Projections for 20 years of economic growth and change in the structure of the Thai economy were made for 180 sectors using a computable general equilibrium(CGE) model to compare the following four scenarios:(1) stand...Projections for 20 years of economic growth and change in the structure of the Thai economy were made for 180 sectors using a computable general equilibrium(CGE) model to compare the following four scenarios:(1) standard growth with infinite supply of factors,(2) finite land supply,(3) fixed use of agricultural chemicals,and(4) combined finite land supply with fixed use of agricultural chemicals.The computable projections suggest that the economic cost of hypothetical environmental control in agriculture is small and further weakened by urbanization.The computed structural development points to efficiency improvements specific to sectors to return the economy to balanced growth.展开更多
The uneven distribution of medical resources has led to increasingly frequent patient mobility;however, the interaction between this phenomenon and the healthcare supply-demand relationship remains underexplored. The ...The uneven distribution of medical resources has led to increasingly frequent patient mobility;however, the interaction between this phenomenon and the healthcare supply-demand relationship remains underexplored. The present study constructed the 2023Cross-City Patient Mobility Network in China using one million patient mobility data records obtained from online healthcare platforms. We applied urban network analysis to uncover mobility patterns and used the coupling coordination degree model to assess healthcare supply-demand relationships before and after patient mobility. Explainable machine learning further revealed the impact of supply-demand coupling on patient mobility. The results indicated the following: Patient mobility followed administrative boundaries, although megacities serve areas beyond provincial borders;The scale of healthcare supply and demand displayed a multi-centric spatial pattern with a general decline from east to west, and these characteristics of demand distribution were further solidified by patient mobility;Cities with low supply-demand coupling and undersupply experienced patient outflows, while cities with high coupling and oversupply attracted them. In turn, patient mobility helped balance healthcare supply and demand, optimising the coupling relationship across cities. Thus, this research not only provides a methodological reference for understanding the interaction between patient mobility and healthcare systems but also offers empirical insights for public health policy.展开更多
Understanding the complex mechanisms underlying agricultural space urbanization is essential for sustainable land management.This study identified the spatiotemporal characteristics of the agricultural space urbanizat...Understanding the complex mechanisms underlying agricultural space urbanization is essential for sustainable land management.This study identified the spatiotemporal characteristics of the agricultural space urbanization from 2000 to 2020 in China’s Yangtze River Economic Belt(YREB)using a kilometer-grid-based approach.By employing the partial least squares structural equation modeling method,the intricate drivers of agricultural space urbanization were investigated.The results revealed that from 2000 to 2020,agricultural space urbanization in the YREB covered an area of 28,198 km^(2),accounting for 84.5%of the total increase in urban space.The partial least squares structural equation modeling analysis revealed regional variations in agricultural space urbanization dynamics.In the western YREB,where urbanization is in its initial stage,natural conditions play a weak and indirect role,whereas policy incentives and socioeconomic growth are equally significant in driving agricultural space urbanization.In the eastern YREB,where urbanization is more saturated,the agricultural space urbanization is less constrained by natural factors,showing a high synergy with socioeconomic development.Conversely,in the central Yangtze River Economic Belt,policy influences surpass socioeconomic factors,whereas unfavorable natural conditions and agricultural development act as key drivers of agricultural space urbanization.This study suggests that enhancing agricultural space urbanization quality requires strengthening region-specific policies,providing targeted support for remote areas,rebalancing policy orientation in rapidly urbanizing regions,and establishing a comprehensive evaluation system to ensure policy rationality.展开更多
Murine subarachnoid hemorrhage(SAH)induced using the filament perforation method is a useful in vivo experimental model to investigate the pathophysiological mechanisms in the brain underlying SAH.However,identifying ...Murine subarachnoid hemorrhage(SAH)induced using the filament perforation method is a useful in vivo experimental model to investigate the pathophysiological mechanisms in the brain underlying SAH.However,identifying mice with comorbid acute neurogenic pulmonary edema(NPE),a life-threatening systemic consequence often induced by SAH,in this model is difficult without histopathological investiga-tions.Herein,we present an imaging procedure involving dual-energy X-ray absorp-tiometry(DXA)to identify NPE in a murine model of SAH.We quantified the lung lean mass(LM)and compared the relationship between micro-computed tomography(CT)evidence of Hounsfield unit(HU)values and histopathological findings of PE.Of the 85 mice with successful induction of SAH by filament perforation,16(19%)had NPE,as verified by postmortem histology.The DXA-LM values correlate well with CT-HU levels(r=0.63,p<0.0001).Regarding the relationship between LM and HU in mice with post-SAH NPE,the LM was positively associated with HU values(r2=0.43;p=0.0056).A receiver operating characteristics curve of LM revealed a sensitivity of 87%and specificity of 57%for detecting PE,with a similar area under the curve as the HU(0.79±0.06 vs.0.84±0.07;p=0.21).These data suggest that confirming acute NPE using DXA-LM is a valuable method for selecting a clinically relevant murine NPE model that could be used in future experimental SAH studies.展开更多
Osyris lanceolata is heavily and illegally exploited in East Africa for its essential oils, yet little is known about its population status and ecological requirements. This study examined its population structure and...Osyris lanceolata is heavily and illegally exploited in East Africa for its essential oils, yet little is known about its population status and ecological requirements. This study examined its population structure and environmental factors influencing its distribution in the semi-arid Karamoja sub-region, Uganda. We surveyed 388 plots (5 m radius) at different altitudes, recording life stages, stem diameters, and regeneration patterns, and analyzed soil samples. Multivariate analyses, including Canonical Correspondence Analysis (CCA), Detrended Correspondence Analysis (DCA), Non-metric Multidimensional Scaling (NMDS), and Multiple Regression Modeling (MRM), identified key environmental factors affecting its distribution. Findings show that O. lanceolata populations in Moroto, Nakapiripirit, and Amudat districts are severely degraded due to overexploitation. The species is primarily regenerating through coppicing rather than seedlings, with an exploitation intensity of 56.6%. Population densities are low, distribution is irregular, and sustainable harvesting is not viable. Soil properties, particularly Ca2+, N, P, K+, Na+, and organic matter, significantly influence its abundance. Conservation efforts should focus on identifying suitable provenances for genetic preservation and plantation establishment. Areas with at least 9 trees per hectare in Moroto, Nakapiripirit, and Amudat could serve as potential sites for ex-situ plantations. Further research should explore how biotic interactions, genetic diversity, and morphology affect oil yield and quality to support restoration, breeding, and domestication initiatives.展开更多
The study measures productive efficiency of tomato growers in village Akbarpura of Disctrict Nowshera in Khyber Pakhtunkhwa （KPK） province of Northern Pakistan. The study uses household level data collected in summe...The study measures productive efficiency of tomato growers in village Akbarpura of Disctrict Nowshera in Khyber Pakhtunkhwa （KPK） province of Northern Pakistan. The study uses household level data collected in summer 2010 from sample farmers selected by multi-staged sampling. The study uses a theoretical framework to measure productive efficiency and estimates the Cobb-Douglas frontier production and cost models. The study found that technical efficiency indices varied significantly, with technical efficiency index averaging at 65%. The indices of allocative efficiency also varied widely, with an average of 56%. There was a wide gap between the highest and lowest economic efficiency indices, with a mean economic efficiency of 35%. The study concluded that farmer education, extension visits, age and access to credit contributed significantly and positively to productive efficiencies. A policy implication of this study is that there is enough potential for farmers to increase tomato production and net profits. The study recommends that the government should further invest in public education and strengthen extension services farmer education and because extension visits constituted important determinants of productive efficiencies.展开更多
While migration is widely recognized as a valid option for improving farmers’ income, the welfare effects of migration on left-behind family members are ambiguous. This study examines the impacts of migration on left...While migration is widely recognized as a valid option for improving farmers’ income, the welfare effects of migration on left-behind family members are ambiguous. This study examines the impacts of migration on left-behind family members’ food consumption and nutrient intake, particularly in remote rural areas in China. Based on household survey data collected from 611 smallholder rubber farmers in Xishuangbanna Dai Autonomous Prefecture of southwestern China, the empirical results suggest that the migration of family members contributes to improving household net income, whereas it negatively affects left-behind family members’ consumption of grain and pork. Migration also leads to a decrease in left-behind family members’ nutrient intake. Surprisingly, the economic returns of farmers’ migration not only do not foster the transformation of household food consumption from a staple food-dominated dietary structure to one including more meat and dairy products but also reduce left-behind family members’ nutrient intake. This study adds to the literature on the impact of farmers’ migration. The findings have important implications for better understanding the impacts of migration on farmers’ livelihood and human capital development in rural China.展开更多
The huge migration of rural workers has new characteristics such as the bad order, high degree of concentration, low level of collective action, marginality in social status, unfair treatment, difficult integration of...The huge migration of rural workers has new characteristics such as the bad order, high degree of concentration, low level of collective action, marginality in social status, unfair treatment, difficult integration of the new generation, and the new return trend of rural migrants, which causes ‘urban diseases’ in China. Countermeasures should be taken to develop medium-sized and small cities, integrate the labor market of the city and countryside, provide necessary public services, social security and vocational training, guide the rural migrant workers to return rationally, and help the new generation live in harmony with urban residents.展开更多
This study analyzes the misperceptions of the Chinese public about air pollution levels and other potential predictors of participation in pro-environmental behaviors based on the 2013 Chinese General Social Survey(CG...This study analyzes the misperceptions of the Chinese public about air pollution levels and other potential predictors of participation in pro-environmental behaviors based on the 2013 Chinese General Social Survey(CGSS).In this paper,misperception is defined as the difference between subjective perceptions of air pollution and measurements through objective monitoring.We find that pessimistic respondents are more likely to participate in pro-environmental behaviors.The media use and evaluation of the environmental performance of the local government significantly stimulate pro-environmental participation.The results reveal that knowledge and concern about the environment can mitigate the negative effect of optimistic bias on pro-environmental behaviors.In regions where environmental information is widely available,environmental pessimists are especially more likely to participate in such activities.This finding suggests that the government should provide not only accurate information about environmental pollution but also relevant education to enhance the environmental awareness of the public and stimulate pro-environmental participation.展开更多
A separation integrated technology for isolating refined solanesol from tobacco extracts was provided. Some experimental installations applied in the separation integrated technology were designed. The experimental in...A separation integrated technology for isolating refined solanesol from tobacco extracts was provided. Some experimental installations applied in the separation integrated technology were designed. The experimental installations included saponification and extraction installation, cryogenic centrifugation crystallization installation and continuous midium pressure column chromatography separation installation In the paper, a separation integrated technology route was designed： saponification and extraction-crystallization - silica gel column chromatography-recrystallization. Finally, refined solanesol （-95.5%） was successfully got. The new method featured shorter experimental times, as well as lower solvent consumption, compared with the conventional extraction methods. So it showed great potential for efficient sample preparation and large-scale industrial application in the near future.展开更多
Departing from the long debates on the role of faith/belief, recent interdisciplinary research has turned to characterize the features of the psychophysical processes underlying believing. Here we review recent cognit...Departing from the long debates on the role of faith/belief, recent interdisciplinary research has turned to characterize the features of the psychophysical processes underlying believing. Here we review recent cognitive neuroscience models of the believing process and propose a conceptual framework that integrates current theoretical and empiric knowledge about the processes of believing. There are theories that elegantly explain believing as a self-organization process of cognitive and emotional elements. Adding to the component of self-organized belief representation, dual-component models assume a belief evaluation component, which is probably supported by the right dorsolateral prefrontal cortex (DLPFC) and explains the stability of the belief despite the changing environment. Borrowing an idea from the neural models for the mental representation of action or situation, inclusion of both perceptive and action informations as the construct of belief representation allows the intimate relationship between a specific belief and a specific range of behaviour. Furthermore, inclusion of the personal value or affective information in the representation explains the deep impact of one’s emotional and physical state on the believing process. For associating perception, action, and value in a representation, the medial frontal cortex (MFC) may play a key role. Recent neuro-cognitive models of self-cognition explain the developmental origin of such a representation and the hierarchically nested structure of three levels of complexity in the representations: basic physical level, interpersonal level, and higher social level. The integrated model provides a comprehensive perspective of the believing process which suggests the importance and future directions of this interdisciplinary approach.展开更多
AIM： To investigate the selective cytotoxic effect of constructed hybrid protein on cells expressing granulocyte macrophage colony stimulating factor （GM-CSF） receptor. METHODS： HepG2 （human hepatoma） and LS174T...AIM： To investigate the selective cytotoxic effect of constructed hybrid protein on cells expressing granulocyte macrophage colony stimulating factor （GM-CSF） receptor. METHODS： HepG2 （human hepatoma） and LS174T （colon carcinoma） were used in this study. The fused gene was induced with 0.02% of arabinose for 4 h and the expressed protein was detected by Western blotting. The chimeric protein expressed in E..coli was checked for its cytotoxic activity on these cells and apoptosis was measured by comet assay and nudear staining. RESULTS： The chimeric protein was found to be cytotoxic to the colon cancer cell line expressing GM-CSFRs, but not to HepG2 lacking these receptors. Maximum activity was observed at the concentration of 40 ng/mL after 24 h incubation. The IC50 was 20 ± 3.5 ng/mL. CONCLUSION： Selective cytotoxic effect of the hybrid protein on the colon cancer cell line expressing GMCSF receptors （GM-CSFRs） receptor and apoptosis can be observed in this cell line. The hybrid protein can be considered as a therapeutic agent.展开更多
The objective of this study is to examine the effect of accounting standards and investor protection on value relevance of earnings and book value of equity among European Union countries during the years 1999-2007. T...The objective of this study is to examine the effect of accounting standards and investor protection on value relevance of earnings and book value of equity among European Union countries during the years 1999-2007. The results indicate that the adoption of International Financial Reporting Standards [IFRS] leads to improvement in value relevance, particularly on earnings. We also examine the impact of investor protection and the deviation of local accounting standards from IFRS on the effectiveness of the IFRS adoption. The results show supporting evidence for investor protection but inconclusive evidence for accounting standard deviation. However, additional analysis indicates that the countries which apparently benefit from adopting IFRS are those with high deviation of local accounting standards from IFRS and high investor protection. The findings imply that adopting IFRS alone cannot improve value relevance of accounting information, but standard setters and regulators need to strengthen their investor protection mechanisms in order to improve the quality of accounting information.展开更多
Introduction A new civilization based on green energy is needed,with ecological civilization decoupling from ever-increasing carbon emissions.A new development theory is also needed that makes use of historical self-r...Introduction A new civilization based on green energy is needed,with ecological civilization decoupling from ever-increasing carbon emissions.A new development theory is also needed that makes use of historical self-reflection,academic conscious-展开更多
This paper interrogates the impact of policy events on the efficiency of carbon market in China.The analysis covers five piloting emission trading schemes(Beijing, Shanghai, Guangdong,Shenzhen and Hubei), particularly...This paper interrogates the impact of policy events on the efficiency of carbon market in China.The analysis covers five piloting emission trading schemes(Beijing, Shanghai, Guangdong,Shenzhen and Hubei), particularly focusing on Guangdong pilot for its weak form efficiency and the richness of policy events. Twenty-five policy events between 2014 and 2016 are categorized into seven groups. The efficiency test indicates that only Guangdong ETS has reached weak form efficiency. After exploring the policy events occurred in Guangdong ETS, it finds that although a clear long-term climate policy has been set up over the country, China's carbon market still has a conservative risk appetite and its governing institutions still needs further development. The policy makers need to be aware of and avoid the negative impacts of policy events to the market evolvement, by introducing effective consultancy process with the stakeholders and nurturing market expectations in the long run. We also find that events like allowance auctions have considerably less impacts than previously expected and argue that auction approach should be considered a preferable option over a free allocation system in the future policy design.展开更多
Pancreatic trauma,commonly arising from blunt or penetrating injuries,poses clinical challenges due to its proneness to complications and the difficulty in trauma evaluation(Everson et al.,2023).Most current studies o...Pancreatic trauma,commonly arising from blunt or penetrating injuries,poses clinical challenges due to its proneness to complications and the difficulty in trauma evaluation(Everson et al.,2023).Most current studies on pancreatic trauma primarily revolve around diagnostic and surgical advancements(Ayoob et al.,2021),with relatively little attention to the processes and mechanisms underlying pancreatic repair after trauma.展开更多
Background:When a privately owned firm or privatized government entity raises capital by selling its stocks for the first time to general public,is known as initial public offering(IPO).The underpricing phenomenon and...Background:When a privately owned firm or privatized government entity raises capital by selling its stocks for the first time to general public,is known as initial public offering(IPO).The underpricing phenomenon and ownership structure are important characteristics of IPO process that significantly affect the short-run and long-run performance of private firm and privitized entity.This study compares the short-and long-run performance,and factors affecting these performances for both private IPOs and privatized IPOs in Pakistan.It further investigates the relationship between capital structor and initial underpricing for both group of IPOs.Methods:Event study methodology is used to compares short-and long-run performance spanning from March 2000 to June 2015 of two categories of IPOs issued in the Karachi Stock Exchange(KSE).Multivariate regression analysis is applied to examine the factors that affect the short-run and long-run performance as well as for investigating the relationship betwen underpricing and ownership structure for both group of IPOs.Results:We find that both categories outperform in IPOs at which they are offered to investors on first day of trading,although differences in mean are insignificant.Over a five-year buy-and hold strategy,privatizing IPOs outperform and private IPOs underperform returns on the benchmark KSE 100 Stock Index.The results reveal that the size of the private firm or government entity,aftermarket risk of IPOs,and subscription ratio are significantly associated with the underpricing of IPO shares brought to market.First-day returns,market volatility and retained ownership are associated with higher five-year performance.We find that the concentration of ownership is similar,for both categories of IPOs;and significantly positive related to underpricing.The size of the firm/entity,aftermarket risk,return on assets and subscription ratio also affect ownership concentration.Conclusions:Same level of underpricing in both private and privatized IPOs reveals that Pakistan’s government is committed to its privatization policies as they developed capital markets by underpricing of IPOs.To make dispersion in ownership structure and to involve more small investors,the regulatory authorities such as Securities and Exchange Commission of Pakistan(SECP are required to take some steps to minimize concentration in ownership structure).There is a need of some specific range of underpricing by issuers and SECP.展开更多
Hippocampal neurogenesis as a therapeutic target for neurological disorders：Mature granule cells are continuously differentiated from neural stem and progenitor cells and integrated into the preexisting neural system...Hippocampal neurogenesis as a therapeutic target for neurological disorders：Mature granule cells are continuously differentiated from neural stem and progenitor cells and integrated into the preexisting neural system in the subgranular zone of the hippocampal dentate gyrus throughout life.展开更多
Transformation and reform are two major themes of China's urbanization at the present stage.This paper argues that population urbanization,which lags behind land urbanization,is ignored in the process of tradition...Transformation and reform are two major themes of China's urbanization at the present stage.This paper argues that population urbanization,which lags behind land urbanization,is ignored in the process of traditional urbanization.The most important transformation of urbanization is citizenship process for rural migrants who have been semiurbanized.In order to promote urban transformation,a coordinated improving reform must consider the following basic issues:population,financing,land and urban system.展开更多
The accumulation of amyloid β peptide 1 - 42 (Aβ1-42) in the brain of Alzheimer’s disease (AD) patients is known to be associated with neurodegeneration and memory impairment. More recently, we reported that madeca...The accumulation of amyloid β peptide 1 - 42 (Aβ1-42) in the brain of Alzheimer’s disease (AD) patients is known to be associated with neurodegeneration and memory impairment. More recently, we reported that madecassoside, an active component of Centella asiatica, improved memory impairment in an Aβ1-42 infusion rat model of AD, ameliorated neurotoxicity in SH-SY5Y cells, and inhibited in vitro Aβ1-42 fibril formation. In the present study, we investigated the utility of in silico analyses in corroborating observed in vivo and in vitro effects of madecassoside in AD to further assess the therapeutic benefits of madecassoside. The 3D structure of Aβ1-42 was downloaded from the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB). The binding of madecassoside to Aβ1-42 was assessed by molecular docking. The chemical structure of madecassoside was modeled and converted to the PDB format. Madecassoside was found to successfully dock with Aβ1-42. Computational demonstration of the binding of madecassoside to Aβ1-42 further corroborated the inhibitory effect of madecassoside on Aβ1-42 fibrillogenesis which was demonstrated in our previous study. These data showed the potential utility of madecassoside as a preventive medication in Aβ1-42-induced neurodegenerative diseases such as AD.展开更多
基金supported by School of Social and Environmental Development,National Institute of Development Administration,Bangkok,Thailand[grant date:8 August 2012]
文摘Projections for 20 years of economic growth and change in the structure of the Thai economy were made for 180 sectors using a computable general equilibrium(CGE) model to compare the following four scenarios:(1) standard growth with infinite supply of factors,(2) finite land supply,(3) fixed use of agricultural chemicals,and(4) combined finite land supply with fixed use of agricultural chemicals.The computable projections suggest that the economic cost of hypothetical environmental control in agriculture is small and further weakened by urbanization.The computed structural development points to efficiency improvements specific to sectors to return the economy to balanced growth.
基金Humanities and Social Sciences Fund of Ministry of Education of China,No.24YJA630097National Natural Science Foundation of China,No.42471304。
文摘The uneven distribution of medical resources has led to increasingly frequent patient mobility;however, the interaction between this phenomenon and the healthcare supply-demand relationship remains underexplored. The present study constructed the 2023Cross-City Patient Mobility Network in China using one million patient mobility data records obtained from online healthcare platforms. We applied urban network analysis to uncover mobility patterns and used the coupling coordination degree model to assess healthcare supply-demand relationships before and after patient mobility. Explainable machine learning further revealed the impact of supply-demand coupling on patient mobility. The results indicated the following: Patient mobility followed administrative boundaries, although megacities serve areas beyond provincial borders;The scale of healthcare supply and demand displayed a multi-centric spatial pattern with a general decline from east to west, and these characteristics of demand distribution were further solidified by patient mobility;Cities with low supply-demand coupling and undersupply experienced patient outflows, while cities with high coupling and oversupply attracted them. In turn, patient mobility helped balance healthcare supply and demand, optimising the coupling relationship across cities. Thus, this research not only provides a methodological reference for understanding the interaction between patient mobility and healthcare systems but also offers empirical insights for public health policy.
基金Fellowship Program of the CPSF,No.GZC20231970National Natural Science Foundation of China,No.41871182。
文摘Understanding the complex mechanisms underlying agricultural space urbanization is essential for sustainable land management.This study identified the spatiotemporal characteristics of the agricultural space urbanization from 2000 to 2020 in China’s Yangtze River Economic Belt(YREB)using a kilometer-grid-based approach.By employing the partial least squares structural equation modeling method,the intricate drivers of agricultural space urbanization were investigated.The results revealed that from 2000 to 2020,agricultural space urbanization in the YREB covered an area of 28,198 km^(2),accounting for 84.5%of the total increase in urban space.The partial least squares structural equation modeling analysis revealed regional variations in agricultural space urbanization dynamics.In the western YREB,where urbanization is in its initial stage,natural conditions play a weak and indirect role,whereas policy incentives and socioeconomic growth are equally significant in driving agricultural space urbanization.In the eastern YREB,where urbanization is more saturated,the agricultural space urbanization is less constrained by natural factors,showing a high synergy with socioeconomic development.Conversely,in the central Yangtze River Economic Belt,policy influences surpass socioeconomic factors,whereas unfavorable natural conditions and agricultural development act as key drivers of agricultural space urbanization.This study suggests that enhancing agricultural space urbanization quality requires strengthening region-specific policies,providing targeted support for remote areas,rebalancing policy orientation in rapidly urbanizing regions,and establishing a comprehensive evaluation system to ensure policy rationality.
基金supported by the Grants-in-Aid for Scientific Research from Japan Society for the Promotion of Science KAKENHI 22K09110.
文摘Murine subarachnoid hemorrhage(SAH)induced using the filament perforation method is a useful in vivo experimental model to investigate the pathophysiological mechanisms in the brain underlying SAH.However,identifying mice with comorbid acute neurogenic pulmonary edema(NPE),a life-threatening systemic consequence often induced by SAH,in this model is difficult without histopathological investiga-tions.Herein,we present an imaging procedure involving dual-energy X-ray absorp-tiometry(DXA)to identify NPE in a murine model of SAH.We quantified the lung lean mass(LM)and compared the relationship between micro-computed tomography(CT)evidence of Hounsfield unit(HU)values and histopathological findings of PE.Of the 85 mice with successful induction of SAH by filament perforation,16(19%)had NPE,as verified by postmortem histology.The DXA-LM values correlate well with CT-HU levels(r=0.63,p<0.0001).Regarding the relationship between LM and HU in mice with post-SAH NPE,the LM was positively associated with HU values(r2=0.43;p=0.0056).A receiver operating characteristics curve of LM revealed a sensitivity of 87%and specificity of 57%for detecting PE,with a similar area under the curve as the HU(0.79±0.06 vs.0.84±0.07;p=0.21).These data suggest that confirming acute NPE using DXA-LM is a valuable method for selecting a clinically relevant murine NPE model that could be used in future experimental SAH studies.
文摘Osyris lanceolata is heavily and illegally exploited in East Africa for its essential oils, yet little is known about its population status and ecological requirements. This study examined its population structure and environmental factors influencing its distribution in the semi-arid Karamoja sub-region, Uganda. We surveyed 388 plots (5 m radius) at different altitudes, recording life stages, stem diameters, and regeneration patterns, and analyzed soil samples. Multivariate analyses, including Canonical Correspondence Analysis (CCA), Detrended Correspondence Analysis (DCA), Non-metric Multidimensional Scaling (NMDS), and Multiple Regression Modeling (MRM), identified key environmental factors affecting its distribution. Findings show that O. lanceolata populations in Moroto, Nakapiripirit, and Amudat districts are severely degraded due to overexploitation. The species is primarily regenerating through coppicing rather than seedlings, with an exploitation intensity of 56.6%. Population densities are low, distribution is irregular, and sustainable harvesting is not viable. Soil properties, particularly Ca2+, N, P, K+, Na+, and organic matter, significantly influence its abundance. Conservation efforts should focus on identifying suitable provenances for genetic preservation and plantation establishment. Areas with at least 9 trees per hectare in Moroto, Nakapiripirit, and Amudat could serve as potential sites for ex-situ plantations. Further research should explore how biotic interactions, genetic diversity, and morphology affect oil yield and quality to support restoration, breeding, and domestication initiatives.
文摘The study measures productive efficiency of tomato growers in village Akbarpura of Disctrict Nowshera in Khyber Pakhtunkhwa （KPK） province of Northern Pakistan. The study uses household level data collected in summer 2010 from sample farmers selected by multi-staged sampling. The study uses a theoretical framework to measure productive efficiency and estimates the Cobb-Douglas frontier production and cost models. The study found that technical efficiency indices varied significantly, with technical efficiency index averaging at 65%. The indices of allocative efficiency also varied widely, with an average of 56%. There was a wide gap between the highest and lowest economic efficiency indices, with a mean economic efficiency of 35%. The study concluded that farmer education, extension visits, age and access to credit contributed significantly and positively to productive efficiencies. A policy implication of this study is that there is enough potential for farmers to increase tomato production and net profits. The study recommends that the government should further invest in public education and strengthen extension services farmer education and because extension visits constituted important determinants of productive efficiencies.
基金conducted under the framework of the Sino-German “SURUMER Project” funded by the Bundesministerium für Wissenschaft, Technologie und Forschung (BMBF 01LL0919)+1 种基金supported by the China Postdoctoral Science Foundation (2017M620536)the National Natural Science Foundation of China (71742002, 71673008, and 71761137002)
文摘While migration is widely recognized as a valid option for improving farmers’ income, the welfare effects of migration on left-behind family members are ambiguous. This study examines the impacts of migration on left-behind family members’ food consumption and nutrient intake, particularly in remote rural areas in China. Based on household survey data collected from 611 smallholder rubber farmers in Xishuangbanna Dai Autonomous Prefecture of southwestern China, the empirical results suggest that the migration of family members contributes to improving household net income, whereas it negatively affects left-behind family members’ consumption of grain and pork. Migration also leads to a decrease in left-behind family members’ nutrient intake. Surprisingly, the economic returns of farmers’ migration not only do not foster the transformation of household food consumption from a staple food-dominated dietary structure to one including more meat and dairy products but also reduce left-behind family members’ nutrient intake. This study adds to the literature on the impact of farmers’ migration. The findings have important implications for better understanding the impacts of migration on farmers’ livelihood and human capital development in rural China.
文摘The huge migration of rural workers has new characteristics such as the bad order, high degree of concentration, low level of collective action, marginality in social status, unfair treatment, difficult integration of the new generation, and the new return trend of rural migrants, which causes ‘urban diseases’ in China. Countermeasures should be taken to develop medium-sized and small cities, integrate the labor market of the city and countryside, provide necessary public services, social security and vocational training, guide the rural migrant workers to return rationally, and help the new generation live in harmony with urban residents.
文摘This study analyzes the misperceptions of the Chinese public about air pollution levels and other potential predictors of participation in pro-environmental behaviors based on the 2013 Chinese General Social Survey(CGSS).In this paper,misperception is defined as the difference between subjective perceptions of air pollution and measurements through objective monitoring.We find that pessimistic respondents are more likely to participate in pro-environmental behaviors.The media use and evaluation of the environmental performance of the local government significantly stimulate pro-environmental participation.The results reveal that knowledge and concern about the environment can mitigate the negative effect of optimistic bias on pro-environmental behaviors.In regions where environmental information is widely available,environmental pessimists are especially more likely to participate in such activities.This finding suggests that the government should provide not only accurate information about environmental pollution but also relevant education to enhance the environmental awareness of the public and stimulate pro-environmental participation.
文摘A separation integrated technology for isolating refined solanesol from tobacco extracts was provided. Some experimental installations applied in the separation integrated technology were designed. The experimental installations included saponification and extraction installation, cryogenic centrifugation crystallization installation and continuous midium pressure column chromatography separation installation In the paper, a separation integrated technology route was designed： saponification and extraction-crystallization - silica gel column chromatography-recrystallization. Finally, refined solanesol （-95.5%） was successfully got. The new method featured shorter experimental times, as well as lower solvent consumption, compared with the conventional extraction methods. So it showed great potential for efficient sample preparation and large-scale industrial application in the near future.
文摘Departing from the long debates on the role of faith/belief, recent interdisciplinary research has turned to characterize the features of the psychophysical processes underlying believing. Here we review recent cognitive neuroscience models of the believing process and propose a conceptual framework that integrates current theoretical and empiric knowledge about the processes of believing. There are theories that elegantly explain believing as a self-organization process of cognitive and emotional elements. Adding to the component of self-organized belief representation, dual-component models assume a belief evaluation component, which is probably supported by the right dorsolateral prefrontal cortex (DLPFC) and explains the stability of the belief despite the changing environment. Borrowing an idea from the neural models for the mental representation of action or situation, inclusion of both perceptive and action informations as the construct of belief representation allows the intimate relationship between a specific belief and a specific range of behaviour. Furthermore, inclusion of the personal value or affective information in the representation explains the deep impact of one’s emotional and physical state on the believing process. For associating perception, action, and value in a representation, the medial frontal cortex (MFC) may play a key role. Recent neuro-cognitive models of self-cognition explain the developmental origin of such a representation and the hierarchically nested structure of three levels of complexity in the representations: basic physical level, interpersonal level, and higher social level. The integrated model provides a comprehensive perspective of the believing process which suggests the importance and future directions of this interdisciplinary approach.
文摘AIM： To investigate the selective cytotoxic effect of constructed hybrid protein on cells expressing granulocyte macrophage colony stimulating factor （GM-CSF） receptor. METHODS： HepG2 （human hepatoma） and LS174T （colon carcinoma） were used in this study. The fused gene was induced with 0.02% of arabinose for 4 h and the expressed protein was detected by Western blotting. The chimeric protein expressed in E..coli was checked for its cytotoxic activity on these cells and apoptosis was measured by comet assay and nudear staining. RESULTS： The chimeric protein was found to be cytotoxic to the colon cancer cell line expressing GM-CSFRs, but not to HepG2 lacking these receptors. Maximum activity was observed at the concentration of 40 ng/mL after 24 h incubation. The IC50 was 20 ± 3.5 ng/mL. CONCLUSION： Selective cytotoxic effect of the hybrid protein on the colon cancer cell line expressing GMCSF receptors （GM-CSFRs） receptor and apoptosis can be observed in this cell line. The hybrid protein can be considered as a therapeutic agent.
文摘The objective of this study is to examine the effect of accounting standards and investor protection on value relevance of earnings and book value of equity among European Union countries during the years 1999-2007. The results indicate that the adoption of International Financial Reporting Standards [IFRS] leads to improvement in value relevance, particularly on earnings. We also examine the impact of investor protection and the deviation of local accounting standards from IFRS on the effectiveness of the IFRS adoption. The results show supporting evidence for investor protection but inconclusive evidence for accounting standard deviation. However, additional analysis indicates that the countries which apparently benefit from adopting IFRS are those with high deviation of local accounting standards from IFRS and high investor protection. The findings imply that adopting IFRS alone cannot improve value relevance of accounting information, but standard setters and regulators need to strengthen their investor protection mechanisms in order to improve the quality of accounting information.
文摘Introduction A new civilization based on green energy is needed,with ecological civilization decoupling from ever-increasing carbon emissions.A new development theory is also needed that makes use of historical self-reflection,academic conscious-
文摘This paper interrogates the impact of policy events on the efficiency of carbon market in China.The analysis covers five piloting emission trading schemes(Beijing, Shanghai, Guangdong,Shenzhen and Hubei), particularly focusing on Guangdong pilot for its weak form efficiency and the richness of policy events. Twenty-five policy events between 2014 and 2016 are categorized into seven groups. The efficiency test indicates that only Guangdong ETS has reached weak form efficiency. After exploring the policy events occurred in Guangdong ETS, it finds that although a clear long-term climate policy has been set up over the country, China's carbon market still has a conservative risk appetite and its governing institutions still needs further development. The policy makers need to be aware of and avoid the negative impacts of policy events to the market evolvement, by introducing effective consultancy process with the stakeholders and nurturing market expectations in the long run. We also find that events like allowance auctions have considerably less impacts than previously expected and argue that auction approach should be considered a preferable option over a free allocation system in the future policy design.
基金supported by the National Natural Science Foundation of China(32322026,32192400,and 32270859)the National Key R&D Program of China(2021YFA0805000)。
文摘Pancreatic trauma,commonly arising from blunt or penetrating injuries,poses clinical challenges due to its proneness to complications and the difficulty in trauma evaluation(Everson et al.,2023).Most current studies on pancreatic trauma primarily revolve around diagnostic and surgical advancements(Ayoob et al.,2021),with relatively little attention to the processes and mechanisms underlying pancreatic repair after trauma.
文摘Background:When a privately owned firm or privatized government entity raises capital by selling its stocks for the first time to general public,is known as initial public offering(IPO).The underpricing phenomenon and ownership structure are important characteristics of IPO process that significantly affect the short-run and long-run performance of private firm and privitized entity.This study compares the short-and long-run performance,and factors affecting these performances for both private IPOs and privatized IPOs in Pakistan.It further investigates the relationship between capital structor and initial underpricing for both group of IPOs.Methods:Event study methodology is used to compares short-and long-run performance spanning from March 2000 to June 2015 of two categories of IPOs issued in the Karachi Stock Exchange(KSE).Multivariate regression analysis is applied to examine the factors that affect the short-run and long-run performance as well as for investigating the relationship betwen underpricing and ownership structure for both group of IPOs.Results:We find that both categories outperform in IPOs at which they are offered to investors on first day of trading,although differences in mean are insignificant.Over a five-year buy-and hold strategy,privatizing IPOs outperform and private IPOs underperform returns on the benchmark KSE 100 Stock Index.The results reveal that the size of the private firm or government entity,aftermarket risk of IPOs,and subscription ratio are significantly associated with the underpricing of IPO shares brought to market.First-day returns,market volatility and retained ownership are associated with higher five-year performance.We find that the concentration of ownership is similar,for both categories of IPOs;and significantly positive related to underpricing.The size of the firm/entity,aftermarket risk,return on assets and subscription ratio also affect ownership concentration.Conclusions:Same level of underpricing in both private and privatized IPOs reveals that Pakistan’s government is committed to its privatization policies as they developed capital markets by underpricing of IPOs.To make dispersion in ownership structure and to involve more small investors,the regulatory authorities such as Securities and Exchange Commission of Pakistan(SECP are required to take some steps to minimize concentration in ownership structure).There is a need of some specific range of underpricing by issuers and SECP.
基金supported by Grants-in-aids for Scientific Research Projects 25870538 and 24111535 from the Ministry of Education,Culture,Sports,Science and Technology of Japan
文摘Hippocampal neurogenesis as a therapeutic target for neurological disorders：Mature granule cells are continuously differentiated from neural stem and progenitor cells and integrated into the preexisting neural system in the subgranular zone of the hippocampal dentate gyrus throughout life.
文摘Transformation and reform are two major themes of China's urbanization at the present stage.This paper argues that population urbanization,which lags behind land urbanization,is ignored in the process of traditional urbanization.The most important transformation of urbanization is citizenship process for rural migrants who have been semiurbanized.In order to promote urban transformation,a coordinated improving reform must consider the following basic issues:population,financing,land and urban system.
文摘The accumulation of amyloid β peptide 1 - 42 (Aβ1-42) in the brain of Alzheimer’s disease (AD) patients is known to be associated with neurodegeneration and memory impairment. More recently, we reported that madecassoside, an active component of Centella asiatica, improved memory impairment in an Aβ1-42 infusion rat model of AD, ameliorated neurotoxicity in SH-SY5Y cells, and inhibited in vitro Aβ1-42 fibril formation. In the present study, we investigated the utility of in silico analyses in corroborating observed in vivo and in vitro effects of madecassoside in AD to further assess the therapeutic benefits of madecassoside. The 3D structure of Aβ1-42 was downloaded from the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB). The binding of madecassoside to Aβ1-42 was assessed by molecular docking. The chemical structure of madecassoside was modeled and converted to the PDB format. Madecassoside was found to successfully dock with Aβ1-42. Computational demonstration of the binding of madecassoside to Aβ1-42 further corroborated the inhibitory effect of madecassoside on Aβ1-42 fibrillogenesis which was demonstrated in our previous study. These data showed the potential utility of madecassoside as a preventive medication in Aβ1-42-induced neurodegenerative diseases such as AD.
