In this study,we used an extensive sampling network established in central Romania to develop tree height and crown length models.Our analysis included more than 18,000 tree measurements from five different species.In...In this study,we used an extensive sampling network established in central Romania to develop tree height and crown length models.Our analysis included more than 18,000 tree measurements from five different species.Instead of building univariate models for each response variable,we employed a multivariate approach using seemingly unrelated mixed-effects models.These models incorporated variables related to species mixture,tree and stand size,competition,and stand structure.With the inclusion of additional variables in the multivariate seemingly unrelated mixed-effects models,the accuracy of the height prediction models improved by over 10% for all species,whereas the improvement in the crown length models was considerably smaller.Our findings indicate that trees in mixed stands tend to have shorter heights but longer crowns than those in pure stands.We also observed that trees in homogeneous stand structures have shorter crown lengths than those in heterogeneous stands.By employing a multivariate mixed-effects modelling framework,we were able to perform cross-model random-effect predictions,leading to a significant increase in accuracy when both responses were used to calibrate the model.In contrast,the improvement in accuracy was marginal when only height was used for calibration.We demonstrate how multivariate mixed-effects models can be effectively used to develop multi-response allometric models that can be easily calibrated with a limited number of observations while simultaneously achieving better-aligned projections.展开更多
This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble lear...This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.展开更多
Collagen characterization is crucial for disease diagnostics,prevention,and understanding,with growing focus on quantitative analysis at tissue and fibril levels.Numerous models have been developed to quantify structu...Collagen characterization is crucial for disease diagnostics,prevention,and understanding,with growing focus on quantitative analysis at tissue and fibril levels.Numerous models have been developed to quantify structural changes in collagen linked to various pathologies.However,many approaches remain limited to conceptual descriptions or rely on custom software,often requiring programming skills,which re-stricts their clinical application and potential impact.We introduce CollagenFitJ,a plugin for the open-source software platform ImageJ/FIJI,which represents a widely used microscopy image analysis tool.CollagenFitJ makes use of the cylindrical symmetry model for collagen to enable facile quantitative assessment of polarization-resolved second harmonic generation microscopy image stacks.The plugin’s main outputs are collagen structure-related maps(e.g.,orientation and anisotropy of collagen fibrils within the focal volume),which can be accompanied by distribution and randomness maps for a series of structure-related parameters.We describe and validate the use of CollagenFitJ on images acquired on rat-tail tendons,collagen capsules surrounding human thyroid nodules,and mouse colon tumors,using both scanning and widefield second harmonic generation microscopy datasets.The plugin was designed to be user-friendly,requiring little to no experience in image processing and coding to facilitate access for life scientists,medical staff,and microscopy practitioners with limited coding skills or time availability required for coding.展开更多
The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients,intended for coated tablets preparation and further transfer to industrial scale.The work aimed to prove t...The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients,intended for coated tablets preparation and further transfer to industrial scale.The work aimed to prove that an accurate control of the critical granulation parameters can level the input material variability and offer a user-friendly process control strategy.Moreover,an in-line Near-Infrared monitoring method was developed,which offered a real time overview of the moisture level along the granulation process,thus a reliable supervision and control process analytical technology(PAT)tool.The experimental design’s results showed that the use of apparently interchangeable active pharmaceutical ingredients(APIs)and filler sorts that comply with pharmacopoeial specifications,lead to different end-product critical attributes.By adapting critical granulation parameters(i.e.binder spray rate and atomising pressure)as a function of material characteristics,led to granules with average sizes comprised in a narrow range of 280–320μm and low nongranulated fraction of under 5%.Therefore,the accurate control of process parameters according to the formulation particularities achieved the maintenance of product within the design space and removed material related variability.To complete the Quality by design(QbD)strategy,despite its limited spectral domain,the microNIR spectrometer was successfully used as a robust PAT monitoring tool that offered a real time overview of the moisture level and allowed the supervision and control of the granulation process.展开更多
In this paper, the author presented an overview of scientific research in universities of Vietnam in present and analyzed and assessed its effects on the quality of education in universities. The information to write ...In this paper, the author presented an overview of scientific research in universities of Vietnam in present and analyzed and assessed its effects on the quality of education in universities. The information to write this article was obtained in the references and from the management practice for the universities and the research institute.展开更多
The last decade has seen a significant growth in the market for alloys used for implants,especially for those intended for orthopedic implants.Research into biodegradable magnesium-based alloys has made great strides ...The last decade has seen a significant growth in the market for alloys used for implants,especially for those intended for orthopedic implants.Research into biodegradable magnesium-based alloys has made great strides in this period,so huge progress has been made in their use in the medical industry.The important factors that led to the intensification of research in this regard,were social but also economic,wanting to improve the quality of life,by reducing the use of conventionally permanent metallic implants(stainless steel,cobalt-based alloys,and titanium alloys)which involve the second implant removal surgery and other undesirable effects(stress shielding and metal ion releases),with a negative impact on the emotional and physical condition of patients,and by significantly reducing the costs for both the patient and the health system in the field of orthopedics.This paper refers to the impact and importance of biodegradable Mg alloys,reviewing the beginning of their development,the significant characteristics that make them so desirable for such applications(orthopedic implants)but also the characteristics that must be modulated(corrosion rate and mechanical properties)to arrive at the ideal product for the targeted application.It highlights,in detail,the mechanism and aspects related to the corrosion behaviour of Mg alloys,electrochemical characterization techniques/methods,as well as strategies to improve the corrosion behaviour and mechanical properties of these types of biodegradable alloys.The means of optimization,the category and the effect of the alloying elements,the design criteria,the requirements that the implants of biodegradable alloys Mg-based must meet and the aspects related to their efficiency are also presented.Finally,the potential applications in the specialized clinics,as well as the final products currently used and made by important prestigious companies in the world are approached.展开更多
Microalgae has been consumed in human diet for thousands of years.It is an under-exploited crop for production of dietary foods.Microalgae cultivation does not compete with land and resources required for traditional ...Microalgae has been consumed in human diet for thousands of years.It is an under-exploited crop for production of dietary foods.Microalgae cultivation does not compete with land and resources required for traditional crops and has a superior yield compared to terrestrial crops.Its high protein content has exhibited a huge potential to meet the dietary requirements of growing population.Apart from being a source of protein,presence of various bio-active components in microalgae provide an added health benefit.This review describes various microalgal sources of proteins and other bio-active components.One of the heavily studied group of bio-active components are pigments due to their anticarcenogenic,antioxidative and antihypertensive properties.Compared to various plant and floral species,microalgae contain higher amounts of pigments.Microalgal derived proteins have complete Essential Amino Acids(EAA)profiles and their protein content is higher than conventional sources such as meat,poultry and dairy products.However,microalgal based functional foods have not flooded the market.The lack of awareness coupled with scarce incentives for producers result in under-exploitation of microalgal potential.Application of microalgal derived components as dietary and nutraceutical supplements is discussed comprehensively.展开更多
Perovskite-type oxides of LaMnO3 were synthesized by means of the sol-gel method, in the presence of citric acid as gelling agent. The precursors used were Mn（NO3）2·H2O, La2O3, and NaOH,mixed in the stoichiomet...Perovskite-type oxides of LaMnO3 were synthesized by means of the sol-gel method, in the presence of citric acid as gelling agent. The precursors used were Mn（NO3）2·H2O, La2O3, and NaOH,mixed in the stoichiometric ratio to obtain perovskite materials. The obtained gel was heat-treated at 400, 600 and 800 ℃ respectively, for 6 h. X-ray diffraction and FT-IR spectroscopy were used to analyze the phase transformation as a function of temperature, and the Rietveld refinement was used in order to characterize the materials obtained structurally. The average crystallite size of the products was calculated from XRD data and the average particle size was measured from the TEM micrographs. At 600 ℃, the synthesized compound is well-crystallized, showcases a perovskite structure（Pm-3m space group）, and exhibits uniform and homogeneous hexagonally-shaped particles, with sizes in the 20-50 nm range.Complex impedance measurements in the 20-2 × 10^6 Hz frequency range were carried out at different temperatures（26-115 ℃）, and the electrical conduction mechanism is discussed.展开更多
The functional materials based on natural zeolite （clinoptilolite）, TiO2-zeolite and Ag-TiO2-zeolite have been successfully synthesized by solid-state reaction in fast-hydrothermal conditions. The obtained functiona...The functional materials based on natural zeolite （clinoptilolite）, TiO2-zeolite and Ag-TiO2-zeolite have been successfully synthesized by solid-state reaction in fast-hydrothermal conditions. The obtained functional materials were investigated by X-ray diffraction （XRD）, FT-1R （Fourier transform infrared） spectroscopy, DRUV-VIS （diffuse reflectance ultraviolet-visible） spectroscopy, BET （Brunauer-Emmett-Teller） and SEM/EDX （scanning electron microscope/energy dispersive X-ray spectrometer） analyses. The XRD results indicated that the clinoptilolite structure has a good thermal stabilization after the fast-hydrothermal treatment. Also, the high specific surface area about 92.55 m^2.g^-1 was noticed for Ag-TiO2-zeolite functional material. The presence of dopants was evidenced from EDX spectra. The enhanced bactericidal activity of Ag-TiO2-zeolite catalyst is proved through damaging of Enterococcusfaecalis colonies under visible irradiation, at different material doses and irradiation times.展开更多
Platinum catalysts play a major role in the large scale commercialization of direct methanol fuel cells(DMFC).Here,we present a procedure to create a nanostructural graphene-platinum(Gr Pt)composite containing a small...Platinum catalysts play a major role in the large scale commercialization of direct methanol fuel cells(DMFC).Here,we present a procedure to create a nanostructural graphene-platinum(Gr Pt)composite containing a small amount(5.3 wt%)of platinum nanoparticles coated with at least four layers of graphene.The composite,as Gr Pt ink,was deposited on a glassy carbon electrode and its electrocatalytic activity in a methanol oxidation reaction(MOR)was evaluated in a 1 M CH3OH/1 M NaOH solution.The results indicated an enhanced catalytic performance of GrPt towards MOR in alkaline media compared with the Pt/C material.Electron energy-loss spectroscopy and X-ray photoelectron spectroscopy(recorded before and after the electrochemical assays)were employed to analyze the changes in the chemical composition of the nanomaterial and to explain the transformations that took place at the electrode surface.Our findings suggest that growing of graphene on platinum nanoparticles improve the catalytic performance of platinum-graphene composites towards MOR in alkaline media.展开更多
ZnO nanoparticles（ZnO NPs） were synthesized by chemical method（coprecipitation） and biological method using aqueous extracts of garlic（Allium sativum）,rosemary（Rosmarinus officinalis） and basil（Ocimum basili...ZnO nanoparticles（ZnO NPs） were synthesized by chemical method（coprecipitation） and biological method using aqueous extracts of garlic（Allium sativum）,rosemary（Rosmarinus officinalis） and basil（Ocimum basilicum）.The influence of plant extract on the antibacterial and antioxidant activities of green synthesized nanoparticles was investigated.The X-ray diffraction studies reveal that all ZnO samples have hexagonal wurtzite structure.The particle size of ZnO NPs estimated by transmission electron microscopy analysis（between 14 and 27 nm） varies depending on the synthesis method of nanoparticles and the type of extracts from the plants used.The functional groups involved in the biosynthetic procedure were evidenced by Fourier transform infrared spectroscopy.The presence of Mn^（2＋）ions,Zn vacancy complexes and oxygen vacancies in ZnO samples was highlighted by electron paramagnetic resonance spectroscopy.The green synthesized ZnO NPs have shown a good bactericidal activity against Staphylococcus aureus,Bacillus subtilis,Listeria monocytogenes,Escherichia coli,Salmonella typhimurium and Pseudomonas aeruginosa bacterial strains.ZnO NPs synthesized using extracts of the selected plant species have been found to exhibit more enhanced antibacterial and antioxidant activities as compared to chemical ZnO NPs.展开更多
The effects of different climatic conditions on growth and chemical composition of Betula pendula in geographically different European regions,Lithuania and Romania,were compared.Birch species in the entire area have ...The effects of different climatic conditions on growth and chemical composition of Betula pendula in geographically different European regions,Lithuania and Romania,were compared.Birch species in the entire area have a wide natural distribution,but B.pendula is commercially more important in Lithuania than in Romania.Here we evaluated tree ring width,wood density and foliar chemical composition of mature birch trees in two European regions.Trees at the Lithuanian sites had greater radial growth and wood density with no clear changes in foliar chemistry than those at the Romanian sites.Mean wood density was 600-700 kg m^(-3) at Lithuanian and 350-450 kg m^(-3) at Romanian sites.Mean width of wood ring,earlywood and latewood for Lithuanian birch trees were several times higher than the means for Romanian birch trees.We hypothesized that the main differences in birch radial growth and wood density were due to the different climatic conditions in the studied regions.Ca,K and Mg concentrations were significantly higher and Fe and Mn were lower in the birch foliage at the Lithuanian sites compared those at the Romanian sites.Overall assessment of growth showed that silver birch cultivation is more appropriate for colder climate regions and that birch growth may change in the context of a warming climate.展开更多
Nowadays, about 80% of the Danube floodplain--Romanian sector are embanked and arranged with desiccation works and locally with drainage. Once with increasing pressures on the system and the complexity of the issues, ...Nowadays, about 80% of the Danube floodplain--Romanian sector are embanked and arranged with desiccation works and locally with drainage. Once with increasing pressures on the system and the complexity of the issues, there has been developed a number of mechanisms by which human activity （LU change） influence the stability and services of ecosystems and the need for planning tools are changing rapidly. Motivated by dramatic climatic change in recent decades and especially increased frequency of extreme events--2006 and 2010, the study focused on developing models and scenarios of climatic change, especially those related to land use change and flooding affecting local communities/regions. Thus, in the given circumstances, the best option is to foreseen a policy on the Lower Danube riverbed, followed by a series of advanced tools for exploring the 4D reconnection （longitudinal, lateral, vertical and temporal） and a well prepared monitoring system which alert address to detected threats. 4D reconnection of the lower Danube floodplain will provide a spatial planning tool, developed in accordance with this three features, and built to design, analyse and evaluate long-term policies in an ecological, social, economic and cultural context.展开更多
One of the most important goals of EU nature and water framework directives is to ensure healthy aquatic ecosystems by the protection of the most valuable species and habitats form the Natura 2000 network, while at th...One of the most important goals of EU nature and water framework directives is to ensure healthy aquatic ecosystems by the protection of the most valuable species and habitats form the Natura 2000 network, while at the same time ensuring a balance between water/nature protection and the sustainable use of nature’s natural resources. The purpose of this study was to evaluate the physico-chemical and microbiological characteristics of four Romanian salty plain lakes included in Natura 2000 Network, in order to assess the degree of organic pollution and to generate the knowledge required for the design and implementation of appropriate measures for maintaining the balance between the water protection and the sustainable use of these protected ecosystems. The water and sediment sampling was performed in two consecutive years (2015 and 2016), in September and the following standard parameters have been determined: pH, chemical oxygen consumption (COC), the degree of trophicity and salinity of the environment, metals content, microbiological indicators and microbial physiological groups involved in nutrient cycling. The pH ranged from 7.56 to 8.93, close or above the upper normal limit of 8.5, being correlated with a high salinity characteristic of chlorinated, sulphated, high sodium and magnesium content waters. Despite the similar values recorded for the physico-chemical parameters in the two consecutive years suggesting a certain degree of stability of the investigated aquatic ecosystems, the COC values indicate a high degree of hypertrophy, which could be attributed to the reduced surface area, ecological pisciculture and agriculture input. The microbiological parameters revealed the existence of both recent and chronic fecal pollution source. The high hypertrophy degree could represent a positive premise for the high productivity of the investigated ecosystems, but also an alarm signal for excessive organic pollution, with the risk of redox potential decrease which can affect the fish and other life forms. Consequently, it is necessary to identify the sources of pollution and implement the appropriate measures to minimize the negative impact of organic contamination on the status of the respective ecosystems (water quality, biotic components) in order to maintain the health of both ecosystems and the surrounding human communities, allowing at the same time a sustainable use of the local resources.展开更多
We synthesized Zn0.8Fe2.2O4 ferrite powders by coprecipitation and hydrothermal techniques and analyzed the mor-phology and magnetic properties. The morphology and structure of the Zn ferrite powders were investigated...We synthesized Zn0.8Fe2.2O4 ferrite powders by coprecipitation and hydrothermal techniques and analyzed the mor-phology and magnetic properties. The morphology and structure of the Zn ferrite powders were investigated using Scanning Electron Microscopy (SEM) and X-ray Diffraction (XRD) identifying the crystallization planes. Magnetic hysteresis curves were obtained for the Zn ferrites samples.展开更多
The aim of this study was to evaluate a Nature Based Rehabilitation (NBR) for a group of patients with Exhaustion Disorder (ED) in the southwest Sweden. A multidisciplinary team consisting of an occupational therapist...The aim of this study was to evaluate a Nature Based Rehabilitation (NBR) for a group of patients with Exhaustion Disorder (ED) in the southwest Sweden. A multidisciplinary team consisting of an occupational therapist, a physiotherapist, a medical doctor practising symbolic drama and a nurse with gardening experience provided NBR in an agricultural environment. Patients were offered 14 weeks of rehabilitation in a group of eight persons, three mornings per week. Seventeen patients participated in the study and 15 completed the study. A semi-structured interview was conducted at the beginning of the rehabilitation and at the end and a follow-up interview by telephone was done one year after completion of the rehabilitation. The interviews were recorded and transcribed. Assessment scales used included: Stress and Crisis Inventory (SCI-93), Coping Resources Inventory (CRI) and Visual Analogue Scale (VAS). Weekly notes from the staff members were reviewed and compared with the patient’s own experience. The interviews and the staff notes were analysed with semantic thematic analysis. Result showed that this kind of NBR with a multidisciplinary team promotes improved health and improved quality of life for patients with ED and may thus constitute a good alternative to treatment, provided the ED has not become chronic.展开更多
<b><span style="font-family:Verdana;">Background:</span></b></span><span><span><span style="font-family:""><span style="font-family:Verd...<b><span style="font-family:Verdana;">Background:</span></b></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and life-limiting condition. It has no cure hence it is vital to establish effective methods of improving the quality of remaining life in these patients. One of the key components of improving quality of life is pulmonary rehabilitation. However little research has been conducted to understand the perspectives and lived experience of people with IPF on pulmonary rehabilitation. Hence, we aim to fill this gap in the existing literature. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We sought to un</span><span style="font-family:Verdana;">derstand how patients coped with pulmonary rehabilitation. A pa</span><span style="font-family:Verdana;">tient-centred approach was used to explore the physical and psychological impact of pulmonary rehabilitation. Semi-structured interviews were conducted by experienced academics. Interviews used a topic guide but mostly led by the participants. An inductive thematic approach was used to analyse data, allowing us to identify common themes in the participants’ experiences. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Of fifty invited participants, ten took part in the study (aged 53 - 81 years). Inductive analysis of interviews identified seven second-order themes and eleven first-order themes, represented by two General Dimensions: </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">“</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">motivation</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">”</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> and </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">“</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">Advantages and disadvantages</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">”</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">. Overall, participants found the pulmonary rehabilitation programme to be useful and they experienced an increase in their quality of life following rehabilitation.展开更多
基金supported by the European Union and the Romanian Government through the Competitiveness Operational Programme 2014–2020, under the project“Increasing the economic competitiveness of the forestry sector and the quality of life through knowledge transfer,technology and CDI skills”(CRESFORLIFE),ID P 40 380/105506, subsidiary contract no. 17/2020partially by the FORCLIMSOC Nucleu Programme (Contract 12N/2023)+2 种基金project PN 23090101CresPerfInst project (Contract 34PFE/December 30, 2021)“Increasing the institutional capacity and performance of INCDS ‘Marin Drǎcea’in RDI activities-CresPer”LM was financially supported by the Research Council of Finland's flagship ecosystem for Forest-Human-Machine Interplay–Building Resilience, Redefining Value Networks and Enabling Meaningful Experiences (UNITE)(decision number 357909)
文摘In this study,we used an extensive sampling network established in central Romania to develop tree height and crown length models.Our analysis included more than 18,000 tree measurements from five different species.Instead of building univariate models for each response variable,we employed a multivariate approach using seemingly unrelated mixed-effects models.These models incorporated variables related to species mixture,tree and stand size,competition,and stand structure.With the inclusion of additional variables in the multivariate seemingly unrelated mixed-effects models,the accuracy of the height prediction models improved by over 10% for all species,whereas the improvement in the crown length models was considerably smaller.Our findings indicate that trees in mixed stands tend to have shorter heights but longer crowns than those in pure stands.We also observed that trees in homogeneous stand structures have shorter crown lengths than those in heterogeneous stands.By employing a multivariate mixed-effects modelling framework,we were able to perform cross-model random-effect predictions,leading to a significant increase in accuracy when both responses were used to calibrate the model.In contrast,the improvement in accuracy was marginal when only height was used for calibration.We demonstrate how multivariate mixed-effects models can be effectively used to develop multi-response allometric models that can be easily calibrated with a limited number of observations while simultaneously achieving better-aligned projections.
基金the University of Transport Technology under the project entitled“Application of Machine Learning Algorithms in Landslide Susceptibility Mapping in Mountainous Areas”with grant number DTTD2022-16.
文摘This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and AB-RBFN.Additionally,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and validation.The models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to roads.These factors were instrumental in predicting the output variable,which was the probability of landslide occurrence.Statistical analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other models.The AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of 0.926.These results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.
基金supported by the Ministry of Research,Innovation and Digitalization,CNCS-UEFISCDI[Grant Nos.RO-NO-2019-0601(MEDYCONAI),PN-III-P4-PCE-2021-0444(RESONANO)]PN-IV-P1-PCE-2023-1137+2 种基金supported in part by IN2SIGHT,European Union’s Horizon 2020(GA.no.964481)by the Research Council of Lithuania(LMTLTAgreement No.P-MIP-23-237).
文摘Collagen characterization is crucial for disease diagnostics,prevention,and understanding,with growing focus on quantitative analysis at tissue and fibril levels.Numerous models have been developed to quantify structural changes in collagen linked to various pathologies.However,many approaches remain limited to conceptual descriptions or rely on custom software,often requiring programming skills,which re-stricts their clinical application and potential impact.We introduce CollagenFitJ,a plugin for the open-source software platform ImageJ/FIJI,which represents a widely used microscopy image analysis tool.CollagenFitJ makes use of the cylindrical symmetry model for collagen to enable facile quantitative assessment of polarization-resolved second harmonic generation microscopy image stacks.The plugin’s main outputs are collagen structure-related maps(e.g.,orientation and anisotropy of collagen fibrils within the focal volume),which can be accompanied by distribution and randomness maps for a series of structure-related parameters.We describe and validate the use of CollagenFitJ on images acquired on rat-tail tendons,collagen capsules surrounding human thyroid nodules,and mouse colon tumors,using both scanning and widefield second harmonic generation microscopy datasets.The plugin was designed to be user-friendly,requiring little to no experience in image processing and coding to facilitate access for life scientists,medical staff,and microscopy practitioners with limited coding skills or time availability required for coding.
基金This work was supported by the Romanian National Authority for Scientific Research and Innovation,CNCS-UEFISCDI[project number PN-III-P2-2.1-BG-2016-0201].
文摘The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients,intended for coated tablets preparation and further transfer to industrial scale.The work aimed to prove that an accurate control of the critical granulation parameters can level the input material variability and offer a user-friendly process control strategy.Moreover,an in-line Near-Infrared monitoring method was developed,which offered a real time overview of the moisture level along the granulation process,thus a reliable supervision and control process analytical technology(PAT)tool.The experimental design’s results showed that the use of apparently interchangeable active pharmaceutical ingredients(APIs)and filler sorts that comply with pharmacopoeial specifications,lead to different end-product critical attributes.By adapting critical granulation parameters(i.e.binder spray rate and atomising pressure)as a function of material characteristics,led to granules with average sizes comprised in a narrow range of 280–320μm and low nongranulated fraction of under 5%.Therefore,the accurate control of process parameters according to the formulation particularities achieved the maintenance of product within the design space and removed material related variability.To complete the Quality by design(QbD)strategy,despite its limited spectral domain,the microNIR spectrometer was successfully used as a robust PAT monitoring tool that offered a real time overview of the moisture level and allowed the supervision and control of the granulation process.
文摘In this paper, the author presented an overview of scientific research in universities of Vietnam in present and analyzed and assessed its effects on the quality of education in universities. The information to write this article was obtained in the references and from the management practice for the universities and the research institute.
基金performed under contracts no.46N/2019-project no.PN19310102/2019 and 30PFE/2018 between the National Institute for Research and Development in Electrical Engineering ICPE-CA and the Romanian Ministry of Research and Innovation
文摘The last decade has seen a significant growth in the market for alloys used for implants,especially for those intended for orthopedic implants.Research into biodegradable magnesium-based alloys has made great strides in this period,so huge progress has been made in their use in the medical industry.The important factors that led to the intensification of research in this regard,were social but also economic,wanting to improve the quality of life,by reducing the use of conventionally permanent metallic implants(stainless steel,cobalt-based alloys,and titanium alloys)which involve the second implant removal surgery and other undesirable effects(stress shielding and metal ion releases),with a negative impact on the emotional and physical condition of patients,and by significantly reducing the costs for both the patient and the health system in the field of orthopedics.This paper refers to the impact and importance of biodegradable Mg alloys,reviewing the beginning of their development,the significant characteristics that make them so desirable for such applications(orthopedic implants)but also the characteristics that must be modulated(corrosion rate and mechanical properties)to arrive at the ideal product for the targeted application.It highlights,in detail,the mechanism and aspects related to the corrosion behaviour of Mg alloys,electrochemical characterization techniques/methods,as well as strategies to improve the corrosion behaviour and mechanical properties of these types of biodegradable alloys.The means of optimization,the category and the effect of the alloying elements,the design criteria,the requirements that the implants of biodegradable alloys Mg-based must meet and the aspects related to their efficiency are also presented.Finally,the potential applications in the specialized clinics,as well as the final products currently used and made by important prestigious companies in the world are approached.
基金the Fundamental Research Grant Scheme,Malaysia[FRGS/1/2015/SG05/UNIM/03/1]the Ministry of Science and Technology,Malaysia[MOSTI02-02-12-SF0256]+1 种基金the Prototype Research Grant Scheme,Malaysia[PRGS/2/2015/SG05/UNIM/03/1]International Cooperation Seeds Funding of Nanjing Agricultural University(Grant number:2018-AH-04).
文摘Microalgae has been consumed in human diet for thousands of years.It is an under-exploited crop for production of dietary foods.Microalgae cultivation does not compete with land and resources required for traditional crops and has a superior yield compared to terrestrial crops.Its high protein content has exhibited a huge potential to meet the dietary requirements of growing population.Apart from being a source of protein,presence of various bio-active components in microalgae provide an added health benefit.This review describes various microalgal sources of proteins and other bio-active components.One of the heavily studied group of bio-active components are pigments due to their anticarcenogenic,antioxidative and antihypertensive properties.Compared to various plant and floral species,microalgae contain higher amounts of pigments.Microalgal derived proteins have complete Essential Amino Acids(EAA)profiles and their protein content is higher than conventional sources such as meat,poultry and dairy products.However,microalgal based functional foods have not flooded the market.The lack of awareness coupled with scarce incentives for producers result in under-exploitation of microalgal potential.Application of microalgal derived components as dietary and nutraceutical supplements is discussed comprehensively.
基金Project supported by the Experimental Demonstrative Project 48PED/2017-Executive Unit for Financing Higher Education,Research,Development and Innovation(UEFISCDI)
文摘Perovskite-type oxides of LaMnO3 were synthesized by means of the sol-gel method, in the presence of citric acid as gelling agent. The precursors used were Mn（NO3）2·H2O, La2O3, and NaOH,mixed in the stoichiometric ratio to obtain perovskite materials. The obtained gel was heat-treated at 400, 600 and 800 ℃ respectively, for 6 h. X-ray diffraction and FT-IR spectroscopy were used to analyze the phase transformation as a function of temperature, and the Rietveld refinement was used in order to characterize the materials obtained structurally. The average crystallite size of the products was calculated from XRD data and the average particle size was measured from the TEM micrographs. At 600 ℃, the synthesized compound is well-crystallized, showcases a perovskite structure（Pm-3m space group）, and exhibits uniform and homogeneous hexagonally-shaped particles, with sizes in the 20-50 nm range.Complex impedance measurements in the 20-2 × 10^6 Hz frequency range were carried out at different temperatures（26-115 ℃）, and the electrical conduction mechanism is discussed.
基金Supported by the Sectoral Operational Programme Human Resources Development(SOP HRD)Financed from the European Social Fundthe Romanian Government under the Contract Number POSDRU/89/1.5/S/63700
文摘The functional materials based on natural zeolite （clinoptilolite）, TiO2-zeolite and Ag-TiO2-zeolite have been successfully synthesized by solid-state reaction in fast-hydrothermal conditions. The obtained functional materials were investigated by X-ray diffraction （XRD）, FT-1R （Fourier transform infrared） spectroscopy, DRUV-VIS （diffuse reflectance ultraviolet-visible） spectroscopy, BET （Brunauer-Emmett-Teller） and SEM/EDX （scanning electron microscope/energy dispersive X-ray spectrometer） analyses. The XRD results indicated that the clinoptilolite structure has a good thermal stabilization after the fast-hydrothermal treatment. Also, the high specific surface area about 92.55 m^2.g^-1 was noticed for Ag-TiO2-zeolite functional material. The presence of dopants was evidenced from EDX spectra. The enhanced bactericidal activity of Ag-TiO2-zeolite catalyst is proved through damaging of Enterococcusfaecalis colonies under visible irradiation, at different material doses and irradiation times.
基金financially supported by Romanian National Authority for Scientific Research and Innovation (ANCSI) by NUCLEU Program PN 18 03 02 02
文摘Platinum catalysts play a major role in the large scale commercialization of direct methanol fuel cells(DMFC).Here,we present a procedure to create a nanostructural graphene-platinum(Gr Pt)composite containing a small amount(5.3 wt%)of platinum nanoparticles coated with at least four layers of graphene.The composite,as Gr Pt ink,was deposited on a glassy carbon electrode and its electrocatalytic activity in a methanol oxidation reaction(MOR)was evaluated in a 1 M CH3OH/1 M NaOH solution.The results indicated an enhanced catalytic performance of GrPt towards MOR in alkaline media compared with the Pt/C material.Electron energy-loss spectroscopy and X-ray photoelectron spectroscopy(recorded before and after the electrochemical assays)were employed to analyze the changes in the chemical composition of the nanomaterial and to explain the transformations that took place at the electrode surface.Our findings suggest that growing of graphene on platinum nanoparticles improve the catalytic performance of platinum-graphene composites towards MOR in alkaline media.
基金supported by the Romanian Ministry of Education and Research within the Nucleu Programme(Project PN 09-44)
文摘ZnO nanoparticles（ZnO NPs） were synthesized by chemical method（coprecipitation） and biological method using aqueous extracts of garlic（Allium sativum）,rosemary（Rosmarinus officinalis） and basil（Ocimum basilicum）.The influence of plant extract on the antibacterial and antioxidant activities of green synthesized nanoparticles was investigated.The X-ray diffraction studies reveal that all ZnO samples have hexagonal wurtzite structure.The particle size of ZnO NPs estimated by transmission electron microscopy analysis（between 14 and 27 nm） varies depending on the synthesis method of nanoparticles and the type of extracts from the plants used.The functional groups involved in the biosynthetic procedure were evidenced by Fourier transform infrared spectroscopy.The presence of Mn^（2＋）ions,Zn vacancy complexes and oxygen vacancies in ZnO samples was highlighted by electron paramagnetic resonance spectroscopy.The green synthesized ZnO NPs have shown a good bactericidal activity against Staphylococcus aureus,Bacillus subtilis,Listeria monocytogenes,Escherichia coli,Salmonella typhimurium and Pseudomonas aeruginosa bacterial strains.ZnO NPs synthesized using extracts of the selected plant species have been found to exhibit more enhanced antibacterial and antioxidant activities as compared to chemical ZnO NPs.
基金supported financially by Agency for ScienceInnovation and Technology,Lithuania。
文摘The effects of different climatic conditions on growth and chemical composition of Betula pendula in geographically different European regions,Lithuania and Romania,were compared.Birch species in the entire area have a wide natural distribution,but B.pendula is commercially more important in Lithuania than in Romania.Here we evaluated tree ring width,wood density and foliar chemical composition of mature birch trees in two European regions.Trees at the Lithuanian sites had greater radial growth and wood density with no clear changes in foliar chemistry than those at the Romanian sites.Mean wood density was 600-700 kg m^(-3) at Lithuanian and 350-450 kg m^(-3) at Romanian sites.Mean width of wood ring,earlywood and latewood for Lithuanian birch trees were several times higher than the means for Romanian birch trees.We hypothesized that the main differences in birch radial growth and wood density were due to the different climatic conditions in the studied regions.Ca,K and Mg concentrations were significantly higher and Fe and Mn were lower in the birch foliage at the Lithuanian sites compared those at the Romanian sites.Overall assessment of growth showed that silver birch cultivation is more appropriate for colder climate regions and that birch growth may change in the context of a warming climate.
文摘Nowadays, about 80% of the Danube floodplain--Romanian sector are embanked and arranged with desiccation works and locally with drainage. Once with increasing pressures on the system and the complexity of the issues, there has been developed a number of mechanisms by which human activity （LU change） influence the stability and services of ecosystems and the need for planning tools are changing rapidly. Motivated by dramatic climatic change in recent decades and especially increased frequency of extreme events--2006 and 2010, the study focused on developing models and scenarios of climatic change, especially those related to land use change and flooding affecting local communities/regions. Thus, in the given circumstances, the best option is to foreseen a policy on the Lower Danube riverbed, followed by a series of advanced tools for exploring the 4D reconnection （longitudinal, lateral, vertical and temporal） and a well prepared monitoring system which alert address to detected threats. 4D reconnection of the lower Danube floodplain will provide a spatial planning tool, developed in accordance with this three features, and built to design, analyse and evaluate long-term policies in an ecological, social, economic and cultural context.
文摘One of the most important goals of EU nature and water framework directives is to ensure healthy aquatic ecosystems by the protection of the most valuable species and habitats form the Natura 2000 network, while at the same time ensuring a balance between water/nature protection and the sustainable use of nature’s natural resources. The purpose of this study was to evaluate the physico-chemical and microbiological characteristics of four Romanian salty plain lakes included in Natura 2000 Network, in order to assess the degree of organic pollution and to generate the knowledge required for the design and implementation of appropriate measures for maintaining the balance between the water protection and the sustainable use of these protected ecosystems. The water and sediment sampling was performed in two consecutive years (2015 and 2016), in September and the following standard parameters have been determined: pH, chemical oxygen consumption (COC), the degree of trophicity and salinity of the environment, metals content, microbiological indicators and microbial physiological groups involved in nutrient cycling. The pH ranged from 7.56 to 8.93, close or above the upper normal limit of 8.5, being correlated with a high salinity characteristic of chlorinated, sulphated, high sodium and magnesium content waters. Despite the similar values recorded for the physico-chemical parameters in the two consecutive years suggesting a certain degree of stability of the investigated aquatic ecosystems, the COC values indicate a high degree of hypertrophy, which could be attributed to the reduced surface area, ecological pisciculture and agriculture input. The microbiological parameters revealed the existence of both recent and chronic fecal pollution source. The high hypertrophy degree could represent a positive premise for the high productivity of the investigated ecosystems, but also an alarm signal for excessive organic pollution, with the risk of redox potential decrease which can affect the fish and other life forms. Consequently, it is necessary to identify the sources of pollution and implement the appropriate measures to minimize the negative impact of organic contamination on the status of the respective ecosystems (water quality, biotic components) in order to maintain the health of both ecosystems and the surrounding human communities, allowing at the same time a sustainable use of the local resources.
文摘We synthesized Zn0.8Fe2.2O4 ferrite powders by coprecipitation and hydrothermal techniques and analyzed the mor-phology and magnetic properties. The morphology and structure of the Zn ferrite powders were investigated using Scanning Electron Microscopy (SEM) and X-ray Diffraction (XRD) identifying the crystallization planes. Magnetic hysteresis curves were obtained for the Zn ferrites samples.
文摘The aim of this study was to evaluate a Nature Based Rehabilitation (NBR) for a group of patients with Exhaustion Disorder (ED) in the southwest Sweden. A multidisciplinary team consisting of an occupational therapist, a physiotherapist, a medical doctor practising symbolic drama and a nurse with gardening experience provided NBR in an agricultural environment. Patients were offered 14 weeks of rehabilitation in a group of eight persons, three mornings per week. Seventeen patients participated in the study and 15 completed the study. A semi-structured interview was conducted at the beginning of the rehabilitation and at the end and a follow-up interview by telephone was done one year after completion of the rehabilitation. The interviews were recorded and transcribed. Assessment scales used included: Stress and Crisis Inventory (SCI-93), Coping Resources Inventory (CRI) and Visual Analogue Scale (VAS). Weekly notes from the staff members were reviewed and compared with the patient’s own experience. The interviews and the staff notes were analysed with semantic thematic analysis. Result showed that this kind of NBR with a multidisciplinary team promotes improved health and improved quality of life for patients with ED and may thus constitute a good alternative to treatment, provided the ED has not become chronic.
文摘<b><span style="font-family:Verdana;">Background:</span></b></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and life-limiting condition. It has no cure hence it is vital to establish effective methods of improving the quality of remaining life in these patients. One of the key components of improving quality of life is pulmonary rehabilitation. However little research has been conducted to understand the perspectives and lived experience of people with IPF on pulmonary rehabilitation. Hence, we aim to fill this gap in the existing literature. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We sought to un</span><span style="font-family:Verdana;">derstand how patients coped with pulmonary rehabilitation. A pa</span><span style="font-family:Verdana;">tient-centred approach was used to explore the physical and psychological impact of pulmonary rehabilitation. Semi-structured interviews were conducted by experienced academics. Interviews used a topic guide but mostly led by the participants. An inductive thematic approach was used to analyse data, allowing us to identify common themes in the participants’ experiences. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Of fifty invited participants, ten took part in the study (aged 53 - 81 years). Inductive analysis of interviews identified seven second-order themes and eleven first-order themes, represented by two General Dimensions: </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">“</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">motivation</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">”</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> and </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">“</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">Advantages and disadvantages</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">”</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">. Overall, participants found the pulmonary rehabilitation programme to be useful and they experienced an increase in their quality of life following rehabilitation.
