-stage cancers and improving survival outcomes,underscoring its potential as a more effective screening tool for early lung cancer detection in this population.展开更多
Dear Editor,Trichomonas vaginalis is a common human protozoan parasite.Infection with T.vaginalis often manifests with symptoms such as vaginitis,itching,and dysuria,and in severe cases,infertility may occur[1,2].Howe...Dear Editor,Trichomonas vaginalis is a common human protozoan parasite.Infection with T.vaginalis often manifests with symptoms such as vaginitis,itching,and dysuria,and in severe cases,infertility may occur[1,2].However,some infected individuals may not exhibit typical symptoms.For example,T.vaginalis is highly prevalent in rural South Africa and often presents without symptoms[3,4].Moreover,T.vaginalis is primarily known to infect the genitourinary system,and infection beyond this system are uncommon.A previous study reported T.vaginalis in the routine urine test of a 5-day-old newborn[5].A study explored the correlation between trichomoniasis and prostate and bladder diseases[6].Another study reported that trichomonads were detected in bronchoalveolar lavage fluid[7].However,accurately diagnosing infectious diseases caused by trichomonads remains a significant challenge in clinical practice.展开更多
文摘Objective： Analysis of abstinence rates of smokers per gender at 3, 6, 9 and 12 months in a Smoking Cessation Unit from January 2008 to December 2009. Methods： Descriptive retrospective study. Analysis of socio-demographic variables, smoking patterns, associated comorbidities, continuous abstinence rates, success, relapses, failure and dropping out. Results： 278 smokers started treatment （33%）; 55.4% males and 44.6% females （mean age of 48.3 and 44.06 years, respectively）. The main associated comorbidities were： psychiatric （38.7%）, cardiovascular （dyslipemia 25%） and respiratory （COPD （chronic obstructive pulmonary disease） 9.7%） in females; cardiovascular （dyslipemia 34.4%）, psychiatric （34.4%） and respiratory （COPD 19.5%） in males. VRN （Varenicline） was prescribed in 40.2% males and 32.2% females; NRT （nicotine replacement therapy） was used in 46.6% and 38.7%, respectively; bupropion was employed in 6.5% and 21.8%, respectively. Psychological counseling was offered only to 7.8% males and 8.1% females. The continuous abstinence rates in males at 3, 6, 9 and 12 months were 51.3%, 37.7%, 32.5% and 30.5%, respectively, and were 45.2%, 29.8%, 25.0% and 24.2% for females. Failure was 9.7% for females and 18.8% for males. Success was more frequent for those on VRN （n = 41 males; n = 12 females）. No relapses were indicated for 42 females and 71 males. The percentage of relapses was higher at 3 months （29.0% females, 19.5% males）. Conclusions： The study observed differences in treating abstinence between genders （in the abstinence rates and failure index）. This implies having to consider incorporating the gender variable into the diagnosis, treatment and prevention of smoking.
基金National Key Research and Development Program of China(No.2018YFC1311900)National Natural Science Foundation of China(Nos.91859203,and 81871890)+2 种基金Key Program from the Department of Science and Technology,Sichuan Province,China(No.2021YFS0072)1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYJC18001)Central Guide Place-Free Exploration Project,Sichuan Provincial Department of Science and Technology(No.2020ZYD005)。
文摘To the Editor:Lung cancer continues to be the most common cause of tumor-related death globally.Screening by low-dose computed tomography(CT)has been proven to greatly reduce the mortality of lung cancer patients.Although the recommended screened population varies among different guidelines,elderly smokers are always the most important subjects.However,a substantial group of lung cancer patients has been found to be young without tobacco consumptionJ11 Non-smoking lung cancer was even considered to be an independent disease and the seventh leading cause of cancer mortality.
基金supported by Non-communicable Chronic Diseases-National Science and Technology Major Project(Grant No.2023ZD0506102/2023ZD0506100)the National Natural Science Foundation of China(Grant No.92159302)+5 种基金the Science and Technology Project of Sichuan(Grant No.2022ZDZX0018)1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(Grant No.ZYGD22009)the Natural Science Foundation of Sichuan Province(Grant No.2023NSFSC1458),1·3·5 Project of State Key Laboratory of Respiratory Health and Multimorbidity,West China Hospital,Sichuan University(Grant No.RHM24204)the Science and Technology Project of Sichuan(Grant No.2020YFS0573)the Major research programs of the Natural Science Foundation of China(Grant No.91859203)Key R&D plan of Sichuan Provincial Department of science and technology(Grant No.2021YFS0072)。
文摘Background:Current lung cancer screening guidelines recommend annual low-dose computed tomography(LDCT)for high-risk individuals.However,the effectiveness of LDCT in non-high-risk individuals remains inadequately explored.With the incidence of lung cancer steadily increasing among non-high-risk individuals,this study aims to assess the risk of lung cancer in non-high-risk individuals and evaluate the potential of thin-section LDCT reconstruction combined with artificial intelligence(LDCT-TRAI)as a screening tool.Methods:A real-world cohort study on lung cancer screening was conducted at the West China Hospital of Sichuan University from January 2010 to July 2021.Participants were screened using either LDCT-TRAI or traditional thick-section LDCT without AI(traditional LDCT).The AI system employed was the uAI-ChestCare software.Lung cancer diagnoses were confirmed through pathological examination.Results:Among the 259121 enrolled non-high-risk participants,87260(33.7%)had positive screening results.Within 1 year,728(0.3%)participants were diagnosed with lung cancer,of whom 87.1%(634/728)were never-smokers,and 92.7%(675/728)presented with stage I disease.Compared with traditional LDCT,LDCT-TRAI demonstrated a higher lung cancer detection rate(0.3%vs.0.2%,P<0.001),particularly for stage I cancers(94.4%vs.83.2%,P<0.001),and was associated with improved survival outcomes(5-year overall survival rate:95.4%vs.81.3%,P<0.0001).Conclusion:These findings highlight the importance of expanding lung cancer screening to non-high-risk populations,especially never-smokers.LDCT-TRAI outperformed traditional LDCT in detecting early-stage cancers and improving survival outcomes,underscoring its potential as a more effective screening tool for early lung cancer detection in this population.
基金supported by the grants from the National Key Research and Development Project of China(Grant No.2022YFC2406804)the Chongqing Youth and Middle-aged Medical Top Talent Project(Grant No.202129)+2 种基金the Chongqing Bureau of Science and Technology and Chongqing Municipal Health Commission joint research project(Grant No.2024GDRC004)Scientific Research Fund of Yunnan Provincial Department of Education(Grant No.2024J0304)Yunnan Provincial Science and Technology Plan Project of Kunming Medical Joint Special Project(GrantNo.202401AY070001-295).
文摘Dear Editor,Trichomonas vaginalis is a common human protozoan parasite.Infection with T.vaginalis often manifests with symptoms such as vaginitis,itching,and dysuria,and in severe cases,infertility may occur[1,2].However,some infected individuals may not exhibit typical symptoms.For example,T.vaginalis is highly prevalent in rural South Africa and often presents without symptoms[3,4].Moreover,T.vaginalis is primarily known to infect the genitourinary system,and infection beyond this system are uncommon.A previous study reported T.vaginalis in the routine urine test of a 5-day-old newborn[5].A study explored the correlation between trichomoniasis and prostate and bladder diseases[6].Another study reported that trichomonads were detected in bronchoalveolar lavage fluid[7].However,accurately diagnosing infectious diseases caused by trichomonads remains a significant challenge in clinical practice.
