We were aiming to delineate, by the utility of the biological data results, in our investigations the link between the purine and pyrimidine metabolism and development of the glioblastoma. We analyzed the sets of the ...We were aiming to delineate, by the utility of the biological data results, in our investigations the link between the purine and pyrimidine metabolism and development of the glioblastoma. We analyzed the sets of the genes, belonging to the purine and pyrimidine metabolism by the utility of GSEA software as well as MSIgnDB application of the GSEA. The GEO database, GEOR2 tools were serving for the visualization of the genes expression profiles of the disease. The Cancer Proteome Atlas as well as the tools of the data sets were also used to collect and analyze the results. We concluded and came to the following consequential results. 1) Neurogenesis and Glioblastoma are sharing some common genes. 2) Purine and pyrimidine metabolism-linked enzymes and genes are responsible for the upregulation of DNA and mRNA synthesis in the settings of the tumor development. 3) EGFR expression responsible genes, mRNA as well as protein is upregulated during the development of the glioblastoma. 4) GMPS genes are more strongly upregulated in the settings of the glioblastoma than ADSL. 5) PRPS1 is strongly synthetized in neurospheres in contrast to the mature tissue during glioblastoma development.展开更多
Recent developments in wireless communication and embedded computing technologies have led to the advent of wireless sensor network technology. Hundreds of thousands of these micro sensors can be deployed in many area...Recent developments in wireless communication and embedded computing technologies have led to the advent of wireless sensor network technology. Hundreds of thousands of these micro sensors can be deployed in many areas including health, environment and battlefield in order to monitor the domain with desired level of accuracy. When wireless sensors are deployed in an area, the lifetime of the network should last as long as possible according to the original amount of energy. Therefore, reducing energy consumption in WSNs is of primary concern. We have proposed a node scheduling solution that solves the coverage and connectivity problem in sensor networks in an integrated manner. In this way we will divide network life time to finite number of rounds and in each round we will generate a coverage bitmap of sensors of the domain and based on this bitmap it will decided which sensors remain active or go to sleep. We will check the connection of the sensor network by using Laplacian of adjancy graph of active nodes in each round. Also the network will be capable of producing desired percentage of coverage by using coverage bitmap. We will define the connected coverage problem as an optimization problem and we will seek a solution for the problem by using Genetic Algorithm optimization method.展开更多
The modeling of physical processes is an integral part of scientific and technical research. In this area, the Extendible C++ Application in Quantum Technologies (ECAQT) package provides the numerical simulations and ...The modeling of physical processes is an integral part of scientific and technical research. In this area, the Extendible C++ Application in Quantum Technologies (ECAQT) package provides the numerical simulations and modeling of complex quantum systems in the presence of decoherence with wide applications in photonics. It allows creating models of interacting complex systems and simulates their time evolution with a number of available time-evolution drivers. Physical simulations require massive amounts of calculations are often executed on distributed computing infrastructures. It is often difficult for non expert users to use such computational infrastructures or even to use advanced libraries over the infrastructures, because they often require being familiar with middleware and tools, parallel programming techniques and packages. The Parallel Grid Run-time and Application Development Environment (P-RADE) Grid Portal is a Grid portal solution that allows users to manage the whole life-cycle for executing a parallel application on the computing Grid infrastructures. The article describes the functionality and the structure of the web portal based on ECAQT package.展开更多
Finding out the desired drug combinations is a challenging task because of the number of different combinations that exist and the adversarial effects that may arise. In this work, we generate drug combinations over m...Finding out the desired drug combinations is a challenging task because of the number of different combinations that exist and the adversarial effects that may arise. In this work, we generate drug combinations over multiple stages using distance calculation metrics from supervised learning, clustering, and a statistical similarity calculation metric for deriving the optimal treatment sequences. The combination generation happens for each patient based on the characteristics (features) observed during each stage of treatment. Our approach considers not the drug-to-drug (one-to-one) effect, but rather the effect of group of drugs with another group of drugs. We evaluate the combinations using an FNN model and identify future improvement directions.展开更多
Purpose: The purpose of this study is to introduce a new concept and term into the scientometric discourse and research—scientometric implosion—and test the idea on the example of the Armenian journals. The article ...Purpose: The purpose of this study is to introduce a new concept and term into the scientometric discourse and research—scientometric implosion—and test the idea on the example of the Armenian journals. The article argues that the existence of a compressed scientific area in the country makes pressure on the journals and after some time this pressure makes one or several journals explode—break the limited national scientific area and move to the international arena. As soon as one of the local journals breaks through this compressed space and appears at an international level, further explosion happens, which makes the other journals follow the same path.Design/methodology/approach: Our research is based on three international scientific databases—WoS, Scopus, and RISC CC, from where we have retrieved information about the Armenian journals indexed there and citations received by those journals and one national database—the Armenian Science Citation Index. Armenian Journal Impact Factor(ArmJIF) was calculated for the local Armenian journals based on the general impact factor formula. Journals were classified according to Gl?nzel and Schubert(2003). Findings: Our results show that the science policy developed by the scientific authorities of Armenia and the introduction of ArmJIF have made the Armenian journals comply with international standards and resulted in some local journals to break the national scientific territory and be indexed in international scientific databases of RISC, Scopus, and WoS. Apart from complying with technical requirements, the journals start publishing articles also in foreign languages. Although nearly half of the local journals are in the fields of social sciences and humanities, only one journal from that field is indexed in international scientific databases. Research limitation: One of the limitations of the study is that it was performed on the example of only one state and the second one is that more time passage is needed to firmly evaluate the results. However, the introduction of the concept can inspire other similar case study. Practical implications: The new term and relevant model offered in the article can practically be used for the development of national journals.Originality/value: The article proposes a new term and a concept in scientometrics.展开更多
Purpose:Nearly 122 scientific journals are currently being published in Armenia-of which only six are indexed by WoS and/or Scopus databases.The majority of the national journals are published in the Armenian language...Purpose:Nearly 122 scientific journals are currently being published in Armenia-of which only six are indexed by WoS and/or Scopus databases.The majority of the national journals are published in the Armenian language,solely possessing abstracts written in English,although there are also English-language and multi-language journals with articles not only in Armenian but also in other foreign languages.The aim of this article is to study the visibility of the(non-indexed)national Armenian journals in the WoS database through citation analysis.In consideration of the existence of a relevant Armenian“diaspora”in the world,this article also attempts to estimate its impact in terms of citation statistics.Design/methodology/approach:For this end,we have identified citations to the national/domestic Armenian journals in the WoS database in comparison with the share of citations received from“diaspora”researchers(researchers of Armenian origin born in foreign countries and those originally from Armenia who have emigrated to foreign countries).Findings:Among the 116 Armenian domestic journals analyzed(not indexed by WoS),only 47 were found to be cited in WoS.Of these journals,almost 12%are citations by“diaspora”researchers,most of which concern Social Science and Humanities journals.Research limitations:Although the surnames of Armenians end with-i(y)an,sometimes,the Diaspora Armenians,surnames are changed or modified or they are not ending with-i(y)an,in this case we may fail to identify them.Practical implications:This study can help to build new,more deep and comprehensive relations with scientific diasporas.Originality/value:This study offers a new understanding of multifaced research collaboration with scientific diasporas and their role in internationalization of domestic journals.展开更多
A proper edge t-coloring of a graph G is a coloring of its edges with colors 1,2,???,t such that all colors are used, and no two adjacent edges receive the same color. A cyclically interval t-coloring of a graph G is ...A proper edge t-coloring of a graph G is a coloring of its edges with colors 1,2,???,t such that all colors are used, and no two adjacent edges receive the same color. A cyclically interval t-coloring of a graph G is a proper edge t-coloring of G such that for each its vertex x, either the set of colors used on edges incident to x or the set of colors not used on edges incident to x forms an interval of integers. For an arbitrary simple cycle, all possible values of t are found, for which the graph has a cyclically interval t-coloring.展开更多
The parallel scaling (parallel performance up to 48 cores) of NAMD package has been investigated by estimation of the sensitivity of interconnection on speedup and benchmark results—testing the parallel performance o...The parallel scaling (parallel performance up to 48 cores) of NAMD package has been investigated by estimation of the sensitivity of interconnection on speedup and benchmark results—testing the parallel performance of Myrinet, Infiniband and Gigabit Ethernet networks. The system of ApoA1 of 92 K atoms, as well as 1000 K, 330 K, 210 K, 110 K, 54 K, 27 K and 16 K has been used as testing systems. The Armenian grid infrastructure (ArmGrid) has been used as a main platform for series of benchmarks. According to the results, due to the high performance of Myrinet and Infiniband networks, the ArmCluster system and the cluster located in the Yerevan State University show reasonable values, meanwhile the scaling of clusters with various types of Gigabit Ethernet interconnections breaks down when interconnection is activated. However, the clusters equipped by Gigabit Ethernet network are sensitive to change of system, particularly for 1000 K systems no breakdown in scaling is observed. The infiniband supports in comparison with Myrinet, make it possible to receive almost ideally results regardless of system size. In addition, a benchmarking formula is suggested, which provides the computational throughput depending on the number of processors. These results should be important, for instance, to choose most appropriate amount of processors for studied system.展开更多
文摘We were aiming to delineate, by the utility of the biological data results, in our investigations the link between the purine and pyrimidine metabolism and development of the glioblastoma. We analyzed the sets of the genes, belonging to the purine and pyrimidine metabolism by the utility of GSEA software as well as MSIgnDB application of the GSEA. The GEO database, GEOR2 tools were serving for the visualization of the genes expression profiles of the disease. The Cancer Proteome Atlas as well as the tools of the data sets were also used to collect and analyze the results. We concluded and came to the following consequential results. 1) Neurogenesis and Glioblastoma are sharing some common genes. 2) Purine and pyrimidine metabolism-linked enzymes and genes are responsible for the upregulation of DNA and mRNA synthesis in the settings of the tumor development. 3) EGFR expression responsible genes, mRNA as well as protein is upregulated during the development of the glioblastoma. 4) GMPS genes are more strongly upregulated in the settings of the glioblastoma than ADSL. 5) PRPS1 is strongly synthetized in neurospheres in contrast to the mature tissue during glioblastoma development.
文摘Recent developments in wireless communication and embedded computing technologies have led to the advent of wireless sensor network technology. Hundreds of thousands of these micro sensors can be deployed in many areas including health, environment and battlefield in order to monitor the domain with desired level of accuracy. When wireless sensors are deployed in an area, the lifetime of the network should last as long as possible according to the original amount of energy. Therefore, reducing energy consumption in WSNs is of primary concern. We have proposed a node scheduling solution that solves the coverage and connectivity problem in sensor networks in an integrated manner. In this way we will divide network life time to finite number of rounds and in each round we will generate a coverage bitmap of sensors of the domain and based on this bitmap it will decided which sensors remain active or go to sleep. We will check the connection of the sensor network by using Laplacian of adjancy graph of active nodes in each round. Also the network will be capable of producing desired percentage of coverage by using coverage bitmap. We will define the connected coverage problem as an optimization problem and we will seek a solution for the problem by using Genetic Algorithm optimization method.
文摘The modeling of physical processes is an integral part of scientific and technical research. In this area, the Extendible C++ Application in Quantum Technologies (ECAQT) package provides the numerical simulations and modeling of complex quantum systems in the presence of decoherence with wide applications in photonics. It allows creating models of interacting complex systems and simulates their time evolution with a number of available time-evolution drivers. Physical simulations require massive amounts of calculations are often executed on distributed computing infrastructures. It is often difficult for non expert users to use such computational infrastructures or even to use advanced libraries over the infrastructures, because they often require being familiar with middleware and tools, parallel programming techniques and packages. The Parallel Grid Run-time and Application Development Environment (P-RADE) Grid Portal is a Grid portal solution that allows users to manage the whole life-cycle for executing a parallel application on the computing Grid infrastructures. The article describes the functionality and the structure of the web portal based on ECAQT package.
文摘Finding out the desired drug combinations is a challenging task because of the number of different combinations that exist and the adversarial effects that may arise. In this work, we generate drug combinations over multiple stages using distance calculation metrics from supervised learning, clustering, and a statistical similarity calculation metric for deriving the optimal treatment sequences. The combination generation happens for each patient based on the characteristics (features) observed during each stage of treatment. Our approach considers not the drug-to-drug (one-to-one) effect, but rather the effect of group of drugs with another group of drugs. We evaluate the combinations using an FNN model and identify future improvement directions.
文摘Purpose: The purpose of this study is to introduce a new concept and term into the scientometric discourse and research—scientometric implosion—and test the idea on the example of the Armenian journals. The article argues that the existence of a compressed scientific area in the country makes pressure on the journals and after some time this pressure makes one or several journals explode—break the limited national scientific area and move to the international arena. As soon as one of the local journals breaks through this compressed space and appears at an international level, further explosion happens, which makes the other journals follow the same path.Design/methodology/approach: Our research is based on three international scientific databases—WoS, Scopus, and RISC CC, from where we have retrieved information about the Armenian journals indexed there and citations received by those journals and one national database—the Armenian Science Citation Index. Armenian Journal Impact Factor(ArmJIF) was calculated for the local Armenian journals based on the general impact factor formula. Journals were classified according to Gl?nzel and Schubert(2003). Findings: Our results show that the science policy developed by the scientific authorities of Armenia and the introduction of ArmJIF have made the Armenian journals comply with international standards and resulted in some local journals to break the national scientific territory and be indexed in international scientific databases of RISC, Scopus, and WoS. Apart from complying with technical requirements, the journals start publishing articles also in foreign languages. Although nearly half of the local journals are in the fields of social sciences and humanities, only one journal from that field is indexed in international scientific databases. Research limitation: One of the limitations of the study is that it was performed on the example of only one state and the second one is that more time passage is needed to firmly evaluate the results. However, the introduction of the concept can inspire other similar case study. Practical implications: The new term and relevant model offered in the article can practically be used for the development of national journals.Originality/value: The article proposes a new term and a concept in scientometrics.
基金The work was supported by the Science Committee of RA,in the frames of the research project No.20TTCG-5I013.
文摘Purpose:Nearly 122 scientific journals are currently being published in Armenia-of which only six are indexed by WoS and/or Scopus databases.The majority of the national journals are published in the Armenian language,solely possessing abstracts written in English,although there are also English-language and multi-language journals with articles not only in Armenian but also in other foreign languages.The aim of this article is to study the visibility of the(non-indexed)national Armenian journals in the WoS database through citation analysis.In consideration of the existence of a relevant Armenian“diaspora”in the world,this article also attempts to estimate its impact in terms of citation statistics.Design/methodology/approach:For this end,we have identified citations to the national/domestic Armenian journals in the WoS database in comparison with the share of citations received from“diaspora”researchers(researchers of Armenian origin born in foreign countries and those originally from Armenia who have emigrated to foreign countries).Findings:Among the 116 Armenian domestic journals analyzed(not indexed by WoS),only 47 were found to be cited in WoS.Of these journals,almost 12%are citations by“diaspora”researchers,most of which concern Social Science and Humanities journals.Research limitations:Although the surnames of Armenians end with-i(y)an,sometimes,the Diaspora Armenians,surnames are changed or modified or they are not ending with-i(y)an,in this case we may fail to identify them.Practical implications:This study can help to build new,more deep and comprehensive relations with scientific diasporas.Originality/value:This study offers a new understanding of multifaced research collaboration with scientific diasporas and their role in internationalization of domestic journals.
文摘A proper edge t-coloring of a graph G is a coloring of its edges with colors 1,2,???,t such that all colors are used, and no two adjacent edges receive the same color. A cyclically interval t-coloring of a graph G is a proper edge t-coloring of G such that for each its vertex x, either the set of colors used on edges incident to x or the set of colors not used on edges incident to x forms an interval of integers. For an arbitrary simple cycle, all possible values of t are found, for which the graph has a cyclically interval t-coloring.
文摘The parallel scaling (parallel performance up to 48 cores) of NAMD package has been investigated by estimation of the sensitivity of interconnection on speedup and benchmark results—testing the parallel performance of Myrinet, Infiniband and Gigabit Ethernet networks. The system of ApoA1 of 92 K atoms, as well as 1000 K, 330 K, 210 K, 110 K, 54 K, 27 K and 16 K has been used as testing systems. The Armenian grid infrastructure (ArmGrid) has been used as a main platform for series of benchmarks. According to the results, due to the high performance of Myrinet and Infiniband networks, the ArmCluster system and the cluster located in the Yerevan State University show reasonable values, meanwhile the scaling of clusters with various types of Gigabit Ethernet interconnections breaks down when interconnection is activated. However, the clusters equipped by Gigabit Ethernet network are sensitive to change of system, particularly for 1000 K systems no breakdown in scaling is observed. The infiniband supports in comparison with Myrinet, make it possible to receive almost ideally results regardless of system size. In addition, a benchmarking formula is suggested, which provides the computational throughput depending on the number of processors. These results should be important, for instance, to choose most appropriate amount of processors for studied system.
