Soft actuators have garnered substantial attention in current years in view of their potential appliances in diverse domains like robotics,biomedical devices,and biomimetic systems.These actuators mimic the natural mo...Soft actuators have garnered substantial attention in current years in view of their potential appliances in diverse domains like robotics,biomedical devices,and biomimetic systems.These actuators mimic the natural movements of living organisms,aiming to attain enhanced flexibility,adaptability,and versatility.On the other hand,angle-independent structural color has been achieved through innovative design strategies and engineering approaches.By carefully controlling the size,shape,and arrangement of nanostructures,researchers have been able to create materials exhibiting consistent colors regardless of the viewing angle.One promising class of materials that holds great potential for bioinspired soft actuators is MXenes in view of their exceptional mechanical,electrical,and optical properties.The integration of MXenes for bioinspired soft actuators with angle-independent structural color offers exciting possibilities.Overcoming material compatibility issues,improving color reproducibility,scalability,durability,power supply efficiency,and cost-effectiveness will play vital roles in advancing these technologies.This perspective appraises the development of bioinspired MXene-centered soft actuators with angleindependent structural color in soft robotics.展开更多
MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology,combining real-time biosensing,therapeutic capabilities,and user comfort in a single platform.These devices tak...MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology,combining real-time biosensing,therapeutic capabilities,and user comfort in a single platform.These devices take the advantage of the exceptional electrical conductivity,mechanical flexibility,and biocompatibility of two-dimensional MXenes to enable noninvasive,tear-based monitoring of key physiological markers such as intraocular pressure and glucose levels.Recent developments focus on the integration of transparent MXene films into the conventional lens materials,allowing multifunctional performance including photothermal therapy,antimicrobial and anti-inflammation protection,and dehydration resistance.These innovations offer promising strategies for ocular disease management and eye protection.In addition to their multifunctionality,improvements in MXene synthesis and device engineering have enhanced the stability,transparency,and wearability of these lenses.Despite these advances,challenges remain in long-term biostability,scalable production,and integration with wireless communication systems.This review summarizes the current progress,key challenges,and future directions of MXene-based smart contact lenses,highlighting their transformative potential in next-generation digital healthcare and ophthalmic care.展开更多
In this paper, the author proposes two methods of estimation of the regression coefficients whenthe errors are not distributed identically and independently and have a nonzero mean. The estimatesproved in this paper a...In this paper, the author proposes two methods of estimation of the regression coefficients whenthe errors are not distributed identically and independently and have a nonzero mean. The estimatesproved in this paper are shown to be strongly consistent and mean square consistent.展开更多
As AI systems scale, the limitations of cloud-based architectures, including latency, bandwidth, and privacy concerns, demand decentralized alternatives. Federated learning (FL) and Edge AI provide a paradigm shift by...As AI systems scale, the limitations of cloud-based architectures, including latency, bandwidth, and privacy concerns, demand decentralized alternatives. Federated learning (FL) and Edge AI provide a paradigm shift by combining privacy preserving training with efficient, on device computation. This paper introduces a cutting-edge FL-edge integration framework, achieving a 10% to 15% increase in model accuracy and reducing communication costs by 25% in heterogeneous environments. Blockchain based secure aggregation ensures robust and tamper-proof model updates, while exploratory quantum AI techniques enhance computational efficiency. By addressing key challenges such as device variability and non-IID data, this work sets the stage for the next generation of adaptive, privacy-first AI systems, with applications in IoT, healthcare, and autonomous systems.展开更多
Oral cancer is one of the malignant neoplasms that present major global health challenge.It is the sixth most prevalent type of cancer in the world,with a high incidence and mortality rate.This letter is a review of t...Oral cancer is one of the malignant neoplasms that present major global health challenge.It is the sixth most prevalent type of cancer in the world,with a high incidence and mortality rate.This letter is a review of the study by Yin et al which was published in the World Journal of Clinical Cases(2024).The study evaluated the effect of Tongluo Jiedu as an adjuvant treatment for oral cancer.Over the years,there has been a continuous search for effective and less invasive treatments for oral cancer.This article emphasizes and discusses various therapeutic options currently available,and it highlights that early intervention and multidisciplinary management are crucial for improving outcomes.Traditional Chinese medicine,particularly Tongluo Jiedu,presents potential complementary approach to co-nventional oral cancer therapies.Future research on Tongluo Jiedu should be focused on validation of its efficacy and safety through large,well-designed clinical trials,as well as better understanding of the molecular mechanisms in-volved,and optimization of therapeutic combinations.Additionally,continuous education of health professionals is key to the effective and safe integration of this traditional medicine into clinical practice.Continuous research is essential for optimization of therapeutic strategies and for addressing the challenges presented by this neoplasm.展开更多
In the article“Deep Learning-Enhanced Brain Tumor Prediction via Entropy-Coded BPSO in CIELAB Color Space”by Mudassir Khalil,Muhammad Imran Sharif,Ahmed Naeem,Muhammad Umar Chaudhry,Hafiz Tayyab Rauf,Adham E.Ragab C...In the article“Deep Learning-Enhanced Brain Tumor Prediction via Entropy-Coded BPSO in CIELAB Color Space”by Mudassir Khalil,Muhammad Imran Sharif,Ahmed Naeem,Muhammad Umar Chaudhry,Hafiz Tayyab Rauf,Adham E.Ragab Computers,Materials&Continua,2023,Vol.77,No.2,pp.2031–2047.DOI:10.32604/cmc.2023.043687,URL:https://www.techscience.com/cmc/v77n2/54831,there was an error regarding the affiliation for the author Hafiz Tayyab Rauf.Instead of“Centre for Smart Systems,AI and Cybersecurity,Staffordshire University,Stoke-on-Trent,ST42DE,UK”,the affiliation should be“Independent Researcher,Bradford,BD80HS,UK”.展开更多
In the article“A Lightweight Approach for Skin Lesion Detection through Optimal Features Fusion”by Khadija Manzoor,Fiaz Majeed,Ansar Siddique,Talha Meraj,Hafiz Tayyab Rauf,Mohammed A.El-Meligy,Mohamed Sharaf,Abd Ela...In the article“A Lightweight Approach for Skin Lesion Detection through Optimal Features Fusion”by Khadija Manzoor,Fiaz Majeed,Ansar Siddique,Talha Meraj,Hafiz Tayyab Rauf,Mohammed A.El-Meligy,Mohamed Sharaf,Abd Elatty E.Abd Elgawad Computers,Materials&Continua,2022,Vol.70,No.1,pp.1617–1630.DOI:10.32604/cmc.2022.018621,URL:https://www.techscience.com/cmc/v70n1/44361,there was an error regarding the affiliation for the author Hafiz Tayyab Rauf.Instead of“Centre for Smart Systems,AI and Cybersecurity,Staffordshire University,Stoke-on-Trent,UK”,the affiliation should be“Independent Researcher,Bradford,BD80HS,UK”.展开更多
At the point of death,a human being only has had the experience of nonexistence before birth and the experience of having lived his/her life after they were born.In the final analysis from the perspective of strict em...At the point of death,a human being only has had the experience of nonexistence before birth and the experience of having lived his/her life after they were born.In the final analysis from the perspective of strict empiricism,the individual only has two options:the nonexistence before birth or the eventual reliving of one’s life.The return of one’s life is supported by the paradigm of a multiverse and an antimatter universe.This is atheism’s logical certainty.展开更多
Exploring the concept of death within Judaism may seem audacious,yet it is encouraged by the tradition of inquiry intrinsic to Jewish thought.Despite the caution urged by rabbinic authorities,Jewish texts ranging from...Exploring the concept of death within Judaism may seem audacious,yet it is encouraged by the tradition of inquiry intrinsic to Jewish thought.Despite the caution urged by rabbinic authorities,Jewish texts ranging from the Torah to mystical writings offer rich perspectives on death,the soul,and the afterlife.This article examines how death is represented in Jewish belief and practice,considering diverse expressions from ritual law,poetic literature,Kabbalistic cosmology,and esoteric traditions.Emphasis is placed on ritual practices,mourning customs,and metaphysical understandings of the soul,including Sheol,Gehenna,and Eden.The evolution of these beliefs is explored through rabbinic,mystical,and popular sources,across historical and cultural contexts.展开更多
Dispersion measure in an FRB’s signal is produced by the photons of the radio waves interacting with the free electrons in the IGM. In New Tired Light (NTL), redshifts are produced by the photons of light interacting...Dispersion measure in an FRB’s signal is produced by the photons of the radio waves interacting with the free electrons in the IGM. In New Tired Light (NTL), redshifts are produced by the photons of light interacting with these self-same electrons and so, one would expect a direct relationship between the DM of an FRB and the redshift of the host galaxy. However, workers in this field assume expansion and weight the DM by dividing it by the scale factor (1 + z) to allow for expansion. Once this weighting is removed, it was predicted back in 2016 (when the first FRB was localized) and later presented at a conference and published in the proceedings that, as more FRB’s were localized, a graph of DM versus ln(1 + z) would be a straight line of gradient (mec/2hre) or 7.32 × 1025 m−2 in SI units. The original paper had twenty-four data points but this has risen significantly to sixty-four useable FRB’s and so this corrigendum updates that paper so that all sixty-four are used. The data give a straight-line graph of gradient 7.12 × 1025 m−2, a difference of 3% from (mec/2hre) predicted nine years earlier.展开更多
This paper critically re-examines the anthropocentric“Goldilocks Zone”paradigm that has dominated the search for extraterrestrial life.As of 2024,more than 5,500 exoplanets have been identified,yet only about 2%are ...This paper critically re-examines the anthropocentric“Goldilocks Zone”paradigm that has dominated the search for extraterrestrial life.As of 2024,more than 5,500 exoplanets have been identified,yet only about 2%are located within the traditionally defined habitable zone(National Aeronautics and Space Administration(NASA)Exoplanet Archive,2024;Kane et al.,2023).Moreover,the discovery of extremophiles-organisms thriving in high-radiation,extreme heat,or vacuum environments-demonstrates that the boundaries of life far exceed Earth-like conditions(Rothschild&Mancinelli,2001).展开更多
In the Turkish Economy,there were radical changes in the structure of the economy with the policies of opening up to the outside world and transition to a free market economy in the 1980s,and the last step of this ope...In the Turkish Economy,there were radical changes in the structure of the economy with the policies of opening up to the outside world and transition to a free market economy in the 1980s,and the last step of this opening up and liberalization process was realized with the decision number 32 in 1989.We can say that with the liberalization of capital movements in the 1990s,economic growth and development were tried to be achieved through hot money inflows rather than direct foreign investments.This trend made the economy more open to crises,and for the first time,a crisis occurred in the form of the 1994 economic crisis,which was understood to be caused by hot money.The same economic structure experienced a financial and economic crisis caused by hot money again in November 2000 and February 2001.While the crisis was overcome with the stand-by agreement made with the IMF(International Monetary Fund)and the announced Transition to a Strong Economy program,the economy started to grow rapidly with the ease of using foreign resources,and political stability seems to have enabled this economic growth process to continue uninterruptedly except 2009.There was also a decrease in inflation rates.The same economic structure continued in the period between 2010 and 2020,and the financing need of economic growth was met by outsourcing.However,this process was different from the previous decade and there was no economic and financial crisis other than the sudden increase in exchange rates in 2018.We can say that the sudden exchange rate increase in 2018 was perceived as a harbinger of possible exchange rate shocks in the following years.展开更多
Based on the Many Worlds Interpretation,I describe reality as a multilayer spacetime,where parallel layers play the role of alternative timelines.I link physics to ethics,arguing that one’s moral choices shape one’s...Based on the Many Worlds Interpretation,I describe reality as a multilayer spacetime,where parallel layers play the role of alternative timelines.I link physics to ethics,arguing that one’s moral choices shape one’s course in the multiverse.I consider one’s ethical decisions as decoherence events,leading to movement between alternative timelines,lighter(higher)or heavier(lower)realities.Sometimes in one’s curvilinear path in spacetime,one can even experience falling toward lower layers,slipping through wormholes.This theory supports free will and the simulation hypothesis.With this background,I explore the idea that a new theory of gravity might open new possibilities to shape matter and change our worldview through the invention of new technology,transforming information into waves and then into solid matter,paving the way for a new Multiverse Aeon for humanity.展开更多
Choline supports phospholipid synthesis,membrane integrity,neurotransmission,verylowdensity lipoprotein export,and one-carbon/epigenetic pathways,yet most United States adults fall short of adequate intake.Fatty liver...Choline supports phospholipid synthesis,membrane integrity,neurotransmission,verylowdensity lipoprotein export,and one-carbon/epigenetic pathways,yet most United States adults fall short of adequate intake.Fatty liver is now viewed as a mitochondrial-centric metabolic-inflammatory disorder;ethanol and excess linoleic acid(LA)can magnify bioenergetic stress when choline is insufficient to sustain phosphatidylcholine/phosphatidylethanolamine.This narrative review examines whether optimized choline delivery,alongside reduced exposure to mitochondrial toxicants,offers a rational therapeutic approach.Low choline intake associates with higher liver fat and aminotransferases.In rodents,choline deficiency combined with ethanol or LA lowers mitochondrial membrane potential,limitsβ-oxidation,and promotes steatosis and inflammation.Advanced formulations-especially citicoline-demonstrate favorable absorption and tissue choline delivery and may lessen trimethylamine-N-oxide formation versus free choline salts.Early,small human studies suggest that choline repletion,together with curtailed ethanol or dietary LA,can reduce intrahepatic triglyceride content and improve insulin sensitivity,though large randomized trials are lacking.Framing fatty liver as nutrition-modifiable mitochondrial toxicosis highlights correctable choline insufficiency when the liver is burdened by ethanol or excess LA.A dual strategy-using higher-bioavailability,gutmicrobial trimethylamineNoxide-sparing choline forms and mitigating mitochondrial toxicants-targets core bioenergetic defects,may reverse early steatosis,and warrants testing in adequately powered clinical trials.展开更多
Concerns about air quality in dental clinics where aerosol generation during procedures poses significant health risks,have prompted investigations on advanced disinfection technologies.This editorial describes the st...Concerns about air quality in dental clinics where aerosol generation during procedures poses significant health risks,have prompted investigations on advanced disinfection technologies.This editorial describes the strengths and limitations of ventilation and aerosol control measures in dental offices,especially with respect to the use of graphene nanocomposites.The potential of graphene nanocomposites as an innovative solution to aerosol-associated health risks is examined in this review due to the unique properties of graphene(e.g.,high con-ductivity,mechanical strength,and antimicrobial activity).These properties have produced promising results in various fields,but the application of graphene in dentistry remains unexplored.The recent study by Ju et al which was published in World Journal of Clinical Cases evaluated the effectiveness of graphene-based air disinfection systems in dental clinics.The study demonstrated that graphene-based disinfection techniques produced significant reductions in suspended particulate matter and bacterial colony counts,when co-mpared with traditional methods.Despite these positive results,challenges such as material saturation,frequency of filter replacement,and associated costs must be addressed before widespread adoption of graphene-based disinfection techniques in clinical practice.Therefore,there is need for further research on material structure optimization,long-term safety evaluations,and broader clinical applications,in order to maximize their positive impact on public health.展开更多
Cardiovascular disease(CVD)remains the leading cause of mortality worldwide despite major advances in prevention and treatment.The odd-chain saturated fatty acid pentadecanoic acid(C15:0),primarily obtained from dairy...Cardiovascular disease(CVD)remains the leading cause of mortality worldwide despite major advances in prevention and treatment.The odd-chain saturated fatty acid pentadecanoic acid(C15:0),primarily obtained from dairy fat,has been associated with cardiometabolic benefits.To summarize recent advances in understanding the role of pentadecanoic acid(C15:0)in CVD biology and risk,and to identify knowledge gaps and future research priorities.A narrative review was conducted,drawing on 115 PubMed-indexed studies on odd-chain fatty acids(OCFAs)and cardiovascular outcomes,as well as illustrative mechanistic studies of C15:0.This narrative review synthesized evidence from approximately 115 PubMed-indexed studies on OCFAs and cardiovascular outcomes,along with mechanistic studies of C15:0,identified through targeted searches in PubMed,Scopus,and Web of Science from January 2000 through May 2025.展开更多
The purpose of this qualitative inquiry is to explore Jesus Christ's teachings through the lens of the Spiritism Doctrine(SD),a relatively novel Christian religion.Further,SD literature is fundamentally rooted in ...The purpose of this qualitative inquiry is to explore Jesus Christ's teachings through the lens of the Spiritism Doctrine(SD),a relatively novel Christian religion.Further,SD literature is fundamentally rooted in the faith in the hereafter;the spirits'messages and teachings through mediums;Jesus Christ's teachings(the Gospel)as well as His behavior as a role model that must be followed by all human beings;and the practice of charity.Overall,the findings showed a rich body of knowledge,teachings,and lessons aiming to help the spiritual progress of humankind.That is,it was identified three larger themes,i.e.,mankind,who is Jesus,and His legacy,which shape a theoretical contribution of Jesus Christ's spiritual legacy in our lives.Jesus Christ carried out an authentic work-applied management through which He conveyed a new vision and superior values that continue inspiring us to change the way we think and behave.Furthermore,Jesus Christ's life and message may certainly help us handle the sensitive situations that may affect our lives on the planet,including the way our organizations and institutions are run as well as our professional careers are approached by inspiring new paths and wisdom behavior.展开更多
The strong association between human papillomavirus(HPV)infection and oropharyngeal squamous cell carcinoma(SCC)is well-documented,with p16 expression serving as a reliable predictor of HPV involvement.HPV-related tum...The strong association between human papillomavirus(HPV)infection and oropharyngeal squamous cell carcinoma(SCC)is well-documented,with p16 expression serving as a reliable predictor of HPV involvement.HPV-related tumors are characterized by distinct mechanisms affecting p16 and p53 protein pathways.However,the prevalence of HPV and the combined predictive utility of p16 and p53 expression in head and neck cutaneous SCC remain less explored,necessitating further research to understand their role in this subset of SCC.HPV,p16,and p53 statuses were determined using immunohistochemistry staining methods rather than more sensitive techniques such as polymerase chain reaction or HPV genotyping,limiting the ability to assess specific area HPV types poten-tially associated with prognosis.Further studies assessing multiple molecular markers in head and neck cutaneous patients will better predict the diverse outcomes and potentially the type of treatment targeted to those markers.展开更多
The evolution of human societal systems rarely manifests qualitative leaps or revolutionary transformations.More commonly observed are subtle,cumulative evolutionary processes characterized by smooth transitions of in...The evolution of human societal systems rarely manifests qualitative leaps or revolutionary transformations.More commonly observed are subtle,cumulative evolutionary processes characterized by smooth transitions of incremental developments.Such evolutionary trajectories can generally be described through quantitative change patterns within societal systems.Yet,what constitutes sustainable development in human society?How might sustainable development be articulated or operationalized?The Three Chains Theory under the framework of System Exchange Theory provides a preliminary exploration and analysis of these questions,offering tentative interpretations.展开更多
文摘Soft actuators have garnered substantial attention in current years in view of their potential appliances in diverse domains like robotics,biomedical devices,and biomimetic systems.These actuators mimic the natural movements of living organisms,aiming to attain enhanced flexibility,adaptability,and versatility.On the other hand,angle-independent structural color has been achieved through innovative design strategies and engineering approaches.By carefully controlling the size,shape,and arrangement of nanostructures,researchers have been able to create materials exhibiting consistent colors regardless of the viewing angle.One promising class of materials that holds great potential for bioinspired soft actuators is MXenes in view of their exceptional mechanical,electrical,and optical properties.The integration of MXenes for bioinspired soft actuators with angle-independent structural color offers exciting possibilities.Overcoming material compatibility issues,improving color reproducibility,scalability,durability,power supply efficiency,and cost-effectiveness will play vital roles in advancing these technologies.This perspective appraises the development of bioinspired MXene-centered soft actuators with angleindependent structural color in soft robotics.
文摘MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology,combining real-time biosensing,therapeutic capabilities,and user comfort in a single platform.These devices take the advantage of the exceptional electrical conductivity,mechanical flexibility,and biocompatibility of two-dimensional MXenes to enable noninvasive,tear-based monitoring of key physiological markers such as intraocular pressure and glucose levels.Recent developments focus on the integration of transparent MXene films into the conventional lens materials,allowing multifunctional performance including photothermal therapy,antimicrobial and anti-inflammation protection,and dehydration resistance.These innovations offer promising strategies for ocular disease management and eye protection.In addition to their multifunctionality,improvements in MXene synthesis and device engineering have enhanced the stability,transparency,and wearability of these lenses.Despite these advances,challenges remain in long-term biostability,scalable production,and integration with wireless communication systems.This review summarizes the current progress,key challenges,and future directions of MXene-based smart contact lenses,highlighting their transformative potential in next-generation digital healthcare and ophthalmic care.
文摘In this paper, the author proposes two methods of estimation of the regression coefficients whenthe errors are not distributed identically and independently and have a nonzero mean. The estimatesproved in this paper are shown to be strongly consistent and mean square consistent.
文摘As AI systems scale, the limitations of cloud-based architectures, including latency, bandwidth, and privacy concerns, demand decentralized alternatives. Federated learning (FL) and Edge AI provide a paradigm shift by combining privacy preserving training with efficient, on device computation. This paper introduces a cutting-edge FL-edge integration framework, achieving a 10% to 15% increase in model accuracy and reducing communication costs by 25% in heterogeneous environments. Blockchain based secure aggregation ensures robust and tamper-proof model updates, while exploratory quantum AI techniques enhance computational efficiency. By addressing key challenges such as device variability and non-IID data, this work sets the stage for the next generation of adaptive, privacy-first AI systems, with applications in IoT, healthcare, and autonomous systems.
文摘Oral cancer is one of the malignant neoplasms that present major global health challenge.It is the sixth most prevalent type of cancer in the world,with a high incidence and mortality rate.This letter is a review of the study by Yin et al which was published in the World Journal of Clinical Cases(2024).The study evaluated the effect of Tongluo Jiedu as an adjuvant treatment for oral cancer.Over the years,there has been a continuous search for effective and less invasive treatments for oral cancer.This article emphasizes and discusses various therapeutic options currently available,and it highlights that early intervention and multidisciplinary management are crucial for improving outcomes.Traditional Chinese medicine,particularly Tongluo Jiedu,presents potential complementary approach to co-nventional oral cancer therapies.Future research on Tongluo Jiedu should be focused on validation of its efficacy and safety through large,well-designed clinical trials,as well as better understanding of the molecular mechanisms in-volved,and optimization of therapeutic combinations.Additionally,continuous education of health professionals is key to the effective and safe integration of this traditional medicine into clinical practice.Continuous research is essential for optimization of therapeutic strategies and for addressing the challenges presented by this neoplasm.
文摘In the article“Deep Learning-Enhanced Brain Tumor Prediction via Entropy-Coded BPSO in CIELAB Color Space”by Mudassir Khalil,Muhammad Imran Sharif,Ahmed Naeem,Muhammad Umar Chaudhry,Hafiz Tayyab Rauf,Adham E.Ragab Computers,Materials&Continua,2023,Vol.77,No.2,pp.2031–2047.DOI:10.32604/cmc.2023.043687,URL:https://www.techscience.com/cmc/v77n2/54831,there was an error regarding the affiliation for the author Hafiz Tayyab Rauf.Instead of“Centre for Smart Systems,AI and Cybersecurity,Staffordshire University,Stoke-on-Trent,ST42DE,UK”,the affiliation should be“Independent Researcher,Bradford,BD80HS,UK”.
文摘In the article“A Lightweight Approach for Skin Lesion Detection through Optimal Features Fusion”by Khadija Manzoor,Fiaz Majeed,Ansar Siddique,Talha Meraj,Hafiz Tayyab Rauf,Mohammed A.El-Meligy,Mohamed Sharaf,Abd Elatty E.Abd Elgawad Computers,Materials&Continua,2022,Vol.70,No.1,pp.1617–1630.DOI:10.32604/cmc.2022.018621,URL:https://www.techscience.com/cmc/v70n1/44361,there was an error regarding the affiliation for the author Hafiz Tayyab Rauf.Instead of“Centre for Smart Systems,AI and Cybersecurity,Staffordshire University,Stoke-on-Trent,UK”,the affiliation should be“Independent Researcher,Bradford,BD80HS,UK”.
文摘At the point of death,a human being only has had the experience of nonexistence before birth and the experience of having lived his/her life after they were born.In the final analysis from the perspective of strict empiricism,the individual only has two options:the nonexistence before birth or the eventual reliving of one’s life.The return of one’s life is supported by the paradigm of a multiverse and an antimatter universe.This is atheism’s logical certainty.
文摘Exploring the concept of death within Judaism may seem audacious,yet it is encouraged by the tradition of inquiry intrinsic to Jewish thought.Despite the caution urged by rabbinic authorities,Jewish texts ranging from the Torah to mystical writings offer rich perspectives on death,the soul,and the afterlife.This article examines how death is represented in Jewish belief and practice,considering diverse expressions from ritual law,poetic literature,Kabbalistic cosmology,and esoteric traditions.Emphasis is placed on ritual practices,mourning customs,and metaphysical understandings of the soul,including Sheol,Gehenna,and Eden.The evolution of these beliefs is explored through rabbinic,mystical,and popular sources,across historical and cultural contexts.
文摘Dispersion measure in an FRB’s signal is produced by the photons of the radio waves interacting with the free electrons in the IGM. In New Tired Light (NTL), redshifts are produced by the photons of light interacting with these self-same electrons and so, one would expect a direct relationship between the DM of an FRB and the redshift of the host galaxy. However, workers in this field assume expansion and weight the DM by dividing it by the scale factor (1 + z) to allow for expansion. Once this weighting is removed, it was predicted back in 2016 (when the first FRB was localized) and later presented at a conference and published in the proceedings that, as more FRB’s were localized, a graph of DM versus ln(1 + z) would be a straight line of gradient (mec/2hre) or 7.32 × 1025 m−2 in SI units. The original paper had twenty-four data points but this has risen significantly to sixty-four useable FRB’s and so this corrigendum updates that paper so that all sixty-four are used. The data give a straight-line graph of gradient 7.12 × 1025 m−2, a difference of 3% from (mec/2hre) predicted nine years earlier.
文摘This paper critically re-examines the anthropocentric“Goldilocks Zone”paradigm that has dominated the search for extraterrestrial life.As of 2024,more than 5,500 exoplanets have been identified,yet only about 2%are located within the traditionally defined habitable zone(National Aeronautics and Space Administration(NASA)Exoplanet Archive,2024;Kane et al.,2023).Moreover,the discovery of extremophiles-organisms thriving in high-radiation,extreme heat,or vacuum environments-demonstrates that the boundaries of life far exceed Earth-like conditions(Rothschild&Mancinelli,2001).
文摘In the Turkish Economy,there were radical changes in the structure of the economy with the policies of opening up to the outside world and transition to a free market economy in the 1980s,and the last step of this opening up and liberalization process was realized with the decision number 32 in 1989.We can say that with the liberalization of capital movements in the 1990s,economic growth and development were tried to be achieved through hot money inflows rather than direct foreign investments.This trend made the economy more open to crises,and for the first time,a crisis occurred in the form of the 1994 economic crisis,which was understood to be caused by hot money.The same economic structure experienced a financial and economic crisis caused by hot money again in November 2000 and February 2001.While the crisis was overcome with the stand-by agreement made with the IMF(International Monetary Fund)and the announced Transition to a Strong Economy program,the economy started to grow rapidly with the ease of using foreign resources,and political stability seems to have enabled this economic growth process to continue uninterruptedly except 2009.There was also a decrease in inflation rates.The same economic structure continued in the period between 2010 and 2020,and the financing need of economic growth was met by outsourcing.However,this process was different from the previous decade and there was no economic and financial crisis other than the sudden increase in exchange rates in 2018.We can say that the sudden exchange rate increase in 2018 was perceived as a harbinger of possible exchange rate shocks in the following years.
文摘Based on the Many Worlds Interpretation,I describe reality as a multilayer spacetime,where parallel layers play the role of alternative timelines.I link physics to ethics,arguing that one’s moral choices shape one’s course in the multiverse.I consider one’s ethical decisions as decoherence events,leading to movement between alternative timelines,lighter(higher)or heavier(lower)realities.Sometimes in one’s curvilinear path in spacetime,one can even experience falling toward lower layers,slipping through wormholes.This theory supports free will and the simulation hypothesis.With this background,I explore the idea that a new theory of gravity might open new possibilities to shape matter and change our worldview through the invention of new technology,transforming information into waves and then into solid matter,paving the way for a new Multiverse Aeon for humanity.
文摘Choline supports phospholipid synthesis,membrane integrity,neurotransmission,verylowdensity lipoprotein export,and one-carbon/epigenetic pathways,yet most United States adults fall short of adequate intake.Fatty liver is now viewed as a mitochondrial-centric metabolic-inflammatory disorder;ethanol and excess linoleic acid(LA)can magnify bioenergetic stress when choline is insufficient to sustain phosphatidylcholine/phosphatidylethanolamine.This narrative review examines whether optimized choline delivery,alongside reduced exposure to mitochondrial toxicants,offers a rational therapeutic approach.Low choline intake associates with higher liver fat and aminotransferases.In rodents,choline deficiency combined with ethanol or LA lowers mitochondrial membrane potential,limitsβ-oxidation,and promotes steatosis and inflammation.Advanced formulations-especially citicoline-demonstrate favorable absorption and tissue choline delivery and may lessen trimethylamine-N-oxide formation versus free choline salts.Early,small human studies suggest that choline repletion,together with curtailed ethanol or dietary LA,can reduce intrahepatic triglyceride content and improve insulin sensitivity,though large randomized trials are lacking.Framing fatty liver as nutrition-modifiable mitochondrial toxicosis highlights correctable choline insufficiency when the liver is burdened by ethanol or excess LA.A dual strategy-using higher-bioavailability,gutmicrobial trimethylamineNoxide-sparing choline forms and mitigating mitochondrial toxicants-targets core bioenergetic defects,may reverse early steatosis,and warrants testing in adequately powered clinical trials.
文摘Concerns about air quality in dental clinics where aerosol generation during procedures poses significant health risks,have prompted investigations on advanced disinfection technologies.This editorial describes the strengths and limitations of ventilation and aerosol control measures in dental offices,especially with respect to the use of graphene nanocomposites.The potential of graphene nanocomposites as an innovative solution to aerosol-associated health risks is examined in this review due to the unique properties of graphene(e.g.,high con-ductivity,mechanical strength,and antimicrobial activity).These properties have produced promising results in various fields,but the application of graphene in dentistry remains unexplored.The recent study by Ju et al which was published in World Journal of Clinical Cases evaluated the effectiveness of graphene-based air disinfection systems in dental clinics.The study demonstrated that graphene-based disinfection techniques produced significant reductions in suspended particulate matter and bacterial colony counts,when co-mpared with traditional methods.Despite these positive results,challenges such as material saturation,frequency of filter replacement,and associated costs must be addressed before widespread adoption of graphene-based disinfection techniques in clinical practice.Therefore,there is need for further research on material structure optimization,long-term safety evaluations,and broader clinical applications,in order to maximize their positive impact on public health.
文摘Cardiovascular disease(CVD)remains the leading cause of mortality worldwide despite major advances in prevention and treatment.The odd-chain saturated fatty acid pentadecanoic acid(C15:0),primarily obtained from dairy fat,has been associated with cardiometabolic benefits.To summarize recent advances in understanding the role of pentadecanoic acid(C15:0)in CVD biology and risk,and to identify knowledge gaps and future research priorities.A narrative review was conducted,drawing on 115 PubMed-indexed studies on odd-chain fatty acids(OCFAs)and cardiovascular outcomes,as well as illustrative mechanistic studies of C15:0.This narrative review synthesized evidence from approximately 115 PubMed-indexed studies on OCFAs and cardiovascular outcomes,along with mechanistic studies of C15:0,identified through targeted searches in PubMed,Scopus,and Web of Science from January 2000 through May 2025.
文摘The purpose of this qualitative inquiry is to explore Jesus Christ's teachings through the lens of the Spiritism Doctrine(SD),a relatively novel Christian religion.Further,SD literature is fundamentally rooted in the faith in the hereafter;the spirits'messages and teachings through mediums;Jesus Christ's teachings(the Gospel)as well as His behavior as a role model that must be followed by all human beings;and the practice of charity.Overall,the findings showed a rich body of knowledge,teachings,and lessons aiming to help the spiritual progress of humankind.That is,it was identified three larger themes,i.e.,mankind,who is Jesus,and His legacy,which shape a theoretical contribution of Jesus Christ's spiritual legacy in our lives.Jesus Christ carried out an authentic work-applied management through which He conveyed a new vision and superior values that continue inspiring us to change the way we think and behave.Furthermore,Jesus Christ's life and message may certainly help us handle the sensitive situations that may affect our lives on the planet,including the way our organizations and institutions are run as well as our professional careers are approached by inspiring new paths and wisdom behavior.
文摘The strong association between human papillomavirus(HPV)infection and oropharyngeal squamous cell carcinoma(SCC)is well-documented,with p16 expression serving as a reliable predictor of HPV involvement.HPV-related tumors are characterized by distinct mechanisms affecting p16 and p53 protein pathways.However,the prevalence of HPV and the combined predictive utility of p16 and p53 expression in head and neck cutaneous SCC remain less explored,necessitating further research to understand their role in this subset of SCC.HPV,p16,and p53 statuses were determined using immunohistochemistry staining methods rather than more sensitive techniques such as polymerase chain reaction or HPV genotyping,limiting the ability to assess specific area HPV types poten-tially associated with prognosis.Further studies assessing multiple molecular markers in head and neck cutaneous patients will better predict the diverse outcomes and potentially the type of treatment targeted to those markers.
文摘The evolution of human societal systems rarely manifests qualitative leaps or revolutionary transformations.More commonly observed are subtle,cumulative evolutionary processes characterized by smooth transitions of incremental developments.Such evolutionary trajectories can generally be described through quantitative change patterns within societal systems.Yet,what constitutes sustainable development in human society?How might sustainable development be articulated or operationalized?The Three Chains Theory under the framework of System Exchange Theory provides a preliminary exploration and analysis of these questions,offering tentative interpretations.
