Previous studies have demonstrated that hand shadows may activate the motor cortex associated with the mirror neuron system in human brain. However, there is no evidence of activity of the human mirror neuron system d...Previous studies have demonstrated that hand shadows may activate the motor cortex associated with the mirror neuron system in human brain. However, there is no evidence of activity of the human mirror neuron system during the observation of intransitive movements by shadows and line drawings of hands. This study examined the suppression of electroencephalography mu waves （8-13 Hz） induced by observation of stimuli in 18 healthy students. Three stimuli were used： real hand actions, hand shadow actions and actions made by line drawings of hands. The results showed significant desynchronization of the mu rhythm （＂mu suppression＂） across the sensodmotor cortex （recorded at C3, Cz and C4）, the frontal cortex （recorded at F3, Fz and F4） and the central and right posterior parietal cortex （recorded at Pz and P4） under all three conditions. Our experimental findings suggest that the observation of ＂impoverished hand actions＂, such as intransitive movements of shadows and line drawings of hands, is able to activate widespread cortical areas related to the putative human mirror neuron system.展开更多
This paper deals with the robust control problem for a class of uncertain nonlinear networked systems with stochastic communication delays via sliding mode conception （SMC）. A sequence of variables obeying Bernoulli...This paper deals with the robust control problem for a class of uncertain nonlinear networked systems with stochastic communication delays via sliding mode conception （SMC）. A sequence of variables obeying Bernoulli distribution are employed to model the randomly occurring communication delays which could be different for different state variables. A discrete switching function that is different from those in the existing literature is first proposed. Then, expressed as the feasibility of a linear matrix inequality （LMI） with an equality constraint, sufficient conditions are derived in order to ensure the globally mean-square asymptotic stability of the system dynamics on the sliding surface. A discrete-time SMC controller is then synthesized to guarantee the discrete-time sliding mode reaching condition with the specified sliding surface. Finally, a simulation example is given to show the effectiveness of the proposed method.展开更多
This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture desi...This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture design, combinatorial testing process and agile project management. The paper uses point of care diagnostics as a case study where the software and hardware must be robust, reliable to provide accurate diagnosis of diseases. As software and software intensive systems are becoming increasingly complex, the impact of failures can lead to significant property damage, or damage to the environment. Within the medical diagnostic device software domain such failures can result in misdiagnosis leading to clinical complications and in some cases death. Software faults can arise due to the interaction among the software, the hardware, third party software and the operating environment. Unanticipated environmental changes and latent coding errors lead to operation faults despite of the fact that usually a significant effort has been expended in the design, verification and validation of the software system. It is becoming increasingly more apparent that one needs to adopt different approaches, which will guarantee that a complex software system meets all safety, security, and reliability requirements, in addition to complying with standards such as IEC 62304. There are many initiatives taken to develop safety and security critical systems, at different development phases and in different contexts, ranging from infrastructure design to device design. Different approaches are implemented to design error free software for safety critical systems. By adopting the strategies and processes presented in this paper one can overcome the challenges in developing error free software for medical devices (or safety critical systems).展开更多
高维多目标优化是指对目标维数大于三维的多目标问题(multi-objective optimization problem,简称MOP)进行优化.大多数传统的多目标进化算法采用Pareto支配关系指导搜索,很难在高维多目标优化问题上得到较为理想的结果.为此,提出了一种...高维多目标优化是指对目标维数大于三维的多目标问题(multi-objective optimization problem,简称MOP)进行优化.大多数传统的多目标进化算法采用Pareto支配关系指导搜索,很难在高维多目标优化问题上得到较为理想的结果.为此,提出了一种基于信息分离的高维多目标进化算法(multi-objective evolutionary algorithm based on information separation,简称ISEA).该算法在目标空间中将原坐标系进行旋转,使第1条坐标轴与向量(1,1,…,1)T平行.ISEA定义转换坐标的第1个坐标值为收敛信息(convergence information,简称CI),剩余的坐标代表个体分布信息(diversity information,简称DI).同时,采用一种基于分层选择的邻域惩罚机制,利用一种由两个超圆锥组成的邻域形状保持种群的分布性,当个体被选入归档集后,其邻域内的个体将被惩罚进入下一层选择,防止邻近的个体同时被选入归档集.邻域形状的第1部分利用分布信息覆盖邻近的个体,第2部分覆盖边界上的差个体.与NNIA,?-MOEA,MSOPS,AR+DMO以及IBEA这5种经典算法进行了比较.实验结果表明,ISEA在处理高维多目标优化问题时具有良好的收敛性和分布性.展开更多
High throughput gene expression analysis is swiftly becoming the focal point for deciphering molecular mechanisms underlying various dif-ferent biological questions. Testament to this is the fact that vast volumes of ...High throughput gene expression analysis is swiftly becoming the focal point for deciphering molecular mechanisms underlying various dif-ferent biological questions. Testament to this is the fact that vast volumes of expression profiles are being generated rapidly by scientists worldwide and subsequently stored in publicly available data repositories such as ArrayEx-press and the Gene Expression Omnibus (GEO). Such wealth of biological data has motivated biologists to compare expression profiles gen-erated from biologically-related microarray ex-periments in order to unravel biological mecha-nisms underlying various states of diseases. However, without the availability of appropriate software and tools, they are compelled to use manual or labour-intensive methods of com-parisons. A scrutiny of current literature makes it apparent that there is a soaring need for such bioinformatics tools that cater for the multiple analyses of expression profiles. In order to contribute towards this need, we have developed an efficient software pipeline for the analysis of multiple gene expression data-sets, called Micropath, which implements three principal functions;1) it searches for common genes amongst n number of datasets using a number crunching method of comparison as well as applying the principle of permutations and combinations in the form of a search strat-egy, 2) it extracts gene expression patterns both graphically and statistically, and 3) it streams co-expressed genes to all molecular pathways belonging to KEGG in a live fashion. We sub-jected MicroPath to several expression datasets generated from our tolerance-related in-house microarray experiments as well as published data and identified a set of 31 candidate genes that were found to be co-expressed across all interesting datasets. Pathway analysis revealed their putative roles in regulating immune toler-ance. MicroPath is freely available to download from: www.1066technologies.co.uk/micropath.展开更多
The purpose of this exploratory research was to study the relationship between the mood of computer users and their use of keyboard and mouse to examine the possibility of creating a generic or individualized mood mea...The purpose of this exploratory research was to study the relationship between the mood of computer users and their use of keyboard and mouse to examine the possibility of creating a generic or individualized mood measure. To examine this, a field study （n = 26） and a controlled study （n = 16） were conducted. In the field study, interaction data and self-reported mood measurements were collected during normal PC use over several days. In the controlled study, participants worked on a programming task while listening to high or low arousing background music. Besides subjective mood measurement, galvanic skin response （GSR） data was also collected. Results found no generic relationship between the interaction data and the mood data. However, the re- suits of the studies found significant average correlations be- tween mood measurement and personalized regression models based on keyboard and mouse interaction data. Together the results suggest that individualized mood prediction is pos- sible from interaction behaviour with keyboard and mouse.展开更多
基金supported by the grants from the National Natural Science Foundation of China,No.60775019,60970062 and 61173116the Research Fund for the Doctoral Program of Higher Education of China,No.201100702110014
文摘Previous studies have demonstrated that hand shadows may activate the motor cortex associated with the mirror neuron system in human brain. However, there is no evidence of activity of the human mirror neuron system during the observation of intransitive movements by shadows and line drawings of hands. This study examined the suppression of electroencephalography mu waves （8-13 Hz） induced by observation of stimuli in 18 healthy students. Three stimuli were used： real hand actions, hand shadow actions and actions made by line drawings of hands. The results showed significant desynchronization of the mu rhythm （＂mu suppression＂） across the sensodmotor cortex （recorded at C3, Cz and C4）, the frontal cortex （recorded at F3, Fz and F4） and the central and right posterior parietal cortex （recorded at Pz and P4） under all three conditions. Our experimental findings suggest that the observation of ＂impoverished hand actions＂, such as intransitive movements of shadows and line drawings of hands, is able to activate widespread cortical areas related to the putative human mirror neuron system.
基金supported by the Engineering and Physical Sciences Research Council(EPSRC)of the UK(No.GR/S27658/01)the Royal Society of the UK and the Alexander von Humboldt Foundation of Germany
文摘This paper deals with the robust control problem for a class of uncertain nonlinear networked systems with stochastic communication delays via sliding mode conception （SMC）. A sequence of variables obeying Bernoulli distribution are employed to model the randomly occurring communication delays which could be different for different state variables. A discrete switching function that is different from those in the existing literature is first proposed. Then, expressed as the feasibility of a linear matrix inequality （LMI） with an equality constraint, sufficient conditions are derived in order to ensure the globally mean-square asymptotic stability of the system dynamics on the sliding surface. A discrete-time SMC controller is then synthesized to guarantee the discrete-time sliding mode reaching condition with the specified sliding surface. Finally, a simulation example is given to show the effectiveness of the proposed method.
文摘This paper presents a holistic methodology for the design of medical device software, which encompasses of a new way of eliciting requirements, system design process, security design guideline, cloud architecture design, combinatorial testing process and agile project management. The paper uses point of care diagnostics as a case study where the software and hardware must be robust, reliable to provide accurate diagnosis of diseases. As software and software intensive systems are becoming increasingly complex, the impact of failures can lead to significant property damage, or damage to the environment. Within the medical diagnostic device software domain such failures can result in misdiagnosis leading to clinical complications and in some cases death. Software faults can arise due to the interaction among the software, the hardware, third party software and the operating environment. Unanticipated environmental changes and latent coding errors lead to operation faults despite of the fact that usually a significant effort has been expended in the design, verification and validation of the software system. It is becoming increasingly more apparent that one needs to adopt different approaches, which will guarantee that a complex software system meets all safety, security, and reliability requirements, in addition to complying with standards such as IEC 62304. There are many initiatives taken to develop safety and security critical systems, at different development phases and in different contexts, ranging from infrastructure design to device design. Different approaches are implemented to design error free software for safety critical systems. By adopting the strategies and processes presented in this paper one can overcome the challenges in developing error free software for medical devices (or safety critical systems).
文摘高维多目标优化是指对目标维数大于三维的多目标问题(multi-objective optimization problem,简称MOP)进行优化.大多数传统的多目标进化算法采用Pareto支配关系指导搜索,很难在高维多目标优化问题上得到较为理想的结果.为此,提出了一种基于信息分离的高维多目标进化算法(multi-objective evolutionary algorithm based on information separation,简称ISEA).该算法在目标空间中将原坐标系进行旋转,使第1条坐标轴与向量(1,1,…,1)T平行.ISEA定义转换坐标的第1个坐标值为收敛信息(convergence information,简称CI),剩余的坐标代表个体分布信息(diversity information,简称DI).同时,采用一种基于分层选择的邻域惩罚机制,利用一种由两个超圆锥组成的邻域形状保持种群的分布性,当个体被选入归档集后,其邻域内的个体将被惩罚进入下一层选择,防止邻近的个体同时被选入归档集.邻域形状的第1部分利用分布信息覆盖邻近的个体,第2部分覆盖边界上的差个体.与NNIA,?-MOEA,MSOPS,AR+DMO以及IBEA这5种经典算法进行了比较.实验结果表明,ISEA在处理高维多目标优化问题时具有良好的收敛性和分布性.
文摘High throughput gene expression analysis is swiftly becoming the focal point for deciphering molecular mechanisms underlying various dif-ferent biological questions. Testament to this is the fact that vast volumes of expression profiles are being generated rapidly by scientists worldwide and subsequently stored in publicly available data repositories such as ArrayEx-press and the Gene Expression Omnibus (GEO). Such wealth of biological data has motivated biologists to compare expression profiles gen-erated from biologically-related microarray ex-periments in order to unravel biological mecha-nisms underlying various states of diseases. However, without the availability of appropriate software and tools, they are compelled to use manual or labour-intensive methods of com-parisons. A scrutiny of current literature makes it apparent that there is a soaring need for such bioinformatics tools that cater for the multiple analyses of expression profiles. In order to contribute towards this need, we have developed an efficient software pipeline for the analysis of multiple gene expression data-sets, called Micropath, which implements three principal functions;1) it searches for common genes amongst n number of datasets using a number crunching method of comparison as well as applying the principle of permutations and combinations in the form of a search strat-egy, 2) it extracts gene expression patterns both graphically and statistically, and 3) it streams co-expressed genes to all molecular pathways belonging to KEGG in a live fashion. We sub-jected MicroPath to several expression datasets generated from our tolerance-related in-house microarray experiments as well as published data and identified a set of 31 candidate genes that were found to be co-expressed across all interesting datasets. Pathway analysis revealed their putative roles in regulating immune toler-ance. MicroPath is freely available to download from: www.1066technologies.co.uk/micropath.
文摘The purpose of this exploratory research was to study the relationship between the mood of computer users and their use of keyboard and mouse to examine the possibility of creating a generic or individualized mood measure. To examine this, a field study （n = 26） and a controlled study （n = 16） were conducted. In the field study, interaction data and self-reported mood measurements were collected during normal PC use over several days. In the controlled study, participants worked on a programming task while listening to high or low arousing background music. Besides subjective mood measurement, galvanic skin response （GSR） data was also collected. Results found no generic relationship between the interaction data and the mood data. However, the re- suits of the studies found significant average correlations be- tween mood measurement and personalized regression models based on keyboard and mouse interaction data. Together the results suggest that individualized mood prediction is pos- sible from interaction behaviour with keyboard and mouse.
