The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades,among which magnesium alloy is widely considered a favorable...The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades,among which magnesium alloy is widely considered a favorable choice as its appropriate biodegradability and evident antibacterial activity.Here,we reveal a semisolid rheo-formed Mg–Zn–Sr alloy ureteral implant that displayed suitable degradability and biocompatibility in a pig model.Refined non-dendritic microstructure was observed in the rheo-formed alloy,which led to ca.47%increase in ultimate tensile strength(from 195.0 MPa to 288.1 MPa)and more homogeneous degradation process compared with the untreated alloy.No post-interventional inflammation or pathological changes of the test animals were observed during the implantation period,and the corrosion rate(0.22±0.04 mm·y^(-1))perfectly fitted the clinical ureteral stent indwelling time.The urine bacteria numbers decreased from 88±13 CFU·mL^(-1)at 7 weeks post operation to 59±8 CFU·mL^(-1)at 14 weeks post operation,which confirmed the evident antibacterial activity of the alloy.Our study demonstrates that the Mg–Zn–Sr alloy is clinically safe for urinary system,enabling its efficacious use as ureteral implant materials.展开更多
A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a challenge.Here we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable ...A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a challenge.Here we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties,adjustable indwelling time in urinary tract and evident antibacterial activity via in vivo experiments in a swine model.Attributed to the rheo-solidification process,equiaxial microstructure and significantly refined grains(average grain size:27.1μm)were achieved.Mg17Sr2 and Mg4Ag were found as the primary precipitates in the matrix,due to which the alloy obtained ca.111%increase in ultimate tensile strength in comparison to pure magnesium.Both the in vitro and in vivo results demonstrated the satisfactory biocompatibility of the alloy.Histological evaluation and bioindicators analysis suggested that there was no tissue damage,inflammation and lesions in the urinary system caused by the degradation process.The stent also improved the post-operative bladder functions viewed from the urodynamic results.Our findings highlight the potential of this alloy as antibacterial biodegradable urinary implant material.展开更多
Perovskite photoelectrocatalysis enables solar-driven conversion of CO_(2)to value-added chemicals,but instability in water and insufficient C–C coupling still constrain performance.Herein,we present a synergistic ap...Perovskite photoelectrocatalysis enables solar-driven conversion of CO_(2)to value-added chemicals,but instability in water and insufficient C–C coupling still constrain performance.Herein,we present a synergistic approach for aqueous-phase CO_(2)conversion that combines perovskite-based photoelectrocatalysis with localized surface plasmon resonance(LSPR)enhancement.To address the inherent instability of lead-halide perovskites,we developed a modified hot-injection route that enables the in situ formation of water-stable CsPbBr_(3)@TiO_(2)core–shell nanoparticles.Titanium butoxide and water were introduced after Cs-oleate injection,enabling controlled TiO_(2)shell growth without post-treatment.Electron microscopy,XRD,and XPS confirm the core–shell architecture,while optical/electrical probes indicate efficient charge separation across the CsPbBr_(3)/TiO_(2)junction.Subsequently,we investigated electrocatalytic,photocatalytic,and photoelectrochemical carbon dioxide reduction(CO_(2)RR)on CsPbBr_(3)@TiO_(2)/Au and CsPbBr_(3)@TiO_(2).Gas chromatography revealed tunable product selectivity,yielding H_(2),CO,CH_(4),and multicarbon(C_(2),C_(3))products including C_(2)H_(4)(ethylene)and C_(3)H_(6)(propene).Our main findings indicate that the CsPbBr_(3)@TiO_(2)/Au exhibits high selectivity toward C_(3)(propene)in photocatalysis and C_(2)(ethylene)in photoelectrochemistry,reaching up to 70%and 58%,respectively.These results highlight perovskite heterostructures as a viable platform for efficient CO_(2)utilization and the sustainable production of value-added C_(2)/C_(3)chemicals.展开更多
基金National Natural Science Foundation of China(grant numbers 51771045 and U1764254)the Fundamental Research Funds for the Central Universities(grant number N2002016)for the financial supports。
文摘The introduction of biodegradable implant materials has significantly improved the postoperative subjective feelings of patients within the past few decades,among which magnesium alloy is widely considered a favorable choice as its appropriate biodegradability and evident antibacterial activity.Here,we reveal a semisolid rheo-formed Mg–Zn–Sr alloy ureteral implant that displayed suitable degradability and biocompatibility in a pig model.Refined non-dendritic microstructure was observed in the rheo-formed alloy,which led to ca.47%increase in ultimate tensile strength(from 195.0 MPa to 288.1 MPa)and more homogeneous degradation process compared with the untreated alloy.No post-interventional inflammation or pathological changes of the test animals were observed during the implantation period,and the corrosion rate(0.22±0.04 mm·y^(-1))perfectly fitted the clinical ureteral stent indwelling time.The urine bacteria numbers decreased from 88±13 CFU·mL^(-1)at 7 weeks post operation to 59±8 CFU·mL^(-1)at 14 weeks post operation,which confirmed the evident antibacterial activity of the alloy.Our study demonstrates that the Mg–Zn–Sr alloy is clinically safe for urinary system,enabling its efficacious use as ureteral implant materials.
基金This work was supported by National Natural Science Foundation of China(grant numbers 51771045 and U1764254)Special thanks are due to the instrumental analysis from Analytical and Testing Center,Northeastern University.The authors sincerely acknowledge the Animal Experimental Center of China Medical University for the in vivo experiments.
文摘A biodegradable metallic ureteral stent with suitable mechanical properties and antibacterial activity remains a challenge.Here we reveal the scientific significance of a biodegradable Mg-Sr-Ag alloy with a favorable combination of balanced mechanical properties,adjustable indwelling time in urinary tract and evident antibacterial activity via in vivo experiments in a swine model.Attributed to the rheo-solidification process,equiaxial microstructure and significantly refined grains(average grain size:27.1μm)were achieved.Mg17Sr2 and Mg4Ag were found as the primary precipitates in the matrix,due to which the alloy obtained ca.111%increase in ultimate tensile strength in comparison to pure magnesium.Both the in vitro and in vivo results demonstrated the satisfactory biocompatibility of the alloy.Histological evaluation and bioindicators analysis suggested that there was no tissue damage,inflammation and lesions in the urinary system caused by the degradation process.The stent also improved the post-operative bladder functions viewed from the urodynamic results.Our findings highlight the potential of this alloy as antibacterial biodegradable urinary implant material.
基金financially supported by the National Natural Science Foundation of China(Project No.62350610272)the Department of Science and Technology of Shandong Province(Grant KY0020240040)+1 种基金the Priority 2030 Federal Academic Leadership Programthe support from the Ministry of Science and Higher Education of the Russian Federation(Project No.FSRZ 2023-0006)。
文摘Perovskite photoelectrocatalysis enables solar-driven conversion of CO_(2)to value-added chemicals,but instability in water and insufficient C–C coupling still constrain performance.Herein,we present a synergistic approach for aqueous-phase CO_(2)conversion that combines perovskite-based photoelectrocatalysis with localized surface plasmon resonance(LSPR)enhancement.To address the inherent instability of lead-halide perovskites,we developed a modified hot-injection route that enables the in situ formation of water-stable CsPbBr_(3)@TiO_(2)core–shell nanoparticles.Titanium butoxide and water were introduced after Cs-oleate injection,enabling controlled TiO_(2)shell growth without post-treatment.Electron microscopy,XRD,and XPS confirm the core–shell architecture,while optical/electrical probes indicate efficient charge separation across the CsPbBr_(3)/TiO_(2)junction.Subsequently,we investigated electrocatalytic,photocatalytic,and photoelectrochemical carbon dioxide reduction(CO_(2)RR)on CsPbBr_(3)@TiO_(2)/Au and CsPbBr_(3)@TiO_(2).Gas chromatography revealed tunable product selectivity,yielding H_(2),CO,CH_(4),and multicarbon(C_(2),C_(3))products including C_(2)H_(4)(ethylene)and C_(3)H_(6)(propene).Our main findings indicate that the CsPbBr_(3)@TiO_(2)/Au exhibits high selectivity toward C_(3)(propene)in photocatalysis and C_(2)(ethylene)in photoelectrochemistry,reaching up to 70%and 58%,respectively.These results highlight perovskite heterostructures as a viable platform for efficient CO_(2)utilization and the sustainable production of value-added C_(2)/C_(3)chemicals.
