Adopted by the 2nd IANR Annual Conference General Assembly,Beijing,China,April 2009 and amended by the:8th IANR Annual Conference General Assembly,Tehran,Iran,April 201514th IANR Annual Conference,Xi'an,China,Marc...Adopted by the 2nd IANR Annual Conference General Assembly,Beijing,China,April 2009 and amended by the:8th IANR Annual Conference General Assembly,Tehran,Iran,April 201514th IANR Annual Conference,Xi'an,China,March 20231.With the rapid advancement of basic and clinical research in neurorestoration,Neurorestoratology has become a distinct medical discipline based on both the neurorestorative potential findings and neurorestorable theory of the central nervous system(CNS).Several relevant academic organizations,institutions,clinical centers and departments have been established worldwide,and many guidelines and expert consensus documents have been released for the purpose of promoting CNS restoration.The International Association of Neurorestoratology(IANR)is one of the most important academic platforms for this discipline.展开更多
The Neurorestoratology discipline is getting worldwide attention from the clinicians,basic scientists,students and policy makers alike.Accordingly,this year too,the discipline has made profound advances and great achi...The Neurorestoratology discipline is getting worldwide attention from the clinicians,basic scientists,students and policy makers alike.Accordingly,this year too,the discipline has made profound advances and great achievements for the benefit of the mankind.In this report,of the 2018 Neurorestoratology Yearbook,salient features of new developments are summarized.This Yearbook consists 3 key themes namely(i)the new findings on pathogenesis of neurological diseases or degeneration;(ii)the new mechanisms of neurorestorative aspects;and(iii)the achievements and progresses made in the clinical field of neurorestorative therapies.The new trend has emerged in clinical studies that are based on greater levels of evidence-based medical practices both in clinical therapies and clinical trials based on standard designs.展开更多
Clinical cell therapies(CTs)for neurological diseases and cellular damage have been explored for more than 2 decades.According to the United States Food and Drug Administration,there are 2 types of cell categories for...Clinical cell therapies(CTs)for neurological diseases and cellular damage have been explored for more than 2 decades.According to the United States Food and Drug Administration,there are 2 types of cell categories for therapy,namely stem cell-derived CT products and mature/functionally differentiated cell-derived CT products.However,regardless of the type of CT used,the majority of reports of clinical CTs from either small sample sizes based on single-center phase 1 or 2 unblinded trials or retrospective clinical studies showed effects on neurological improvement and the ability to either partially or temporarily thwart the deteriorating cellular processes of the neurodegenerative diseases.There have been only a few prospective,multicenter,randomized,double-blind placebo-control clinical trials of CTs so far in this developing novel area that have shown negative results,and more clinical trials are needed.This will expand our knowledge in exploring the type of cells that yield promising results and restore damaged neurological structure and functions of the central nervous system based on higher level evidence-based medical data.In this review,we briefly introduce the developmental process,current state,and future prospective for clinical neurorestorative CT.展开更多
文摘Adopted by the 2nd IANR Annual Conference General Assembly,Beijing,China,April 2009 and amended by the:8th IANR Annual Conference General Assembly,Tehran,Iran,April 201514th IANR Annual Conference,Xi'an,China,March 20231.With the rapid advancement of basic and clinical research in neurorestoration,Neurorestoratology has become a distinct medical discipline based on both the neurorestorative potential findings and neurorestorable theory of the central nervous system(CNS).Several relevant academic organizations,institutions,clinical centers and departments have been established worldwide,and many guidelines and expert consensus documents have been released for the purpose of promoting CNS restoration.The International Association of Neurorestoratology(IANR)is one of the most important academic platforms for this discipline.
文摘The Neurorestoratology discipline is getting worldwide attention from the clinicians,basic scientists,students and policy makers alike.Accordingly,this year too,the discipline has made profound advances and great achievements for the benefit of the mankind.In this report,of the 2018 Neurorestoratology Yearbook,salient features of new developments are summarized.This Yearbook consists 3 key themes namely(i)the new findings on pathogenesis of neurological diseases or degeneration;(ii)the new mechanisms of neurorestorative aspects;and(iii)the achievements and progresses made in the clinical field of neurorestorative therapies.The new trend has emerged in clinical studies that are based on greater levels of evidence-based medical practices both in clinical therapies and clinical trials based on standard designs.
文摘Clinical cell therapies(CTs)for neurological diseases and cellular damage have been explored for more than 2 decades.According to the United States Food and Drug Administration,there are 2 types of cell categories for therapy,namely stem cell-derived CT products and mature/functionally differentiated cell-derived CT products.However,regardless of the type of CT used,the majority of reports of clinical CTs from either small sample sizes based on single-center phase 1 or 2 unblinded trials or retrospective clinical studies showed effects on neurological improvement and the ability to either partially or temporarily thwart the deteriorating cellular processes of the neurodegenerative diseases.There have been only a few prospective,multicenter,randomized,double-blind placebo-control clinical trials of CTs so far in this developing novel area that have shown negative results,and more clinical trials are needed.This will expand our knowledge in exploring the type of cells that yield promising results and restore damaged neurological structure and functions of the central nervous system based on higher level evidence-based medical data.In this review,we briefly introduce the developmental process,current state,and future prospective for clinical neurorestorative CT.
