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Evaluation of Radon Concentration and the Health Risk in the Offices of the Institute of Science and Technology of the “École Normale Supérieure”, Burkina Faso
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作者 Rouamba M. M. Jonathan Bambara Telado Luc +3 位作者 Doumounia Ali Kohio Nièssan Ouédraogo Soumaila François Zougmore 《World Journal of Nuclear Science and Technology》 2023年第3期41-54,共14页
The second most important cause of lung cancer after smoking is radon gas. Thus, the determination of indoor radon concentrations in residential buildings and workplaces is an important public health concern. The purp... The second most important cause of lung cancer after smoking is radon gas. Thus, the determination of indoor radon concentrations in residential buildings and workplaces is an important public health concern. The purpose of this research was to measure the concentration of radon gas in the offices of the Institute of Science and Technology and to evaluate the effective dose in the lungs and the risk of cancer. This study used Corentium’s AIR THINGS digital radon detector to determine the radon concentration in sixteen (16) offices. The digital radon detector air Things of Corentium was placed in each office for a minimum period of one week and the concentration values were recorded every 24 hours. The values recorded in each office were the short-term average and the long-term average during seven days of measurement. The short-term radon concentrations vary between 5.286 Bq/m<sup>3</sup> and 192.714 Bq/m3</sup> with an average of 48.01 Bq/m3</sup> and those in the long-term were between 6.143 Bq/m3</sup> and 172.571 Bq/m3</sup> with an average of 52.46 Bq/m3</sup>. The measurements in office N°6 and 13 were above the lower limit of 100 Bq/m3</sup> proposed by the WHO. The short-term and long-term effective doses in the lungs for offices N°6 and 13 were above the “normal” background level of 1.1 mSv/year proposed by UNSCEAR-2000. The short-term effective dose in the lungs for office N°6 was above the lower limit of 3 mSv per the ICRP-23 recommendation. The average number of lung cancer cases per year per million people was 15. 展开更多
关键词 RADON CONCENTRATION Absorbed Dose Effective Dose
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Research on flexible display at Ulsan National Institute of Science and Technology 被引量:5
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作者 Jihun Park Sanghyun Heo +6 位作者 Kibog Park Myoung Hoon Song Ju-Young Kim Gyouhyung Kyung Rodney Scott Ruoff Jang-Ung Park Franklin Bien 《npj Flexible Electronics》 SCIE 2017年第1期47-59,共13页
Displays represent information visually,so they have become the fundamental building block to visualize the data of current electronics including smartphones.Recently,electronics have been advanced toward flexible and... Displays represent information visually,so they have become the fundamental building block to visualize the data of current electronics including smartphones.Recently,electronics have been advanced toward flexible and wearable electronics that can be bent,folded,or stretched while maintaining their performance under various deformations.Here,recent advances in research to demonstrate flexible and wearable displays are reviewed.We introduce these results by dividing them into several categories according to the components of the display:active-matrix backplane,touch screen panel,light sources,integrated circuit for fingerprint touch screen panel,and characterization tests;and we also present mechanical tests in nano-meter scale and visual ergonomics research. 展开更多
关键词 dividing ELECTRONICS PANEL
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A review of electroslag remelting composite technologies
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作者 Yu Wang Yan-chun Lou +5 位作者 Fang Wang Heng Cao Yun-bao Gao Ling Zhao Zhi Han Meng Li 《China Foundry》 2026年第1期1-19,共19页
Electroslag remelting(ESR) is an important metallurgical process for producing high-purity materials with homogeneous compositions and sound microstructures,and its typical products are ingots or simple castings.The c... Electroslag remelting(ESR) is an important metallurgical process for producing high-purity materials with homogeneous compositions and sound microstructures,and its typical products are ingots or simple castings.The core principle involves the resistive melting of a consumable electrode within a slag pool,followed by the refining of molten metal droplets as they traverse the slag,and subsequent sequential solidification in a water-cooled mold.However,conventional ESR processes face limitations in producing large or complex-shaped components,enhancing production efficiency,achieving highly specialized microstructures,and meeting ultra-high purity demands for advanced applications.Advanced composite ESR technologies have been developed to overcome these limitations by innovatively modifying key process aspects.For instance,electrode systems are improved using vibration,rotation,or multiple electrodes.Enhanced mold design and solidification control are achieved through techniques including conductive molds,mold rotation,and ingot withdrawal.Precise control of the process is realized through the use of protective gas,vacuum,or elevated pressure,as well as the application of external fields such as magnetic fields or ultrasonic vibration.This review comprehensively summarizes these advanced techniques,examining their principles and characteristics,and discussing their specific advantages and challenges. 展开更多
关键词 electroslag remelting(ESR) composite electroslag technology near-net shape casting high purity materials process modification external field assisted casting
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Regulation of dendrite and axon growth and arborization by CD40L-reverse signaling:Interrelationships among JNK,PKC,and ERK1/2 signaling pathways
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作者 Paulina Carriba 《Neural Regeneration Research》 2026年第3期1116-1117,共2页
The nervous system function requires a precise but plastic neural architecture.The neuronal shape dictates how neurons interact with each other and with other cells,being the morphology of dendrites and axons the cent... The nervous system function requires a precise but plastic neural architecture.The neuronal shape dictates how neurons interact with each other and with other cells,being the morphology of dendrites and axons the central determinant of the functional properties of neurons and neural circuits.The topological and structural morphology of axons and dendrites defines and determines how synapses are conformed.The morphological diversity of axon and dendrite arborization governs the neuron’s inputs,synaptic integration,neuronal computation,signal transmission,and network circuitry,hence defining the particular connectivity and function of the different brain areas. 展开更多
关键词 CD L dendrite growth dendrite arborization nervous system neural architecturethe reverse signaling PKC JNK
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Emerging Role of 2D Materials in Photovoltaics:Efficiency Enhancement and Future Perspectives
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作者 Ghulam Dastgeer Muhammad Wajid Zulfiqar +7 位作者 Sobia Nisar Rimsha Zulfiqar Muhammad Imran Swagata Panchanan Subhajit Dutta Kamran Akbar Alberto Vomiero Zhiming Wang 《Nano-Micro Letters》 2026年第1期843-895,共53页
The growing global energy demand and worsening climate change highlight the urgent need for clean,efficient and sustainable energy solutions.Among emerging technologies,atomically thin two-dimensional(2D)materials off... The growing global energy demand and worsening climate change highlight the urgent need for clean,efficient and sustainable energy solutions.Among emerging technologies,atomically thin two-dimensional(2D)materials offer unique advantages in photovoltaics due to their tunable optoelectronic properties,high surface area and efficient charge transport capabilities.This review explores recent progress in photovoltaics incorporating 2D materials,focusing on their application as hole and electron transport layers to optimize bandgap alignment,enhance carrier mobility and improve chemical stability.A comprehensive analysis is presented on perovskite solar cells utilizing 2D materials,with a particular focus on strategies to enhance crystallization,passivate defects and improve overall cell efficiency.Additionally,the application of 2D materials in organic solar cells is examined,particularly for reducing recombination losses and enhancing charge extraction through work function modification.Their impact on dye-sensitized solar cells,including catalytic activity and counter electrode performance,is also explored.Finally,the review outlines key challenges,material limitations and performance metrics,offering insight into the future development of nextgeneration photovoltaic devices encouraged by 2D materials. 展开更多
关键词 2D materials Photovoltaics Interface engineering Work function tuning Energy harvesting
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Chirality-Induced Suppression of Singlet Oxygen in Lithium-Oxygen Batteries with Extended Cycle Life
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作者 Kyunghee Chae Youngbi Kim +11 位作者 Yookyeong Oh Hosik Hahn Jaehyun Son Youngsin Kim Hyuk‑Joon Kim Hyun Jeong Lee Dohyub Jang Jooho Moon Kisuk Kang Jeong Woo Han Filipe Marques Mota Dong Ha Kim 《Nano-Micro Letters》 2026年第2期124-137,共14页
Lithium-oxygen(Li-O2)batteries are perceived as a promising breakthrough in sustainable electrochemical energy storage,utilizing ambient air as an energy source,eliminating the need for costly cathode materials,and of... Lithium-oxygen(Li-O2)batteries are perceived as a promising breakthrough in sustainable electrochemical energy storage,utilizing ambient air as an energy source,eliminating the need for costly cathode materials,and offering the highest theoretical energy density(~3.5 k Wh kg^(-1))among discussed candidates.Contributing to the poor cycle life of currently reported Li-O_(2)cells is singlet oxygen(1O_(2))formation,inducing parasitic reactions,degrading key components,and severely deteriorating cell performance.Here,we harness the chirality-induced spin selectivity effect of chiral cobalt oxide nanosheets(Co_(3)O_(4)NSs)as cathode materials to suppress 1O_(2)in Li-O_(2)batteries for the first time.Operando photoluminescence spectroscopy reveals a 3.7-fold and 3.23-fold reduction in 1O_(2)during discharge and charge,respectively,compared to conventional carbon paperbased cells,consistent with differential electrochemical mass spectrometry results,which indicate a near-theoretical charge-to-O_(2)ratio(2.04 e-/O_(2)).Density functional theory calculations demonstrate that chirality induces a peak shift near the Fermi level,enhancing Co 3d-O 2p hybridization,stabilizing reaction intermediates,and lowering activation barriers for Li_(2)O_(2)formation and decomposition.These findings establish a new strategy for improving the stability and energy efficiency of sustainable Li-O_(2)batteries,abridging the current gap to commercialization. 展开更多
关键词 Singlet oxygen suppression Chirality-induced spin selectivity effect Lithium–oxygen batteries Oxygen evolution reaction Battery stability
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Expert recommendation system based on analyzing expertise and networks of human resources in National Science & Technology Information Service 被引量:2
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作者 YANG Myung-seok KANG Nam-kyu +3 位作者 KIM Yun-jeong KIM Jae-soo CHOI Kwang-nam KIM Young-kuk 《Journal of Central South University》 SCIE EI CAS 2013年第8期2212-2218,共7页
This work aims to implement expert and collaborative group recommendation services through an analysis of expertise and network relations NTIS. First of all, expertise database has been constructed by extracting keywo... This work aims to implement expert and collaborative group recommendation services through an analysis of expertise and network relations NTIS. First of all, expertise database has been constructed by extracting keywords after indexing national R&D information in Korea (human resources, project and outcome) and applying expertise calculation algorithm. In consideration of the characteristics of national R&D information, weight values have been selected. Then, expertise points were calculated by applying weighted values. In addition, joint research and collaborative relations were implemented in a knowledge map format through network analysis using national R&D information. 展开更多
关键词 human networks network analysis NTIS R&D information
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Dynamics and interactions of blog-based science communication:A case study of blogging activities in China related to 2011 Japanese seismic and nuclear power crisis 被引量:2
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作者 Yuxian LIU Li LIU +1 位作者 Ronald ROUSSEAU Yang YANG 《Chinese Journal of Library and Information Science》 2013年第1期33-51,共19页
Purpose: This paper tries to understand the dynamics of scientific communication systems during crises by investigating as a case study the blogging activities that took place during the period of the 2011 earthquake ... Purpose: This paper tries to understand the dynamics of scientific communication systems during crises by investigating as a case study the blogging activities that took place during the period of the 2011 earthquake and related events in Japan. Interactions between bloggers and registered users are studied quantitatively and qualitatively at Sciencenet.cn, an influential science-related blogosphere in China.Design/methodology/approach: The editors of Sciencenet.cn compiled a special issue of science blog articles under the title Analysis of the Japanese Earthquake. We developed a spider program and downloaded from this special issue the metadata about title, content,publishing time, total read count, reply count and recommendation count, and further collected information about bloggers and recommenders. We then sent a short message to the bloggers who wrote articles on these emergencies, asking for their educational and professional background.Findings: We found that knowledge reflected in the blog articles is strongly related to the educational and professional background of bloggers. Knowledge diffusion is facilitated by interactions, such as recommendations, comments and answers. Interactions via comments and recommendations are of an assortative nature: A blog article is more likelyto be commented on and recommended by those bloggers who write on the same or similar topics than by those writing on a different one. Registered users tend to give comments on articles dealing with the topic that they recommend, and vice versa.Interaction in the intersection of two or three topics is more intense than that within one topic. The impact of blog articles is also influenced by other factors, such as the reputation of the blogger and the type of information they contain.Implications and limitations: It is confirmed that studying blogs is a valid approach within informetric studies. Yet, we only studied one triple(earthquake, tsunami, nuclear disaster) event based on data originating from one Chinese blog website. More events should be studied.Originality/value: Informetric studies based on blogs are still relatively few. Using science blogs and combining comments on a triple event with the knowledge background of bloggers in China is even less common. As such this contribution enhances our knowledge on this new form of science communication activity. 展开更多
关键词 Chinese blogosphere INFORMETRICS Temporal characteristics Knowledge diffusion Assortativity
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Toward understanding the role of genomic repeat elements in neurodegenerative diseases 被引量:1
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作者 Zhengyu An Aidi Jiang Jingqi Chen 《Neural Regeneration Research》 SCIE CAS 2025年第3期646-659,共14页
Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage se... Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements. 展开更多
关键词 Alzheimer's disease ATAXIA deep learning long-read sequencing NEURODEGENERATION neurodegenerative diseases Parkinson's disease repeat element structural variant
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An explorative study on document type assignment of review articles in Web of Science,Scopus and journals’websites
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作者 Manman Zhu Xinyue Lu +2 位作者 Fuyou Chen Liying Yang Zhesi Shen 《Journal of Data and Information Science》 CSCD 2024年第1期11-36,共26页
Purpose:Accurately assigning the document type of review articles in citation index databases like Web of Science(WoS)and Scopus is important.This study aims to investigate the document type assignation of review arti... Purpose:Accurately assigning the document type of review articles in citation index databases like Web of Science(WoS)and Scopus is important.This study aims to investigate the document type assignation of review articles in Web of Science,Scopus and Publisher’s websites on a large scale.Design/methodology/approach:27,616 papers from 160 journals from 10 review journal series indexed in SCI are analyzed.The document types of these papers labeled on journals’websites,and assigned by WoS and Scopus are retrieved and compared to determine the assigning accuracy and identify the possible reasons for wrongly assigning.For the document type labeled on the website,we further differentiate them into explicit review and implicit review based on whether the website directly indicates it is a review or not.Findings:Overall,WoS and Scopus performed similarly,with an average precision of about 99% and recall of about 80%.However,there were some differences between WoS and Scopus across different journal series and within the same journal series.The assigning accuracy of WoS and Scopus for implicit reviews dropped significantly,especially for Scopus.Research limitations:The document types we used as the gold standard were based on the journal websites’labeling which were not manually validated one by one.We only studied the labeling performance for review articles published during 2017-2018 in review journals.Whether this conclusion can be extended to review articles published in non-review journals and most current situation is not very clear.Practical implications:This study provides a reference for the accuracy of document type assigning of review articles in WoS and Scopus,and the identified pattern for assigning implicit reviews may be helpful to better labeling on websites,WoS and Scopus.Originality/value:This study investigated the assigning accuracy of document type of reviews and identified the some patterns of wrong assignments. 展开更多
关键词 Document type Web of Science SCOPUS Review article
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Data-Driven Healthcare:The Role of Computational Methods in Medical Innovation 被引量:1
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作者 Hariharasakthisudhan Ponnarengan Sivakumar Rajendran +2 位作者 Vikas Khalkar Gunapriya Devarajan Logesh Kamaraj 《Computer Modeling in Engineering & Sciences》 SCIE EI 2025年第1期1-48,共48页
The purpose of this review is to explore the intersection of computational engineering and biomedical science,highlighting the transformative potential this convergence holds for innovation in healthcare and medical r... The purpose of this review is to explore the intersection of computational engineering and biomedical science,highlighting the transformative potential this convergence holds for innovation in healthcare and medical research.The review covers key topics such as computational modelling,bioinformatics,machine learning in medical diagnostics,and the integration of wearable technology for real-time health monitoring.Major findings indicate that computational models have significantly enhanced the understanding of complex biological systems,while machine learning algorithms have improved the accuracy of disease prediction and diagnosis.The synergy between bioinformatics and computational techniques has led to breakthroughs in personalized medicine,enabling more precise treatment strategies.Additionally,the integration of wearable devices with advanced computational methods has opened new avenues for continuous health monitoring and early disease detection.The review emphasizes the need for interdisciplinary collaboration to further advance this field.Future research should focus on developing more robust and scalable computational models,enhancing data integration techniques,and addressing ethical considerations related to data privacy and security.By fostering innovation at the intersection of these disciplines,the potential to revolutionize healthcare delivery and outcomes becomes increasingly attainable. 展开更多
关键词 Computational models biomedical engineering BIOINFORMATICS machine learning wearable technology
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The Application of Quantitative Methods to the Landscape Architecture Science of China
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作者 QIAO Lifang CAO Wei ZHANG Shaowei 《Journal of Northeast Agricultural University(English Edition)》 CAS 2008年第4期70-75,共6页
Influenced by traditional methods in the landscape architecture,the studies in landscape architecture science of China are fundamentally subjective and qualitative,and aim at aesthetic elements.The quantitative method... Influenced by traditional methods in the landscape architecture,the studies in landscape architecture science of China are fundamentally subjective and qualitative,and aim at aesthetic elements.The quantitative methods are commonly used in the physicism domain,and there is a great potential for the application of quantitative methods to landscape architecture science.The paper summarized the progress in the application of quantitative methods to landscape architecture science in China,in which the evaluation of eco-effect,sightseeing effect,result of disposing,economic benefit,engineering quality,greenbelts landscape,landscape patterns and usage of greenbelts,etc.were involved.It proves that quantitative methods have aroused general concern and have been well applied in certain fields and there are still some shortcomings in the researches to be improved.Finally,the important directions of Chinese landscape architecture science are proposed. 展开更多
关键词 quantitative methods landscape architecture APPLICATION
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Data driven prediction of fragment velocity distribution under explosive loading conditions 被引量:4
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作者 Donghwan Noh Piemaan Fazily +4 位作者 Songwon Seo Jaekun Lee Seungjae Seo Hoon Huh Jeong Whan Yoon 《Defence Technology(防务技术)》 2025年第1期109-119,共11页
This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key de... This study presents a machine learning-based method for predicting fragment velocity distribution in warhead fragmentation under explosive loading condition.The fragment resultant velocities are correlated with key design parameters including casing dimensions and detonation positions.The paper details the finite element analysis for fragmentation,the characterizations of the dynamic hardening and fracture models,the generation of comprehensive datasets,and the training of the ANN model.The results show the influence of casing dimensions on fragment velocity distributions,with the tendencies indicating increased resultant velocity with reduced thickness,increased length and diameter.The model's predictive capability is demonstrated through the accurate predictions for both training and testing datasets,showing its potential for the real-time prediction of fragmentation performance. 展开更多
关键词 Data driven prediction Dynamic fracture model Dynamic hardening model FRAGMENTATION Fragment velocity distribution High strain rate Machine learning
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Impact of Letian Pottery Workshop for the Students of Fine Arts Department of Jingdezhen Ceramic Institute
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作者 Chunlei Zhao Hongbo Zhang 《International English Education Research》 2015年第2期23-25,共3页
"Jingdezhen is a very spiritual place, and a lot of people want to engage in pottery complacent here". It is no exaggeration to say that Pottery Workshop chooses Jingdezhen, which has long history of ceramics and pr... "Jingdezhen is a very spiritual place, and a lot of people want to engage in pottery complacent here". It is no exaggeration to say that Pottery Workshop chooses Jingdezhen, which has long history of ceramics and profound culture, and the local development is promising. It is not only young artists and students to communicate with the creation of the stage, like a pottery family. Someone said that it was the "798" of Jingdezhen, not only because it is a gathering place for foreign potters, the bigger reason is that it is becoming a ceramic culture and a model of the market economy model. Here not only can give you a display space, more importantly, you can gain practical experience and recognition for their work. 展开更多
关键词 Pottery Workshop Affect STUDENTS
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Panel Discussion on“Development Trends of Computer Science in the New Era”
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作者 Andrew Yao Nancy M.Amato +3 位作者 Ann Copestake Sukyoung Ryu Yike Guo Yaqin Zhang 《计算机教育》 2024年第3期26-29,共4页
At the panel session of the 3rd Global Forum on the Development of Computer Science,attendees had an opportunity to deliberate recent issues affecting computer science departments as a result of the recent growth in t... At the panel session of the 3rd Global Forum on the Development of Computer Science,attendees had an opportunity to deliberate recent issues affecting computer science departments as a result of the recent growth in the field.6 heads of university computer science departments participated in the discussions,including the moderator,Professor Andrew Yao.The first issue was how universities are managing the growing number of applicants in addition to swelling class sizes.Several approaches were suggested,including increasing faculty hiring,implementing scalable teaching tools,and working closer with other departments through degree programs that integrate computer science with other fields.The second issue was about the position and role of computer science within broader science.Participants generally agreed that all fields are increasingly relying on computer science techniques,and that effectively disseminating these techniques to others is a key to unlocking broader scientific progress. 展开更多
关键词 Development trends Computer science
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Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives 被引量:2
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作者 Chuanping Lin Jun Xu +4 位作者 Delong Jiang Jiayang Hou Ying Liang Zhongyue Zou Xuesong Mei 《Journal of Energy Chemistry》 2025年第1期739-759,共21页
The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational per... The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ensemble methods for battery SOH estimation. The convergence of advanced machine learning with ensemble learning is anticipated to yield valuable avenues for research. Accelerated research in ensemble learning holds promising prospects for achieving more accurate and reliable battery SOH estimation under real-world conditions. 展开更多
关键词 Lithium-ion battery State-of-health estimation DATA-DRIVEN Machine learning Ensemble learning Ensemble diversity
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Novel mouse model of Alzheimer's disease exhibits pathology through synergistic interactions among amyloid-β,tau,and reactive astrogliosis 被引量:1
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作者 Young-Eun Han Sunhwa Lim +2 位作者 Seung Eun Lee Min-Ho Nam Soo-Jin Oh 《Zoological Research》 2025年第1期41-53,共13页
Alzheimer'sdisease(AD)isaprogressive neurodegenerative disorder characterized by cognitive impairment and distinct neuropathological features,including amyloid-βplaques,neurofibrillary tangles,and reactive astrog... Alzheimer'sdisease(AD)isaprogressive neurodegenerative disorder characterized by cognitive impairment and distinct neuropathological features,including amyloid-βplaques,neurofibrillary tangles,and reactive astrogliosis.Developing effective diagnostic,preventative,and therapeutic strategies for AD necessitates the establishment of animal models that accurately recapitulate the pathophysiological processes of the disease.Existing transgenic mouse models have significantly contributed to understanding AD pathology but often fail to replicate the complexity of human AD.Additionally,these models are limited in their ability to elucidate the interplay among amyloid-βplaques,neurofibrillary tangles,and reactive astrogliosis due to the absence of spatially and temporally specific genetic manipulation.In this study,we introduce a novel AD mouse model(APP/PS1-TauP301L-Adeno mice)designed to rapidly induce pathological symptoms and enhance understanding of AD mechanisms.Neurofibrillary tangles and severe reactive astrogliosis were induced by injecting AAVDJ-EF1a-hTauP301L-EGFP and Adeno-GFAP-GFP viruses into the hippocampi of 5-month-old APP/PS1 mice.Three months post-injection,these mice exhibited pronounced astrogliosis,substantial amyloid-βplaque accumulation,extensiveneurofibrillarytangles,accelerated neuronal loss,elevated astrocytic GABA levels,and significant spatial memory deficits.Notably,these pathological features were less severe in AAVTauP301L-expressing APP/PS1 mice without augmented reactive astrogliosis.These findings indicate an exacerbating role of severe reactive astrogliosis in amyloid-βplaque and neurofibrillary tangle-associated pathology.The APP/PS1-TauP301L-Adeno mouse model provides a valuable tool for advancing therapeutic research aimed at mitigating the progression of AD. 展开更多
关键词 Alzheimer's disease mouse model Neurofibrillary tangles Amyloid-βplaques Reactive astrogliosis Alzheimer’s disease pathology
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D-A-D-A-D conjugated pyrenoviologens for electrochromism,electrofluorochromism,and detection of picric acid 被引量:1
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作者 Tianle Cao Ni Yan +5 位作者 Yawen Li Xinyi Zhang Yue Zhu Naiyao Li Zengrong Wang Gang He 《Chinese Chemical Letters》 2025年第10期298-305,共8页
π-Conjugated donor-acceptor-donor-acceptor-donor(D-A-D-A-D)type pyrenoviologens(PyV^(2+)),with the 2,7 positions of pyrene serving as connection bridges,were synthesized through SN2 reactions.Specifically,pyrenoviolo... π-Conjugated donor-acceptor-donor-acceptor-donor(D-A-D-A-D)type pyrenoviologens(PyV^(2+)),with the 2,7 positions of pyrene serving as connection bridges,were synthesized through SN2 reactions.Specifically,pyrenoviologen 3c was modified with a methylnaphthalene group,while 3a and 3b were modified with methyl and benzyl groups,respectively,for comparison.These pyrenoviologens exhibit reversible redox properties and strong fluorescence emission.Electrochromic devices(ECDs)were prepared using pyrenoviologens as the active materials.Notably,naphthalene-containing pyrenoviologen 3c,with its DA-D-A-D conjugated structure,possesses more stable free radicals,enabling it to maintain the radical color for a longer duration after power loss.A series of color-changing devices were successfully assembled.Due to the strong fluorescence of pyrenoviologens and the unique electron transfer effect between them and picric acid(PA),a sensor film with good selectivity and high sensitivity for PA in aqueous solution was prepared using pyrenoviologens as the fluorescent probe.Specifically,3c exhibited the highest sensitivity to PA due to its lowest energy gap.The introduction of the D-A-D-A-D structure is a strategic approach to enhancing photoelectric performance and broadening the application of viologens. 展开更多
关键词 VIOLOGEN D-A-D-A-D conjugation Electrofluorochromism Flexible ECDs Sensor
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Electromagnetic wave absorption and corrosion resistance performance of carbon nanoclusters/Ce-Mn codoped barium ferrite composite materials 被引量:2
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作者 Bo Li Lin Ma +7 位作者 Sinan Li Jiewu Cui Xiaohui Liang Wei Sun Pengjie Zhang Nan Huang Song Ma Zhidong Zhang 《International Journal of Minerals,Metallurgy and Materials》 2025年第3期699-709,共11页
To realize the application of electromagnetic wave absorption(EWA)devices in humid marine environments,bifunctional EWA materials with better EWA capacities and anticorrosion properties have great exploration signific... To realize the application of electromagnetic wave absorption(EWA)devices in humid marine environments,bifunctional EWA materials with better EWA capacities and anticorrosion properties have great exploration significance and systematic research re-quirements.By utilizing the low-cost and excellent magnetic and stable chemical characteristics of barium ferrite(BaFe_(12)O_(19))and using the high dielectric loss and excellent chemical inertia of nanocarbon clusters,a new type of nanocomposites with carbon nanoclusters en-capsulating BaFe_(12)O_(19)was designed and synthesized by combining an impregnation method and a high-temperature calcination strategy.Furthermore,Ce-Mn ions were introduced into the BaFe_(12)O_(19)lattice to improve the dielectric and magnetic properties of BaFe_(12)O_(19)cores significantly,and the energy band structure of the doped lattice and the orders of Ce replacing Fe sites were calculated.Benefiting from Ce-Mn ion doping and carbon nanocluster encapsulation,the composite material exhibited excellent dual functionality of corrosion resist-ance and EWA.When BaCe_(0.2)Mn_(0.3)Fe_(11.5)O_(19)-C(BCM-C)was calcined at 600°C,the minimum reflection loss of-20.1 dB was achieved at 14.43 GHz.The Ku band’s effective absorption bandwidth of 4.25 GHz was achieved at an absorber thickness of only 1.3 mm.The BCM-C/polydimethylsiloxane coating had excellent corrosion resistance in the simulated marine environment(3.5wt%NaCl solution).The|Z|0.01Hz value of BCM-C remained at 106Ω·cm^(2)after 12 soaking days.The successful preparation of the BaFe_(12)O_(19)composite en-capsulated with carbon nanoclusters provides new insights into the preparation of multifunctional absorbent materials and the fabrication of absorbent devices applied in humid marine environments in the future. 展开更多
关键词 electromagnetic wave absorption ANTICORROSION barium ferrite cerium and manganese doping carbon nanoclusters
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Lewis and Brønsted acid synergistic catalysis in zeolite for boosting hydrogen storage performance of LiBH_(4) 被引量:1
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作者 Guo-Quan Na Wen-Gang Cui +8 位作者 Hang-Yan Shi Zheng-Long Li Fan Gao Xing-Qiang Wang Ke Wang Yong Gao Ya-Xiong Yang Zi-Chao Shen Hong-Ge Pan 《Rare Metals》 2025年第4期2379-2392,共14页
High-capacity LiBH_(4)is a promising solid hydrogen storage material.However,the large electron cloud density between the B-H bonds in LiBH_(4)induces high dehydrogenation temperatures and sluggish dehydrogenation kin... High-capacity LiBH_(4)is a promising solid hydrogen storage material.However,the large electron cloud density between the B-H bonds in LiBH_(4)induces high dehydrogenation temperatures and sluggish dehydrogenation kinetics.To solve the above problems,it is proposed to enhance the hydrogen storage properties of LiBH_(4)through the synergistic effect of Brønsted and Lewis acid in Hβzeolite.Composite hydrogen storage systems with different mass ratios were prepared by simple ball-milling.At a LiBH_(4)-to-Hβmass ratio of 6:4,the 6LiBH_(4)-4Hβsystem released hydrogen at 190℃and achieved a hydrogen release capacity of 7.0 wt%H_(2)upon heating to 400℃.More importantly,the hydrogen release capacity of the system reached 6.02 wt%at 350℃under isothermal conditions after 100 min and 7.2 wt%at 400℃under isothermal conditions after 80 min,whereas the pristine LiBH_(4)only achieved 2.2 wt%.The improvement in hydrogen storage performance of the system was mainly attributed to two factors:(i)Lewis acid sites with acceptable electrons in the Hβweaken the electron density of B-H bonds in LiBH_(4),and(ii)the H+proton from the Brønsted acid sites and H−of LiBH_(4)undergo a H^(+)+H^(−)=H_(2)reaction.Theoretical calculations revealed that the Lewis and Brønsted acid sites in the Hβzeolite are conducive to the weakening of B-H bonds and that storage charge transfer occurs near the Lewis acid sites.The present work provides new insights into improving the hydrogen storage performance of LiBH_(4)by weakening the B-H bonds in the LiBH_(4). 展开更多
关键词 Hydrogen storage LiBH_(4) Lewis acid Bronsted acid ZEOLITE
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