Toll and Toll-like receptors(TLRs)are pivotal components of the innate immune system,playing a crucial role in the early defense against invading pathogens.These receptors basically recognize microbial components and ...Toll and Toll-like receptors(TLRs)are pivotal components of the innate immune system,playing a crucial role in the early defense against invading pathogens.These receptors basically recognize microbial components and thus spread the presence of pathogens to the host and activate signaling pathways that lead to an appropriate immune response.Their discoveries and studies in the late 80s/early90s have initiated the understanding of how organisms detect and respond to microbial infections(Hoffmann et al.,1999;Medzhitov and Janeway,2000;Akira et al.,2006;Nusslein-Volhard,2021).展开更多
The host antimicrobial immune response relies on a complex interplay of molecular mechanisms to effectively combat microbial infections.Herein,we investigate the functional role of Cullin-3(Cul3),one critical constitu...The host antimicrobial immune response relies on a complex interplay of molecular mechanisms to effectively combat microbial infections.Herein,we investigate the functional role of Cullin-3(Cul3),one critical constituent of Cullin-RING ubiquitin ligases,in the Drosophila melanogaster(fruit fly)antimicrobial immune defense.Weshow that silencing of Cul3 leads to a decreased induction of antimicrobial peptides and high mortality in adult flies after bacterial infection.Through biochemical approaches,we demonstrate that Cul3 predominantly relies on its BTB-binding domain and neddylation domain to physically associate with death-associated inhibitor of apoptosis 2(Diap2).Importantly,Cul3 ameliorates the Diap2-mediated ubiquitination of death-related ced-3/Nedd2-like caspase(Dredd),a process essential for robust immune deficiency signaling upon bacterial infection.Taken together,our findings highlight a previously unrecognized regulatory axis of Cul3/Diap2/Dredd in the fly antimicrobial immune defense,providing potential insights into therapeutic strategies for combating bacterial infections in humans.展开更多
Four heavyweight vips in the field of public health gathered together.No-bel Laureate Jules A Hoffmann,Academician George Fu Gao,Professor Chris Walzer and Professor Jiahai Lu discussed how to deal with global publi...Four heavyweight vips in the field of public health gathered together.No-bel Laureate Jules A Hoffmann,Academician George Fu Gao,Professor Chris Walzer and Professor Jiahai Lu discussed how to deal with global public health crises,such as the recent coronavirus disease 2019(COVID-19)pandemic,as well as the role of international organizations.The concept of“One Health”emerged as the latest approach to disease prevention and control.This concept emphasizes the intertwined health of humans,animals and the environment.The experts shared their thoughts and insights on how humanity can address emerging global public health crises through international cooperation.展开更多
Scientific journals are platforms for communication between authors and readers,and also among readers and the wider public.To promote health science and related medical science fields,we are pleased to announce the l...Scientific journals are platforms for communication between authors and readers,and also among readers and the wider public.To promote health science and related medical science fields,we are pleased to announce the launch of a transdisciplinary journal named hLife,which combines the ideas of a healthier,happier and harmonious life together.hLife is a peer-reviewed,open-access monthly journal published online,sponsored by the Institute of Microbiology,Chinese Academy of Sciences,in cooperation with the Chinese Society of Biotechnology and the Shanghai Immune Therapy Institute.The editorial board consists of around 60 scientists from 12 countries or regions worldwide,among them two Nobel Laureates.Now,hLife is one of the“high starting point journals”of the Chinese Action Plan for Journal Excellence.展开更多
基金support has been provided by the University of Strasbourg Institute for Advanced Study(to J.A.H.)the International Science and Technology Innovation Cooperation between Governments for National Key R&D Program Projects(2023YFE0107700)。
文摘Toll and Toll-like receptors(TLRs)are pivotal components of the innate immune system,playing a crucial role in the early defense against invading pathogens.These receptors basically recognize microbial components and thus spread the presence of pathogens to the host and activate signaling pathways that lead to an appropriate immune response.Their discoveries and studies in the late 80s/early90s have initiated the understanding of how organisms detect and respond to microbial infections(Hoffmann et al.,1999;Medzhitov and Janeway,2000;Akira et al.,2006;Nusslein-Volhard,2021).
基金supported by grants from the National Natural Science Foundation of China(32100702).
文摘The host antimicrobial immune response relies on a complex interplay of molecular mechanisms to effectively combat microbial infections.Herein,we investigate the functional role of Cullin-3(Cul3),one critical constituent of Cullin-RING ubiquitin ligases,in the Drosophila melanogaster(fruit fly)antimicrobial immune defense.Weshow that silencing of Cul3 leads to a decreased induction of antimicrobial peptides and high mortality in adult flies after bacterial infection.Through biochemical approaches,we demonstrate that Cul3 predominantly relies on its BTB-binding domain and neddylation domain to physically associate with death-associated inhibitor of apoptosis 2(Diap2).Importantly,Cul3 ameliorates the Diap2-mediated ubiquitination of death-related ced-3/Nedd2-like caspase(Dredd),a process essential for robust immune deficiency signaling upon bacterial infection.Taken together,our findings highlight a previously unrecognized regulatory axis of Cul3/Diap2/Dredd in the fly antimicrobial immune defense,providing potential insights into therapeutic strategies for combating bacterial infections in humans.
文摘Four heavyweight vips in the field of public health gathered together.No-bel Laureate Jules A Hoffmann,Academician George Fu Gao,Professor Chris Walzer and Professor Jiahai Lu discussed how to deal with global public health crises,such as the recent coronavirus disease 2019(COVID-19)pandemic,as well as the role of international organizations.The concept of“One Health”emerged as the latest approach to disease prevention and control.This concept emphasizes the intertwined health of humans,animals and the environment.The experts shared their thoughts and insights on how humanity can address emerging global public health crises through international cooperation.
文摘Scientific journals are platforms for communication between authors and readers,and also among readers and the wider public.To promote health science and related medical science fields,we are pleased to announce the launch of a transdisciplinary journal named hLife,which combines the ideas of a healthier,happier and harmonious life together.hLife is a peer-reviewed,open-access monthly journal published online,sponsored by the Institute of Microbiology,Chinese Academy of Sciences,in cooperation with the Chinese Society of Biotechnology and the Shanghai Immune Therapy Institute.The editorial board consists of around 60 scientists from 12 countries or regions worldwide,among them two Nobel Laureates.Now,hLife is one of the“high starting point journals”of the Chinese Action Plan for Journal Excellence.
