BACKGROUND Little is known about disparities in diagnosis and treatment among colorectal cancer(CRC)patients with and without disabilities.AIM To investigate the patterns of diagnosis,treatment,and survival for people...BACKGROUND Little is known about disparities in diagnosis and treatment among colorectal cancer(CRC)patients with and without disabilities.AIM To investigate the patterns of diagnosis,treatment,and survival for people with and without disabilities who had CRC.METHODS We performed a retrospective analysis using the Korean National Health Insurance Service database,disability registration data,and Korean Central Cancer Registry data.The analysis included 21449 patients with disabilities who were diagnosed with CRC and 86492 control patients diagnosed with CRC.RESULTS The overall distribution of CRC stage was not affected by disability status.Subjects with disabilities were less likely than those without disabilities to undergo surgery[adjusted odds ratio(aOR):0.85;95%confidence interval(95%CI):0.82-0.88],chemotherapy(aOR:0.84;95%CI:0.81-0.87),or radiotherapy(aOR:0.90;95%CI:0.84-0.95).The rate of no treatment was higher in patients with disabilities than in those without disabilities(aOR:1.48;95%CI:1.41-1.55).The overall mortality rate was higher in patients with disabilities[adjusted hazard ratio(aHR):1.24;95%CI:1.22-1.28],particularly severe disabilities(aHR:1.57;95%CI:1.51-1.63),than in those without disabilities.CONCLUSION Patients with severe disabilities tended to have a late or unknown diagnosis.Patients with CRC and disabilities had lower rates of treatment with almost all modalities compared with those without disabilities.During the follow-up period,the mortality rate was higher in patients with disabilities than in those without disabilities.The diagnosis and treatment of CRC need improvement in patients with disabilities.展开更多
Objective:To explore the possible neuroprotective activities of Humulus japonicus extract against Parkinson's disease(PD)in a cellular model.Methods:PD was modeled in PC12 cells using 6-hydroxydopamine(6-OHDA).The...Objective:To explore the possible neuroprotective activities of Humulus japonicus extract against Parkinson's disease(PD)in a cellular model.Methods:PD was modeled in PC12 cells using 6-hydroxydopamine(6-OHDA).The cell activity,intracellular levels of reactive oxygen species(ROS),anti-oxidative and anti-apoptotic effects,and other related indicators and related signaling pathways were evaluated to elucidate the neuroprotective effects of Humulus japonicus extract.Results:Humulus japonicus extract exhibited anti-oxidative and anti-apoptotic effects in 6-OHDA-stimulated PC12 cells.It also reduced oxidative stress-induced ROS accumulation;upregulated antioxidant enzymes,such as glutathione,catalase,heme oxidase-1,and 8-oxguanine glycosylase 1;promoted cell survival by decreasing BAX and increasing Bcl-2 and sirtuin 1 expression via the MAPK and/or Nrf2 signaling pathways.Conclusions:Humulus japonicus extract has antioxidative and anti-apoptotic effects and could be developed as a promising candidate for preventing and treating oxidative stress-related neurodegenerative diseases.展开更多
基金Supported by the R&D grant from the Korea National Rehabilitation Center Research Institute,Ministry of Health&Welfare,No.2016007Grants from the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.2022R1I1A1A01068449 and No.2022R1I1A3070074.
文摘BACKGROUND Little is known about disparities in diagnosis and treatment among colorectal cancer(CRC)patients with and without disabilities.AIM To investigate the patterns of diagnosis,treatment,and survival for people with and without disabilities who had CRC.METHODS We performed a retrospective analysis using the Korean National Health Insurance Service database,disability registration data,and Korean Central Cancer Registry data.The analysis included 21449 patients with disabilities who were diagnosed with CRC and 86492 control patients diagnosed with CRC.RESULTS The overall distribution of CRC stage was not affected by disability status.Subjects with disabilities were less likely than those without disabilities to undergo surgery[adjusted odds ratio(aOR):0.85;95%confidence interval(95%CI):0.82-0.88],chemotherapy(aOR:0.84;95%CI:0.81-0.87),or radiotherapy(aOR:0.90;95%CI:0.84-0.95).The rate of no treatment was higher in patients with disabilities than in those without disabilities(aOR:1.48;95%CI:1.41-1.55).The overall mortality rate was higher in patients with disabilities[adjusted hazard ratio(aHR):1.24;95%CI:1.22-1.28],particularly severe disabilities(aHR:1.57;95%CI:1.51-1.63),than in those without disabilities.CONCLUSION Patients with severe disabilities tended to have a late or unknown diagnosis.Patients with CRC and disabilities had lower rates of treatment with almost all modalities compared with those without disabilities.During the follow-up period,the mortality rate was higher in patients with disabilities than in those without disabilities.The diagnosis and treatment of CRC need improvement in patients with disabilities.
基金financially supported by the Ministry of Small and Medium Enterprise and Startups (MSS),Korea,under the Social Economy Innovation Growth Project (R&D)(Project number P0013037)
文摘Objective:To explore the possible neuroprotective activities of Humulus japonicus extract against Parkinson's disease(PD)in a cellular model.Methods:PD was modeled in PC12 cells using 6-hydroxydopamine(6-OHDA).The cell activity,intracellular levels of reactive oxygen species(ROS),anti-oxidative and anti-apoptotic effects,and other related indicators and related signaling pathways were evaluated to elucidate the neuroprotective effects of Humulus japonicus extract.Results:Humulus japonicus extract exhibited anti-oxidative and anti-apoptotic effects in 6-OHDA-stimulated PC12 cells.It also reduced oxidative stress-induced ROS accumulation;upregulated antioxidant enzymes,such as glutathione,catalase,heme oxidase-1,and 8-oxguanine glycosylase 1;promoted cell survival by decreasing BAX and increasing Bcl-2 and sirtuin 1 expression via the MAPK and/or Nrf2 signaling pathways.Conclusions:Humulus japonicus extract has antioxidative and anti-apoptotic effects and could be developed as a promising candidate for preventing and treating oxidative stress-related neurodegenerative diseases.
