Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for sign...Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for signal transduction.The plasticity of spine morphologies provides a tunable handle to regulate calcium signal dynamics,allowing rapid regulation of protein expression necessary to establish and maintain synapses(Cornejo et al.,2022).If excitatory inputs were to be located primarily on dendritic shafts,dendrites would frequently short-circuit,preventing voltage signals from propagating(Cornejo et al.,2022).It is thus not surprising that the structural plasticity of dendritic spines is closely linked to synaptic plasticity and memory formation(Berry and Nedivi,2017).While comprehensive in vitro studies have been conducted,in vivo studies that directly tackle the mechanism of dendritic transport and translation in regulating spine plasticity spatiotemporally are limited.展开更多
由于在医疗行业、畜牧养殖业和农业生产活动中的广泛使用,氨基糖苷类抗生素(Aminoglycosides,AGs)在食品介质中广泛残留。但由于其种类多样,且具有强极性,分子结构上缺乏发色和荧光基团等特点,目前该类物质的同时测定分析方法要比其他...由于在医疗行业、畜牧养殖业和农业生产活动中的广泛使用,氨基糖苷类抗生素(Aminoglycosides,AGs)在食品介质中广泛残留。但由于其种类多样,且具有强极性,分子结构上缺乏发色和荧光基团等特点,目前该类物质的同时测定分析方法要比其他类抗生素更为复杂。在已报道的多种检测方法中,液相色谱-串联质谱法(Liquid Chromatography-Tandem Mass Spectrometry,LC-MS/MS)在食品介质中多种AGs的同时测定中发挥重要作用。综述了LC-MS/MS用于检测食品中氨基糖苷类抗生素残留的前处理方法和仪器条件,以及AGs在食物中的污染现状,以期为食品中氨基糖苷类抗生素的残留分析提供理论参考。展开更多
基金supported by the National Natural Science Foundation of China(NSFC/RGC/JRF N_HKU735/21)Research Grant Council of Hong Kong,China(17102120,17108821,17103922,C1024-22GF,C7074-21G)+1 种基金Health and Medical Research Fund(HMRF 09200966)(to CSWL)FRQS Postdoctoral Fellowship(to AHKF).
文摘Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for signal transduction.The plasticity of spine morphologies provides a tunable handle to regulate calcium signal dynamics,allowing rapid regulation of protein expression necessary to establish and maintain synapses(Cornejo et al.,2022).If excitatory inputs were to be located primarily on dendritic shafts,dendrites would frequently short-circuit,preventing voltage signals from propagating(Cornejo et al.,2022).It is thus not surprising that the structural plasticity of dendritic spines is closely linked to synaptic plasticity and memory formation(Berry and Nedivi,2017).While comprehensive in vitro studies have been conducted,in vivo studies that directly tackle the mechanism of dendritic transport and translation in regulating spine plasticity spatiotemporally are limited.
文摘由于在医疗行业、畜牧养殖业和农业生产活动中的广泛使用,氨基糖苷类抗生素(Aminoglycosides,AGs)在食品介质中广泛残留。但由于其种类多样,且具有强极性,分子结构上缺乏发色和荧光基团等特点,目前该类物质的同时测定分析方法要比其他类抗生素更为复杂。在已报道的多种检测方法中,液相色谱-串联质谱法(Liquid Chromatography-Tandem Mass Spectrometry,LC-MS/MS)在食品介质中多种AGs的同时测定中发挥重要作用。综述了LC-MS/MS用于检测食品中氨基糖苷类抗生素残留的前处理方法和仪器条件,以及AGs在食物中的污染现状,以期为食品中氨基糖苷类抗生素的残留分析提供理论参考。
