Background:Minimally invasive surgeries are increasingly central to modern medicine,particularly in liver transplantation.These techniques,which offer reduced trauma,precise operations,minimal bleeding,and swift recov...Background:Minimally invasive surgeries are increasingly central to modern medicine,particularly in liver transplantation.These techniques,which offer reduced trauma,precise operations,minimal bleeding,and swift recovery,are,however,unevenly adopted across China.Only a limited number of centers routinely perform minimally invasive donor hepatectomies,indicating a significant imbalance in the development and application of these advanced procedures.Additionally,there lacks a set of standardized guidelines that are tailored to meet China’s unique healthcare challenges and conditions.Methods:In August 2023,the Branch of Organ Transplant of Chinese Medical Association and the Branch of Organ Transplant Physicians of Chinese Medical Doctor Association convened a group of national liver transplantation experts to establish a guideline development committee.This committee conducted a thorough review of relevant literature,evaluated existing guidelines and consensus,and assessed factors such as the evidence base,patient preferences,and the cost-effectiveness of interventions within China.After multiple rounds of discussions,both online and offline,the committee finalized the guidelines.Results:This collaborative effort led to the creation of the“Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation(2024 edition)”.These guidelines address crucial aspects such as the safety and advantages of minimally invasive surgery for living donor liver transplantation,donor selection criteria,anesthesia strategies,surgical technical details,and learning curves associated with these procedures,resulting in a comprehensive set of 26 recommendations.Conclusions:The formulation of these guidelines represents a significant advancement towards standardizing minimally invasive liver transplantation surgeries in China.They are designed to enhance outcomes for both donors and recipients by synthesizing expert consensus with contemporary research and clinical practices.Moreover,they serve as a crucial reference for surgeons and medical institutions,promoting the refinement and adoption of minimally invasive surgical techniques in liver transplantation.展开更多
Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway ...Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to disease.Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity.Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important biomarkers.The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and cancer.Clarification of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic.展开更多
基金supported by grants from National Key R&D Program of China(No.2022YFC2304705 to Jiayin Yang)National Natural Science Foundation of China(No.82270691 to Jiayin Yang)+2 种基金Sichuan Province Key Research and Development Project(Nos.2023YFS0026 and 23ZDYF2182 to Jiayin Yang)Chengdu Province Key Research and Development Project(No.2022YF0900009SN to Jiayin Yang)1.3.5 Project for Disciplines of Excellence from West China Hospital of Sichuan University(No.ZYGD24002 to Jiayin Yang).
文摘Background:Minimally invasive surgeries are increasingly central to modern medicine,particularly in liver transplantation.These techniques,which offer reduced trauma,precise operations,minimal bleeding,and swift recovery,are,however,unevenly adopted across China.Only a limited number of centers routinely perform minimally invasive donor hepatectomies,indicating a significant imbalance in the development and application of these advanced procedures.Additionally,there lacks a set of standardized guidelines that are tailored to meet China’s unique healthcare challenges and conditions.Methods:In August 2023,the Branch of Organ Transplant of Chinese Medical Association and the Branch of Organ Transplant Physicians of Chinese Medical Doctor Association convened a group of national liver transplantation experts to establish a guideline development committee.This committee conducted a thorough review of relevant literature,evaluated existing guidelines and consensus,and assessed factors such as the evidence base,patient preferences,and the cost-effectiveness of interventions within China.After multiple rounds of discussions,both online and offline,the committee finalized the guidelines.Results:This collaborative effort led to the creation of the“Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation(2024 edition)”.These guidelines address crucial aspects such as the safety and advantages of minimally invasive surgery for living donor liver transplantation,donor selection criteria,anesthesia strategies,surgical technical details,and learning curves associated with these procedures,resulting in a comprehensive set of 26 recommendations.Conclusions:The formulation of these guidelines represents a significant advancement towards standardizing minimally invasive liver transplantation surgeries in China.They are designed to enhance outcomes for both donors and recipients by synthesizing expert consensus with contemporary research and clinical practices.Moreover,they serve as a crucial reference for surgeons and medical institutions,promoting the refinement and adoption of minimally invasive surgical techniques in liver transplantation.
基金the National Natural Science Foundation of China(NSFC Grant No.81872021,32200462)Beijing Jiaotong University undergraduate innovation and entrepreneurship training project(No.220171097,220171072,220171037,220171088,220171104)+3 种基金R&D Program of Beijing Municipal Education Commission(Grant No.KM202110025004)Beijing Hospitals Authority Youth Programme(grant No.QML20231602)JH,KC and JMW were also funded in part by Federal funds from the National Cancer Institute,National Institutes of Health(under Contract No.HHSN261200800001E)the Intramural Research Programs of the NCI,CCR,and NIH.
文摘Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to disease.Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity.Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important biomarkers.The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and cancer.Clarification of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic.
