Nanomaterials with electroactive properties have taken a big leap for tissue repair and regeneration due to their unique physiochemical properties and biocompatibility.MXenes,an emerging class of electroactive materia...Nanomaterials with electroactive properties have taken a big leap for tissue repair and regeneration due to their unique physiochemical properties and biocompatibility.MXenes,an emerging class of electroactive materials have generated considerable interest for their biomedical applications from bench to bedside.Recently,the application of these two-dimensional wonder materials have been extensively investigated in the areas of bio-sensors,bioimaging and repair of electroactive organs,owing to their outstanding electromechanical properties,photothermal capabilities,hydrophilicity,and flexibility.The currently available data reports that there is sig-nificant potential to employ MXene nanomaterials for repair,regeneration and functioning of electroactive tis-sues and organs such as brain,spinal cord,heart,bone,skeletal muscle and skin.The current review is the first report that compiles the most recent advances in the application of MXenes in bioelectronics and the develop-ment of biomimetic scaffolds for repair,regeneration and functioning of electroactive tissues and organs including heart,nervous system,skin,bone and skeletal muscle.The content in this article focuses on unique features of MXenes,synthesis process,with emphasis on MXene-based electroactive tissue engineering con-structs,biosensors and wearable biointerfaces.Additionally,a section on the future of MXenes is presented with a focus on the clinical applications of MXenes.展开更多
基金supported by funding from the Canadian Institutes of Health Research(CIHR#PJT178254)Natural Sciences and Engineering Research Council of Canada(NSERC,RGPIN-2021-03951)to Dr.Sanjiv Dhingrasupport from the European Union’s Horizon Europe program under the Marie Sklodowska-Curie grant agreement No.101086184(MX-MAP).
文摘Nanomaterials with electroactive properties have taken a big leap for tissue repair and regeneration due to their unique physiochemical properties and biocompatibility.MXenes,an emerging class of electroactive materials have generated considerable interest for their biomedical applications from bench to bedside.Recently,the application of these two-dimensional wonder materials have been extensively investigated in the areas of bio-sensors,bioimaging and repair of electroactive organs,owing to their outstanding electromechanical properties,photothermal capabilities,hydrophilicity,and flexibility.The currently available data reports that there is sig-nificant potential to employ MXene nanomaterials for repair,regeneration and functioning of electroactive tis-sues and organs such as brain,spinal cord,heart,bone,skeletal muscle and skin.The current review is the first report that compiles the most recent advances in the application of MXenes in bioelectronics and the develop-ment of biomimetic scaffolds for repair,regeneration and functioning of electroactive tissues and organs including heart,nervous system,skin,bone and skeletal muscle.The content in this article focuses on unique features of MXenes,synthesis process,with emphasis on MXene-based electroactive tissue engineering con-structs,biosensors and wearable biointerfaces.Additionally,a section on the future of MXenes is presented with a focus on the clinical applications of MXenes.
