It is a common observation that whenever patients arrives at the front desk of a hospital,outpatient clinic,or other health-associated centers,they have to first queue up in a line and wait to fill in their registrati...It is a common observation that whenever patients arrives at the front desk of a hospital,outpatient clinic,or other health-associated centers,they have to first queue up in a line and wait to fill in their registration form to get admitted.The long waiting time without any status updates is the most common complaint,concerning health officials.In this paper,UrNext,a location-aware mobile-based solution using Bluetooth low-energy(BLE)technology is presented to solve the problem.Recently,a technology-oriented method,the Internet of Things(IoT),has been gaining popularity in helping to solve some of the healthcare sector’s problems.The implementation of this solution could be illustrated through a simple example of when a patient arrives at a clinic for a consultation.Instead of having to wait in long lines,that patient will be greeted automatically,receive a push notification of an admittance along with an estimated waiting time for a consultation session.This will not only provide the patients with a sense of freedom but would also reduce the uncertainty levels that are generally observed,thus saving both time and money.This work aims to improve the clinics’quality of services,organize queues and minimize waiting times,leading to patients’comfort while reducing the burden on nurses and receptionists.The results demonstrate that the presented system is successful in its performance and helps achieves a plea-sant and conducive clinic visitation process with higher productivity.展开更多
Speech recognition systems have become a unique human-computer interaction(HCI)family.Speech is one of the most naturally developed human abilities;speech signal processing opens up a transparent and hand-free computa...Speech recognition systems have become a unique human-computer interaction(HCI)family.Speech is one of the most naturally developed human abilities;speech signal processing opens up a transparent and hand-free computation experience.This paper aims to present a retrospective yet modern approach to the world of speech recognition systems.The development journey of ASR(Automatic Speech Recognition)has seen quite a few milestones and breakthrough technologies that have been highlighted in this paper.A step-by-step rundown of the fundamental stages in developing speech recognition systems has been presented,along with a brief discussion of various modern-day developments and applications in this domain.This review paper aims to summarize and provide a beginning point for those starting in the vast field of speech signal processing.Since speech recognition has a vast potential in various industries like telecommunication,emotion recognition,healthcare,etc.,this review would be helpful to researchers who aim at exploring more applications that society can quickly adopt in future years of evolution.展开更多
Face liveness detection is essential for securing biometric authentication systems against spoofing attacks,including printed photos,replay videos,and 3D masks.This study systematically evaluates pre-trained CNN model...Face liveness detection is essential for securing biometric authentication systems against spoofing attacks,including printed photos,replay videos,and 3D masks.This study systematically evaluates pre-trained CNN models—DenseNet201,VGG16,InceptionV3,ResNet50,VGG19,MobileNetV2,Xception,and InceptionResNetV2—leveraging transfer learning and fine-tuning to enhance liveness detection performance.The models were trained and tested on NUAA and Replay-Attack datasets,with cross-dataset generalization validated on SiW-MV2 to assess real-world adaptability.Performance was evaluated using accuracy,precision,recall,FAR,FRR,HTER,and specialized spoof detection metrics(APCER,NPCER,ACER).Fine-tuning significantly improved detection accuracy,with DenseNet201 achieving the highest performance(98.5%on NUAA,97.71%on Replay-Attack),while MobileNetV2 proved the most efficient model for real-time applications(latency:15 ms,memory usage:45 MB,energy consumption:30 mJ).A statistical significance analysis(paired t-tests,confidence intervals)validated these improvements.Cross-dataset experiments identified DenseNet201 and MobileNetV2 as the most generalizable architectures,with DenseNet201 achieving 86.4%accuracy on Replay-Attack when trained on NUAA,demonstrating robust feature extraction and adaptability.In contrast,ResNet50 showed lower generalization capabilities,struggling with dataset variability and complex spoofing attacks.These findings suggest that MobileNetV2 is well-suited for low-power applications,while DenseNet201 is ideal for high-security environments requiring superior accuracy.This research provides a framework for improving real-time face liveness detection,enhancing biometric security,and guiding future advancements in AI-driven anti-spoofing techniques.展开更多
Background: Erythrodermic psoriasis (EP) is a rare, severe variant of psoriasis characterized by widespread erythema, scaling, and systemic complications. Despite advances in systemic treatments, the management of EP ...Background: Erythrodermic psoriasis (EP) is a rare, severe variant of psoriasis characterized by widespread erythema, scaling, and systemic complications. Despite advances in systemic treatments, the management of EP remains challenging, particularly in patients with comorbidities or contraindications to standard therapies. Objectives: To evaluate the effectiveness of ozonated water as an adjunctive treatment for EP, delivered using a patented robotic therapy system designed for hygiene and infection prevention in non-self-sufficient patients. Methods: We report the case of a 90-year-old male patient with acute EP who received daily skin treatments with ozonated water in conjunction with supportive care, including rehydration and antibiotics. The intervention was facilitated by the robotic system “COPERNICO Surveillance & Prevention,” which ensured standardized hygiene practices and clinical documentation. Results: Within one week of treatment, the patient showed complete desquamation of necrotic skin, resolution of erythema, and significant metabolic recovery. Fever subsided, renal function improved, and the patient was discharged in stable condition. Follow-up confirmed sustained clinical improvement, and no adverse events were reported. Conclusions: Ozonated water demonstrated efficacy in alleviating the dermatological and systemic manifestations of EP in a high-risk elderly patient. This case highlights the potential of ozone therapy as a safe, cost-effective adjunctive treatment for EP and underscores the utility of robotic systems in managing complex dermatological conditions. Further research is warranted to validate these findings in larger cohorts.展开更多
Adaptive robust secure framework plays a vital role in implementing intelligent automation and decentralized decision making of Industry 5.0.Latency,privacy risks and the complexity of industrial networks have been pr...Adaptive robust secure framework plays a vital role in implementing intelligent automation and decentralized decision making of Industry 5.0.Latency,privacy risks and the complexity of industrial networks have been preventing attempts at traditional cloud-based learning systems.We demonstrate that,to overcome these challenges,for instance,the EdgeGuard-IoT framework,a 6G edge intelligence framework enhancing cybersecurity and operational resilience of the smart grid,is needed on the edge to integrate Secure Federated Learning(SFL)and Adaptive Anomaly Detection(AAD).With ultra-reliable low latency communication(URLLC)of 6G,artificial intelligence-based network orchestration,and massive machine type communication(mMTC),EdgeGuard-IoT brings real-time,distributed intelligence on the edge,and mitigates risks in data transmission and enhances privacy.EdgeGuard-IoT,with a hierarchical federated learning framework,helps edge devices to collaboratively train models without revealing the sensitive grid data,which is crucial in the smart grid where real-time power anomaly detection and the decentralization of the energy management are a big deal.The hybrid AI models driven adaptive anomaly detection mechanism immediately raises the thumb if the grid stability and strength are negatively affected due to cyber threats,faults,and energy distribution,thereby keeping the grid stable with resilience.The proposed framework also adopts various security means within the blockchain and zero-trust authentication techniques to reduce the adversarial attack risks and model poisoning during federated learning.EdgeGuard-IoT shows superior detection accuracy,response time,and scalability performance at a much reduced communication overhead via extensive simulations and deployment in real-world case studies in smart grids.This research pioneers a 6G-driven federated intelligence model designed for secure,self-optimizing,and resilient Industry 5.0 ecosystems,paving the way for next-generation autonomous smart grids and industrial cyber-physical systems.展开更多
Parkinson’s disease(PD)is a progressive neurodegenerative disorder characterized by tremors,rigidity,and decreased movement.PD poses risks to individuals’lives and independence.Early detection of PD is essential bec...Parkinson’s disease(PD)is a progressive neurodegenerative disorder characterized by tremors,rigidity,and decreased movement.PD poses risks to individuals’lives and independence.Early detection of PD is essential because it allows timely intervention,which can slow disease progression and improve outcomes.Manual diagnosis of PD is problematic because it is difficult to capture the subtle patterns and changes that help diagnose PD.In addition,the subjectivity and lack of doctors compared to the number of patients constitute an obstacle to early diagnosis.Artificial intelligence(AI)techniques,especially deep and automated learning models,provide promising solutions to address deficiencies in manual diagnosis.This study develops robust systems for PD diagnosis by analyzing handwritten helical and wave graphical images.Handwritten graphic images of the PD dataset are enhanced using two overlapping filters,the average filter and the Laplacian filter,to improve image quality and highlight essential features.The enhanced images are segmented to isolate regions of interest(ROIs)from the rest of the image using a gradient vector flow(GVF)algorithm,which ensures that features are extracted from only relevant regions.The segmented ROIs are fed into convolutional neural network(CNN)models,namely DenseNet169,MobileNet,and VGG16,to extract fine and deep feature maps that capture complex patterns and representations relevant to PD diagnosis.Fine and deep feature maps extracted from individual CNN models are combined into fused feature vectors for DenseNet169-MobileNet,MobileNet-VGG16,DenseNet169-VGG16,and DenseNet169-MobileNet-VGG16 models.This fusion technique aims to combine complementary and robust features from several models,which improves the extracted features.Two feature selection algorithms are considered to remove redundancy and weak correlations within the combined feature set:Ant Colony Optimization(ACO)and Maximum Entropy Score-based Selection(MESbS).These algorithms identify and retain the most strongly correlated features while eliminating redundant and weakly correlated features,thus optimizing the features to improve system performance.The fused and enhanced feature vectors are fed into two powerful classifiers,XGBoost and random forest(RF),for accurate classification and differentiation between individuals with PD and healthy controls.The proposed hybrid systems show superior performance,where the RF classifier used the combined features from the DenseNet169-MobileNet-VGG16 models with the ACO feature selection method,achieving outstanding results:area under the curve(AUC)of 99%,sensitivity of 99.6%,99.3%accuracy,99.35%accuracy,and 99.65%specificity.展开更多
The implementation of Countermeasure Techniques(CTs)in the context of Network-On-Chip(NoC)based Multiprocessor System-On-Chip(MPSoC)routers against the Flooding Denial-of-Service Attack(F-DoSA)falls under Multi-Criter...The implementation of Countermeasure Techniques(CTs)in the context of Network-On-Chip(NoC)based Multiprocessor System-On-Chip(MPSoC)routers against the Flooding Denial-of-Service Attack(F-DoSA)falls under Multi-Criteria Decision-Making(MCDM)due to the three main concerns,called:traffic variations,multiple evaluation criteria-based traffic features,and prioritization NoC routers as an alternative.In this study,we propose a comprehensive evaluation of various NoC traffic features to identify the most efficient routers under the F-DoSA scenarios.Consequently,an MCDM approach is essential to address these emerging challenges.While the recent MCDM approach has some issues,such as uncertainty,this study utilizes Fuzzy-Weighted Zero-Inconsistency(FWZIC)to estimate the criteria weight values and Fuzzy Decision by Opinion Score Method(FDOSM)for ranking the routers with fuzzy Single-valued Neutrosophic under names(SvN-FWZIC and SvN-FDOSM)to overcome the ambiguity.The results obtained by using the SvN-FWZIC method indicate that the Max packet count has the highest importance among the evaluated criteria,with a weighted score of 0.1946.In contrast,the Hop count is identified as the least significant criterion,with a weighted score of 0.1090.The remaining criteria fall within a range of intermediate importance,with enqueue time scoring 0.1845,packet count decremented and traversal index scoring 0.1262,packet count incremented scoring 0.1124,and packet count index scoring 0.1472.In terms of ranking,SvN-FDOSM has two approaches:individual and group.Both the individual and group ranking processes show that(Router 4)is the most effective router,while(Router 3)is the lowest router under F-DoSA.The sensitivity analysis provides a high stability in ranking among all 10 scenarios.This approach offers essential feedback in making proper decisions in the design of countermeasure techniques in the domain of NoC-based MPSoC.展开更多
Software defect prediction plays a critical role in software development and quality assurance processes. Effective defect prediction enables testers to accurately prioritize testing efforts and enhance defect detecti...Software defect prediction plays a critical role in software development and quality assurance processes. Effective defect prediction enables testers to accurately prioritize testing efforts and enhance defect detection efficiency. Additionally, this technology provides developers with a means to quickly identify errors, thereby improving software robustness and overall quality. However, current research in software defect prediction often faces challenges, such as relying on a single data source or failing to adequately account for the characteristics of multiple coexisting data sources. This approach may overlook the differences and potential value of various data sources, affecting the accuracy and generalization performance of prediction results. To address this issue, this study proposes a multivariate heterogeneous hybrid deep learning algorithm for defect prediction (DP-MHHDL). Initially, Abstract Syntax Tree (AST), Code Dependency Network (CDN), and code static quality metrics are extracted from source code files and used as inputs to ensure data diversity. Subsequently, for the three types of heterogeneous data, the study employs a graph convolutional network optimization model based on adjacency and spatial topologies, a Convolutional Neural Network-Bidirectional Long Short-Term Memory (CNN-BiLSTM) hybrid neural network model, and a TabNet model to extract data features. These features are then concatenated and processed through a fully connected neural network for defect prediction. Finally, the proposed framework is evaluated using ten promise defect repository projects, and performance is assessed with three metrics: F1, Area under the curve (AUC), and Matthews correlation coefficient (MCC). The experimental results demonstrate that the proposed algorithm outperforms existing methods, offering a novel solution for software defect prediction.展开更多
A lightning arrester is used for electrical equipment protection against damage due to lightning strikes.One example of protected electrical equipment is electrical power transformer.If there is no lightning arrester ...A lightning arrester is used for electrical equipment protection against damage due to lightning strikes.One example of protected electrical equipment is electrical power transformer.If there is no lightning arrester installed to the transformer,when a lightning strike happens,it may receive a very high lightning overvoltage,which is certainly resulted in the transformer damage at its insulation.Usually,a lightning arrester specification data attached to a lightning arrester contains the rating data of the lightning arrester current and voltage.In the use of lightning arrester,the possibility of receiving multiple lightning strikes is not taken into account sometimes.In fact,in some places,the number of multiple strikes in short duration is quiet high in number.This condition makes the lightning arrester being stroked by multiple lightning strikes.Therefore,it may change the lightning arrester's properties,and then the arrester may not be able to provide good electrical equipment protection against lightning strike anymore.This condition will result in great loss to electrical companies and electrical consumers.Therefore,this research studied the effect of applying multiple lightning strikes to ZnO lightning arrester block.Every time a group of lightning impulse current is applied to the ZnO lightning arrester block,it is followed by the measuring of its 50 Hz voltage and current characteristic. The changing in the ZnO lightning arrester block 50 Hz characteristic then can be analyzed.It was found that by applying more numbers of lightning strikes which made the arrester becoming worse,even though,actually,the lightning impulse peak current was still under the rating of the lightning arrester current.In this case for a 5 kA,24 kV lightning arrester,even though the lightning impulse peak current flowing through the ZnO lightning arrester block was still 2500 A,the lightning arrester ZnO block had already been damaged.Having been damaged,an alternating current flowing through the damaged ZnO block was about 10000 times as much current flowing to the good one.The maximum of impulse energy absorbed by a ZnO block recorded was 334.7 J/cm^3.The damaged ZnO block should be replaced by a good one.展开更多
Nowadays, use of alternative and complementary therapies with mainstream medicine has gained the momentum. Aromatherapy is one of the complementary therapies which use essential oils as the major therapeutic agents to...Nowadays, use of alternative and complementary therapies with mainstream medicine has gained the momentum. Aromatherapy is one of the complementary therapies which use essential oils as the major therapeutic agents to treat several diseases. The essential or volatile oils are extracted from the flowers, barks, stem, leaves, roots, fruits and other parts of the plant by various methods. It came into existence after the scientists deciphered the antiseptic and skin permeability properties of essential oils. Inhalation, local application and baths are the major methods used in aromatherapy that utilize these oils to penetrate the human skin surface with marked aura. Once the oils are in the system, they remodulate themselves and work in a friendly manner at the site of malfunction or at the affected area. This type of therapy utilizes various permutation and combinations to get relief from numerous ailments like depression, indigestion, headache, insomnia, muscular pain, respiratory problems, skin ailments, swollen joints, urine associated complications etc. The essential oils are found to be more beneficial when other aspects of life and diet are given due consideration. This review explores the information available in the literature regarding therapeutic, medical, cosmetic, psychological, olfactory, massage aromatherapy, safety issues and different plants used in aromatherapy. All the available information was compiled from electronic databases such as Academic Journals, Ethnobotany, Google Scholar, PubM ed, Science Direct, Web of Science, and library search.展开更多
Nigella sativa(N.sativa)(Family Ranunculaceae)is a widely used medicinal plant throughout the world.It is very popular in various traditional systems of medicine like Unani and Tibb,Ayurveda and Siddha.Seeds and oil h...Nigella sativa(N.sativa)(Family Ranunculaceae)is a widely used medicinal plant throughout the world.It is very popular in various traditional systems of medicine like Unani and Tibb,Ayurveda and Siddha.Seeds and oil have a long history of folklore usage in various systems of medicines and food.The seeds of N.saliva have been widely used in the treatment of different diseases and ailments.In Islamic literature,it is considered as one of the greatest forms of healing medicine.It has been recommended for using on regular basis in Tibb-e-Nabwi(Prophetic Medicine).It has been widely used as antihypertensive,liver tonics,diuretics,digestive,anti-diarrheal,appetite stimulant,analgesics,anti-bacterial and in skin disorders.Extensive studies on N.sativa have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antidiabetic,anticancer,immunomodulator,analgesic,antimicrobial,anti-inflammatory,spasmolytic,bronchodilator,hepato-protective,renal protective,gaslro-prolective,antioxidant properties,etc.Due to its miraculous power of healing,N.sativa has got the place among the top ranked evidence based herbal medicines.This is also revealed that most of the therapeutic,properties of this plant are due to the presence of thymoquinone which is major bioactive component of the essential oil.The present review is an effort to provide a detailed survey of the literature on scientific researches of pharmacognostical characteristics,chemical composition and pharmacological activities of the seeds of this plant.展开更多
The K-means algorithm is one of the most popular techniques in clustering. Nevertheless, the performance of the Kmeans algorithm depends highly on initial cluster centers and converges to local minima. This paper prop...The K-means algorithm is one of the most popular techniques in clustering. Nevertheless, the performance of the Kmeans algorithm depends highly on initial cluster centers and converges to local minima. This paper proposes a hybrid evolutionary programming based clustering algorithm, called PSO-SA, by combining particle swarm optimization (PSO) and simulated annealing (SA). The basic idea is to search around the global solution by SA and to increase the information exchange among particles using a mutation operator to escape local optima. Three datasets, Iris, Wisconsin Breast Cancer, and Ripley's Glass, have been considered to show the effectiveness of the proposed clustering algorithm in providing optimal clusters. The simulation results show that the PSO-SA clustering algorithm not only has a better response but also converges more quickly than the K-means, PSO, and SA algorithms.展开更多
Edge devices in Internet of Things(IoT)applications can form peers to communicate in peer-to-peer(P2P)networks over P2P protocols.Using P2P networks ensures scalability and removes the need for centralized management....Edge devices in Internet of Things(IoT)applications can form peers to communicate in peer-to-peer(P2P)networks over P2P protocols.Using P2P networks ensures scalability and removes the need for centralized management.However,due to the open nature of P2P networks,they often suffer from the existence of malicious peers,especially malicious peers that unite in groups to raise each other’s ratings.This compromises users’safety and makes them lose their confidence about the files or services they are receiving.To address these challenges,we propose a neural networkbased algorithm,which uses the advantages of a machine learning algorithm to identify whether or not a peer is malicious.In this paper,a neural network(NN)was chosen as the machine learning algorithm due to its efficiency in classification.The experiments showed that the NNTrust algorithm is more effective and has a higher potential of reducing the number of invalid files and increasing success rates than other well-known trust management systems.展开更多
Objective: To evaluate the cardioprotective effect of Nigella sativa L.(N.sativa) in isoproterenol-induced myocardial infarction(MI).Methods: Groups were treated with different doses of ethanol extract of N.sativa(EEN...Objective: To evaluate the cardioprotective effect of Nigella sativa L.(N.sativa) in isoproterenol-induced myocardial infarction(MI).Methods: Groups were treated with different doses of ethanol extract of N.sativa(EENS)and N.sativa oil alone and along with enalapril for 28 days.MI was induced by subcutaneous administration of isoproterenol(85 mg/kg) in two consecutive doses.Levels of cardiac biomarkers and antioxidant enzymes such as creatine kinase–N-acetyl-L-cysteine, lactate dehydrogenase, aspartate aminotransferase, malondialdehyde, superoxide dismutase, reduced glutathione and catalase were evaluated along with gross histopathological examination.Results: Isoproterenol(85 mg/kg) induced MI by causing the significant(P < 0.01)reduction in the activity of cardiac biomarkers(creatine kinase–N-acetyl-L-cysteine,lactate dehydrogenase, aspartate aminotransferase) and antioxidant markers(superoxide dismutase, catalase, glutathione) along with significant(P < 0.01) increase in the level of malondialdehyde.Furthermore, histopathological evaluation also confirmed the isoproterenol-induced MI.Pretreatment with EENS(800 mg/kg) and combination of EENS(800 mg/kg) with enalapril(1 mg/kg) significantly(P < 0.01) prevented the development of these alteration and restored activity of cardiac biomarkers as well as antioxidant markers almost near to normal levels.Histopathological evaluation of cardiac tissue further confirmed the restoration of biochemical activity.Conclusions: Experimental findings thus indicate that EENS(800 mg/kg) demonstrated cardioprotective effect against isoproterenol-induced MI by restoring cardiac biomarkers and antioxidant status.展开更多
The entropy squeezing of an atom with a k-photon in the Jaynes Cummings model is investigated. For comparison, we also study the corresponding variance squeezing and atomic inversion. Analytical results show that entr...The entropy squeezing of an atom with a k-photon in the Jaynes Cummings model is investigated. For comparison, we also study the corresponding variance squeezing and atomic inversion. Analytical results show that entropy squeezing is preferable to variance squeezing for zero atomic inversion. Moreover, for initial conditions of the system the relation between squeezing and photon transition number is also discussed. This provides a theoretical approach to finding out the optimal entropy squeezing.展开更多
COVID-19,being the virus of fear and anxiety,is one of the most recent and emergent of various respiratory disorders.It is similar to the MERS-COV and SARS-COV,the viruses that affected a large population of different...COVID-19,being the virus of fear and anxiety,is one of the most recent and emergent of various respiratory disorders.It is similar to the MERS-COV and SARS-COV,the viruses that affected a large population of different countries in the year 2012 and 2002,respectively.Various standard models have been used for COVID-19 epidemic prediction but they suffered from low accuracy due to lesser data availability and a high level of uncertainty.The proposed approach used a machine learning-based time-series Facebook NeuralProphet model for prediction of the number of death as well as confirmed cases and compared it with Poisson Distribution,and Random Forest Model.The analysis upon dataset has been performed considering the time duration from January 1st 2020 to16th July 2021.The model has been developed to obtain the forecast values till September 2021.This study aimed to determine the pandemic prediction of COVID-19 in the second wave of coronavirus in India using the latest Time-Series model to observe and predict the coronavirus pandemic situation across the country.In India,the cases are rapidly increasing day-by-day since mid of Feb 2021.The prediction of death rate using the proposed model has a good ability to forecast the COVID-19 dataset essentially in the second wave.To empower the prediction for future validation,the proposed model works effectively.展开更多
Objective:To investigate the anxiolytic activity of newly isolated compound by our lab called ursolic acid stearoyl glucoside(UASG) from the leaves of Lantana camam(L camam).Methods: Column chromatography was used to ...Objective:To investigate the anxiolytic activity of newly isolated compound by our lab called ursolic acid stearoyl glucoside(UASG) from the leaves of Lantana camam(L camam).Methods: Column chromatography was used to isolate UASG.Anxiolytic potential was experimentally proved and demonstrated through Elevated plus-maze,Open field and light and dark test. Results:The UASG showed marked increased in time spent(%) and number of frequent movements made by animals in open arm of elevated plus-maze apparatus.In light and dark model,UASG produced marked increase in time spent by animal,number of crossing and reduced duration of immobility in light box.Conclusions:UASG showed significant increase in number of rearing,assisted rearing and number of square crossed in open field established test model.UASG showed its anxiolytic effect in dose dependent manner.展开更多
Objective:To carry out the physicochemical and phytochemical standardization with high performance thin layer chromatography fingerprinting of Piper nigrum L.(P.nigrum)fruits in order to ascertain the standard pharmac...Objective:To carry out the physicochemical and phytochemical standardization with high performance thin layer chromatography fingerprinting of Piper nigrum L.(P.nigrum)fruits in order to ascertain the standard pharmacognostical parameters of this king of spices.Methods:Many standardization parameters like extractive values,total ash value,water soluble ash value and acid insoluble ash,moisture content,loss on drying and pH values of P.nigrum L.fruits were analyzed.The method of Harborne was adopted for the preliminary phytochemicals screening.Analysis of total phenolic and flavonoid contents,pesticides residues,aflatoxin and heavy metals were also performed.CAMAG-high performance thin layer chromatography system was used for fingerprinting of methanolic extract of P.nigrum L.fruits.Results:The results of phytochemicals testing indicated the presence of carbohydrates,phenolic compounds,flavonoids,alkaloids,proteins,saponins,lipids,sterols and tannins in various solvent extracts.Total phenolic and flavonoid contents in methanolic extract were found to be 1.728 1 mg/g and 1.087 ug/g,respectively.Heavy metals concentrations were found to be within standard limits.Aflatoxins and pesticides residues were absent.Conclusions:The outcome of this study might prove beneficial in herbal industries for identification,purification and standardization of P.nigrum L.fruits.展开更多
Objective:To evaluate a novel polyherbal formulation(BSVT)containing the standardized extracts from the leaves of Boerhavia diffusa,Solidago virgaurea,Vitex negundo,and thymoquinone in CCl4 induced hepatorenal toxicit...Objective:To evaluate a novel polyherbal formulation(BSVT)containing the standardized extracts from the leaves of Boerhavia diffusa,Solidago virgaurea,Vitex negundo,and thymoquinone in CCl4 induced hepatorenal toxicity in rats.Methods:A total of 36 rats were divided into six groups including normal control,CCl4(2 mL/kg,i.p.),CCl4(2 mL/kg,i.p.)+Cystone?(750 mg/kg p.o.),CCl4(2 mL/kg,i.p.)+BSVT(25 mg/kg,p.o.),CCl4(2 mL/kg,i.p.)+BSVT(50 mg/kg,p.o.),and CCl4(2 mL/kg,i.p.)+BSVT(100 mg/kg,p.o.).All treatments were given for four weeks.Serum levels of aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,total protein,serum urea,blood urea nitrogen and creatinine were assessed.Superoxide dismutase,malondialdehyde,and glutathione peroxidase were evaluated in tissue homogenate.The histopathological study of liver and kidney tissues was also done.Results:Aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,serum urea,blood urea nitrogen and creatinine were significantly elevated(P<0.001)while total protein was considerably reduced in the CCl4 group as compared to the normal control(P<0.001),which indicated hepatorenal toxicity.In addition,superoxide dismutase and glutathione peroxidase activities were significantly decreased(P<0.001)while malondialdehyde levels were increased markedly(P<0.001).Treatment with BSVT formulation recovered these parameters towards a normal level in a dose-dependent manner.Conclusions:BSVT formulation ameliorates the hepatorenal toxicity in a dose-dependent manner.Furthermore,clinical studies are required to confirm its efficacy.展开更多
This paper stuides numerically the model equation in a one dimensional defective photonic lattice by modifying the potential function to a periodic function. It is found that defect modes （DMs） can be regarded as Bl...This paper stuides numerically the model equation in a one dimensional defective photonic lattice by modifying the potential function to a periodic function. It is found that defect modes （DMs） can be regarded as Bloch modes which are excited from the extended photonie band-gap structure at Bloch wave-numbers with kx = 0. The DMs for both positive and negative defects are considered in this method.展开更多
基金The author extends her appreciation to the Deanship of Scientific Research at King Saud University for funding this work through the Undergraduate Research Support Program,Project no.(URSP-3-18-89).
文摘It is a common observation that whenever patients arrives at the front desk of a hospital,outpatient clinic,or other health-associated centers,they have to first queue up in a line and wait to fill in their registration form to get admitted.The long waiting time without any status updates is the most common complaint,concerning health officials.In this paper,UrNext,a location-aware mobile-based solution using Bluetooth low-energy(BLE)technology is presented to solve the problem.Recently,a technology-oriented method,the Internet of Things(IoT),has been gaining popularity in helping to solve some of the healthcare sector’s problems.The implementation of this solution could be illustrated through a simple example of when a patient arrives at a clinic for a consultation.Instead of having to wait in long lines,that patient will be greeted automatically,receive a push notification of an admittance along with an estimated waiting time for a consultation session.This will not only provide the patients with a sense of freedom but would also reduce the uncertainty levels that are generally observed,thus saving both time and money.This work aims to improve the clinics’quality of services,organize queues and minimize waiting times,leading to patients’comfort while reducing the burden on nurses and receptionists.The results demonstrate that the presented system is successful in its performance and helps achieves a plea-sant and conducive clinic visitation process with higher productivity.
文摘Speech recognition systems have become a unique human-computer interaction(HCI)family.Speech is one of the most naturally developed human abilities;speech signal processing opens up a transparent and hand-free computation experience.This paper aims to present a retrospective yet modern approach to the world of speech recognition systems.The development journey of ASR(Automatic Speech Recognition)has seen quite a few milestones and breakthrough technologies that have been highlighted in this paper.A step-by-step rundown of the fundamental stages in developing speech recognition systems has been presented,along with a brief discussion of various modern-day developments and applications in this domain.This review paper aims to summarize and provide a beginning point for those starting in the vast field of speech signal processing.Since speech recognition has a vast potential in various industries like telecommunication,emotion recognition,healthcare,etc.,this review would be helpful to researchers who aim at exploring more applications that society can quickly adopt in future years of evolution.
基金funded by Centre for Advanced Modelling and Geospatial Information Systems(CAMGIS),Faculty of Engineering and IT,University of Technology Sydney.Moreover,Ongoing Research Funding Program(ORF-2025-14)King Saud University,Riyadh,Saudi Arabia,under Project ORF-2025-。
文摘Face liveness detection is essential for securing biometric authentication systems against spoofing attacks,including printed photos,replay videos,and 3D masks.This study systematically evaluates pre-trained CNN models—DenseNet201,VGG16,InceptionV3,ResNet50,VGG19,MobileNetV2,Xception,and InceptionResNetV2—leveraging transfer learning and fine-tuning to enhance liveness detection performance.The models were trained and tested on NUAA and Replay-Attack datasets,with cross-dataset generalization validated on SiW-MV2 to assess real-world adaptability.Performance was evaluated using accuracy,precision,recall,FAR,FRR,HTER,and specialized spoof detection metrics(APCER,NPCER,ACER).Fine-tuning significantly improved detection accuracy,with DenseNet201 achieving the highest performance(98.5%on NUAA,97.71%on Replay-Attack),while MobileNetV2 proved the most efficient model for real-time applications(latency:15 ms,memory usage:45 MB,energy consumption:30 mJ).A statistical significance analysis(paired t-tests,confidence intervals)validated these improvements.Cross-dataset experiments identified DenseNet201 and MobileNetV2 as the most generalizable architectures,with DenseNet201 achieving 86.4%accuracy on Replay-Attack when trained on NUAA,demonstrating robust feature extraction and adaptability.In contrast,ResNet50 showed lower generalization capabilities,struggling with dataset variability and complex spoofing attacks.These findings suggest that MobileNetV2 is well-suited for low-power applications,while DenseNet201 is ideal for high-security environments requiring superior accuracy.This research provides a framework for improving real-time face liveness detection,enhancing biometric security,and guiding future advancements in AI-driven anti-spoofing techniques.
文摘Background: Erythrodermic psoriasis (EP) is a rare, severe variant of psoriasis characterized by widespread erythema, scaling, and systemic complications. Despite advances in systemic treatments, the management of EP remains challenging, particularly in patients with comorbidities or contraindications to standard therapies. Objectives: To evaluate the effectiveness of ozonated water as an adjunctive treatment for EP, delivered using a patented robotic therapy system designed for hygiene and infection prevention in non-self-sufficient patients. Methods: We report the case of a 90-year-old male patient with acute EP who received daily skin treatments with ozonated water in conjunction with supportive care, including rehydration and antibiotics. The intervention was facilitated by the robotic system “COPERNICO Surveillance & Prevention,” which ensured standardized hygiene practices and clinical documentation. Results: Within one week of treatment, the patient showed complete desquamation of necrotic skin, resolution of erythema, and significant metabolic recovery. Fever subsided, renal function improved, and the patient was discharged in stable condition. Follow-up confirmed sustained clinical improvement, and no adverse events were reported. Conclusions: Ozonated water demonstrated efficacy in alleviating the dermatological and systemic manifestations of EP in a high-risk elderly patient. This case highlights the potential of ozone therapy as a safe, cost-effective adjunctive treatment for EP and underscores the utility of robotic systems in managing complex dermatological conditions. Further research is warranted to validate these findings in larger cohorts.
基金supported by Department of Information Technology,University of Tabuk,Tabuk,71491,Saudi Arabia.
文摘Adaptive robust secure framework plays a vital role in implementing intelligent automation and decentralized decision making of Industry 5.0.Latency,privacy risks and the complexity of industrial networks have been preventing attempts at traditional cloud-based learning systems.We demonstrate that,to overcome these challenges,for instance,the EdgeGuard-IoT framework,a 6G edge intelligence framework enhancing cybersecurity and operational resilience of the smart grid,is needed on the edge to integrate Secure Federated Learning(SFL)and Adaptive Anomaly Detection(AAD).With ultra-reliable low latency communication(URLLC)of 6G,artificial intelligence-based network orchestration,and massive machine type communication(mMTC),EdgeGuard-IoT brings real-time,distributed intelligence on the edge,and mitigates risks in data transmission and enhances privacy.EdgeGuard-IoT,with a hierarchical federated learning framework,helps edge devices to collaboratively train models without revealing the sensitive grid data,which is crucial in the smart grid where real-time power anomaly detection and the decentralization of the energy management are a big deal.The hybrid AI models driven adaptive anomaly detection mechanism immediately raises the thumb if the grid stability and strength are negatively affected due to cyber threats,faults,and energy distribution,thereby keeping the grid stable with resilience.The proposed framework also adopts various security means within the blockchain and zero-trust authentication techniques to reduce the adversarial attack risks and model poisoning during federated learning.EdgeGuard-IoT shows superior detection accuracy,response time,and scalability performance at a much reduced communication overhead via extensive simulations and deployment in real-world case studies in smart grids.This research pioneers a 6G-driven federated intelligence model designed for secure,self-optimizing,and resilient Industry 5.0 ecosystems,paving the way for next-generation autonomous smart grids and industrial cyber-physical systems.
文摘Parkinson’s disease(PD)is a progressive neurodegenerative disorder characterized by tremors,rigidity,and decreased movement.PD poses risks to individuals’lives and independence.Early detection of PD is essential because it allows timely intervention,which can slow disease progression and improve outcomes.Manual diagnosis of PD is problematic because it is difficult to capture the subtle patterns and changes that help diagnose PD.In addition,the subjectivity and lack of doctors compared to the number of patients constitute an obstacle to early diagnosis.Artificial intelligence(AI)techniques,especially deep and automated learning models,provide promising solutions to address deficiencies in manual diagnosis.This study develops robust systems for PD diagnosis by analyzing handwritten helical and wave graphical images.Handwritten graphic images of the PD dataset are enhanced using two overlapping filters,the average filter and the Laplacian filter,to improve image quality and highlight essential features.The enhanced images are segmented to isolate regions of interest(ROIs)from the rest of the image using a gradient vector flow(GVF)algorithm,which ensures that features are extracted from only relevant regions.The segmented ROIs are fed into convolutional neural network(CNN)models,namely DenseNet169,MobileNet,and VGG16,to extract fine and deep feature maps that capture complex patterns and representations relevant to PD diagnosis.Fine and deep feature maps extracted from individual CNN models are combined into fused feature vectors for DenseNet169-MobileNet,MobileNet-VGG16,DenseNet169-VGG16,and DenseNet169-MobileNet-VGG16 models.This fusion technique aims to combine complementary and robust features from several models,which improves the extracted features.Two feature selection algorithms are considered to remove redundancy and weak correlations within the combined feature set:Ant Colony Optimization(ACO)and Maximum Entropy Score-based Selection(MESbS).These algorithms identify and retain the most strongly correlated features while eliminating redundant and weakly correlated features,thus optimizing the features to improve system performance.The fused and enhanced feature vectors are fed into two powerful classifiers,XGBoost and random forest(RF),for accurate classification and differentiation between individuals with PD and healthy controls.The proposed hybrid systems show superior performance,where the RF classifier used the combined features from the DenseNet169-MobileNet-VGG16 models with the ACO feature selection method,achieving outstanding results:area under the curve(AUC)of 99%,sensitivity of 99.6%,99.3%accuracy,99.35%accuracy,and 99.65%specificity.
文摘The implementation of Countermeasure Techniques(CTs)in the context of Network-On-Chip(NoC)based Multiprocessor System-On-Chip(MPSoC)routers against the Flooding Denial-of-Service Attack(F-DoSA)falls under Multi-Criteria Decision-Making(MCDM)due to the three main concerns,called:traffic variations,multiple evaluation criteria-based traffic features,and prioritization NoC routers as an alternative.In this study,we propose a comprehensive evaluation of various NoC traffic features to identify the most efficient routers under the F-DoSA scenarios.Consequently,an MCDM approach is essential to address these emerging challenges.While the recent MCDM approach has some issues,such as uncertainty,this study utilizes Fuzzy-Weighted Zero-Inconsistency(FWZIC)to estimate the criteria weight values and Fuzzy Decision by Opinion Score Method(FDOSM)for ranking the routers with fuzzy Single-valued Neutrosophic under names(SvN-FWZIC and SvN-FDOSM)to overcome the ambiguity.The results obtained by using the SvN-FWZIC method indicate that the Max packet count has the highest importance among the evaluated criteria,with a weighted score of 0.1946.In contrast,the Hop count is identified as the least significant criterion,with a weighted score of 0.1090.The remaining criteria fall within a range of intermediate importance,with enqueue time scoring 0.1845,packet count decremented and traversal index scoring 0.1262,packet count incremented scoring 0.1124,and packet count index scoring 0.1472.In terms of ranking,SvN-FDOSM has two approaches:individual and group.Both the individual and group ranking processes show that(Router 4)is the most effective router,while(Router 3)is the lowest router under F-DoSA.The sensitivity analysis provides a high stability in ranking among all 10 scenarios.This approach offers essential feedback in making proper decisions in the design of countermeasure techniques in the domain of NoC-based MPSoC.
文摘Software defect prediction plays a critical role in software development and quality assurance processes. Effective defect prediction enables testers to accurately prioritize testing efforts and enhance defect detection efficiency. Additionally, this technology provides developers with a means to quickly identify errors, thereby improving software robustness and overall quality. However, current research in software defect prediction often faces challenges, such as relying on a single data source or failing to adequately account for the characteristics of multiple coexisting data sources. This approach may overlook the differences and potential value of various data sources, affecting the accuracy and generalization performance of prediction results. To address this issue, this study proposes a multivariate heterogeneous hybrid deep learning algorithm for defect prediction (DP-MHHDL). Initially, Abstract Syntax Tree (AST), Code Dependency Network (CDN), and code static quality metrics are extracted from source code files and used as inputs to ensure data diversity. Subsequently, for the three types of heterogeneous data, the study employs a graph convolutional network optimization model based on adjacency and spatial topologies, a Convolutional Neural Network-Bidirectional Long Short-Term Memory (CNN-BiLSTM) hybrid neural network model, and a TabNet model to extract data features. These features are then concatenated and processed through a fully connected neural network for defect prediction. Finally, the proposed framework is evaluated using ten promise defect repository projects, and performance is assessed with three metrics: F1, Area under the curve (AUC), and Matthews correlation coefficient (MCC). The experimental results demonstrate that the proposed algorithm outperforms existing methods, offering a novel solution for software defect prediction.
文摘A lightning arrester is used for electrical equipment protection against damage due to lightning strikes.One example of protected electrical equipment is electrical power transformer.If there is no lightning arrester installed to the transformer,when a lightning strike happens,it may receive a very high lightning overvoltage,which is certainly resulted in the transformer damage at its insulation.Usually,a lightning arrester specification data attached to a lightning arrester contains the rating data of the lightning arrester current and voltage.In the use of lightning arrester,the possibility of receiving multiple lightning strikes is not taken into account sometimes.In fact,in some places,the number of multiple strikes in short duration is quiet high in number.This condition makes the lightning arrester being stroked by multiple lightning strikes.Therefore,it may change the lightning arrester's properties,and then the arrester may not be able to provide good electrical equipment protection against lightning strike anymore.This condition will result in great loss to electrical companies and electrical consumers.Therefore,this research studied the effect of applying multiple lightning strikes to ZnO lightning arrester block.Every time a group of lightning impulse current is applied to the ZnO lightning arrester block,it is followed by the measuring of its 50 Hz voltage and current characteristic. The changing in the ZnO lightning arrester block 50 Hz characteristic then can be analyzed.It was found that by applying more numbers of lightning strikes which made the arrester becoming worse,even though,actually,the lightning impulse peak current was still under the rating of the lightning arrester current.In this case for a 5 kA,24 kV lightning arrester,even though the lightning impulse peak current flowing through the ZnO lightning arrester block was still 2500 A,the lightning arrester ZnO block had already been damaged.Having been damaged,an alternating current flowing through the damaged ZnO block was about 10000 times as much current flowing to the good one.The maximum of impulse energy absorbed by a ZnO block recorded was 334.7 J/cm^3.The damaged ZnO block should be replaced by a good one.
基金Funded by the Deanship of Scientific Research,King Abdulaziz University,Jeddah under grant number(G-1436-156-590)
文摘Nowadays, use of alternative and complementary therapies with mainstream medicine has gained the momentum. Aromatherapy is one of the complementary therapies which use essential oils as the major therapeutic agents to treat several diseases. The essential or volatile oils are extracted from the flowers, barks, stem, leaves, roots, fruits and other parts of the plant by various methods. It came into existence after the scientists deciphered the antiseptic and skin permeability properties of essential oils. Inhalation, local application and baths are the major methods used in aromatherapy that utilize these oils to penetrate the human skin surface with marked aura. Once the oils are in the system, they remodulate themselves and work in a friendly manner at the site of malfunction or at the affected area. This type of therapy utilizes various permutation and combinations to get relief from numerous ailments like depression, indigestion, headache, insomnia, muscular pain, respiratory problems, skin ailments, swollen joints, urine associated complications etc. The essential oils are found to be more beneficial when other aspects of life and diet are given due consideration. This review explores the information available in the literature regarding therapeutic, medical, cosmetic, psychological, olfactory, massage aromatherapy, safety issues and different plants used in aromatherapy. All the available information was compiled from electronic databases such as Academic Journals, Ethnobotany, Google Scholar, PubM ed, Science Direct, Web of Science, and library search.
基金Supported by Deanship of Scientific Research,King Abdulaziz University,Jeddah,Saudi Arabia(Grant No.431-044)
文摘Nigella sativa(N.sativa)(Family Ranunculaceae)is a widely used medicinal plant throughout the world.It is very popular in various traditional systems of medicine like Unani and Tibb,Ayurveda and Siddha.Seeds and oil have a long history of folklore usage in various systems of medicines and food.The seeds of N.saliva have been widely used in the treatment of different diseases and ailments.In Islamic literature,it is considered as one of the greatest forms of healing medicine.It has been recommended for using on regular basis in Tibb-e-Nabwi(Prophetic Medicine).It has been widely used as antihypertensive,liver tonics,diuretics,digestive,anti-diarrheal,appetite stimulant,analgesics,anti-bacterial and in skin disorders.Extensive studies on N.sativa have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antidiabetic,anticancer,immunomodulator,analgesic,antimicrobial,anti-inflammatory,spasmolytic,bronchodilator,hepato-protective,renal protective,gaslro-prolective,antioxidant properties,etc.Due to its miraculous power of healing,N.sativa has got the place among the top ranked evidence based herbal medicines.This is also revealed that most of the therapeutic,properties of this plant are due to the presence of thymoquinone which is major bioactive component of the essential oil.The present review is an effort to provide a detailed survey of the literature on scientific researches of pharmacognostical characteristics,chemical composition and pharmacological activities of the seeds of this plant.
文摘The K-means algorithm is one of the most popular techniques in clustering. Nevertheless, the performance of the Kmeans algorithm depends highly on initial cluster centers and converges to local minima. This paper proposes a hybrid evolutionary programming based clustering algorithm, called PSO-SA, by combining particle swarm optimization (PSO) and simulated annealing (SA). The basic idea is to search around the global solution by SA and to increase the information exchange among particles using a mutation operator to escape local optima. Three datasets, Iris, Wisconsin Breast Cancer, and Ripley's Glass, have been considered to show the effectiveness of the proposed clustering algorithm in providing optimal clusters. The simulation results show that the PSO-SA clustering algorithm not only has a better response but also converges more quickly than the K-means, PSO, and SA algorithms.
文摘Edge devices in Internet of Things(IoT)applications can form peers to communicate in peer-to-peer(P2P)networks over P2P protocols.Using P2P networks ensures scalability and removes the need for centralized management.However,due to the open nature of P2P networks,they often suffer from the existence of malicious peers,especially malicious peers that unite in groups to raise each other’s ratings.This compromises users’safety and makes them lose their confidence about the files or services they are receiving.To address these challenges,we propose a neural networkbased algorithm,which uses the advantages of a machine learning algorithm to identify whether or not a peer is malicious.In this paper,a neural network(NN)was chosen as the machine learning algorithm due to its efficiency in classification.The experiments showed that the NNTrust algorithm is more effective and has a higher potential of reducing the number of invalid files and increasing success rates than other well-known trust management systems.
基金the University Grants Commission,New Delhi (Grant No.7-268/2009 BSR) for fellowship
文摘Objective: To evaluate the cardioprotective effect of Nigella sativa L.(N.sativa) in isoproterenol-induced myocardial infarction(MI).Methods: Groups were treated with different doses of ethanol extract of N.sativa(EENS)and N.sativa oil alone and along with enalapril for 28 days.MI was induced by subcutaneous administration of isoproterenol(85 mg/kg) in two consecutive doses.Levels of cardiac biomarkers and antioxidant enzymes such as creatine kinase–N-acetyl-L-cysteine, lactate dehydrogenase, aspartate aminotransferase, malondialdehyde, superoxide dismutase, reduced glutathione and catalase were evaluated along with gross histopathological examination.Results: Isoproterenol(85 mg/kg) induced MI by causing the significant(P < 0.01)reduction in the activity of cardiac biomarkers(creatine kinase–N-acetyl-L-cysteine,lactate dehydrogenase, aspartate aminotransferase) and antioxidant markers(superoxide dismutase, catalase, glutathione) along with significant(P < 0.01) increase in the level of malondialdehyde.Furthermore, histopathological evaluation also confirmed the isoproterenol-induced MI.Pretreatment with EENS(800 mg/kg) and combination of EENS(800 mg/kg) with enalapril(1 mg/kg) significantly(P < 0.01) prevented the development of these alteration and restored activity of cardiac biomarkers as well as antioxidant markers almost near to normal levels.Histopathological evaluation of cardiac tissue further confirmed the restoration of biochemical activity.Conclusions: Experimental findings thus indicate that EENS(800 mg/kg) demonstrated cardioprotective effect against isoproterenol-induced MI by restoring cardiac biomarkers and antioxidant status.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 10674038 and 10604042)the National Basic Research Program of China (Grant No. 2006CB302901)
文摘The entropy squeezing of an atom with a k-photon in the Jaynes Cummings model is investigated. For comparison, we also study the corresponding variance squeezing and atomic inversion. Analytical results show that entropy squeezing is preferable to variance squeezing for zero atomic inversion. Moreover, for initial conditions of the system the relation between squeezing and photon transition number is also discussed. This provides a theoretical approach to finding out the optimal entropy squeezing.
基金This work was supported by the Taif University Researchers supporting Project Number(TURSP-2020/254).
文摘COVID-19,being the virus of fear and anxiety,is one of the most recent and emergent of various respiratory disorders.It is similar to the MERS-COV and SARS-COV,the viruses that affected a large population of different countries in the year 2012 and 2002,respectively.Various standard models have been used for COVID-19 epidemic prediction but they suffered from low accuracy due to lesser data availability and a high level of uncertainty.The proposed approach used a machine learning-based time-series Facebook NeuralProphet model for prediction of the number of death as well as confirmed cases and compared it with Poisson Distribution,and Random Forest Model.The analysis upon dataset has been performed considering the time duration from January 1st 2020 to16th July 2021.The model has been developed to obtain the forecast values till September 2021.This study aimed to determine the pandemic prediction of COVID-19 in the second wave of coronavirus in India using the latest Time-Series model to observe and predict the coronavirus pandemic situation across the country.In India,the cases are rapidly increasing day-by-day since mid of Feb 2021.The prediction of death rate using the proposed model has a good ability to forecast the COVID-19 dataset essentially in the second wave.To empower the prediction for future validation,the proposed model works effectively.
文摘Objective:To investigate the anxiolytic activity of newly isolated compound by our lab called ursolic acid stearoyl glucoside(UASG) from the leaves of Lantana camam(L camam).Methods: Column chromatography was used to isolate UASG.Anxiolytic potential was experimentally proved and demonstrated through Elevated plus-maze,Open field and light and dark test. Results:The UASG showed marked increased in time spent(%) and number of frequent movements made by animals in open arm of elevated plus-maze apparatus.In light and dark model,UASG produced marked increase in time spent by animal,number of crossing and reduced duration of immobility in light box.Conclusions:UASG showed significant increase in number of rearing,assisted rearing and number of square crossed in open field established test model.UASG showed its anxiolytic effect in dose dependent manner.
基金Supported by AYUSH.Ministry of Health and Family Welfare.Government of India[Grant No.CCRUM-UPC-Ⅱ(3-15/2009.CCRUM/UPC)]
文摘Objective:To carry out the physicochemical and phytochemical standardization with high performance thin layer chromatography fingerprinting of Piper nigrum L.(P.nigrum)fruits in order to ascertain the standard pharmacognostical parameters of this king of spices.Methods:Many standardization parameters like extractive values,total ash value,water soluble ash value and acid insoluble ash,moisture content,loss on drying and pH values of P.nigrum L.fruits were analyzed.The method of Harborne was adopted for the preliminary phytochemicals screening.Analysis of total phenolic and flavonoid contents,pesticides residues,aflatoxin and heavy metals were also performed.CAMAG-high performance thin layer chromatography system was used for fingerprinting of methanolic extract of P.nigrum L.fruits.Results:The results of phytochemicals testing indicated the presence of carbohydrates,phenolic compounds,flavonoids,alkaloids,proteins,saponins,lipids,sterols and tannins in various solvent extracts.Total phenolic and flavonoid contents in methanolic extract were found to be 1.728 1 mg/g and 1.087 ug/g,respectively.Heavy metals concentrations were found to be within standard limits.Aflatoxins and pesticides residues were absent.Conclusions:The outcome of this study might prove beneficial in herbal industries for identification,purification and standardization of P.nigrum L.fruits.
基金funded by the Deanship of Scientific Research(DSR),King Abdulaziz University,Jeddah,under grant no.(G-567-156-1439).
文摘Objective:To evaluate a novel polyherbal formulation(BSVT)containing the standardized extracts from the leaves of Boerhavia diffusa,Solidago virgaurea,Vitex negundo,and thymoquinone in CCl4 induced hepatorenal toxicity in rats.Methods:A total of 36 rats were divided into six groups including normal control,CCl4(2 mL/kg,i.p.),CCl4(2 mL/kg,i.p.)+Cystone?(750 mg/kg p.o.),CCl4(2 mL/kg,i.p.)+BSVT(25 mg/kg,p.o.),CCl4(2 mL/kg,i.p.)+BSVT(50 mg/kg,p.o.),and CCl4(2 mL/kg,i.p.)+BSVT(100 mg/kg,p.o.).All treatments were given for four weeks.Serum levels of aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,total protein,serum urea,blood urea nitrogen and creatinine were assessed.Superoxide dismutase,malondialdehyde,and glutathione peroxidase were evaluated in tissue homogenate.The histopathological study of liver and kidney tissues was also done.Results:Aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,serum urea,blood urea nitrogen and creatinine were significantly elevated(P<0.001)while total protein was considerably reduced in the CCl4 group as compared to the normal control(P<0.001),which indicated hepatorenal toxicity.In addition,superoxide dismutase and glutathione peroxidase activities were significantly decreased(P<0.001)while malondialdehyde levels were increased markedly(P<0.001).Treatment with BSVT formulation recovered these parameters towards a normal level in a dose-dependent manner.Conclusions:BSVT formulation ameliorates the hepatorenal toxicity in a dose-dependent manner.Furthermore,clinical studies are required to confirm its efficacy.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 10674038 and 10604042)the National Basic Research Program of China (Grant No. 2006CB302901)
文摘This paper stuides numerically the model equation in a one dimensional defective photonic lattice by modifying the potential function to a periodic function. It is found that defect modes （DMs） can be regarded as Bloch modes which are excited from the extended photonie band-gap structure at Bloch wave-numbers with kx = 0. The DMs for both positive and negative defects are considered in this method.
