Exposure of the human body to the aerospace environment is capable of producing various physiological changes,which contributes to greater susceptibility of acquiring viral and/or bacterial infections.Objective:To rev...Exposure of the human body to the aerospace environment is capable of producing various physiological changes,which contributes to greater susceptibility of acquiring viral and/or bacterial infections.Objective:To review studies on the use of antimicrobials in space to provide up-to-date information on the treatment of infectious diseases and contribute to the safety and well-being of astronauts on space voyages.Method:Integrative literature review,using DeCS(https://decs.bvsalud.org/)and PubMed(https://pubmed.ncbi.nlm.nih.gov/).Results and Discussion:Prolonged exposure to microgravity,radiation,and confinement can potentially affect the dynamics of interactions between microorganisms and Homo sapiens,causing astronauts to be more susceptible to infections in the aerospace environment.This context becomes more complex when we consider the greater possibility of drug-resistant bacterial strains emerging-due to radiation-related mutations-and the conditions that affect antimicrobial stability,especially excessive vibrations,a carbon dioxide-rich atmosphere,and variations in humidity temperature fluctuations.Additionally,physiological changes experienced by humans in the extraterrestrial environment-e.g.,cardiovascular,respiratory,and renal-can alter the pharmacokinetics of antimicrobials.Conclusion:Understanding the context in which astronauts are inserted,the risks involved,and how to avoid theses is essential for ensuring the safety and continuity of space missions with regards to diseases and the use of antimicrobials,which will allow humanity in space to have a“long and prosperous life”.展开更多
Preparation and planning are critical when facing an epidemic or pandemic.Timely solutions must be incorporated in addition to existing guidelines in the case of a fast-spreading epidemic.Advances in space health have...Preparation and planning are critical when facing an epidemic or pandemic.Timely solutions must be incorporated in addition to existing guidelines in the case of a fast-spreading epidemic.Advances in space health have been driven by the need to preserve human health in an austere environment,in which medical assistance or resupply from the ground is not possible.This paper speculates on the similarities between human spaceflight and epidemics,extended to pandemics,identifying implementable solutions for immediate use by healthcare personnel and healthcare systems.We believe aerospace medical research can be seen as a resource to improve terrestrial medical care and the management of patients on Earth.展开更多
文摘Exposure of the human body to the aerospace environment is capable of producing various physiological changes,which contributes to greater susceptibility of acquiring viral and/or bacterial infections.Objective:To review studies on the use of antimicrobials in space to provide up-to-date information on the treatment of infectious diseases and contribute to the safety and well-being of astronauts on space voyages.Method:Integrative literature review,using DeCS(https://decs.bvsalud.org/)and PubMed(https://pubmed.ncbi.nlm.nih.gov/).Results and Discussion:Prolonged exposure to microgravity,radiation,and confinement can potentially affect the dynamics of interactions between microorganisms and Homo sapiens,causing astronauts to be more susceptible to infections in the aerospace environment.This context becomes more complex when we consider the greater possibility of drug-resistant bacterial strains emerging-due to radiation-related mutations-and the conditions that affect antimicrobial stability,especially excessive vibrations,a carbon dioxide-rich atmosphere,and variations in humidity temperature fluctuations.Additionally,physiological changes experienced by humans in the extraterrestrial environment-e.g.,cardiovascular,respiratory,and renal-can alter the pharmacokinetics of antimicrobials.Conclusion:Understanding the context in which astronauts are inserted,the risks involved,and how to avoid theses is essential for ensuring the safety and continuity of space missions with regards to diseases and the use of antimicrobials,which will allow humanity in space to have a“long and prosperous life”.
文摘Preparation and planning are critical when facing an epidemic or pandemic.Timely solutions must be incorporated in addition to existing guidelines in the case of a fast-spreading epidemic.Advances in space health have been driven by the need to preserve human health in an austere environment,in which medical assistance or resupply from the ground is not possible.This paper speculates on the similarities between human spaceflight and epidemics,extended to pandemics,identifying implementable solutions for immediate use by healthcare personnel and healthcare systems.We believe aerospace medical research can be seen as a resource to improve terrestrial medical care and the management of patients on Earth.
