1 Introduction New technologies and other developments haye changedthe information seeking behaviors of the academic communityand the general public.Nowhere is this more evident than inthe exponential growth of the Wo...1 Introduction New technologies and other developments haye changedthe information seeking behaviors of the academic communityand the general public.Nowhere is this more evident than inthe exponential growth of the World Wide Web and cellularphone usage.Responding to these user needs and newtechnologies,libraries are moving from being InformationWarehouses to becoming Information Portals.Full-text。展开更多
This paper presents CMOS circuit designs of a ternary adder and a ternary multiplier,formulated using transmission function theory.Binary carry signals appearing in these designs allow conventional look-ahead carry te...This paper presents CMOS circuit designs of a ternary adder and a ternary multiplier,formulated using transmission function theory.Binary carry signals appearing in these designs allow conventional look-ahead carry techniques to be used.Compared with previous similar designs,the circuits proposed in this paper have advantages such as low dissipation,low output impedance,and simplicity of construction.展开更多
Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nai...Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nail bed related changes encountered in UET recipients in the literature.The differential diagnosis of nail abnormalities in UET includes a wide range of systemic,local and iatrogenic conditions other than immune responses to the allograft.It requires interdisciplinary evaluation by primary transplant surgeons,pathologists,dermatologists and immunologists.The possible underlying mechanisms of nail pathology in UET and the management are discussed.It also underscores the importance of onychodystrophy and need for timely intervention and to improve outcomes in UET recipients.展开更多
Vehicular speeds are of particular interest in areas with a high number of pedestrians due to the fact that 14-percent of all fatal crashes involve pedestrians. This study investigated the effect of a radar speed disp...Vehicular speeds are of particular interest in areas with a high number of pedestrians due to the fact that 14-percent of all fatal crashes involve pedestrians. This study investigated the effect of a radar speed display sign placed for an extended period of time, at a location frequented by law enforcement on a road segment entering a university campus with a high number of pedestrians and vehicle speed violations. The statistical analysis included a comparison between AM peak, PM peak, and midday speeds collected one year apart. The data suggested that radar speed display signs can remain effective over a long period of time;causing drivers to decelerate when warned of a speeding violation. While other studies have examined long-term impacts of similar technologies, none have included a road entering a University campus. Thus, these findings support that other similar locations entering university campuses could see long-term benefits to stationary radar speed display signs.展开更多
Soil organic carbon(C)sequestration and nitrogen(N)and phosphorus(P)burial were measured in two floodplain wetlands'soils of the West Fork of the White River watershed(Indiana,United States)whose catchments differ...Soil organic carbon(C)sequestration and nitrogen(N)and phosphorus(P)burial were measured in two floodplain wetlands'soils of the West Fork of the White River watershed(Indiana,United States)whose catchments differed in land use to better understand how land use practices affect wetland C and nutrient retention.The catchment of one floodplain,UpperWest Fork,is dominated by row crop agriculture(61%)whereas the second catchment,Beanblossom Creek,is mostly forested(85%).Soils(0-30cm)of the two floodplain wetlands had similar bulk density(1.23 g/cm^(3)).Soil organic C and N were low in both floodplains but the percent organic C and N was two times greater(3.3%C,0.22%N)in the agricultural floodplain than in the floodplain in the forested catchment(1.5%C,0.14%N).Soil P was three times greater in the agricultural(1100μg/g)than in the forested floodplain(350μg/g).Recent soil accretion based on ^(137)Cs which provides a historical record since 1964(60 years),was two times greater in the agricultural floodplain(2.2mm/year)than in the forested catchment(1.0mm/year).Sediment deposition(2500 g/m^(2)/year),C sequestration(90 g/m^(2)/year),and N burial(7.5g/m^(2)/year)were three times greater in the agricultural floodplain and P burial was seven times greater(3.0 vs.0.41 g/m^(2)/year).Long-term measurements(100 years)based on 210Pb did not show large differences in C sequestration and N burial between the two floodplains though soil accretion and sediment deposition were greater in the forested floodplain.We attribute these higher rates to greater erosion in the watershed before 1950 when the catchment had more agricultural land and before instruction on best management practices to reduce soil erosion.These findings confirm previously published studies that show that P enrichment and accumulation in floodplain soils represent legacy effects of agricultural land use in the catchment.展开更多
Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery ...Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.展开更多
Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically poor.We used a plasmalemmal fusogen,polyethylene g...Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically poor.We used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic nerves.We have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor recovery.Furthermore,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target muscles.In this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic nerve.Young adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of PEG.Compound action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury site.The success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days postoperatively.At 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish peroxidase.PEG-fusion repair reestablished axonal continuity.Compared to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal areas.Unexpectedly,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repair.This central reorganization may contribute to the improved behavioral recovery seen after PEG-fusion repair,supporting the use of this novel repair methodology over currently available treatments.展开更多
Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration...Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal cord.Here we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord injury.We report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal directions.Such Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder functions.Importantly,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord injury.These findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.展开更多
Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Walle...Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian Degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary behaviors.The preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion repair.In the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-Dawley and inbred Lewis rats.Mechanical nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the hindpaws.Dorsal von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve transections.Baseline withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not sex.Withdrawal thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated rats.Following sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the injury.However,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative Control rats.Furthermore,PEG-fused rats with significantly improved Sciatic Functional Index scores at or after 4 weeks postoperatively exhibited yet-earlier von Frey filament recove ry compared with those without Sciatic Functional Index recovery,suggesting a correlation between successful PEG-fusion and both motor-dominant and sensory-dominant behavioral recoveries.This correlation was independent of the sex or strain of the rat.Furthermore,our data showed that the acceleration of von Frey filament sensory recovery to baseline was solely due to the PEG-fused sciatic nerve and not saphenous nerve collateral outgrowths.No chronic hypersensitivity developed in any rat up to 12 weeks.All these data suggest that PEG-fusion repair of transection peripheral nerve injuries co uld have important clinical benefits.展开更多
Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong disability.Currently,there are no FDA-approved therapies a...Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong disability.Currently,there are no FDA-approved therapies available to promote nerve regeneration.Tacrolimus accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve surgery.The authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug exposure.Tacrolimus is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 days.Size and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible byproducts.Tacrolimus released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic delivery.Given its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.展开更多
Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivo...Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivotal to basic cellular processes.Close to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and localization.In this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in diseases.Furthermore,we have focused on N-acetyltransferase 9 and its role in microtubule stability.We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases.We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.展开更多
Perivascular epithelioid cell tumors(PEComas)are a diverse group of mesenchymal neoplasms.While they have been described throughout the genitourinary system,PEComas are quite rare within the bladder.We present the cas...Perivascular epithelioid cell tumors(PEComas)are a diverse group of mesenchymal neoplasms.While they have been described throughout the genitourinary system,PEComas are quite rare within the bladder.We present the case of a 37-year-old male who presented in clot retention and was found to have a bladder PEComa.Staging images seemingly demonstrated solid tumor confinement to the bladder and pelvis.Intraoperative pathology revealed peritoneal metastasis.The patient underwent a pelvic mass excision and partial cystectomy.The patient had plans for adjuvant chemotherapy,but later returned to the hospital and passed away from acute hypoxic respiratory failure.展开更多
Conceptualizations of empathy have been most fully developed in a variety of fields in recent years.Many approaches to empathy dwell on the cognitive,affective,and behavioral aspects,the intra-psychic processes that c...Conceptualizations of empathy have been most fully developed in a variety of fields in recent years.Many approaches to empathy dwell on the cognitive,affective,and behavioral aspects,the intra-psychic processes that cause one to feel emotions more like those of another,rather than the interpersonal functions of empathy,which may be influenced by the variables during the communication process.Therefore,this study designed and implemented a virtual ethnographic intercultural project between Chinese and American university students with WeChat as the main social medium.The whole process included three phases:exploring the unique cultural experiences of Chinese and American students,seeking an empathy based on commonality and seeking a relational empathy,a form of harmonization and integration through interactive and continuous intercultural dialogues.During the process,the method of discourse-centered online ethnography(DCOE)was employed,which involved systematic observation and interaction with WeChat users.We used the collective data to analyze how relational empathy was developed through understanding cultural differences,seeking similarities,and creating a third culture by engaging students in a substantial and dynamic natural and interactive setting.The study shows that the most challenging process to nurture relational empathy is to move from Phases One and Two to Phase Three,during which,some strategies to build relational empathy need to be taught and practiced in a specific cultural setting.In conclusion,virtual ethnographic intercultural teaching is an effective approach to offer students a long-term intercultural dialogue and insight into developing shared meaning,or dynamic relational empathy with culturally different others.展开更多
Objective Helicobacter pylori(HP)infection is associated with non-alcoholic fatty liver disease(NAFLD)and insulin resistance;however,the correlation between HP eradication and NAFLD remains controversial.This systemat...Objective Helicobacter pylori(HP)infection is associated with non-alcoholic fatty liver disease(NAFLD)and insulin resistance;however,the correlation between HP eradication and NAFLD remains controversial.This systematic review and meta-analysis examined the effect of HP treatment on clinical and laboratory parameters in NAFLD patients.Methods We conducted a literature search of the PubMed,Embase,Scopus,and Web of Science databases through Septem-ber 2023 for randomized controlled trials(RCTs)examining the effect of HP treatment on NAFLD patients versus lifestyle changes alone.The primary outcome was the change in steatosis parameters.The secondary endpoints were changes in anthropometric parameters,inflammatory markers(TNF-α),and metabolic parameters(fasting blood glucose,homeostasis model assessment of insulin resistance,AST/ALT,and lipid profile).The random effects model was used to calculate the standardized mean difference(SMD)with associated 95%confidence intervals(CIs)for our desired outcome.Results Four RCTs met our inclusion criteria.A total of 453 patients were included(mean age 42.8 years,58.5%males),228(50.3%)of whom were in the HP eradication group and 225(49.7%)of whom were in the lifestyle modification group.Compared with lifestyle modification alone,HP eradication had a significant effect on reducing liver steatosis and TNF-αlevels(SMD:-0.9;95%CI-14.67,-3.82,I^(2)=0%and SMD:-6.3;95%CI-9.04,-3.56,I^(2)=0%,respectively).No sig-nificant effect on other metabolic parameters was found.Conclusions HP eradication significantly reduced liver steatosis and TNF-αlevels in NAFLD patients.However,HP eradi-cation did not significantly affect other metabolic indices compared to lifestyle changes alone.展开更多
Endoscopic ultrasound(EUS)guided vascular interventions have expanded the reach of therapeutic endoscopy to include vascular pathology previously inaccessible by endoscopists.Gastric variceal bleeding comprises 20%of ...Endoscopic ultrasound(EUS)guided vascular interventions have expanded the reach of therapeutic endoscopy to include vascular pathology previously inaccessible by endoscopists.Gastric variceal bleeding comprises 20%of all variceal bleeding and is associated with high morbidity and mortality.Historically,endoscopic injection of thrombosis-inducing agents such as glue has been used.However,glue injection carries potential risks including systemic embolization,damage to the endoscope,and recurrent bleeding.The introduction of hemostatic coils has revolutionized the endoscopic approach,with EUS-guided coil embolization emerging as an effective and safe modality for the management of gastric varices(GVs).When compared with conventional glue injection,EUSguided embolization is associated with improved visualization,higher efficacy,and better safety profile.Despite its expanding adoption,the standardization of EUS guided embolization remains a challenge.High-quality studies are needed to standardize this promising technique and define its role in clinical practice.In this review,we will discuss the indications,efficacy,techniques,and various approaches for EUS-guided embolization of GVs.展开更多
Lower Paleozoic black shales are important source rocks worldwide.The Upper Ordovician-Lower Silurian Renheqiao Formation of the Baoshan Block is a low-maturity equivalent of the Wufeng-Longmaxi(WF-LMX)Shale of the Si...Lower Paleozoic black shales are important source rocks worldwide.The Upper Ordovician-Lower Silurian Renheqiao Formation of the Baoshan Block is a low-maturity equivalent of the Wufeng-Longmaxi(WF-LMX)Shale of the Sichuan Basin.However,organic matter(OM)characteristics in these low-maturity Lower Paleozoic shales are not well understood.In this study,50 Renheqiao Formation shale samples collected from seven outcrop sections and one drill core were investigated with organic petrology,organic geochemistry,R_(o)ck-Eval pyrolysis,N_(2) and CO_(2) adsorption,and scanning electron microscope(SEM)analyses to study the OM content,type,thermal maturity,and the development of OM-hosted pores in these Lower Paleozoic shales.The total organic carbon(TOC)content of the Renheqiao Formation shales varies,with the maximum content of 10.07 wt%.R_(o)ck-Eval pyrolysis results show that present OM in the Renheqiao Formation shales is Type IV kerogen,a result of advanced thermal maturation.Graptolite reflectance(GR_(o))ranges from 1.26%to 1.85%,and equivalent vitrinite reflectance(EqR_(o))converted from GR_(o) ranges from 1.08%to 1.51%,indicating that the studied Renheqiao Formation shales are dominantly within the late-mature stage.EqR_(o) based on R_(o)ck-Eval T_(max) shows large variations,which indicates that R_(o)ck-Eval T_(max) is not a reliable thermal maturity indicator for the Lower Paleozoic Renheqiao Formation shales.Caution should be applied when assessing the thermal maturity of high-maturity black shales based on T_(max) when the S2 values are too low.Organic petrographic observations show that OM in these shales is dominated by solid bitumen(>70 vol%of total OM),with minor contributions by graptolites and chitinozoans.The specific surface area and pore volume of shales are controlled by TOC content.Organic pores are hosted by solid bitumen and were not observed in graptolites when examined under the SEM.Although the Renheqiao Formation has a lower thermal maturity than the over-mature WF-LMX Shale,it is mature enough that primary oil-prone macerals have been thermally transformed and could not be identified under the microscope.展开更多
The discovery of quantum dots(QDs)stands as one of the paramount technological breakthroughs of the 20th century.Their versatility spans from everyday applications to cutting-edge scientific research,encompassing area...The discovery of quantum dots(QDs)stands as one of the paramount technological breakthroughs of the 20th century.Their versatility spans from everyday applications to cutting-edge scientific research,encompassing areas such as displays,lighting,photocatalysis,bio-imaging,and photonics devices and so on.Among the myriad QDs technologies,industrially relevant CuInS_(2)(CIS)QDs have emerged as promising alternatives to traditional Cd-and Pb-based QDs.Their tunable optoelectronic properties,high absorption coefficient,compositional flexibility,remarkable stability as well as Restriction of Hazardous Substances-compliance,with recent trends revealing a renewed interest in this material for various visible and near-infrared technological applications.This review focuses on recent advancements in CIS QDs as multidisciplinary field from its genesis in the mid-1990 to date with an emphasis on key breakthroughs in their synthesis,surface chemistry,post-synthesis modifications,and various applications.First,the comparation of properties of CIS QDs with relevant knowledge from other classes of QDs and from Ⅰ-Ⅱ-Ⅲ semiconductors as well is summarized.Second,recent advances in the synthesis methods,structure-optoelectronic properties,their defects,and passivation strategies as well as CIS-based heterostructures are discussed.Third,the state-of-the-art applications of CIS QDs ranging from solar cells,luminescence solar concentrations,photocatalysis,light emitting diodes,bioimaging and some emerging applications are summarized.Finally,we discuss open challenges and future perspectives for further advancement in this field.展开更多
South Florida’s natural forest ecosystems,including pine rocklands and hardwood hammocks,are threatened by land use change and urbanization,invasive species,and climate change.It is critical to understand the respons...South Florida’s natural forest ecosystems,including pine rocklands and hardwood hammocks,are threatened by land use change and urbanization,invasive species,and climate change.It is critical to understand the responses of these ecosystems to anthropogenic disturbances to conserve the remnants of the USA natural subtropical forests.Using dendrochronology,long-term growth patterns were characterized in three dominant native tree species:Bursera simaruba,Swietenia mahagoni,and Pinus elliottii.Core samples were collected from>30 individuals of each species in hardwood hammocks(B.simaruba and S.mahagoni)and pine rocklands(P.elliottii)to examine growth patterns.Relationships between annual tree growth rates and climatic variables were assessed to address three questions:(1)What are the climatic drivers of growth in these three South Florida tree species?(2)Are their growth rates stable or changing through time?and(3)Are tree growth rates affected by urbanization?Standardized growth rates of the three species have changed through time,with small young trees showing accelerated growth through time,whereas larger,older trees showed declining growth rates.S.mahagoni and B.simaruba grew faster in urbanized parks than in more natural parks,whereas P.elliottii grew slower in urban parks.There were positive correlations between tree growth and the current year’s fall precipitation and no discernable effects of the current year’s monthly temperatures on growth rates of any of the species.These results suggest that the foundational tree species of the southern USA endangered pine rocklands and hardwood hammocks may be vulnerable to ongoing changes in precipitation and temperature as well as other environmental effects associated with urbanization.展开更多
BACKGROUND Necrotizing fasciitis(NF)is a potentially fatal bacterial infection of the soft tissues.Liver cirrhosis appears to be a contributing factor to higher morbidity and mor-tality in patients with NF.This resear...BACKGROUND Necrotizing fasciitis(NF)is a potentially fatal bacterial infection of the soft tissues.Liver cirrhosis appears to be a contributing factor to higher morbidity and mor-tality in patients with NF.This research article explores the relationship between these two conditions.AIM To evaluate whether liver cirrhosis increases morbidity and mortality in patients with NF,focusing on inpatient mortality,septic shock,length of stay,and hospital costs.METHODS This retrospective cohort study utilized data from the Healthcare Cost and Utilization Project 2019 National Inpatient Sample.Cases were identified as pa-tients with both NF and cirrhosis,while controls were non-cirrhotic.The study focused on inpatient mortality as the primary outcome,with secondary outcomes including surgical limb amputation,mechanical ventilation rates,septic shock,length of stay,and hospital costs.RESULTS A total of 14920 patients were admitted to the hospital for management of NF,of which 2.11%had liver cirrhosis.Inpatient mortality was higher in cirrhotic patients(9.5%vs 3%;adjusted odds ratio=3.78;P value=0.02).Cirrhotic patients also had higher rates of septic shock(10.5%vs 4.9%,P value<0.01).Length of hospital stay,total charges,and rates of mechanical ventilation were not statistically different between groups.CONCLUSION Liver cirrhosis is an independent risk factor of in-hospital mortality and morbidity in patients with NF.Clinicians should be aware of this association to ensure better clinical outcomes and spare healthcare expenditure.展开更多
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and poor sleep are common among people with human immunodeficiency virus(PWH)and may mediate the impaired health-related quality of life(HRQoL)...BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and poor sleep are common among people with human immunodeficiency virus(PWH)and may mediate the impaired health-related quality of life(HRQoL)seen in PWH and in people with MASLD.However,the prevalence and burden of poor sleep in PWH and MASLD is not well described.AIM To study the prevalence and multi-faceted relationship between MASLD,poor sleep,and HRQoL in PWH.METHODS In this cross-sectional,observational study,adult PWH and no other known cause of liver disease underwent controlled attenuated parameter(for hepatic fat)and liver stiffness measurement via vibration-controlled transient elastography at eight United States.centers(July 2021 to November 2024).Sleep quality was assessed by Pittsburgh Sleep Quality Index(PSQI)and HRQoL by Rand 36-Item Short Form Health Survey.Outcomes were compared using standard methods.Multivariate regression examined associations between sleep quality,HRQoL,and clinical factors.RESULTS PWH(n=1005)on suppressive antiretroviral therapy had mean age 55 years and were 65%non-White and 27%cisgender female;77%had body mass index(BMI)>25 kg/m2,44%had MASLD(controlled attenuated parameter≥263 dB/minute),13%liver fibrosis(liver stiffness measurement≥8 kPa)and 64%poor sleep quality(PSQI>5).The mean±SD of PSQI was 6.6±4.1,with no differences by MASLD status;MASLD+fibrosis was associated with poorer sleep.HRQoL was low(<50)overall:A step-wise decline in physical component summary(PCS)scores was associated with worse liver disease,from no MASLD to MASLD+fibrosis.Among poor sleepers,a similar step-wise PCS worsening occurred.In multivariate analysis,MASLD+fibrosis was associated with lower PCS and poor sleep was associated with worse physical and mental HRQoL.CONCLUSION In this cohort of PWH,there was no association between MASLD and sleep quality.Poor sleep,MASLD and liver fibrosis were independently associated with poor HRQoL.展开更多
文摘1 Introduction New technologies and other developments haye changedthe information seeking behaviors of the academic communityand the general public.Nowhere is this more evident than inthe exponential growth of the World Wide Web and cellularphone usage.Responding to these user needs and newtechnologies,libraries are moving from being InformationWarehouses to becoming Information Portals.Full-text。
基金Project supported by the National Natural Science Foundation of China.
文摘This paper presents CMOS circuit designs of a ternary adder and a ternary multiplier,formulated using transmission function theory.Binary carry signals appearing in these designs allow conventional look-ahead carry techniques to be used.Compared with previous similar designs,the circuits proposed in this paper have advantages such as low dissipation,low output impedance,and simplicity of construction.
文摘Nail changes following upper extremity transplantation(UET)cannot be overlooked as they possess diagnostic and prognostic relevance in allotransplantation of upper limbs.This comprehensive review explores nail and nail bed related changes encountered in UET recipients in the literature.The differential diagnosis of nail abnormalities in UET includes a wide range of systemic,local and iatrogenic conditions other than immune responses to the allograft.It requires interdisciplinary evaluation by primary transplant surgeons,pathologists,dermatologists and immunologists.The possible underlying mechanisms of nail pathology in UET and the management are discussed.It also underscores the importance of onychodystrophy and need for timely intervention and to improve outcomes in UET recipients.
文摘Vehicular speeds are of particular interest in areas with a high number of pedestrians due to the fact that 14-percent of all fatal crashes involve pedestrians. This study investigated the effect of a radar speed display sign placed for an extended period of time, at a location frequented by law enforcement on a road segment entering a university campus with a high number of pedestrians and vehicle speed violations. The statistical analysis included a comparison between AM peak, PM peak, and midday speeds collected one year apart. The data suggested that radar speed display signs can remain effective over a long period of time;causing drivers to decelerate when warned of a speeding violation. While other studies have examined long-term impacts of similar technologies, none have included a road entering a University campus. Thus, these findings support that other similar locations entering university campuses could see long-term benefits to stationary radar speed display signs.
文摘Soil organic carbon(C)sequestration and nitrogen(N)and phosphorus(P)burial were measured in two floodplain wetlands'soils of the West Fork of the White River watershed(Indiana,United States)whose catchments differed in land use to better understand how land use practices affect wetland C and nutrient retention.The catchment of one floodplain,UpperWest Fork,is dominated by row crop agriculture(61%)whereas the second catchment,Beanblossom Creek,is mostly forested(85%).Soils(0-30cm)of the two floodplain wetlands had similar bulk density(1.23 g/cm^(3)).Soil organic C and N were low in both floodplains but the percent organic C and N was two times greater(3.3%C,0.22%N)in the agricultural floodplain than in the floodplain in the forested catchment(1.5%C,0.14%N).Soil P was three times greater in the agricultural(1100μg/g)than in the forested floodplain(350μg/g).Recent soil accretion based on ^(137)Cs which provides a historical record since 1964(60 years),was two times greater in the agricultural floodplain(2.2mm/year)than in the forested catchment(1.0mm/year).Sediment deposition(2500 g/m^(2)/year),C sequestration(90 g/m^(2)/year),and N burial(7.5g/m^(2)/year)were three times greater in the agricultural floodplain and P burial was seven times greater(3.0 vs.0.41 g/m^(2)/year).Long-term measurements(100 years)based on 210Pb did not show large differences in C sequestration and N burial between the two floodplains though soil accretion and sediment deposition were greater in the forested floodplain.We attribute these higher rates to greater erosion in the watershed before 1950 when the catchment had more agricultural land and before instruction on best management practices to reduce soil erosion.These findings confirm previously published studies that show that P enrichment and accumulation in floodplain soils represent legacy effects of agricultural land use in the catchment.
基金supported by the NIH (R01NS103481, R01NS111776, and R01NS131489)Indiana Department of Health (ISDH58180)(all to WW)。
文摘Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.
基金supported by the Department of Defense AFIRMⅢW81XWH-20-2-0029 grant subcontractLone Star Paralysis gift,UT POC19-1774-13 grant+1 种基金Neuraptive Therapeutics Inc.26-7724-56 grantNational Institutes of Health R01-NS128086(all to GDB)。
文摘Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically poor.We used a plasmalemmal fusogen,polyethylene glycol(PEG),to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic nerves.We have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration,and PEG-fused animals exhibit rapid(within 2–6 weeks)and extensive locomotor recovery.Furthermore,our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific,i.e.,spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target muscles.In this study,we examined the consequences of PEG-fusion for sensory axons of the sciatic nerve.Young adult male and female rats(Sprague–Dawley)received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without(Negative Control)the application of PEG.Compound action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury site.The success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days postoperatively.At 2–42 days postoperatively,we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish peroxidase.PEG-fusion repair reestablished axonal continuity.Compared to unoperated animals,labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn,as well as inappropriate mediolateral and rostrocaudal areas.Unexpectedly,despite having intact peripheral nerves,similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repair.This central reorganization may contribute to the improved behavioral recovery seen after PEG-fusion repair,supporting the use of this novel repair methodology over currently available treatments.
基金supported in part by NIH R01 NS100531,R01 NS103481NIH R21NS130241(to LD)+3 种基金Merit Review Award I01 BX002356,I01 BX003705 from the U.S.Department of Veterans AffairsIndiana Spinal Cord and Brain Injury Research Foundation(No.19919)Mari Hulman George Endowment Funds(to XMX)Indiana Spinal Cord&Brain Injury Research Fund from ISDH(to NKL and LD)。
文摘Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal cord.Here we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord injury.We report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal directions.Such Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder functions.Importantly,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord injury.These findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.
基金supported by DOD AFIRMⅢW81XWH-20-2-0029 subcontract,UT POC19-1774-13Neuraptive Therapeutics Inc.26-7724-56+1 种基金NIH R01-NS128086 grantsLone Star Paralysis gift(to GDB)。
文摘Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian Degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary behaviors.The preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion repair.In the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-Dawley and inbred Lewis rats.Mechanical nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the hindpaws.Dorsal von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve transections.Baseline withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not sex.Withdrawal thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated rats.Following sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the injury.However,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative Control rats.Furthermore,PEG-fused rats with significantly improved Sciatic Functional Index scores at or after 4 weeks postoperatively exhibited yet-earlier von Frey filament recove ry compared with those without Sciatic Functional Index recovery,suggesting a correlation between successful PEG-fusion and both motor-dominant and sensory-dominant behavioral recoveries.This correlation was independent of the sex or strain of the rat.Furthermore,our data showed that the acceleration of von Frey filament sensory recovery to baseline was solely due to the PEG-fused sciatic nerve and not saphenous nerve collateral outgrowths.No chronic hypersensitivity developed in any rat up to 12 weeks.All these data suggest that PEG-fusion repair of transection peripheral nerve injuries co uld have important clinical benefits.
基金supported by the German Research Foundation(DA 2255/1-1to SCD)+4 种基金a SickKids Research Training Competition(RESTRACOMP)Graduate Scholarship(to KJWS)an Ontario Graduate Scholarship(to KJWS)a grant from Natural Sciences and Engineering Research Council of Canada(NSERC)(to KJWS)a Kickstarter grant from the Institute of Biomedical Engineering(BME)at the University of Toronto(to KJWS)the Abe Frank Fund from the Riley’s Children Foundation(GHB)。
文摘Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong disability.Currently,there are no FDA-approved therapies available to promote nerve regeneration.Tacrolimus accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve surgery.The authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug exposure.Tacrolimus is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 days.Size and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible byproducts.Tacrolimus released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic delivery.Given its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.
基金supported by 1RO1EY032959-01 and RO1 supplement from NIH,Schuellein Chair Endowment Fund and STEM Catalyst Grant from the University of Dayton(to AS).
文摘Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivotal to basic cellular processes.Close to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and localization.In this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in diseases.Furthermore,we have focused on N-acetyltransferase 9 and its role in microtubule stability.We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases.We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.
文摘Perivascular epithelioid cell tumors(PEComas)are a diverse group of mesenchymal neoplasms.While they have been described throughout the genitourinary system,PEComas are quite rare within the bladder.We present the case of a 37-year-old male who presented in clot retention and was found to have a bladder PEComa.Staging images seemingly demonstrated solid tumor confinement to the bladder and pelvis.Intraoperative pathology revealed peritoneal metastasis.The patient underwent a pelvic mass excision and partial cystectomy.The patient had plans for adjuvant chemotherapy,but later returned to the hospital and passed away from acute hypoxic respiratory failure.
文摘Conceptualizations of empathy have been most fully developed in a variety of fields in recent years.Many approaches to empathy dwell on the cognitive,affective,and behavioral aspects,the intra-psychic processes that cause one to feel emotions more like those of another,rather than the interpersonal functions of empathy,which may be influenced by the variables during the communication process.Therefore,this study designed and implemented a virtual ethnographic intercultural project between Chinese and American university students with WeChat as the main social medium.The whole process included three phases:exploring the unique cultural experiences of Chinese and American students,seeking an empathy based on commonality and seeking a relational empathy,a form of harmonization and integration through interactive and continuous intercultural dialogues.During the process,the method of discourse-centered online ethnography(DCOE)was employed,which involved systematic observation and interaction with WeChat users.We used the collective data to analyze how relational empathy was developed through understanding cultural differences,seeking similarities,and creating a third culture by engaging students in a substantial and dynamic natural and interactive setting.The study shows that the most challenging process to nurture relational empathy is to move from Phases One and Two to Phase Three,during which,some strategies to build relational empathy need to be taught and practiced in a specific cultural setting.In conclusion,virtual ethnographic intercultural teaching is an effective approach to offer students a long-term intercultural dialogue and insight into developing shared meaning,or dynamic relational empathy with culturally different others.
文摘Objective Helicobacter pylori(HP)infection is associated with non-alcoholic fatty liver disease(NAFLD)and insulin resistance;however,the correlation between HP eradication and NAFLD remains controversial.This systematic review and meta-analysis examined the effect of HP treatment on clinical and laboratory parameters in NAFLD patients.Methods We conducted a literature search of the PubMed,Embase,Scopus,and Web of Science databases through Septem-ber 2023 for randomized controlled trials(RCTs)examining the effect of HP treatment on NAFLD patients versus lifestyle changes alone.The primary outcome was the change in steatosis parameters.The secondary endpoints were changes in anthropometric parameters,inflammatory markers(TNF-α),and metabolic parameters(fasting blood glucose,homeostasis model assessment of insulin resistance,AST/ALT,and lipid profile).The random effects model was used to calculate the standardized mean difference(SMD)with associated 95%confidence intervals(CIs)for our desired outcome.Results Four RCTs met our inclusion criteria.A total of 453 patients were included(mean age 42.8 years,58.5%males),228(50.3%)of whom were in the HP eradication group and 225(49.7%)of whom were in the lifestyle modification group.Compared with lifestyle modification alone,HP eradication had a significant effect on reducing liver steatosis and TNF-αlevels(SMD:-0.9;95%CI-14.67,-3.82,I^(2)=0%and SMD:-6.3;95%CI-9.04,-3.56,I^(2)=0%,respectively).No sig-nificant effect on other metabolic parameters was found.Conclusions HP eradication significantly reduced liver steatosis and TNF-αlevels in NAFLD patients.However,HP eradi-cation did not significantly affect other metabolic indices compared to lifestyle changes alone.
文摘Endoscopic ultrasound(EUS)guided vascular interventions have expanded the reach of therapeutic endoscopy to include vascular pathology previously inaccessible by endoscopists.Gastric variceal bleeding comprises 20%of all variceal bleeding and is associated with high morbidity and mortality.Historically,endoscopic injection of thrombosis-inducing agents such as glue has been used.However,glue injection carries potential risks including systemic embolization,damage to the endoscope,and recurrent bleeding.The introduction of hemostatic coils has revolutionized the endoscopic approach,with EUS-guided coil embolization emerging as an effective and safe modality for the management of gastric varices(GVs).When compared with conventional glue injection,EUSguided embolization is associated with improved visualization,higher efficacy,and better safety profile.Despite its expanding adoption,the standardization of EUS guided embolization remains a challenge.High-quality studies are needed to standardize this promising technique and define its role in clinical practice.In this review,we will discuss the indications,efficacy,techniques,and various approaches for EUS-guided embolization of GVs.
基金supported by the project of“Shale Gas Resources Investigation and Evaluation in the Baoshan Block”from Sinopec Exploration Company and the National Natural Science Foundation of China(41925014 and 42172192)。
文摘Lower Paleozoic black shales are important source rocks worldwide.The Upper Ordovician-Lower Silurian Renheqiao Formation of the Baoshan Block is a low-maturity equivalent of the Wufeng-Longmaxi(WF-LMX)Shale of the Sichuan Basin.However,organic matter(OM)characteristics in these low-maturity Lower Paleozoic shales are not well understood.In this study,50 Renheqiao Formation shale samples collected from seven outcrop sections and one drill core were investigated with organic petrology,organic geochemistry,R_(o)ck-Eval pyrolysis,N_(2) and CO_(2) adsorption,and scanning electron microscope(SEM)analyses to study the OM content,type,thermal maturity,and the development of OM-hosted pores in these Lower Paleozoic shales.The total organic carbon(TOC)content of the Renheqiao Formation shales varies,with the maximum content of 10.07 wt%.R_(o)ck-Eval pyrolysis results show that present OM in the Renheqiao Formation shales is Type IV kerogen,a result of advanced thermal maturation.Graptolite reflectance(GR_(o))ranges from 1.26%to 1.85%,and equivalent vitrinite reflectance(EqR_(o))converted from GR_(o) ranges from 1.08%to 1.51%,indicating that the studied Renheqiao Formation shales are dominantly within the late-mature stage.EqR_(o) based on R_(o)ck-Eval T_(max) shows large variations,which indicates that R_(o)ck-Eval T_(max) is not a reliable thermal maturity indicator for the Lower Paleozoic Renheqiao Formation shales.Caution should be applied when assessing the thermal maturity of high-maturity black shales based on T_(max) when the S2 values are too low.Organic petrographic observations show that OM in these shales is dominated by solid bitumen(>70 vol%of total OM),with minor contributions by graptolites and chitinozoans.The specific surface area and pore volume of shales are controlled by TOC content.Organic pores are hosted by solid bitumen and were not observed in graptolites when examined under the SEM.Although the Renheqiao Formation has a lower thermal maturity than the over-mature WF-LMX Shale,it is mature enough that primary oil-prone macerals have been thermally transformed and could not be identified under the microscope.
基金X.H.acknowledges the financial support by Australian Research Council(ARC)Future Fellowship(FT190100756)M.P.S.gratefully acknowledges the support by the ARC under Discovery Early Career Researcher Award(DECRA)(DE210101565)and Discovery Project(DP230101676).
文摘The discovery of quantum dots(QDs)stands as one of the paramount technological breakthroughs of the 20th century.Their versatility spans from everyday applications to cutting-edge scientific research,encompassing areas such as displays,lighting,photocatalysis,bio-imaging,and photonics devices and so on.Among the myriad QDs technologies,industrially relevant CuInS_(2)(CIS)QDs have emerged as promising alternatives to traditional Cd-and Pb-based QDs.Their tunable optoelectronic properties,high absorption coefficient,compositional flexibility,remarkable stability as well as Restriction of Hazardous Substances-compliance,with recent trends revealing a renewed interest in this material for various visible and near-infrared technological applications.This review focuses on recent advancements in CIS QDs as multidisciplinary field from its genesis in the mid-1990 to date with an emphasis on key breakthroughs in their synthesis,surface chemistry,post-synthesis modifications,and various applications.First,the comparation of properties of CIS QDs with relevant knowledge from other classes of QDs and from Ⅰ-Ⅱ-Ⅲ semiconductors as well is summarized.Second,recent advances in the synthesis methods,structure-optoelectronic properties,their defects,and passivation strategies as well as CIS-based heterostructures are discussed.Third,the state-of-the-art applications of CIS QDs ranging from solar cells,luminescence solar concentrations,photocatalysis,light emitting diodes,bioimaging and some emerging applications are summarized.Finally,we discuss open challenges and future perspectives for further advancement in this field.
基金supported by the Kushlan Fund from the University of Miami Department of Biology.
文摘South Florida’s natural forest ecosystems,including pine rocklands and hardwood hammocks,are threatened by land use change and urbanization,invasive species,and climate change.It is critical to understand the responses of these ecosystems to anthropogenic disturbances to conserve the remnants of the USA natural subtropical forests.Using dendrochronology,long-term growth patterns were characterized in three dominant native tree species:Bursera simaruba,Swietenia mahagoni,and Pinus elliottii.Core samples were collected from>30 individuals of each species in hardwood hammocks(B.simaruba and S.mahagoni)and pine rocklands(P.elliottii)to examine growth patterns.Relationships between annual tree growth rates and climatic variables were assessed to address three questions:(1)What are the climatic drivers of growth in these three South Florida tree species?(2)Are their growth rates stable or changing through time?and(3)Are tree growth rates affected by urbanization?Standardized growth rates of the three species have changed through time,with small young trees showing accelerated growth through time,whereas larger,older trees showed declining growth rates.S.mahagoni and B.simaruba grew faster in urbanized parks than in more natural parks,whereas P.elliottii grew slower in urban parks.There were positive correlations between tree growth and the current year’s fall precipitation and no discernable effects of the current year’s monthly temperatures on growth rates of any of the species.These results suggest that the foundational tree species of the southern USA endangered pine rocklands and hardwood hammocks may be vulnerable to ongoing changes in precipitation and temperature as well as other environmental effects associated with urbanization.
文摘BACKGROUND Necrotizing fasciitis(NF)is a potentially fatal bacterial infection of the soft tissues.Liver cirrhosis appears to be a contributing factor to higher morbidity and mor-tality in patients with NF.This research article explores the relationship between these two conditions.AIM To evaluate whether liver cirrhosis increases morbidity and mortality in patients with NF,focusing on inpatient mortality,septic shock,length of stay,and hospital costs.METHODS This retrospective cohort study utilized data from the Healthcare Cost and Utilization Project 2019 National Inpatient Sample.Cases were identified as pa-tients with both NF and cirrhosis,while controls were non-cirrhotic.The study focused on inpatient mortality as the primary outcome,with secondary outcomes including surgical limb amputation,mechanical ventilation rates,septic shock,length of stay,and hospital costs.RESULTS A total of 14920 patients were admitted to the hospital for management of NF,of which 2.11%had liver cirrhosis.Inpatient mortality was higher in cirrhotic patients(9.5%vs 3%;adjusted odds ratio=3.78;P value=0.02).Cirrhotic patients also had higher rates of septic shock(10.5%vs 4.9%,P value<0.01).Length of hospital stay,total charges,and rates of mechanical ventilation were not statistically different between groups.CONCLUSION Liver cirrhosis is an independent risk factor of in-hospital mortality and morbidity in patients with NF.Clinicians should be aware of this association to ensure better clinical outcomes and spare healthcare expenditure.
基金Supported by National Institutes of Health,No.R01DK121378,No.R01DK126042,and No.P30DK120515.
文摘BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and poor sleep are common among people with human immunodeficiency virus(PWH)and may mediate the impaired health-related quality of life(HRQoL)seen in PWH and in people with MASLD.However,the prevalence and burden of poor sleep in PWH and MASLD is not well described.AIM To study the prevalence and multi-faceted relationship between MASLD,poor sleep,and HRQoL in PWH.METHODS In this cross-sectional,observational study,adult PWH and no other known cause of liver disease underwent controlled attenuated parameter(for hepatic fat)and liver stiffness measurement via vibration-controlled transient elastography at eight United States.centers(July 2021 to November 2024).Sleep quality was assessed by Pittsburgh Sleep Quality Index(PSQI)and HRQoL by Rand 36-Item Short Form Health Survey.Outcomes were compared using standard methods.Multivariate regression examined associations between sleep quality,HRQoL,and clinical factors.RESULTS PWH(n=1005)on suppressive antiretroviral therapy had mean age 55 years and were 65%non-White and 27%cisgender female;77%had body mass index(BMI)>25 kg/m2,44%had MASLD(controlled attenuated parameter≥263 dB/minute),13%liver fibrosis(liver stiffness measurement≥8 kPa)and 64%poor sleep quality(PSQI>5).The mean±SD of PSQI was 6.6±4.1,with no differences by MASLD status;MASLD+fibrosis was associated with poorer sleep.HRQoL was low(<50)overall:A step-wise decline in physical component summary(PCS)scores was associated with worse liver disease,from no MASLD to MASLD+fibrosis.Among poor sleepers,a similar step-wise PCS worsening occurred.In multivariate analysis,MASLD+fibrosis was associated with lower PCS and poor sleep was associated with worse physical and mental HRQoL.CONCLUSION In this cohort of PWH,there was no association between MASLD and sleep quality.Poor sleep,MASLD and liver fibrosis were independently associated with poor HRQoL.
