BACKGROUND Myotonic dystrophy(MD)is sometimes accompanied by metabolic/endocrine disorders,including dyslipidemia,central obesity,and hypogonadism.Due to considerable individual differences in the severity and progres...BACKGROUND Myotonic dystrophy(MD)is sometimes accompanied by metabolic/endocrine disorders,including dyslipidemia,central obesity,and hypogonadism.Due to considerable individual differences in the severity and progression of myopathy,MD patients with minimal-to-mild muscle symptoms might be followed as having other diseases,such as non-alcoholic fatty liver disease(NAFLD).CASE SUMMARY A 40-year-old non-obese man without a history of regular ethanol consumption was referred to our hospital due to persistent liver dysfunction and hyperlipidemia.His body mass index was 23.4 kg/m2.Liver histology demonstrated macrovesicular steatosis,ballooned hepatocytes with eosinophilic inclusion bodies,and perisinusoidal fibrosis,leading to the diagnosis of nonalcoholic steatohepatitis(NASH).Although he had no discernable muscle pain or weakness,persistently high serum creatine kinase(CK)and myoglobin levels as well as the presence of frontal baldness,a hatched face,history of cataract surgery,and grip myotonia indicated the possibility of MD.Southern blotting of the patient’s DNA revealed the presence of CTG repeats,confirming the diagnosis.CONCLUSION When gastroenterologists encounter NAFLD/NASH patients,serum CK should be verified.If hyperCKemia,frontal baldness,a hatched face,history of cataract surgery,and grip myotonia are noted,the possibility of MD may be considered.展开更多
Inulin is a soluble and indigestible fiber derived from natural plants such as Jerusalem artichoke (Helianthus tuberosus), “Kikuimo”. In the current study, a nutrigenomics approach was utilized to evaluate the in vi...Inulin is a soluble and indigestible fiber derived from natural plants such as Jerusalem artichoke (Helianthus tuberosus), “Kikuimo”. In the current study, a nutrigenomics approach was utilized to evaluate the in vivo function of “Kikuimo Extract” (KE) in ovariectomized cynomolgus macaque, a post-menopausal non-human primate model. KE was administered orally before feeding, for 3 months for the following examinations: 1) the effect of KE on intestinal microbes was examined by quantitative analyses of the intestinal bacteria using real-time PCR with DNA extracted from monkey feces;2) the effect of KE on gene expression was investigated by real-time RT-PCR using RNA extracted from both the liver and adipose tissue of the monkeys. KE administration modulated menopause-mediated altered microbes to increase Lactobacilli, Veillonella, and Bacteroides in all monkeys. KE administration regulated the altered expression of functional genes, SCAP, LDLR, and LXRA (lipid metabolism);GLUT-4 (glucose transport);CYP1A1 and CYP1A2 (drug metabolism);and CYP-17-2 and CYP-19-2 (E2 synthesis) in the menopausal monkeys. In menopausal monkeys, KE showed potent prebiotic effect on beneficial microflora and regulating effect on altered expression of functional genes associated with metabolism and E2 production. Thus, KE appears to be a practical functional food that alleviates the altered conditions of intestinal microbes and gene expression in the liver and adipose tissue in a menopausal state.展开更多
Extraskeletal osteosarcoma (ESO) is a rare malignant mesenchymal neoplasm accounting for 1% - 2% of all soft tissue sarcomas that produce osteoid, bone, and/or chondroid material. Here we report the first case of a re...Extraskeletal osteosarcoma (ESO) is a rare malignant mesenchymal neoplasm accounting for 1% - 2% of all soft tissue sarcomas that produce osteoid, bone, and/or chondroid material. Here we report the first case of a retroperitoneal ESO in a 35-year-old pregnant woman. A retroperitoneal ESO was incidentally found at cesarean section. Despite treatment, she rapidly died from wide spread dissemination. We focus on histological characteristics including immunohistochemical results and differential diagnosis of ESO.展开更多
This paper is concerned with statistical theory of turbulence by the late lamented Dr. Shunichi Tsugé.? The theory has been applied to the primary flow through a grid fixed vertically with respect to the horizont...This paper is concerned with statistical theory of turbulence by the late lamented Dr. Shunichi Tsugé.? The theory has been applied to the primary flow through a grid fixed vertically with respect to the horizontal axis of the wind tunnel.?The first analytical solution has been obtained and explained the well-known “the inverse-linear decay law” of the turbulent intensity.? It is believed that the present result is the first exact solution in the theory of turbulence.展开更多
Since internal residual stress in polymers causes dimension errors over time,a measurement method for residual stress in polymers,especially in opaque engineering plastics,is strongly required.In this study,we propose...Since internal residual stress in polymers causes dimension errors over time,a measurement method for residual stress in polymers,especially in opaque engineering plastics,is strongly required.In this study,we propose to utilize terahertz(THz)spectroscopy to non-destructively measure internal residual stress in polymers.To verify the validity of the proposed method,we manufactured polytetrafluoroethylene ring samples with and without residual stress,and studied them with THz time domain spectroscopy system.THz spectra of samples without residual stress showed almost no polarization difference,whereas spectra of samples with residual stress showed clear polarization difference.Dimension changes between the samples with and without residual stress were also estimated and it was found that the change had a correlation with THz polarization difference.These experimental analyses confirm the validity for the proposed non-destructive measurement of residual stress in polymer.展开更多
文摘BACKGROUND Myotonic dystrophy(MD)is sometimes accompanied by metabolic/endocrine disorders,including dyslipidemia,central obesity,and hypogonadism.Due to considerable individual differences in the severity and progression of myopathy,MD patients with minimal-to-mild muscle symptoms might be followed as having other diseases,such as non-alcoholic fatty liver disease(NAFLD).CASE SUMMARY A 40-year-old non-obese man without a history of regular ethanol consumption was referred to our hospital due to persistent liver dysfunction and hyperlipidemia.His body mass index was 23.4 kg/m2.Liver histology demonstrated macrovesicular steatosis,ballooned hepatocytes with eosinophilic inclusion bodies,and perisinusoidal fibrosis,leading to the diagnosis of nonalcoholic steatohepatitis(NASH).Although he had no discernable muscle pain or weakness,persistently high serum creatine kinase(CK)and myoglobin levels as well as the presence of frontal baldness,a hatched face,history of cataract surgery,and grip myotonia indicated the possibility of MD.Southern blotting of the patient’s DNA revealed the presence of CTG repeats,confirming the diagnosis.CONCLUSION When gastroenterologists encounter NAFLD/NASH patients,serum CK should be verified.If hyperCKemia,frontal baldness,a hatched face,history of cataract surgery,and grip myotonia are noted,the possibility of MD may be considered.
文摘Inulin is a soluble and indigestible fiber derived from natural plants such as Jerusalem artichoke (Helianthus tuberosus), “Kikuimo”. In the current study, a nutrigenomics approach was utilized to evaluate the in vivo function of “Kikuimo Extract” (KE) in ovariectomized cynomolgus macaque, a post-menopausal non-human primate model. KE was administered orally before feeding, for 3 months for the following examinations: 1) the effect of KE on intestinal microbes was examined by quantitative analyses of the intestinal bacteria using real-time PCR with DNA extracted from monkey feces;2) the effect of KE on gene expression was investigated by real-time RT-PCR using RNA extracted from both the liver and adipose tissue of the monkeys. KE administration modulated menopause-mediated altered microbes to increase Lactobacilli, Veillonella, and Bacteroides in all monkeys. KE administration regulated the altered expression of functional genes, SCAP, LDLR, and LXRA (lipid metabolism);GLUT-4 (glucose transport);CYP1A1 and CYP1A2 (drug metabolism);and CYP-17-2 and CYP-19-2 (E2 synthesis) in the menopausal monkeys. In menopausal monkeys, KE showed potent prebiotic effect on beneficial microflora and regulating effect on altered expression of functional genes associated with metabolism and E2 production. Thus, KE appears to be a practical functional food that alleviates the altered conditions of intestinal microbes and gene expression in the liver and adipose tissue in a menopausal state.
文摘Extraskeletal osteosarcoma (ESO) is a rare malignant mesenchymal neoplasm accounting for 1% - 2% of all soft tissue sarcomas that produce osteoid, bone, and/or chondroid material. Here we report the first case of a retroperitoneal ESO in a 35-year-old pregnant woman. A retroperitoneal ESO was incidentally found at cesarean section. Despite treatment, she rapidly died from wide spread dissemination. We focus on histological characteristics including immunohistochemical results and differential diagnosis of ESO.
文摘This paper is concerned with statistical theory of turbulence by the late lamented Dr. Shunichi Tsugé.? The theory has been applied to the primary flow through a grid fixed vertically with respect to the horizontal axis of the wind tunnel.?The first analytical solution has been obtained and explained the well-known “the inverse-linear decay law” of the turbulent intensity.? It is believed that the present result is the first exact solution in the theory of turbulence.
基金This study was supported by A-STEP program,Japan Science and Technology Agency(JST)Supporting Industry program.Ministry of Economy,Trade and Industry(METI).
文摘Since internal residual stress in polymers causes dimension errors over time,a measurement method for residual stress in polymers,especially in opaque engineering plastics,is strongly required.In this study,we propose to utilize terahertz(THz)spectroscopy to non-destructively measure internal residual stress in polymers.To verify the validity of the proposed method,we manufactured polytetrafluoroethylene ring samples with and without residual stress,and studied them with THz time domain spectroscopy system.THz spectra of samples without residual stress showed almost no polarization difference,whereas spectra of samples with residual stress showed clear polarization difference.Dimension changes between the samples with and without residual stress were also estimated and it was found that the change had a correlation with THz polarization difference.These experimental analyses confirm the validity for the proposed non-destructive measurement of residual stress in polymer.
