Background : Information obtained from arterial pulse waveforms (APW) can be usefulfor characterizing the cardiovascular system. To achieve this, it is necessary to know thedetailed characteristics of APWs in differen...Background : Information obtained from arterial pulse waveforms (APW) can be usefulfor characterizing the cardiovascular system. To achieve this, it is necessary to know thedetailed characteristics of APWs in different states of an organism, which would allowAPW parameters (APW- Ps) to be assigned to particular (patho)physiological conditions.Therefore, our work aimed to characterize 35 APW- Ps in rats under the influence ofisoflurane (ISO) and Zoletil/xylazine (ZO/XY) anesthesia and to study the effect of rootextract from Acanthopanax senticosus (ASRE) in these anesthetic conditions.Methods : The right jugular vein of anesthetized rats was cannulated for the administrationof ASRE and the left carotid artery for the detection of APWs from which 35APW- Ps were evaluated.Results : We obtained data on 35 APW- Ps, which significantly depended on the anesthesia,and thus, they characterized the cardiovascular system under these two conditions.ASRE transiently modulated all 35 APW- Ps, including a transient decrease insystolic and diastolic blood pressure (BP) and heart rate or increases in pulse BP, d P /d t max , and systolic and diastolic areas. Whereas the transient effects of ASRE weresimilar, the extract had prolonged disturbing effects on the cardiovascular system inrats under ZO/XY but not under ISO anesthesia. This negative effect can result fromthe disturbance caused by ZO/XY anesthesia on the cardiovascular system.Conclusions : We characterized 35 APW- Ps of rats under ISO and ZO/XY anesthesiaand found that ASRE contains compounds that can modulate the properties of thecardiovascular system, which significantly depended on the status of the cardiovascularsystem. This should be considered when using ASRE as a nutritional supplementby individuals with cardiovascular problems.展开更多
Purpose： To evaluate a me-vTE-SPGR （multi echo variable TE Spoiled Gradient Echo Sequence） approach for quantitative T2＊ mapping of the ME （menisci）, the PT （patellar tendon）, the ACL （anterior cruciate ligam...Purpose： To evaluate a me-vTE-SPGR （multi echo variable TE Spoiled Gradient Echo Sequence） approach for quantitative T2＊ mapping of the ME （menisci）, the PT （patellar tendon）, the ACL （anterior cruciate ligament）, the PCL （posterior cruciate ligament） and to compare the results between normal and pathological tissue of the ME in the knee joint at 3T （3 Tesla）. Methods： Eighteen consecutive knee patients （35.7± 11.6 years） were examined on 3T. In addition to standard morphological MRI, T2＊-maps were derived from a 0.7 mm isotropic me-vTE-SPGR scan. T2＊-values were assessed by two independent observers using an ROI analysis for the ME （4 different regions： posterior and anterior horn of the medial and lateral meniscus）, PT, ACL and PCL. Intra-class correlation between readers was calculated. Results： On morphological MRI, the PT, ACL and PCL were diagnosed as normal in all cases. Degenerative meniscus and meniscal tears were diagnosed in 13 cases and 9 cases, respectively. T2＊-values of the menisci on me-vTE-SPGR scans, in relation to morphological imaging, were normal （N = 50; 6.0 ±0.9 ms）; degenerative meniscus （N = 13; 8.0± 1.6 ms）; meniscal tears （N = 9; 12.9 ±3.9 ms）, with significant differences between all groups （P 〈 0.05）/ significantly higher T2＊-values in degenerative meniscus and meniscal tears. Mean T2＊ relaxation times for the PT, ACL and PCL were 2.9± 0.8 ms, 8.4 ± 1.6 ms and 8.9 ＋ 1.3 ms respectively. Intra-class correlation values between readers for the ME, PT, ACL and PCL were R2 = 0.962, R2 = 0.927, R2 = 0.594 and R2= 0.648, respectively. Conclusion： Isotropic 3D （three-dimensional） me vTE-SPGR imaging is able to quantify T2＊ values of multiple tissues in the knee joint with short T2 relaxation times.展开更多
We demonstrate an experimental setup for the production of a beam source of cold 87Rb atoms. The atoms are extracted from a trapped cold atomic cloud in an unbalanced three-dimensional magneto-optical trap. Via a radi...We demonstrate an experimental setup for the production of a beam source of cold 87Rb atoms. The atoms are extracted from a trapped cold atomic cloud in an unbalanced three-dimensional magneto-optical trap. Via a radiation pressure difference generated by a specially designed leak tunnel along one trapping laser beam, the atoms are pushed out continuously with low velocities and a high flux. The most-probable velocity in the beam is varied from 9 m/s to 19 m/s by varying the detuning of the trapping laser beams in the magneto-optical trap and the flux can be tuned up to 4× 10^9 s-1 by increasing the intensity of the trapping beams. We also present a simple model for describing the dependence of the beam performance on the magneto optical trap trapping laser intensity and the detuning.展开更多
基金Agency of the Slovak Republic,Grant/Award Number:2/0023/22,2/0066/23 and 2/0091/21Slovak Research&Development Agency,Grant/Award Number:APVV-19-0154 and APVV-22-0154。
文摘Background : Information obtained from arterial pulse waveforms (APW) can be usefulfor characterizing the cardiovascular system. To achieve this, it is necessary to know thedetailed characteristics of APWs in different states of an organism, which would allowAPW parameters (APW- Ps) to be assigned to particular (patho)physiological conditions.Therefore, our work aimed to characterize 35 APW- Ps in rats under the influence ofisoflurane (ISO) and Zoletil/xylazine (ZO/XY) anesthesia and to study the effect of rootextract from Acanthopanax senticosus (ASRE) in these anesthetic conditions.Methods : The right jugular vein of anesthetized rats was cannulated for the administrationof ASRE and the left carotid artery for the detection of APWs from which 35APW- Ps were evaluated.Results : We obtained data on 35 APW- Ps, which significantly depended on the anesthesia,and thus, they characterized the cardiovascular system under these two conditions.ASRE transiently modulated all 35 APW- Ps, including a transient decrease insystolic and diastolic blood pressure (BP) and heart rate or increases in pulse BP, d P /d t max , and systolic and diastolic areas. Whereas the transient effects of ASRE weresimilar, the extract had prolonged disturbing effects on the cardiovascular system inrats under ZO/XY but not under ISO anesthesia. This negative effect can result fromthe disturbance caused by ZO/XY anesthesia on the cardiovascular system.Conclusions : We characterized 35 APW- Ps of rats under ISO and ZO/XY anesthesiaand found that ASRE contains compounds that can modulate the properties of thecardiovascular system, which significantly depended on the status of the cardiovascularsystem. This should be considered when using ASRE as a nutritional supplementby individuals with cardiovascular problems.
文摘Purpose： To evaluate a me-vTE-SPGR （multi echo variable TE Spoiled Gradient Echo Sequence） approach for quantitative T2＊ mapping of the ME （menisci）, the PT （patellar tendon）, the ACL （anterior cruciate ligament）, the PCL （posterior cruciate ligament） and to compare the results between normal and pathological tissue of the ME in the knee joint at 3T （3 Tesla）. Methods： Eighteen consecutive knee patients （35.7± 11.6 years） were examined on 3T. In addition to standard morphological MRI, T2＊-maps were derived from a 0.7 mm isotropic me-vTE-SPGR scan. T2＊-values were assessed by two independent observers using an ROI analysis for the ME （4 different regions： posterior and anterior horn of the medial and lateral meniscus）, PT, ACL and PCL. Intra-class correlation between readers was calculated. Results： On morphological MRI, the PT, ACL and PCL were diagnosed as normal in all cases. Degenerative meniscus and meniscal tears were diagnosed in 13 cases and 9 cases, respectively. T2＊-values of the menisci on me-vTE-SPGR scans, in relation to morphological imaging, were normal （N = 50; 6.0 ±0.9 ms）; degenerative meniscus （N = 13; 8.0± 1.6 ms）; meniscal tears （N = 9; 12.9 ±3.9 ms）, with significant differences between all groups （P 〈 0.05）/ significantly higher T2＊-values in degenerative meniscus and meniscal tears. Mean T2＊ relaxation times for the PT, ACL and PCL were 2.9± 0.8 ms, 8.4 ± 1.6 ms and 8.9 ＋ 1.3 ms respectively. Intra-class correlation values between readers for the ME, PT, ACL and PCL were R2 = 0.962, R2 = 0.927, R2 = 0.594 and R2= 0.648, respectively. Conclusion： Isotropic 3D （three-dimensional） me vTE-SPGR imaging is able to quantify T2＊ values of multiple tissues in the knee joint with short T2 relaxation times.
基金supported by the National Natural Science Foundation of China (Grant No. 50775127)the Major State Basic Research Development Program of China (Grant No. 2010CB922901)the Independent Research Projects of Tsinghua University,China (Grant No. 2009THZ06)
文摘We demonstrate an experimental setup for the production of a beam source of cold 87Rb atoms. The atoms are extracted from a trapped cold atomic cloud in an unbalanced three-dimensional magneto-optical trap. Via a radiation pressure difference generated by a specially designed leak tunnel along one trapping laser beam, the atoms are pushed out continuously with low velocities and a high flux. The most-probable velocity in the beam is varied from 9 m/s to 19 m/s by varying the detuning of the trapping laser beams in the magneto-optical trap and the flux can be tuned up to 4× 10^9 s-1 by increasing the intensity of the trapping beams. We also present a simple model for describing the dependence of the beam performance on the magneto optical trap trapping laser intensity and the detuning.
